Karla Andrea Frydenvang

Research output

Research output per year 1988 1996 1997 1998 2001 2002 2004 2010 2011 2013 2014 2016 2017 2019 2024 2024

• 2420 Citations
• 126 Journal article
• 2 Comment/debate
• 2 Review
• 1 Book chapter
• 2 More
  • 1 Conference abstract in journal
  • 1 Letter

Research output per year

Research output per year

Search results

• 2024

  AI Based Discovery of a New AKR1C3 Inhibitor for Anticancer Applications

  Pippione, A. C., Vigato, C., Tucciarello, C., Hussain, S., Salladini, E., Truong, H. H., Henriksen, N. M., Vanzetti, G., Giordano, G., Zonari, D., Mirza, O. A., Frydenvang, K., Pignochino, Y., Oliaro-Bosso, S., Boschi, D. & Lolli, M. L., 2024, In: ACS Medicinal Chemistry Letters. 15, 8, p. 1269–1278

  Research output: Contribution to journal › Letter › Research › peer-review

• Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spanning positive allosteric modulator BPAM538

  Bay, Y., Cabello, F. J. M., Koens, C. C., Frantsen, S. M., Pickering, D. S., Frydenvang, K., Francotte, P., Pirotte, B., Kristensen, A. S., Bowie, D. & Kastrup, J. S., 2024, In: Journal of Structural Biology. 216, 3, 9 p., 108113.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  2 Downloads (Pure)

• Discovery and Structure-Activity Relationships of 2,5-Dimethoxyphenylpiperidines as Selective Serotonin 5-HT2A Receptor Agonists

  Rørsted, E. M., Jensen, A. A., Smits, G., Frydenvang, K. & Kristensen, J. L., 2024, In: Journal of Medicinal Chemistry. 69, 9, p. 7224–7244

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  16 Downloads (Pure)

• Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators

  Francotte, P., Bay, Y., Goffin, E., Colson, T., Lesenfants, C., Dorosz, J., Laulumaa, S., Fraikin, P., de Tullio, P., Beaufour, C., Botez, I., Pickering, D. S., Frydenvang, K., Danober, L., Kristensen, A. S., Kastrup, J. S. & Pirotte, B., 2024, In: European Journal of Medicinal Chemistry. 264, 15 p., 116036.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure

  Bay, Y., Venskutonytė, R., Frantsen, S. M., Thorsen, T. S., Musgaard, M., Frydenvang, K., Francotte, P., Pirotte, B., Biggin, P. C., Kristensen, A. S., Boesen, T., Pickering, D. S., Gajhede, M. & Kastrup, J. S., 2024, In: FEBS Journal. 291, 7, p. 1506-1529

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer

  Pippione, A. C., Kovachka, S., Vigato, C., Bertarini, L., Mannella, I., Sainas, S., Rolando, B., Denasio, E., Piercy-Mycock, H., Romalho, L., Salladini, E., Adinolfi, S., Zonari, D., Peraldo-Neia, C., Chiorino, G., Passoni, A., Mirza, O. A., Frydenvang, K., Pors, K., Lolli, M. L. & 3 others, Spyrakis, F., Oliaro-Bosso, S. & Boschi, D., 2024, In: European Journal of Medicinal Chemistry. 268, 20 p., 116193.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  3 Citations (Scopus)

  10 Downloads (Pure)

• The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2

  Bay, Y., Egeberg Jeppesen, M., Frydenvang, K., Francotte, P., Pirotte, B., Pickering, D. S., Kristensen, A. S. & Kastrup, J. S., 2024, In: FEBS Letters. 598, 7, p. 743-757

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  1 Citation (Scopus)

  6 Downloads (Pure)
• 2022

  Structural basis for positive allosteric modulation of AMPA and kainate receptors

  Frydenvang, K., Pickering, D. S. & Kastrup, J. S., 2022, In: The Journal of Physiology. 600, 2, p. 181-200

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  16 Citations (Scopus)

  12 Downloads (Pure)
• 2020

  Increasing the Functional Group Diversity in Helical beta-Peptoids: Achievement of Solvent- and pH-Dependent Folding

  Wellhofer, I., Beck, J., Frydenvang, K., Brase, S. & Olsen, C. A., 2020, In: Journal of Organic Chemistry. 85, 16, p. 10466-10478 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• Ionotropic glutamate receptor GluA2 in complex with bicyclic pyrimidinedione-based compounds: when small compound modifications have distinct effects on binding interactions

  Frydenvang, K., Pickering, D. S., Kshirsagar, G. U., Chemi, G., Gemma, S., Sprogøe, D., Kærn, A. M., Brogi, S., Campiani, G., Butini, S. & Kastrup, J. S., 2020, In: ACS Chemical Neuroscience. 11, 12, p. 1791-1800

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• Structure elucidation of prenyl- and geranyl substituted coumarins in Gerbera piloselloides by NMR spectroscopy, electronic circular dichroism calculations, and single crystal X-ray crystallography

  Li, T., Ma, X., Fedotov, D., Kjaerulff, L., Frydenvang, K. A., Coriani, S., Hansen, P. R., Kongstad, K. T. & Stærk, D., 8 Apr 2020, In: Molecules. 25, 25 p., 1706.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  15 Citations (Scopus)

  165 Downloads (Pure)
• 2019

  Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor

  Laulumaa, S., Hansen, K. V., Masternak, M., Drapier, T., Francotte, P., Pirotte, B., Frydenvang, K. & Kastrup, J. S., 14 Mar 2019, In: ACS Medicinal Chemistry Letters. 10, 3, p. 243-247 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  7 Citations (Scopus)

• Design and Synthesis of 2,3-trans-Proline Analogs as Ligands for the Ionotropic Glutamate Receptors and the Excitatory Amino Acid Transporters

  Poulie, C. B. M., Alcaide Lopez, A., Krell-Jørgensen, M. P., Larsen, Y., Astier, E., Bjørn-Yoshimoto, W. E., Yi, F., Syrenne, J. T., Storgaard, M., Nielsen, B., Frydenvang, K. A., Jensen, A. A., Hansen, K. B., Pickering, D. S. & Bunch, L., 19 Jun 2019, In: A C S Chemical Neuroscience. 10, 6, p. 2989-3007 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  4 Citations (Scopus)

• Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

  Giraudo, A., Krall, J., Bavo, F., Nielsen, B., Kongstad, K. T., Rolando, B., De Blasio, R., Gloriam, D. E., Löffler, R., Thiesen, L., Harpsøe, K., Frydenvang, K., Boschi, D., Wellendorph, P., Lolli, M. L., Jensen, A. A. & Frølund, B., 27 Jun 2019, In: Journal of Medicinal Chemistry. 62, 12, p. 5797-5809

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• Functionalized Helical beta-Peptoids

  Wellhofer, I., Frydenvang, K., Kotesova, S., Christiansen, A. M., Laursen, J. S. & Olsen, C. A., 5 Apr 2019, In: Journal of Organic Chemistry. 84, 7, p. 3762-3779

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)

• N-(7-(1H-imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide - a new kainate receptor selective antagonist and analgesic: Synthesis, X-ray crystallography, structure-affinity relationships, in vitro and in vivo pharmacology

  Møllerud, S., Hansen, R. B., Pallesen, J. S., Temperini, P., Pasini, D., Bornholdt, J., Nielsen, B., Mamedova, E., Chalupnik, P., Paternain, A. V., Lerma, J., Del Castillo, M. D., Andreasen, J. T., Frydenvang, K., Kastrup, J. S., Johansen, T. N. & Pickering, D. S., 2019, In: ACS Chemical Neuroscience. 10, p. 4685-4695 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships and in vitro Pharmacology

  Pallesen, J. S., Møllerud, S., Frydenvang, K. A., Pickering, D. S., Bornholt, J., Nielsen, B., Pasini, D., Han, L., Marconi, L., Kastrup, J. S. J. & Johansen, T. N., 20 Mar 2019, In: A C S Chemical Neuroscience. 10, p. 1841-1853 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)

• Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors

  Dawe, G. B., Kadir, M. F., Venskutonyte, R., Perozzo, A. M., Yan, Y., Alexander, R. P. D., Navarrete, C., Santander, E. A., Arsenault, M., Fuentes, C., Aurousseau, M. R. P., Frydenvang, K., Barrera, N. P., Kastrup, J. S., Edwardson, J. M. & Bowie, D., 5 Jun 2019, In: Neuron. 102, 5, p. 976-+

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)

• Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol

  Frydenvang, K., Verkade-Vreeker, M. C. A., Dohmen, F., Commandeur, J. N. M., Rafiq, M., Mirza, O., Jørgensen, F. S. & Geerke, D. P., 2019, In: PLoS ONE. 14, 5, 15 p., e0217292.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  6 Citations (Scopus)

  320 Downloads (Pure)
• 2018

  (S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements, Structural and Biological Investigation.

  Brogi, S., Brindisi, M., Butini, S., Kshirsagar, G., Maramai, S., Chemi, G., Gemma, S., Campiani, G., Novellino, E., Fiorenzani, P., Pinassi, J., Aloisi, A. M., Gynther, M., Venskutonyte, R., Han, L., Frydenvang, K. A., Kastrup, J. S. J. & Pickering, D. S., 8 Mar 2018, In: Journal of Medicinal Chemistry. 61, 5, p. 2124-2130 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)

• 7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

  Goffin, E., Drapier, T., Larsen, A. P., Geubelle, P., Ptak, C. P., Laulumaa, S., Rovinskaja, K., Gilissen, J., Tullio, P. D., Olsen, L., Frydenvang, K., Pirotte, B., Hanson, J., Oswald, R. E., Kastrup, J. S. & Francotte, P., Jan 2018, In: Journal of Medicinal Chemistry. 61, 1, p. 251–264

  Research output: Contribution to journal › Journal article › Research › peer-review
  40 Citations (Scopus)
• 2017

  Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid

  Krogsgaard-Larsen, N., Delgar, C., Koch, K., Brown, P. M. G. E., Møller, C., Han, L., Huynh, T. H. V., Hansen, S. W., Nielsen, B., Bowie, D., Pickering, D. S., Kastrup, J. S. J., Frydenvang, K. A. & Bunch, L., 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 441-457 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors

  Larsen, A. P., Fièvre, S., Frydenvang, K., Francotte, P., Pirotte, B., Kastrup, J. S. & Mulle, C., Jun 2017, In: Molecular Pharmacology. 91, 6, p. 576-585 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• Lessons from crystal structures of kainate receptors

  Møllerud, S., Frydenvang, K. A., Pickering, D. S. & Kastrup, J. S. J., 1 Jan 2017, In: Neuropharmacology. 112, Part A, p. 16-28 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  42 Citations (Scopus)

• Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

  Hassan, A. R., El-Kousy, S. M., El-Toumy, S. A., Frydenvang, K., Tung, T. T., Olsen, J., Nielsen, J. & Christensen, S. B., 27 Oct 2017, In: Journal of Natural Products. 80, p. 2830-2834 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)

• Pharmacology and crystal structure of novel 2,3-quinoxalinediones at kainate receptors

  Møllerud, S., Pallesen, J. S., Pasini, D., Marconi, L., Han, L., Bornholt, J., Johansen, T. N., Kastrup, J. S., Pickering, D. S. & Frydenvang, K. A., Aug 2017, In: Journal of Neurochemistry. 142, S1, p. 124 1 p., MTU07-13.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• Structure and affinity of two bicyclic glutamate analogues at AMPA and kainate receptors

  Møllerud, S., Pinto, A., Marconi, L., Frydenvang, K. A., Thorsen, T. S., Laulumaa, S. K., Venskutonyte, R., Winther, N., Cunado Moral, A. M., Tamborini, L., Conti, P., Pickering, D. S. & Kastrup, J. S. J., 2017, In: A C S Chemical Neuroscience. 8, 9, p. 2056-2064 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)
• 2016

  Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2

  Krintel, C., Francotte, P., Pickering, D. S., Juknaite, L., Pøhlsgaaard, J., Olsen, L., Frydenvang, K. A., Goffin, E., Pirotte, B. & Kastrup, J. S. J., 2016, In: Biophysical Journal. 110, 11, p. 2397-2406 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation

  Jensen, C. M., Chow, H-Q., Chen, M., Zhai, L., Frydenvang, K. A., Liu, H., Franzyk, H. & Christensen, S. B., 2016, In: European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate

  Kristensen, O., Kristensen, L. B., Møllerud, S., Frydenvang, K. A., Pickering, D. S. & Kastrup, J. S. J., 2016, In: Structure. 24, 9, p. 1582-1589 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors

  Szymanska, E., Frydenvang, K. A., Pickering, D. S., Krintel, C., Nielsen, B., Kooshki, A., Zachariassen, L. G., Olsen, L., Kastrup, J. S. J. & Johansen, T. N., 2016, In: Journal of Medicinal Chemistry. 59, 1, p. 448-461 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)

• Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors

  Larsen, A. P., Francotte, P., Frydenvang, K., Tapken, D., Goffin, E., Fraikin, P., Caignard, D-H., Lestage, P., Danober, L., Pirotte, B. & Kastrup, J. S., 16 Mar 2016, In: A C S Chemical Neuroscience. 7, 3, p. 378-90 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• Tweaking subtype-selectivity and agonist efficacy at (S)-2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) receptors in a small series of BnTetAMPA analogues

  Wang, S-Y., Larsen, Y., Navarrete, C. V., Jensen, A. A., Nielsen, B., Al-Musaed, A., Frydenvang, K., Kastrup, J. S., Pickering, D. S. & Clausen, R. P., 2016, In: Journal of Medicinal Chemistry. 59, 5, p. 2244-2254 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)
• 2015

  A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures

  Christiansen, G. B., Harbak, B., Hede, S. E., Gouliaev, A. H., Olsen, L., Frydenvang, K., Egebjerg, J., Kastrup, J. S. & Holm, M. M., 3 Dec 2015, In: Neuroscience. 310, p. 709-22 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1

  Demmer, C. S., Møller, C., Brown, P. M. G. E., Han, L., Pickering, D. S., Nielsen, B., Bowie, D., Frydenvang, K., Kastrup, J. S. & Bunch, L., 9 Apr 2015, In: A C S Chemical Neuroscience. 6, p. 845-854 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• Iminolactones from Schizophyllum commune

  Liu, X., Frydenvang, K. A., Liu, H., Zhai, L., Chen, M., Olsen, C. E. & Christensen, S. B., 2015, In: Journal of Natural Products. 78, 5, p. 1165-1168 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)

• Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid

  Krogsgaard-Larsen, N., Storgaard, M., Møller, C., Demmer, C. S., Hansen, J., Han, L., Monrad, R. N., Nielsen, B., Tapken, D., Pickering, D. S., Kastrup, J. S., Frydenvang, K. & Bunch, L., 2015, In: Journal of Medicinal Chemistry. 58, 15, p. 6131-50 20 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)
• 2014

  Advances towards aromatic oligoamide foldamers: synthesis and X-ray structures of dimeric arylopeptoids with conformation-directing side chains

  Hjelmgaard, T., Plesner, M., Dissing, M. M., Andersen, J. M., Frydenvang, K. A. & Nielsen, J., 2014, In: European Journal of Organic Chemistry. 2014, 19, p. 3971-3975 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)

• Analogues of 3-Hydroxyisoxazole-Containing Glutamate Receptor Ligands Based on the 3-Hydroxypyrazole-Moiety: Design, Synthesis and Pharmacological Characterization

  Jørgensen, L., Nielsen, B., Pickering, D. S., Kristensen, A. S., Frydenvang, K. A., Madsen, U. & Clausen, R. P., 2014, In: Neurochemical Research. 39, 10, p. 1895-1905 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain

  Krintel, C., Frydenvang, K., Ceravalls de Rabassa, A., Kaern, A. M., Gajhede, M., Pickering, D. S. & Kastrup, J. S., 27 Mar 2014, In: F E B S Journal. p. 2422–2430 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)

• Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain

  Venskutonyte, R., Larsen, A. P., Frydenvang, K. A., Gajhede, M., Gefflaut, T., Pickering, D. S., Bunch, L. & Kastrup, J. S. J., 2014, In: ChemMedChem. 9, 10, p. 2254-2259 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides

  Francotte, P., Nørholm, A-B., Deva, T., Olsen, L., Frydenvang, K., Goffin, E., Fraikin, P., de Tullio, P., Challal, S., Thomas, J-Y., Iop, F., Louis, C., Botez-Pop, I., Lestage, P., Danober, L., Kastrup, J. S. J. & Pirotte, B., 26 Nov 2014, In: Journal of Medicinal Chemistry. 57, 22, p. 9539-53 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)
• 2013

  Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

  Assaf, Z., Larsen, A. P., Venskutonyte, R., Han, L., Abrahamsen, B., Nielsen, B., Gajhede, M., Kastrup, J. S., Jensen, A. A., Pickering, D. S., Frydenvang, K., Gefflaut, T. & Bunch, L., 2013, In: Journal of Medicinal Chemistry. 56, 4, p. 1614-1628

  Research output: Contribution to journal › Journal article › Research › peer-review
  38 Citations (Scopus)

• Corrigendum to "Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate" [J. Struct. Biol. 176 (2011) 307-314]

  Venskutonyte, R., Frydenvang, K., Gajhede, M., Bunch, L., Pickering, D. S. & Kastrup, J. S., Nov 2013, In: Journal of Structural Biology. 184, 2, p. 381 1 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review
  1 Citation (Scopus)

• Erratum: Chemoenzymatic synthesis of new 2,4- syn -functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters (Journal of Medicinal Chemistry (2013) 56 (1614-1628))

  Assaf, Z., Larsen, A. P., Venskutonyteì, R., Han, L., Abrahamsen, B., Nielsen, B., Gajhede, M., Kastrup, J. S., Jensen, A. A., Pickering, D. S., Frydenvang, K., Gefflaut, T. & Bunch, L., 25 Jul 2013, In: Journal of Medicinal Chemistry. 56, 14, p. 5985 1 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review

• På jagt efter et virkningssted i hjernen

  Frydenvang, K. A., Juknaite, L. & Kastrup, J. S. J., 2013, In: Lægemiddelforskning. p. 50-52 3 p.

  Research output: Contribution to journal › Journal article › Communication

• Some transformations of tacrolimus, an immunosuppressive drug

  Skytte, D. M., Jaroszewski, J. W., Johansen, K., Hansen, S. H., Hansen, L., G. Nielsen, P. & Frydenvang, K. A., 2013, In: European Journal of Pharmaceutical Sciences. 48, 3, p. 514-522 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

  Krintel, C., Harpsøe, K., Zachariassen, L. G., Peters, D., Frydenvang, K., Pickering, D. S., Gajhede, M. & Kastrup, J. S., 2013, In: Acta Crystallographica Section D: Structural Biology. 69, Pt 9, p. 1645-1652 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization

  Juknaite, L., Sugamata, Y., Tokiwa, K., Ishikawa, Y., Takamizawa, S., Eng, A., Sakai, R., Pickering, D. S., Frydenvang, K., Swanson, G. T., Kastrup, J. S. J. & Oikawa, M., 2013, In: Journal of Medicinal Chemistry. 56, 6, p. 2283-2293

  Research output: Contribution to journal › Journal article › Research › peer-review
  25 Citations (Scopus)

• Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold

  Nørholm, A-B., Francotte, P., Olsen, L., Krintel, C., Frydenvang, K., Goffin, E., Challal, S., Danober, L., Botez-Pop, I., Lestage, P., Pirotte, B. & Kastrup, J. S., 14 Nov 2013, In: Journal of Medicinal Chemistry. 56, 21, p. 8736-45 10 p.

  Research output: Contribution to journal › Journal article › Research
  34 Citations (Scopus)