Jette Sandholm Jensen Kastrup

Search results

• 2013

  Corrigendum to "Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate" [J. Struct. Biol. 176 (2011) 307-314]

  Venskutonyte, R., Frydenvang, K., Gajhede, M., Bunch, L., Pickering, D. S. & Kastrup, J. S., Nov 2013, In: Journal of Structural Biology. 184, 2, p. 381 1 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review
  1 Citation (Scopus)

• Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site

  Kvist, T., Steffensen, T. B., Greenwood, J. R., Mehrzad Tabrizi, F., Hansen, K. B., Gajhede, M., Pickering, D. S., Traynelis, S. F., Kastrup, J. S. & Bräuner-Osborne, H., 2013, In: The Journal of Biological Chemistry. 288, p. 33124-35 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  27 Citations (Scopus)

• Erratum: Chemoenzymatic synthesis of new 2,4- syn -functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters (Journal of Medicinal Chemistry (2013) 56 (1614-1628))

  Assaf, Z., Larsen, A. P., Venskutonyteì, R., Han, L., Abrahamsen, B., Nielsen, B., Gajhede, M., Kastrup, J. S., Jensen, A. A., Pickering, D. S., Frydenvang, K., Gefflaut, T. & Bunch, L., 25 Jul 2013, In: Journal of Medicinal Chemistry. 56, 14, p. 5985 1 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review

• Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy

  Fiorentini, M., Bach, A., Strømgaard, K., Kastrup, J. S. & Gajhede, M., Apr 2013, In: Acta Crystallographica. Section D: Biological Crystallography. 69, Pt 4, p. 587-94 8 p.

  Research output: Contribution to journal › Journal article › Research
  6 Citations (Scopus)

• Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors

  Harpsøe, K., Hald, H., Timmermann, D. B., Jensen, M. L., Dyhring, T., Nielsen, E. Ø., Peters, D., Balle, T., Gajhede, M., Kastrup, J. S. J. & Ahring, P. K., 25 Jan 2013, In: Journal of Biological Chemistry. 288, 4, p. 2559-2570 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  26 Citations (Scopus)

• På jagt efter et virkningssted i hjernen

  Frydenvang, K. A., Juknaite, L. & Kastrup, J. S. J., 2013, In: Lægemiddelforskning. p. 50-52 3 p.

  Research output: Contribution to journal › Journal article › Communication

• Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

  Krintel, C., Harpsøe, K., Zachariassen, L. G., Peters, D., Frydenvang, K., Pickering, D. S., Gajhede, M. & Kastrup, J. S., 2013, In: Acta Crystallographica Section D: Structural Biology. 69, Pt 9, p. 1645-1652 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization

  Juknaite, L., Sugamata, Y., Tokiwa, K., Ishikawa, Y., Takamizawa, S., Eng, A., Sakai, R., Pickering, D. S., Frydenvang, K., Swanson, G. T., Kastrup, J. S. J. & Oikawa, M., 2013, In: Journal of Medicinal Chemistry. 56, 6, p. 2283-2293

  Research output: Contribution to journal › Journal article › Research › peer-review
  26 Citations (Scopus)

• Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold

  Nørholm, A-B., Francotte, P., Olsen, L., Krintel, C., Frydenvang, K., Goffin, E., Challal, S., Danober, L., Botez-Pop, I., Lestage, P., Pirotte, B. & Kastrup, J. S., 14 Nov 2013, In: Journal of Medicinal Chemistry. 56, 21, p. 8736-45 10 p.

  Research output: Contribution to journal › Journal article › Research
  34 Citations (Scopus)

• Synthesis, pharmacology and biostructural characterization of novel a4ß2 nicotinic acetylcholine receptor agonists

  Ussing, C. A., Hansen, C. P., Petersen, J. G., Jensen, A. A., Rohde, L. A. H., Ahring, P. K., Nielsen, E. Ø., Kastrup, J. S., Gajhede, M., Frølund, B. & Balle, T., 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 940-951

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors.

  Olsen, J. A., Kastrup, J. S. J., Peters, D., Gajhede, M., Balle, T. & Ahring, P. K., 13 Dec 2013, In: Journal of Biological Chemistry. 288, 50, p. 35997 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  37 Citations (Scopus)
• 2012

  A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

  Bach, A., Clausen, B. H., Møller, M., Vestergaard, B., Chi, C. N., Round, A., Sørensen, P. L., Nissen, K. B., Kastrup, J. S., Gajhede, M., Jemth, P., Kristensen, A. S., Lundström, P., Lambertsen, K. L. & Strømgaard, K. C., 28 Feb 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3317-3322

  Research output: Contribution to journal › Journal article › Research › peer-review
  157 Citations (Scopus)

• Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism

  Shahsavar, A., Kastrup, J. S., Nielsen, E. Ø., Kristensen, J. L., Gajhede, M. & Balle, T., 2012, In: P L o S One. 7, 8, p. e40757

  Research output: Contribution to journal › Journal article › Research › peer-review
  40 Citations (Scopus)

• Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: Unique role of halogen bonding revealed

  Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. Ø., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, K., Gajhede, M., Kastrup, J. S. & Balle, T., 3 Feb 2012, In: The Journal of Biological Chemistry. 287, 6, p. 4248-4259

  Research output: Contribution to journal › Journal article › peer-review
  42 Citations (Scopus)

• Kainate induces various domain closures in AMPA and kainate receptors

  Venskutonyte, R., Frydenvang, K., Hald, H., Rabassa, A. C. D., Gajhede, M., Ahring, P. K. & Kastrup, J. S., Sep 2012, In: Neurochemistry International. 61, 4, p. 536-545

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors

  Juknaite, L., Venskutonyte, R., Assaf, Z., Faure, S., Gefflaut, T., Aitken, D. J., Nielsen, B., Gajhede, M., Kastrup, J. S. J., Bunch, L., Frydenvang, K. & Pickering, D. S., 2012, In: Journal of Structural Biology. 180, 1, p. 39-46

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)

• Snegleprotein øger forståelsen af vigtige receptorer i hjernen

  Translated title of the contribution: Snail protein increases understanding of important receptors in the brainShahsavar, A., Nielsen, E. Ø., Kristensen, J. L., Gajhede, M., Balle, T. & Kastrup, J. S. J., 2012, In: Lægemiddelforskning. 2012, p. 48-50 3 p.

  Research output: Contribution to journal › Journal article › Communication

• Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors

  Venskutonyte, R., Frydenvang, K., Valadés, E. A., Szymanska, E. M., Johansen, T. N., Kastrup, J. S. & Pickering, D. S., Oct 2012, In: ChemMedChem. 7, 10, p. 1793-1798 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor

  Kristensen, L. H., Nielsen, A. L., Helgstrand, C., Lees, M., Cloos, P., Kastrup, J. S., Helin, K., Olsen, L. & Gajhede, M., Jun 2012, In: F E B S Journal. 279, 11, p. 1905-1914

  Research output: Contribution to journal › Journal article › peer-review
  66 Citations (Scopus)

• Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

  Krintel, C., Frydenvang, K., Olsen, L., Kristensen, M. T., de Barrios, O., Naur, P., Francotte, P., Pirotte, B., Gajhede, M. & Kastrup, J. S., 1 Jan 2012, In: Biochemical Journal. 441, 1, p. 173-178

  Research output: Contribution to journal › Journal article › Research › peer-review
  34 Citations (Scopus)
• 2011

  A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: Synthesis, resolution, pharmacology, and crystal structure

  Szymanska, E., Frydenvang, K., Contreras-Sanz, A., Pickering, D. S., Frola, E., Serafimoska, Z., Nielsen, B., Kastrup, J. S. & Johansen, T. N., 4 Oct 2011, In: Journal of Medicinal Chemistry. 54, 20, p. 7289-7298

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate

  Venskutonyte, R., Frydenvang, K., Gajhede, M., Bunch, L., Pickering, D. S. & Kastrup, J. S., Dec 2011, In: Journal of Structural Biology. 176, 3, p. 307-314

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• Crystal structure of the acetylcholine binding protein (AChBP) from Lymnaea stagnalis in complex with NS3950 (1-(6-bromo-5-ethoxypyridin-3-yl)-1,4-diazepane)

  Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. O., Peters, D., Helgstrand, C., Krintel, C., Harpsoe, K., Gajhede, M., Kastrup, J. S. & Balle, T., 14 Dec 2011

  Research output: Other contribution › Research

• Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

  Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, J. L., Kastrup, J. S., Clausen, R. P., Olsen, L. & Gajhede, M., 23 Jun 2011, In: F E B S Letters. 585, 12, p. 1951-1956

  Research output: Contribution to journal › Journal article › peer-review
  16 Citations (Scopus)

• Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators

  Pøhlsgaard, J., Frydenvang, K. A., Madsen, U. & Kastrup, J. S., 1 Jan 2011, In: Neuropharmacology. 60, 1, p. 135-150

  Research output: Contribution to journal › Review › Research › peer-review
  78 Citations (Scopus)

• Selective kainate receptor (GluK1) ligands structurally based upon1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization

  Venskutonyte, R., Butini, S., Coccone, S. S., Gemma, S., Brindisi, M., Kumar, V., Guarino, E., Maramai, S., Valenti, S., Amir, A., Valades, E. A., Frydenvang, K. A., Kastrup, J. S. J., Novellino, E., Campiani, G. & Pickering, D. S., 14 Jul 2011, In: Journal of Medicinal Chemistry. 54, 13, p. 4793-4805

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)

• Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule

  Kulahin, N., Kristensen, O., Rasmussen, K. K., Olsen, L., Rydberg, P., Vestergaard, B., Kastrup, J. S., Berezin, V., Bock, E., Walmod, P. S. & Gajhede, M., 9 Feb 2011, In: Structure. 19, 2, p. 203-211

  Research output: Contribution to journal › Journal article › Research › peer-review
  23 Citations (Scopus)

• Targeting specific sub-domains of the GluA4 ionotropic glutamate receptor by murine Fab fragments

  Mohr, A. Ø., Riise, E. S., Pickering, D. S., Jensen, A. A., Madden, D., Kastrup, J. S. J., Clausen, R. P. & Skottrup, P. D., 16 Jun 2011.

  Research output: Contribution to conference › Poster › Research › peer-review
• 2010

  Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid

  Frydenvang, K. A., Pickering, D. S., Greenwood, J. R., Krogsgaard-Larsen, N., Brehm, L., Nielsen, B., Vogensen, S. B., Hald, H., Kastrup, J. S., Krogsgaard-Larsen, P. & Clausen, R. P., 10 Nov 2010, In: Journal of Medicinal Chemistry. 53, 23, p. 8354-8361

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)

• Biostructure-based drug design

  Jørgensen, F. S. & Kastrup, J. S., 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 29-42

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

• Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor

  Owczarek, S., Kiryushko, D., Hald Larsen, M., Kastrup, J. S. J., Gajhede, M., Sandi, C., Berezin, V., Bock, E. & Soroka, V., 2010, In: The FASEB Journal. 24, 4, p. 1139-1150 12 p.

  Research output: Contribution to journal › Journal article › peer-review
  46 Citations (Scopus)

• Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus

  Wang, X., Hald, H., Ernst, H. A., Egebjerg, J., Christensen, K. V., Gajhede, M., Kastrup, J. S. & Mirza, O. A., 2010, In: Protein Expression and Purification. 71, 2, p. 179-183

  Research output: Contribution to journal › Journal article › peer-review
  1 Citation (Scopus)
• 2009

  At være eller ikke være en antagonist

  Frydenvang, K. A., Naur, P., Gajhede, M. & Kastrup, J. S. J., 2009, In: Lægemiddelforskning. p. 43-45

  Research output: Contribution to journal › Journal article › Communication

  Open Access

  File
  2383 Downloads (Pure)

• Crystal structure of NCAM2 IgIV-Fn3I

  Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, J. S. J., Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, M., 2009

  Research output: Non-textual form › Dataset › Research

• Crystal structure of NCAM2 IgIV-Fn3II

  Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, J. S. J., Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, M., 2009

  Research output: Non-textual form › Dataset › Research

• Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2

  Hald, H., Ahring, P. K., Timmermann, D. B., Liljefors, T., Gajhede, M. & Kastrup, J. S., 2009, In: Journal of Molecular Biology. 391, 5, p. 906-917

  Research output: Contribution to journal › Journal article › Research › peer-review
  29 Citations (Scopus)

• Establishment of an immunized murine Fab library for selection of iGluR6 binders by phage display

  Mohr, A. Ø., Skottrup, P. D., Jensen, A. A., Kastrup, J. S. J., Clausen, R. P. & Riise, E. S., 28 May 2009.

  Research output: Contribution to conference › Poster › Research

• Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine

  Frydenvang, K. A., Lash, L. L., Naur, P., Postila, P. A., Pickering, D. S., Smith, C. M., Gajhede, M., Sasaki, M., Sakai, R., Pentikäinen, O. T., Swanson, G. T. & Kastrup, J. S., 2009, In: Journal of Biological Chemistry. 284, 21, p. 14219-14229

  Research output: Contribution to journal › Journal article › Research › peer-review
  51 Citations (Scopus)

• Ligand binding analyses of the putative peptide transporter YjdL from E. coli display a significant selectivity towards dipeptides

  Ernst, H. A., Pham, A., Hald, H., Kastrup, J. S., Rahman, M. & Mirza, O. A., 2009, In: Biochemical and Biophysical Research Communications. 389, 1, p. 112-116

  Research output: Contribution to journal › Journal article › Research › peer-review
  33 Citations (Scopus)

• Modulation of the dimer interface at ionotropic glutamate-like receptor d2 by D-serine and extracellular calcium

  Hansen, K. B., Naur, P., Kurtkaya, N. L., Kristensen, A. S., Gajhede, M., Kastrup, J. S. & Traynelis, S. F., 2009, In: Journal of Neuroscience. 29, 4, p. 907-917

  Research output: Contribution to journal › Journal article › peer-review
  54 Citations (Scopus)

• Structure of the first PDZ domain of human PSD-93

  Fiorentini, M., Nielsen, A. K., Kristensen, O., Kastrup, J. S. & Gajhede, M., 2009, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 65, 12, p. 1254-1257

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• The apo structure of sucrose hydrolase from Xanthomonas campestris pv. campestris shows an open active-site groove

  Champion, E., Remaud-Simeon, M., Skov, L. K., Kastrup, J. S., Gajhede, M. & Mirza, O. A., 2009, In: Acta Crystallographica. Section D: Biological Crystallography. 65, 12, p. 1309-1314

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)

• The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization

  Clausen, R. P., Naur, P., Kristensen, A. S., Greenwood, J. R., Strange, M., Bräuner-Osborne, H., Jensen, A. A., Nielsen, A. S. T., Geneser, U., Ringgaard, L. M., Nielsen, B., Pickering, D. S., Brehm, L., Gajhede, M., Krogsgaard-Larsen, P. & Kastrup, J. S., 2009, In: Journal of Medicinal Chemistry. 52, 15, p. 4911-4922

  Research output: Contribution to journal › Journal article › Research › peer-review
  22 Citations (Scopus)
• 2008

  Computeren viser vejen til et nyt potentielt lægemiddel

  Harpsøe, K., Kaae, B. H., Balle, T., Pickering, D. S. & Kastrup, J. S. J., 2008, In: Lægemiddelforskning. p. 28-30

  Research output: Contribution to journal › Journal article › Communication

  Open Access

  File
  1557 Downloads (Pure)

• Crystal Structure of NCAM2 Ig1 (I4122 Cell Unit)

  Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, J. S. J., Poulsen, J-C. N., Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, M., 2008

  Research output: Non-textual form › Dataset › Research

  Open Access

  File
  1175 Downloads (Pure)

• Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping.

  Rasmussen, K. K., Kulahin, N., Kristensen, O., Poulsen, J-C. N., Sigurskjold, B. W., Kastrup, J. S., Berezin, V., Bock, E., Walmod, P. S. & Gajhede, M., 2008, In: Journal of Molecular Biology. 382, 5, p. 1113-20 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)

• Dimerization effect of sucrose octasulfate on rat FGF1.

  Kulahin, N., Kiselyov, V., Kochoyan, A., Kristensen, O., Kastrup, J. S. J., Berezin, V., Bock, E. M. & Gajhede, M., 2008, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 64, Pt6, p. 448-452 5 p.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  File
  9 Citations (Scopus)

  1226 Downloads (Pure)

• Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4

  Kasper, C., Frydenvang, K. A., Naur, P., Gajhede, M., Pickering, D. S. & Kastrup, J. S. J., 2008, In: FEBS Letters. 582, 29, p. 4089-4094

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Small angle X-ray studies reveal that Aspergillus niger glucoamylase has a defined extended conformation and can form dimers in solution

  Jørgensen, A. D., Nøhr, J., Kastrup, J. S., Gajhede, M., Sigurskjold, B. W., Sauer, J., Svergun, D. I., Svensson, B. & Vestergaard, B., 2008, In: Journal of Biological Chemistry. 283, 21, p. 14772-14780

  Research output: Contribution to journal › Journal article › peer-review
  20 Citations (Scopus)

• Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501

  Røder, G., Kristensen, O., Kastrup, J. S., Buus, S. & Gajhede, M., 2008, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 64, Pt 6, p. 459-62 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)