CURRICULUM VITAE - KAARE TEILUM

Name:                      Kaare Teilum

Date of birth:           02-12-1972

E-mail:                     [email protected]

Phone (work):          +45 35 32 20 29

Phone (mobile):       +45 30 28 18 14

Civil status:             Married, two children

Summary:

My research is focused on conformational dynamics and its importance for the function of enzymes, proteins that interact with other proteins and proteins that aggregates/fibrillates. In all cases the aim is to understand the conformational changes of the proteins in such detail that their behaviour can be rationalized and eventually manipulated. Recent highlights include: Structure and dynamics of the endogeneous capsid protein Arc (paper 49). How the dynamics of metal-ions in Ab and a-synuclein is important for the formation of ROS (papers 45, 38, 34 and 21); ligand binding to a neurotransmitter-sodium symporter by solid-state NMR (paper 40); the design of a stable protein devoid of charges (paper 37,48,54,63); the structure and interactions of PDZ domain proteins (paper 33,35,53,65); specificity and dynamics in ligand binding by glutaredoxin (papers 31 and 22); conformational dynamics and stability in the fold switching protein NCBD (papers 29,27,25,19); optimization of protein stability (papers 51,57,61,62,64,68).

Employments:

Education:

2002:          PhD in protein science, University of Copenhagen.

                   Thesis: “Intermediate and Unfolded States in the Folding of Acyl-Coenzyme A Binding Protein”. Supervisor: Professor Flemming M. Poulsen

1997:          cand. scient. (MSc) in biochemistry, University of Copenhagen.

                   Thesis: “Expression and in vitro folding of barly peroxidase 1 & Deglycosylation studies on horseradish peroxidase”. Supervisor: Associate Professor Karen G. Welinder.

Major grants and fellowships:

Total 22 grants, 16 as PI. Total personal share of grants: ~38 M DKK

2023-26:     Project grant, The Danish Council for Independent Research, PI. 2.9 M DKK

2023-26:     Project grant, the Novo Nordisk Foundation, PI, 3.7 M DKK

2022-25:     Project grant, the Novo Nordisk Foundation, PI, 2.7 M DKK

2020-23:     Project grant, The Danish Council for Independent Research, PI. 2.9 M DKK

2019-24:     NMR Infrastructure grant, the Novo Nordisk Foundation, co-PI, 23.4 M DKK

2019-21:     Project grant, Independent Research Fund Denmark, FSS, PI, 1.4 M DKK

2018-21:     Project grant, Independent Research Fund Denmark, FNU, PI, 2.6 M DKK

2018-20:     Project grant, the Novo Nordisk Foundation, PI, 1 M DKK

2016-17:     Running costs, the Lundbeck Foundation, PI, 0.3 M DKK

2016:          Instrument grant, the Augustinus Foundation, PI, 0.2 M DKK

2016-18:     Project grant, the Novo Nordisk Foundation, co-PI, 2.8 M DKK

2014:          New NMR instrumentation, The Villum Foundation, co-PI, 12 M DKK

2014-16:     Project grant, the Lundbeck Foundation. PI, 1 M DKK

2013-16:     Project grant, The Danish Council for Independent Research, PI. 1.9 M DKK

2012-14:     Project grant from The Danish Council for Independent Research | Technology

                   Co-applicant. 5.4 M DKK

2011-13:     Villum Foundation block grant. Co-applicant. approx. 1.1 M DKK

2011-13:     Project grant from the Lundbeck Foundation. PI, 1 M DKK

2011-12:     Project grant from The Danish Council for Independent Research | Medical Sciences. PI, 2 M DKK

2007-10:     Steno-grant from the Danish Natural Science Research Council. PI 2.7 M DKK

2005-06:     EMBO Long Term Fellowship.

2004-05:     Villum Kann Rasmussen postdoctoral fellowship.

1999-02:     PhD scholarship from the Science Faculty, University of Copenhagen.

Management and organizational work:

I have headed my own research group since 2008 and managed several collaborative projects (see below).

2023-          Deputy Head of Department (teaching), Dept. Biology, Uni. of Copenhagen

2020-          Delegate at the EMBL and EMBC councils.

2016-22:     Head of Section for Biomolecular Sciences, Dept. Biology, Uni. of Copenhagen

2016:          Local organizer of the EUROMAR 2016 conference, Århus, Denmark

2015:          The art of leadership, EMBO, Heidelberg

2006:          Laboratory Management Course, EMBO

1995-97:     Member of the Board, Institute of Molecular Biology, University of Copenhagen.

Students since 2007

Number of PhD students:                             9 graduated. 3 active

• Kristine Steen Jensen, graduated November 2010
• Zigmantas Toleikis,graduated September 2014
• Lisbeth Andersen,graduated October 2014
• Simon Erlendsson,graduated October 2015
• Lau Dalby Nielsengraduated May 2017
• Shanshan Wugraduated February 2018
• Troels Emtekær Linnet,graduated April 2018
• Louise Hamborg Nielsengraduated April 2019
• Christian Parsbæk Pedersengraduated February 2022
• Alexander Saalbach Hebbelstrupexpected graduation spring 2024
• Annette Juma Skæfergaard Nielsen expected graduation spring 2025
• Nadja Joachim expected graduation fall 2026

Number of master students:                          24 graduated,  2 active

• Simon Olssongraduated April 2010
• Michael Hammer Lerchegraduated November 2010
• Lisbeth Andersengraduated January 2011
• Troels Emtekær Linnetgraduated November 2011
• Vytautas Iešmantavičiusgraduated February 2012
• Lau Dalby Nielsengraduated May 2013
• Christian Bersen Borggraduated December 2014
• Casper de Lichtenberggraduated December 2014
• Ulrik Pedersengraduated November 2015
• Ida Kallehauge Nielsengraduated March 2016
• Nikolaj Riis Christensengraduated June 2016
• Tue G. Ehmsengraduated September 2016
• Lasse Sander Dreyergraduated December 2016
• Cecilie Thørring Bonnesengraduated Februar 2016
• Marco Simon Petersengraduated August 2017
• Christian Parsbæk Pedersengraduated August 2018
• Theis Jacobsengraduated December 2018
• Anders Lønstrup Hansengraduated March 2019
• Alexander Saalbach Hebbelstrupgraduated September 2019
• Cecilie Rosholm Oxbjerg graduated April 2020
• Mathilde Bolding Andreasengraduated July 2021
• Nicolas Jonssongraduated September 2021
• Morten Rose Wagnkildegraduated September 2021
• Victor Vestergaardgraduated June 2022
• Peter Kristensen expected graduation summer 2023
• Jens Nicolai Vilstrup Decker expected graduation summer 2023