Research output per year
Research output per year
Personal profile
Short presentation
ResearcherID: A-3249-2017
Scopus ID: 35831810100
CV
PhD student (01-04-2008)
Research assistant (2006-2008)
Cand.Scient in Human Physiology, Københavns Universitet (2006)
Primary fields of research
AMPK regulation, Metformin, Insulin sensitivity.
Current research
Metformin in the regulation of AMPK signalling in muscle and fat tissue.
Metformin is a drug used since the fifties in the treatment of elevated blood glucose in patients with insulin resistance like type II diabetes mellitus. Metformin enhances the ability of skeletal muscle to extract glucose and enhances muscle insulin sensitivity. The molecular mechanism for these effects of metformin are however largely unknown.
AMPK, (5´AMP activated protein kinase is a cellular energy sensor. AMPK is activated by cellular stress inducing a negative energy balance as indicated by an elevate cellular AMP/ATP ratio. For example, AMPK activity is increased by muscle contractile activity during exercise, and recently AMPK activation was related to muscular insulin sensitivity. New studies have also implicated AMPK in the mechanism by which metformin affects muscular glucose metabolism and insulin sensitivity.
The aims of this project are to investigate the acute and chronic effects of metformin in skeletal muscle and adipose tissue in man as well as in animal models. Causality between AMPK signaling, metformin and biological end points will be studied.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
-
Acute Exercise Increases GDF15 and Unfolded Protein Response/Integrated Stress Response in Muscle in Type 2 Diabetes
Sabaratnam, R., Kristensen, J. M., Pedersen, A. J. T., Kruse, R., Handberg, A., Wojtaszewski, J. F. P. & Højlund, K., 2024, In: The Journal of Clinical Endocrinology & Metabolism. 109, 7, p. 1754–1764Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise
Kristensen, J. M., Kjøbsted, R., Larsen, T. J., Carl, C. S., Hingst, J. R., Onslev, J., Birk, J. B., Thorup, A., Steenberg, D. E., Knudsen, J. R., Henriksen, N. S., Needham, E. J., Halling, J. F., Gudiksen, A., Rundsten, C. F., Hanghøj, K. E., Stinson, S. E., Hoier, B., Hansen, C. C., Jensen, T. E. & 11 others, , 2024, (Accepted/In press) In: Nature Metabolism.Research output: Contribution to journal › Letter › Research › peer-review
Open Access1 Citation (Scopus) -
AMPKγ3 Controls Muscle Glucose Uptake in Recovery From Exercise to Recapture Energy Stores
Kido, K., Eskesen, N. O., Henriksen, N. S., Onslev, J., Kristensen, J. M., Larsen, M. R., Hingst, J. R., Knudsen, J. R., Birk, J. B., Andersen, N. R., Jensen, T. E., Pehmoller, C., Wojtaszewski, J. F. P. & Kjøbsted, R., 2023, In: Diabetes. 72, 10, p. 1397-1408 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Citations (Scopus)4 Downloads (Pure) -
TBC1D4-S711 controls skeletal muscle insulin sensitization after exercise and contraction
Kjøbsted, R., Kristensen, J. M., Eskesen, N. O., Kido, K., Fjorder, K., Damgaard, D. F., Larsen, J. K., Andersen, N. R., Birk, J. B., Gudiksen, A., Treebak, J. T., Schjerling, P., Pilegaard, H. & Wojtaszewski, J., 2023, In: Diabetes. 72, 7, p. 857-871 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
File70 Downloads (Pure) -
A signature of exaggerated adipose tissue dysfunction in type 2 diabetes is linked to low plasma adiponectin and increased transcriptional activation of proteasomal degradation in muscle
Sabaratnam, R., Skov, V., Paulsen, S. K., Juhl, S., Kruse, R., Hansen, T., Halkier, C., Kristensen, J. M., Vind, B. F., Richelsen, B., Knudsen, S., Dahlgaard, J., Beck-Nielsen, H., Kruse, T. A. & Højlund, K., 2022, In: Cells. 11, 13, 18 p., 2005.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile5 Citations (Scopus)15 Downloads (Pure) -
Insulin sensitization following a single exercise bout is uncoupled to glycogen in human skeletal muscle: A meta-analysis of 13 single-center human studies
Hingst, J. R., Onslev, J. D., Holm, S., Kjøbsted, R., Frøsig, C., Kido, K., Steenberg, D. E., Larsen, M. R., Kristensen, J. M., Carl, C. S., Sjøberg, K., Thong, F. S. L., Derave, W., Pehmøller, C., Brandt, N., McConell, G., Jensen, J., Kiens, B., Richter, E. A. & Wojtaszewski, J., 2022, In: Diabetes. 71, 11, p. 2237-2250 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
7 Citations (Scopus) -
Metformin improves glycemia independently of skeletal muscle AMPK via enhanced intestinal glucose clearance
Kjøbsted, R., Kristensen, J. M., Birk, J. B., Jørgensen, N. O., Kido, K., Andersen, N. R., Larsen, J. K., Foretz, M., Viollet, B., Nielsen, F., Brøsen, K., Jessen, N., Hellsten, Y., Højlund, K. & Wojtaszewski, J., 24 May 2022, bioRxiv, p. 1-33, 33 p.Research output: Working paper › Preprint › Research
-
Personalized phosphoproteomics identifies functional signaling
Needham, E. J., Hingst, J. R., Parker, B. L., Morrison, K. R., Yang, G., Onslev, J. D., Kristensen, J. M., Højlund, K., Ling, N. X. Y., Oakhill, J. S., Richter, E. A., Kiens, B., Petersen, J., Pehmøller, C., James, D. E., Wojtaszewski, J. & Humphrey, S. J., 2022, In: Nature Biotechnology. 40, 4, p. 576-584 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
45 Citations (Scopus)