Personal profile
CV
Education and employment record
2011- : Industrial postdoc at Uni. Copenhagen/Acesion Pharma,
Co-founder Acesion Pharma
2008-2011: Industrial Ph.D. student at Uni. Copenhagen (Medicine) and NeuroSearch
2008-2008: Research assistant at Uni. Copenhagen (3 months)
2008 : Completes master thesis with top grade (12). MSc. Pharm
Primary scientific focus
- Electrical arrhythmias such as atrial fibrillation and LQT-syndromes 1-3.
- Strong knowledge of biostatistics, cardiovascular physiology, and pharmacology.
Techniques
- Advanced models of atrial fibrillation in large animals with long-term tachypacing of the atria.
- Invented, set up and worked extensively with several new in vivo methods for screening possible anti-AF candidates.
- Langendorff perfused hearts: Isolation of and data acquisition from langendorff hearts from rat, guinea pig and rabbit.
- Patch clamping on isolated cardiomyocytes and heterologous expression systems.
- Isolation of cardiomyocytes from rat and guinea pig.
- Two-electrode voltage clamp on Xenopus oocytes.
Other Activities
Member of the board: The Industrial PhD Association (since 2011)
Member of the board: The Industrial Postdoc Association (since 2013)
Ad hoc reviewer for the following peer reviewed papers:
Circulation, Circulation Arrhythmia and Electrophysiology, Hypertension,
Heart Rhythm, and Reviews of Physiology, Biochemistry & Pharmacology
Collaborations and top research areas from the last five years
Research output
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NaV1.5 or KCa2 channel blockade does not increase arrhythmia risk in hypokalemic rabbit hearts, unlike KV11.1 inhibition with dofetilide
Yan, Y., Abildgaard, L., Skarsfeldt, M. A., Bomholtz, S. H., Sørensen, U., Holst, A. G., Grunnet, M., Diness, J. G. & Bentzen, B. H., 2025, In: IJC Heart and Vasculature. 59, 8 p., 101699.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile20 Downloads (Pure) -
Analysis of drug-induced and spontaneous cardioversions reveals similar patterns leading to termination of atrial fibrillation
van Hunnik, A., Sobota, V., Zeemering, S., Opacic, D., Scaf, B., D’Alessandro, E., Oyaert, K., Kuiper, M., Diness, J. G., Sørensen, U. S., Milnes, J. T., van der Heyden, M. A. G., Jespersen, T., Schotten, U. & Verheule, S., 2024, In: Frontiers in Physiology. 15, 1399037.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)33 Downloads (Pure) -
A phase 1 trial of AP30663, a KCa2 channel inhibitor in development for conversion of atrial fibrillation
Yfanti, C., Vestbjerg, B., van't Westende, J., Edvardsson, N., Monfort, L. M., Olesen, M. S., Bentzen, B. H., Grunnet, M., Eveleens Maarse, B. C., Diness, J. G., Kemme, M. J. B., Sørensen, U., Moerland, M., van Esdonk, M. J., Klaassen, E. S., Gal, P. & Holst, A. G., 2024, In: British Journal of Clinical Pharmacology. 90, 4, p. 1027-1035Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Citations (Scopus)45 Downloads (Pure) -
Inhibition of the KCa2 potassium channel in atrial fibrillation: a randomized phase 2 trial
Holst, A. G., Tomcsányi, J., Vestbjerg, B., Grunnet, M., Sørensen, U. S., Diness, J. G., Bentzen, B. H., Edvardsson, N., Hohnloser, S. H., Bhatt, D. L. & Dorian, P., 2024, In: Nature Medicine. 30, 1, p. 106-111Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile27 Citations (Scopus)19 Downloads (Pure) -
Pharmacological inhibition of SK-channels with AP14145 prevents atrial arrhythmogenic changes in a porcine model for obstructive respiratory events
Linz, B., Hesselkilde, E. M., Skarsfeldt, M. A., Hertel, J. N., Sattler, S. M., Yan, Y., Tfelt-Hansen, J., Diness, J. G., Bentzen, B. H., Linz, D. & Jespersen, T., 2023, In: Journal of Cardiovascular Electrophysiology. 34, 1, p. 126-134 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile8 Citations (Scopus)117 Downloads (Pure) -
Effective termination of atrial fibrillation by SK channel inhibition is associated with a sudden organization of fibrillatory conduction
Gatta, G., Sobota, V., Citerni, C., Diness, J. G., Sørensen, U. S., Jespersen, T., Bentzen, B. H., Zeemering, S., Kuiper, M., Verheule, S., Schotten, U. & Van Hunnik, A., 2021, In: Europace. 23, 11, p. 1847-1859 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile18 Citations (Scopus)68 Downloads (Pure) -
Small conductance calcium activated K+ channel inhibitor decreases stretch induced vulnerability to atrial fibrillation
Yan, Y., Skarsfeldt, M. A., Diness, J. G. & Bentzen, B. H., 2021, In: IJC Heart and Vasculature. 37, 8 p., 100898.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile8 Citations (Scopus)43 Downloads (Pure) -
The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts
Kirchhoff, J. E., Skarsfeldt, M., Muthukumarasamy, K. M., Simó-Vicens, R., Bomholtz, S. H., Abildgaard, L., Jespersen, T., Sørensen, U. S., Grunnet, M., Bentzen, B. H. & Diness, J. G., 2019, In: Frontiers in Pharmacology. 10, 13 p., 668.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile11 Citations (Scopus)217 Downloads (Pure)
Press/Media
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Højteknologifonden vilde med erhvervspostdoc'er
05/12/2011
1 Media contribution
Press/Media: Press / Media
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