Research output per year
Research output per year
Cand. pharm., PhD
Universitetsparken 2
2100 København Ø
Research activity per year
The Receptor Structural Biology group is focusing on structural studies of receptors and their interactions with drugs and tool compounds at the molecular level. The structural information is being used in drug design together with medicinal chemists and pharmacologists, through national and international collaboration.
The research is centered around ionotropic glutamate receptors (iGluRs) and G protein-coupled receptors (GPCRs).
iGluRs are involved in fast synaptic transmission in the central nervous system. These receptors are important for memory and learning, but also involved in severe diseases, e.g. Alzheimer’s disease and epilepsy. The group is one of the leading groups in structural biology of iGluRs and has determined more than 100 structures.
Since 2015, the group has also worked on structural studies of GPCRs as a collaboration with Professor David Gloriam. GPCRs are targets for ~35% of all approved drugs.
February 2022
Brief Research CV: Jette Sandholm Kastrup
Work address: Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 152, DK-2100 CPH Ø, Denmark
Phone: +45 3533 6486; E-mail: [email protected]
Academic Degrees
1980: Studentereksamen (General Certificate of Education A-level) from Holstebro Gymnasium
1986: M.Sc. (pharm.), The Royal Danish School of Pharmacy (RDSP). June 3
1988: PhD (Industrial PhD, Erhvervsforsker). September 23. Cheminova A/S and RDSP
Current and previous positions
1981-1982: 11 Months work experience at Tårnby Apotek
1982-1986: Periodic substitute at Tårnby Apotek
1986-1988: Industrial PhD student (Erhvervsforsker). RDSP & Cheminova Agro
1988: Teaching assistant. Dept. of Organic Chemistry, RDSP (3 months)
1989-1992: Post doc. Dept. of Medicinal Chemistry, RDSP
1993-1994: Senior scientist. Dept. of Medicinal Chemistry, RDSP
1995-2008: Associate professor. Dept. of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences (DUPS)
2008-2016: Professor (MSO) in structure-based drug design. Dept. of Drug Design and Pharmacology (ILF), The Faculty of Health and Medical Sciences, University of Copenhagen
2016-present: Professor in experimental structure-based drug design. ILF, KU
2019-present: Deputy head of ILF, KU with focus on research
Research prizes
45.000 kr. from ”Valborg and Edith Larsens Foundation" 2005
20.000 kr from the Faculty of Pharmaceuitcal Sciences, University of Copenhagen 2007
Major Responsibilities
1999-2002: Member of Board, the Dansync Center for synchrotron radiation
2002-2008: Member of departmental board, Dept. of Medicinal Chemistry, DUPS
2004-2008: Deputy Head of Dept. of Medicinal Chemistry. DUPS and the Faculty of Pharmaceutical Sciences, University of Copenhagen
2004-2006: Member of Academic Council, DUPS
2005-2007: Member of scientific committee, Dept. of Medicinal Chemistry, DUPS
2007-2011: Member of Academic Council, Faculty of Pharmaceutical Sciences, University of Copenhagen
2007: Appointed director of Drug Research Academy, an industry-oriented research education programme at the Faculty of Pharmaceutical Sciences, University of Copenhagen (August-October)
2007-2012: Director of Drug Research Academy, an industry-oriented research education programme at the Faculty of Pharmaceutical Sciences, University of Copenhagen
2008-2013: Head of GluTarget, project within the Programme of Excellence at the University of Copenhagen. 24.5 mio. kr. Project title: Ionotropic glutamate receptors as targets for structure-based drug research: A multidisciplinary programme in structural biology, chemical biology, medicinal chemistry, molecular pharmacology and ex vivo/in vivo pharmacology
2010-2012: Member of board, SHARE's Cross Faculty PhD Initiative, University of Copenhagen
2010-2012: Coordinator of mobility PhD grant on project “Ion channel receptors in brain diseases”
2012: Member of Academic Council, Faculty of Health and Medical Sciences, University of Copenhagen
2012-2018: Member of Research and Innovation Committee, Dept. of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen
2015-2020: Appointed Member of The Danish Council for Independent Research, Natural Sciences (FNU) by the Minister for Higher Education and Science
2016-2018: Member of the PIPPI Advisory Board, an Innovative Training Network (ITN) funded under the European Horizon 2020 programme, DTU.
2017-2020: Member of the Executive Committee, Independent Research Fund Denmark, Natural Sciences (FNU)
2019: Appointed Head of Research Cluster on Neuroprotection, ILF, KU (April-August)
2019-: Deputy Head of Department (ILF, KU) with focus on Research, from September
2019-: Head of Research Committee at ILF, KU, from September
Supervision of PhD students and post docs
February 2022
Brief Teaching CV: Jette Sandholm Kastrup
Work address: Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 162, DK-2100 CPH Ø, Denmark
Phone: +45 3533 6486; E-mail: [email protected]
Teaching at undergraduate courses 1988-2021
Introduction to study (1. semester: lectures, lab courses, project work, planning and evaluation)
Organic chemistry (1.-3. semester: teaching in class-room, lab courses, planning and evaluation)
Biochemistry (2. semester: lectures)
Bioorganic chemistry (3. semester: lectures)
Interdisciplinary course (5. semester: project work)
Basic drug design and discovery (6. or 7. semester: lectures, exams, planning and evaluation)
Bioinformatics and structural biology (7. semester: lectures, computer workshops, exams, planning and evaluation)
Medicinal and biostructural chemistry (7. semester: lectures, computer workshops, teaching in class-room, exams, planning and evaluation)
Structural chemistry (9. semester: lectures, computer workshops, project supervisions, exams, planning and evaluation)
Structural and computational medicinal chemistry (9. semester: lectures, computer workshops, project supervisions, planning and evaluation)
Individualized study unit 2018 (7.5 ECTS; Structural study of the GluA2 ligand-binding domain in complex with the allosteric modulator TDPAM01)
Individualized study unit 2018 (30 ECTS; Structural study of the GluA2 ligand-binding domain in complex with allosteric modulators named TDPAMs)
Individualized study unit 2019 (7.5 ECTS; Structural study of the GluA2 ligand-binding domain in complex with a positive allosteric modulator)
Teaching at PhD courses 1994-2021
Advanced Medicinal Chemistry and Drug Design, Royal Danish School of Pharmacy, 1994-1998 (lectures and workshop)
Cross-Institutional PhD Course on Molecular Biophysics, Royal Danish School of Pharmacy, 2000 (lecture)
Drug Design and Discovery, Royal Danish School of Pharmacy, 1999-2000 (lectures).
Protein Structure and Interaction, Panum Institute, 1995 (lecture)
Advanced Structural Chemistry and Molecular Modelling, Royal Danish School of Pharmacy, 1994-2001 and Danish University of Pharmaceutical Sciences, 2002-2007 (lectures, computer workshops, planning and evaluation)
Analytical Challenges in the Formulation Design of Pharmaceutical Proteins, Royal Danish School of Pharmacy, 2002 and Faculty of Pharmaceutical Sciences, University of Copenhagen 2007, 2009, 2011 and 2013 (lectures)
Biostructures and Molecular Modeling in Drug Research, Faculty of Pharmaceutical Sciences, University of Copenhagen, 2008, 2009 and 2011 (lectures, computer workshops, planning and evaluation)
Receptor Structure and Function, Royal Danish School of Pharmacy, 1999-2001, Danish University of Pharmaceutical Sciences, 2002-2006, Faculty of Pharmaceutical Sciences, University of Copenhagen, 2007-2011 and Faculty of Health and Medical Sciences, University of Copenhagen 2012-2021 (course director, lectures, workshops, exams, planning and evaluation)
Biostructures and Molecular Modeling in Drug Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2012-2017 (lectures; discussion facilitator in 2014)
Analytical Methodology in Protein Formulation Development, Faculty of Health and Medical Sciences, University of Copenhagen, 2018 and 2021 (lectures)
Scientific project planning and management 2 - Project and Career planning, Faculty of Health and Medical Sciences, University of Copenhagen, 2018 and 2019 (lectures)
Training of high school teachers in biotechnology 2010-2012
Course on Biostructure and Biofunction, 2010, 2011 and 2012 (in total 8 one-day courses including lectures, lab exercises, computer exercises, planning and evaluation – more than 200 teachers)
Research dissemination
”Lægemidler mod hjernens sygdomme”. Lectures offered to high school students.
Science in the city festival, Copenhagen June 2014: Science slammer and researcher at exhibition.
Examiner
- at several national and international BSc and MSc project work and Ph.D. defenses, 1997-2022.
Courses on pedagogy
Pedagogic Course, Royal Danish School of Pharmacy, June 1993
Mentor seminar, 2001
Course on supervision of PhD students (PUMA course 1562), University of Copenhagen, Nov. 2009
Course for academic advisors at LIFE, FARMA, SCIENCE AND HEALTH, Department of Science Education (DSE), Faculty of Science, University of Copenhagen, April 15, 2011
English language competence assessment for lecturers at FARMA, course at the Faculty of Pharmaceutical Sciences, University of Copenhagen, December 2011
Course on Responsible Conduct of Research for Academic Staff, University of Copenhagen, April 16, 2015
Course for Department Supervisors, Department of Science Education, KU, 2017
Course for Department Supervisors, Department of Science Education. KU, October 31, 2019
Participation in seminars on pedagogy arranged by the Royal Danish School of Pharmacy, the Danish University of Pharmaceutical Sciences and the University of Copenhagen
Committees
Member of committee for pedagogy/education, Royal Danish School of Pharmacy: 1996-1999
Member of IT political contact organ for university institutions: 1998
Mentor for pedagogy/education, Royal Danish School of Pharmacy: 2001-2002; Danish University of Pharmaceutical Sciences: 2002-2006; Faculty of Pharmaceutical Sciences, University of Copenhagen: 2007-2011; and Faculty of Health and Medical Sciences: 2012-2013, 2019; 2021-2022 (training on teaching as part of course for post docs/assistant professors)
Member of committee concerning toxicology and work environment, Royal Danish School of Pharmacy: 2000-2002
Member of committee concerning internship period at a community (or hospital) pharmacy, Danish University of Pharmaceutical Sciences: 2003
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Review › Research › peer-review
Jette Sandholm Jensen Kastrup (Lecturer)
Activity: Talk or presentation types › Lecture and oral contribution