Jette Sandholm Jensen Kastrup

Research output

Research output per year 1990 1997 2004 2005 2006 2007 2008 2009 2011 2012 2013 2014 2015 2016 2017 2024 2024

• 4442 Citations
• 145 Journal article
• 3 Dataset
• 2 Poster
• 2 Comment/debate
• 6 More
  • 2 Conference abstract in journal
  • 2 Review
  • 1 Book chapter
  • 1 Other contribution

Research output per year

Research output per year

Search results

• 2024

  Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spanning positive allosteric modulator BPAM538

  Bay, Y., Cabello, F. J. M., Koens, C. C., Frantsen, S. M., Pickering, D. S., Frydenvang, K., Francotte, P., Pirotte, B., Kristensen, A. S., Bowie, D. & Kastrup, J. S., 2024, In: Journal of Structural Biology. 216, 3, 9 p., 108113.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  1 Downloads (Pure)

• Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators

  Francotte, P., Bay, Y., Goffin, E., Colson, T., Lesenfants, C., Dorosz, J., Laulumaa, S., Fraikin, P., de Tullio, P., Beaufour, C., Botez, I., Pickering, D. S., Frydenvang, K., Danober, L., Kristensen, A. S., Kastrup, J. S. & Pirotte, B., 2024, In: European Journal of Medicinal Chemistry. 264, 15 p., 116036.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking, and modulation of kinase activity

  Narayanan, D., Larsen, A. S. G., Gauger, S. J., Adafia, R., Hammershøi, R. B., Hamborg, L., Bruus-Jensen, J., Griem-Krey, N., Gee, C. L., Frølund, B., Stratton, M. M., Kuriyan, J., Kastrup, J. S., Langkilde, A. E., Wellendorph, P. & Solbak, S. M. Ø., 2024, In: Protein science : a publication of the Protein Society. 33, 10, 17 p., e5152.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  2 Downloads (Pure)

• Recovery from desensitization in GluA2 AMPA receptors is affected by a single mutation in the N-terminal domain interface

  Larsen, A. H., Perozzo, A. M., Biggin, P. C., Bowie, D. & Kastrup, J. S., 2024, In: Journal of Biological Chemistry. 300, 3, 10 p., 105717.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  1 Citation (Scopus)

  8 Downloads (Pure)

• Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure

  Bay, Y., Venskutonytė, R., Frantsen, S. M., Thorsen, T. S., Musgaard, M., Frydenvang, K., Francotte, P., Pirotte, B., Biggin, P. C., Kristensen, A. S., Boesen, T., Pickering, D. S., Gajhede, M. & Kastrup, J. S., 2024, In: FEBS Journal. 291, 7, p. 1506-1529

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2

  Bay, Y., Egeberg Jeppesen, M., Frydenvang, K., Francotte, P., Pirotte, B., Pickering, D. S., Kristensen, A. S. & Kastrup, J. S., 2024, In: FEBS Letters. 598, 7, p. 743-757

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  1 Citation (Scopus)

  6 Downloads (Pure)
• 2023

  Differences between the GluD1 and GluD2 receptors revealed by GluD1 X-ray crystallography, binding studies and molecular dynamics

  Masternak, M., Koch, A., Laulumaa, S., Tapken, D., Hollmann, M., Jørgensen, F. S. & Kastrup, J. S., 2023, In: F E B S Journal. 290, 15, p. 3781-3801

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  7 Citations (Scopus)

  23 Downloads (Pure)
• 2022

  Structural basis for positive allosteric modulation of AMPA and kainate receptors

  Frydenvang, K., Pickering, D. S. & Kastrup, J. S., 2022, In: The Journal of Physiology. 600, 2, p. 181-200

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  16 Citations (Scopus)

  12 Downloads (Pure)
• 2021

  Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2

  Krintel, C., Dorosz, J., Larsen, A. H., Thorsen, T. S., Venskutonytė, R., Mirza, O., Gajhede, M., Boesen, T. & Kastrup, J. S., 2021, In: The FEBS Journal. 288, p. 995-1007 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors

  Etsè, K. S., Dorosz, J., McLain Christensen, K., Thomas, J. Y., Botez Pop, I., Goffin, E., Colson, T., Lestage, P., Danober, L., Pirotte, B., Kastrup, J. S. & Francotte, P., 2021, In: ACS Chemical Neuroscience. 12, 14, p. 2679-2692

  Research output: Contribution to journal › Journal article › Research › peer-review

  File
  11 Citations (Scopus)
• 2020

  Ionotropic glutamate receptor GluA2 in complex with bicyclic pyrimidinedione-based compounds: when small compound modifications have distinct effects on binding interactions

  Frydenvang, K., Pickering, D. S., Kshirsagar, G. U., Chemi, G., Gemma, S., Sprogøe, D., Kærn, A. M., Brogi, S., Campiani, G., Butini, S. & Kastrup, J. S., 2020, In: ACS Chemical Neuroscience. 11, 12, p. 1791-1800

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)
• 2019

  Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor

  Laulumaa, S., Hansen, K. V., Masternak, M., Drapier, T., Francotte, P., Pirotte, B., Frydenvang, K. & Kastrup, J. S., 14 Mar 2019, In: ACS Medicinal Chemistry Letters. 10, 3, p. 243-247 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  7 Citations (Scopus)

• N-(7-(1H-imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide - a new kainate receptor selective antagonist and analgesic: Synthesis, X-ray crystallography, structure-affinity relationships, in vitro and in vivo pharmacology

  Møllerud, S., Hansen, R. B., Pallesen, J. S., Temperini, P., Pasini, D., Bornholdt, J., Nielsen, B., Mamedova, E., Chalupnik, P., Paternain, A. V., Lerma, J., Del Castillo, M. D., Andreasen, J. T., Frydenvang, K., Kastrup, J. S., Johansen, T. N. & Pickering, D. S., 2019, In: ACS Chemical Neuroscience. 10, p. 4685-4695 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships and in vitro Pharmacology

  Pallesen, J. S., Møllerud, S., Frydenvang, K. A., Pickering, D. S., Bornholt, J., Nielsen, B., Pasini, D., Han, L., Marconi, L., Kastrup, J. S. J. & Johansen, T. N., 20 Mar 2019, In: A C S Chemical Neuroscience. 10, p. 1841-1853 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)

• Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors

  Dawe, G. B., Kadir, M. F., Venskutonyte, R., Perozzo, A. M., Yan, Y., Alexander, R. P. D., Navarrete, C., Santander, E. A., Arsenault, M., Fuentes, C., Aurousseau, M. R. P., Frydenvang, K., Barrera, N. P., Kastrup, J. S., Edwardson, J. M. & Bowie, D., 5 Jun 2019, In: Neuron. 102, 5, p. 976-+

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)

• Use of the 4-Hydroxy-Triazole Moiety as a Bioisosteric Tool for the Development of Ionotropic Glutamate Receptor Ligands

  Sainas, S., Temperini, P., Farnsworth, J. C., Yi, F., Møllerud, S., Jensen, A. A., Nielsen, B., Kastrup, J. S. J., Hansen, K. B., Boschi, D., Pickering, D. S., Clausen, R. P. & Lolli, M., 2019, In: Journal of Medicinal Chemistry. 62, p. 4467-4482

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  20 Citations (Scopus)
• 2018

  (S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements, Structural and Biological Investigation.

  Brogi, S., Brindisi, M., Butini, S., Kshirsagar, G., Maramai, S., Chemi, G., Gemma, S., Campiani, G., Novellino, E., Fiorenzani, P., Pinassi, J., Aloisi, A. M., Gynther, M., Venskutonyte, R., Han, L., Frydenvang, K. A., Kastrup, J. S. J. & Pickering, D. S., 8 Mar 2018, In: Journal of Medicinal Chemistry. 61, 5, p. 2124-2130 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)

• 7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

  Goffin, E., Drapier, T., Larsen, A. P., Geubelle, P., Ptak, C. P., Laulumaa, S., Rovinskaja, K., Gilissen, J., Tullio, P. D., Olsen, L., Frydenvang, K., Pirotte, B., Hanson, J., Oswald, R. E., Kastrup, J. S. & Francotte, P., Jan 2018, In: Journal of Medicinal Chemistry. 61, 1, p. 251–264

  Research output: Contribution to journal › Journal article › Research › peer-review
  40 Citations (Scopus)

• Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds

  Drapier, T., Geubelle, P., Bouckaert, C., Nielsen, L., Laulumaa, S., Goffin, E., Dilly, S., Francotte, P., Hanson, J., Pochet, L., Kastrup, J. S. & Pirotte, B., 28 Jun 2018, In: Journal of Medicinal Chemistry. 61, 12, p. 5279-5291 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  40 Citations (Scopus)

• Invisible detergents for structure determination of membrane proteins by small-angle neutron scattering

  Midtgaard, S. R., Darwish, T. A., Pedersen, M. C., Huda, P., Larsen, A. H., Jensen, G. V., Kynde, S. A. R., Skar-Gislinge, N., Nielsen, A. J. Z., Olesen, C., Blaise, M., Dorosz, J. J., Thorsen, T. S., Venskutonytė, R., Krintel, C., Møller, J. V., Frielinghaus, H., Gilbert, E. P., Martel, A., Kastrup, J. S. J. & 3 others, Jensen, P. E., Nissen, P. & Arleth, L., Jan 2018, In: F E B S Journal. 285, 2, p. 357-371 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  File
  41 Citations (Scopus)

• Small-angle neutron scattering studies on the AMPA receptor GluA2 in the resting, AMPA-bound and GYKI-53655-bound states

  Larsen, A. H., Dorosz, J., Thorsen, T. S., Johansen, N. T., Darwish, T., Midtgaard, S. R., Arleth, L. & Kastrup, J. S., Nov 2018, In: IUCrJ. 5, p. 780-793

  Research output: Contribution to journal › Journal article › Research › peer-review

  File
  7 Citations (Scopus)
• 2017

  Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid

  Krogsgaard-Larsen, N., Delgar, C., Koch, K., Brown, P. M. G. E., Møller, C., Han, L., Huynh, T. H. V., Hansen, S. W., Nielsen, B., Bowie, D., Pickering, D. S., Kastrup, J. S. J., Frydenvang, K. A. & Bunch, L., 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 441-457 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors

  Larsen, A. P., Fièvre, S., Frydenvang, K., Francotte, P., Pirotte, B., Kastrup, J. S. & Mulle, C., Jun 2017, In: Molecular Pharmacology. 91, 6, p. 576-585 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• Lessons from crystal structures of kainate receptors

  Møllerud, S., Frydenvang, K. A., Pickering, D. S. & Kastrup, J. S. J., 1 Jan 2017, In: Neuropharmacology. 112, Part A, p. 16-28 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  42 Citations (Scopus)

• Pharmacology and crystal structure of novel 2,3-quinoxalinediones at kainate receptors

  Møllerud, S., Pallesen, J. S., Pasini, D., Marconi, L., Han, L., Bornholt, J., Johansen, T. N., Kastrup, J. S., Pickering, D. S. & Frydenvang, K. A., Aug 2017, In: Journal of Neurochemistry. 142, S1, p. 124 1 p., MTU07-13.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• Structure and affinity of two bicyclic glutamate analogues at AMPA and kainate receptors

  Møllerud, S., Pinto, A., Marconi, L., Frydenvang, K. A., Thorsen, T. S., Laulumaa, S. K., Venskutonyte, R., Winther, N., Cunado Moral, A. M., Tamborini, L., Conti, P., Pickering, D. S. & Kastrup, J. S. J., 2017, In: A C S Chemical Neuroscience. 8, 9, p. 2056-2064 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region

  Tapken, D., Steffensen, T. B., Leth, R., Kristensen, L. B., Gerbola, A., Gajhede, M., Jørgensen, F. S., Olsen, L. & Kastrup, J. S., 7 Apr 2017, In: Scientific Reports. 7, 12 p., 46145.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  17 Citations (Scopus)

  214 Downloads (Pure)

• The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1

  Meno, K. H., Kastrup, J. S., Kuo, I-C., Chua, K. Y. & Gajhede, M., 1 Apr 2017, In: Allergy. 72, 4, p. 665-670 6 p., 13111.

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)
• 2016

  A parallel panning scheme used for selection of a GluA4-specific Fab targeting the ligand-binding domain

  Clausen, R. P., Mohr, A. Ø., Riise, E., Jensen, A. A., Gill, A., Madden, D. R., Kastrup, J. S. & Skottrup, P. D., 8 Jul 2016, In: International Journal of Biological Macromolecules. 92, p. 779-787 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• A pharmacological profile of the high-affinity GluK5 kainate receptor

  Møllerud, S., Kastrup, J. S. J. & Pickering, D. S., 2016, In: European Journal of Pharmacology. 788, p. 315-320 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)

• Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2

  Krintel, C., Francotte, P., Pickering, D. S., Juknaite, L., Pøhlsgaaard, J., Olsen, L., Frydenvang, K. A., Goffin, E., Pirotte, B. & Kastrup, J. S. J., 2016, In: Biophysical Journal. 110, 11, p. 2397-2406 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

  Kristensen, A. S., Hansen, K. B., Naur, P., Olsen, L., Kurtkaya, N. L., Dravid, S. M., Kvist, T., Yi, F., Pøhlsgaard, J., Clausen, R. P., Gajhede, M., Kastrup, J. S. & Traynelis, S. F., Feb 2016, In: Molecular Pharmacology. 89, 2, p. 253-262 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)

• Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate

  Kristensen, O., Kristensen, L. B., Møllerud, S., Frydenvang, K. A., Pickering, D. S. & Kastrup, J. S. J., 2016, In: Structure. 24, 9, p. 1582-1589 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors

  Szymanska, E., Frydenvang, K. A., Pickering, D. S., Krintel, C., Nielsen, B., Kooshki, A., Zachariassen, L. G., Olsen, L., Kastrup, J. S. J. & Johansen, T. N., 2016, In: Journal of Medicinal Chemistry. 59, 1, p. 448-461 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)

• Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors

  Larsen, A. P., Francotte, P., Frydenvang, K., Tapken, D., Goffin, E., Fraikin, P., Caignard, D-H., Lestage, P., Danober, L., Pirotte, B. & Kastrup, J. S., 16 Mar 2016, In: A C S Chemical Neuroscience. 7, 3, p. 378-90 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• Tweaking subtype-selectivity and agonist efficacy at (S)-2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) receptors in a small series of BnTetAMPA analogues

  Wang, S-Y., Larsen, Y., Navarrete, C. V., Jensen, A. A., Nielsen, B., Al-Musaed, A., Frydenvang, K., Kastrup, J. S., Pickering, D. S. & Clausen, R. P., 2016, In: Journal of Medicinal Chemistry. 59, 5, p. 2244-2254 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)
• 2015

  Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity

  Shahsavar, A., Ahring, P. K., Olsen, J. A., Krintel, C., Kastrup, J. S., Balle, T. & Gajhede, M., Oct 2015, In: Molecular Pharmacology. 88, 4, p. 697-707 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures

  Christiansen, G. B., Harbak, B., Hede, S. E., Gouliaev, A. H., Olsen, L., Frydenvang, K., Egebjerg, J., Kastrup, J. S. & Holm, M. M., 3 Dec 2015, In: Neuroscience. 310, p. 709-22 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1

  Demmer, C. S., Møller, C., Brown, P. M. G. E., Han, L., Pickering, D. S., Nielsen, B., Bowie, D., Frydenvang, K., Kastrup, J. S. & Bunch, L., 9 Apr 2015, In: A C S Chemical Neuroscience. 6, p. 845-854 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface

  Ahring, P. K., Olsen, J. A., Nielsen, E. Ø., Peters, D., Pedersen, M. H. F., Rohde, L. A., Kastrup, J. S. J., Shahsavar, A., Indurthi, D. C., Chebib, M., Gajhede, M. & Balle, T., 2015, In: Neuropharmacology. 92, p. 135-45 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)

• Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine Binding Protein as a Structural Surrogate

  Shahsavar, A., Gajhede, M., Kastrup, J. S. & Balle, T., 17 Nov 2015, In: Basic & Clinical Pharmacology & Toxicology Online. 118, 6, p. 399–407 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  37 Citations (Scopus)

• Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid

  Krogsgaard-Larsen, N., Storgaard, M., Møller, C., Demmer, C. S., Hansen, J., Han, L., Monrad, R. N., Nielsen, B., Tapken, D., Pickering, D. S., Kastrup, J. S., Frydenvang, K. & Bunch, L., 2015, In: Journal of Medicinal Chemistry. 58, 15, p. 6131-50 20 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)
• 2014

  L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain

  Krintel, C., Frydenvang, K., Ceravalls de Rabassa, A., Kaern, A. M., Gajhede, M., Pickering, D. S. & Kastrup, J. S., 27 Mar 2014, In: F E B S Journal. p. 2422–2430 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)

• Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors

  Olsen, J. A., Balle, T., Gajhede, M., Ahring, P. K. & Kastrup, J. S. J., 17 Mar 2014, In: PLOS ONE. 9, 3, p. e91232 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  35 Citations (Scopus)

• Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain

  Venskutonyte, R., Larsen, A. P., Frydenvang, K. A., Gajhede, M., Gefflaut, T., Pickering, D. S., Bunch, L. & Kastrup, J. S. J., 2014, In: ChemMedChem. 9, 10, p. 2254-2259 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides

  Francotte, P., Nørholm, A-B., Deva, T., Olsen, L., Frydenvang, K., Goffin, E., Fraikin, P., de Tullio, P., Challal, S., Thomas, J-Y., Iop, F., Louis, C., Botez-Pop, I., Lestage, P., Danober, L., Kastrup, J. S. J. & Pirotte, B., 26 Nov 2014, In: Journal of Medicinal Chemistry. 57, 22, p. 9539-53 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)

• Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors

  Olsen, J. A., Ahring, P. K., Kastrup, J. S. J., Gajhede, M. & Balle, T., 5 Sep 2014, In: The Journal of Biological Chemistry. 289, 36, p. 24911-21 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  34 Citations (Scopus)

• Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain: Combining Experimental and Computational Methods Unravels Differences in Driving Forces

  Nørholm, A-B., Francotte, P., Goffin, E., Botez, I., Danober, L., Lestage, P., Pirotte, B., Kastrup, J. S. J., Olsen, L. & Oostenbrink, C., 22 Dec 2014, In: Journal of Chemical Information and Modeling. 54, 12, p. 3404-16 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)
• 2013

  Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

  Assaf, Z., Larsen, A. P., Venskutonyte, R., Han, L., Abrahamsen, B., Nielsen, B., Gajhede, M., Kastrup, J. S., Jensen, A. A., Pickering, D. S., Frydenvang, K., Gefflaut, T. & Bunch, L., 2013, In: Journal of Medicinal Chemistry. 56, 4, p. 1614-1628

  Research output: Contribution to journal › Journal article › Research › peer-review
  38 Citations (Scopus)

• Corrigendum to "Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate" [J. Struct. Biol. 176 (2011) 307-314]

  Venskutonyte, R., Frydenvang, K., Gajhede, M., Bunch, L., Pickering, D. S. & Kastrup, J. S., Nov 2013, In: Journal of Structural Biology. 184, 2, p. 381 1 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review
  1 Citation (Scopus)