Research output per year
Research output per year
Universitetsparken 5, 2100 København Ø, 71 Højhus 71, 71-4-T425
Universitetsparken 5
2100 København Ø
Research activity per year
Overview of research (selected papers 2012-2018)
His research is at the interface between synthetic chemistry, biology, and biophysics; it includes peptide and carbohydrate chemical biology and nanoscience. His research group merges design and chemical synthesis of complex bio-molecules with biophysical chemistry in a unique and powerful manner:
(1) Self-assembly of peptides, small proteins, and peptide-oligonucleotide conjugates at the nanoscale, with a focus on control of protein quaternary structure using non-native ligands and on de novo design of artificial proteins. A key aspect has been the use of small-angle X-ray scattering (SAXS) to study peptide and protein topology, in collaboration with colleagues, thus integrating design, synthesis and structural studies by SAXS.
Recent publication: Nature Communications 2016
(2) Peptide medicinal chemistry, in particular peptide hormones such as insulin, Glp-1, and PYY3-36. A focus is on half-life extension through self-organization for the potential treatment of diabetes, obesity, and neurodegenerative diseases.
Recent publication: Angewandte Chemie 2016, ChemMedChem 2016 (comprehensive review)
(3) Enabling several of these projects has been the development of new synthetic methodology and techniques for solid-phase synthesis of peptides with a focus on linkers (handles), instrumentation and use of precise microwave heating.
Chemical Society reviews 2012 (microwave heating in peptide synthesis)
(4) Chemoselective carbohydrate chemistry and chemical glycobiology. Oligosaccharides are secondary gene products and the indirect linkage between the genome and glycome presents a barrier to studying their complex biology. His research group has developed new reagents for protecting group free, chemoselective formation of glycoconjugates. A key element was the discovery that formation of carbohydrate oximes can be catalyzed by aniline catalysis. The crowning achievement was part of a full paper in Nature in 2015, where the synthetic methodology was combined with biophysical chemistry.
Recent publications: Nature 2015 (Full paper, Highly cited paper, Web of Science), ChemBioChem 2017 (Comprehensive review), Nature Protocols 2017, PNAS 2012 (Full paper; Highly cited paper, Web of Science)
(5) Organic chemistry on proteins: site-selective chemistry
Nature Communications 2018
(6) Collaborations in biophysics and chemical biology
Nature Chemical Biology 2017, 2015.
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Education:
University of Copenhagen, Ph.D., Biooranic Chemistry, 1992
University of Copenhagen, M.Sc. Organic Chemistry, 1990
University of Copenhagen, M.A. Philosophy, 1987
Scientific Employment:
University of Copenhagen, Faculty of Science, Denmark
Professor, August 2007 – present; since 2012: Department of Chemistry
University of Copenhagen, Faculty of Life Sciences (Previously, KVL), Denmark
Associate Professor, September 2001 – July 2007
Technical University of Denmark, Department of Organic Chemistry, Denmark
Research Associate Professor, February 2000-August 2001
Technical University of Denmark, Department of Organic Chemistry, Denmark
Assistant Professor, February 1997-January 2000
University of Minnesota, Department of Chemistry, Postdoctoral Fellow, 1993-1996
Honors
Publications (summarized)
Member of Editorial Boards
ChemBioChem, ChemistrySelect, Journal of Peptide Science
Books
Peptide Synthesis and Applications,K. J. Jensen, A. P. Tofteng, S. L. Pedersen (Eds), Springer Protocols, Humana Press, 2013.
Design of Peptides and Proteins, K. J. Jensen (Ed), Wiley, 2009.
Aspects of Philosophy of Chemistry, K. J. Jensen, A. Kildebæk Nielsen (Eds), The Danish Society for the History of Chemistry, 2008.
Administrative experience
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Knud Jørgen Jensen (Editor)
Activity: Peer-review and editorial work types › Editor of Research journal › Communication
Knud Jørgen Jensen (Member)
Activity: Membership types › Membership in review committee
Knud Jørgen Jensen (Organizer)
Activity: Participating in an event - types › Organisation of and participation in conference
Knud Jørgen Jensen (Lecturer)
Activity: Talk or presentation types › Lecture and oral contribution
Knud Jørgen Jensen (Participant)
Activity: Participating in an event - types › Organisation of and participation in conference
Knud Jørgen Jensen (Speaker)
Activity: Talk or presentation types › Lecture and oral contribution
Knud Jørgen Jensen (Member)
Activity: Membership types › Membership in review committee
Knud Jørgen Jensen (Participant)
Activity: Participating in an event - types › Organisation of and participation in conference