Krister Wennerberg

Research output

Research output per year 2002 2014 2015 2017 2018 2019 2020 2021 2023 2024

• 11807 Citations
• 115 Journal article
• 8 Review
• 2 Conference abstract in journal
• 1 Conference abstract for conference

Research output per year

Research output per year

Search results

• 2024

  A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing therapeutics in RB1-deficient cancer cells

  Bulanova, D., Akimov, Y., Senkowski, W., Oikkonen, J., Gall-Mas, L., Timonen, S., Elmadani, M., Hynninen, J., Hautaniemi, S., Aittokallio, T. & Wennerberg, K., 2024, In: Science Advances. 10, 21, 15 p., eadj1564.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  8 Downloads (Pure)

• Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

  Klomp, J. A., Klomp, J. E., Stalnecker, C. A., Bryant, K. L., Edwards, A. C., Drizyte-Miller, K., Hibshman, P. S., Diehl, J. N., Lee, Y. S., Morales, A. J., Taylor, K. E., Peng, S., Tran, N. L., Herring, L. E., Prevatte, A. W., Barker, N. K., Hover, L. D., Hallin, J., Chowdhury, S., Coker, O. & 13 others, Lee, H. M., Goodwin, C. M., Gautam, P., Olson, P., Christensen, J. G., Shen, J. P., Kopetz, S., Graves, L. M., Lim, K. H., Wang-Gillam, A., Wennerberg, K., Cox, A. D. & Der, C. J., 2024, In: Science (New York, N.Y.). 384, 6700, p. eadk0775 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• GDNF/GFRA1 signaling contributes to chemo- and radioresistance in glioblastoma

  Avenel, I. C. N., Ewald, J. D., Ariey-Bonnet, J., Kristensen, I. H., Petterson, S. A., Thesbjerg, M. N., Burton, M., Thomassen, M., Wennerberg, K., Michaelsen, S. R. & Kristensen, B. W., 2024, In: Scientific Reports. 14, 1, 13 p., 17639.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  4 Downloads (Pure)

• Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia

  Adnan Awad, S., Dufva, O., Klievink, J., Karjalainen, E., Ianevski, A., Pietarinen, P., Kim, D., Potdar, S., Wolf, M., Lotfi, K., Aittokallio, T., Wennerberg, K., Porkka, K. & Mustjoki, S., 2024, In: Cell Reports Medicine. 5, 5, 24 p., 101521.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  1 Citation (Scopus)

  3 Downloads (Pure)

• Robust scoring of selective drug responses for patient-tailored therapy selection

  Chen, Y., He, L., Ianevski, A., Ayuda-Durán, P., Potdar, S., Saarela, J., Miettinen, J. J., Kytölä, S., Miettinen, S., Manninen, M., Heckman, C. A., Enserink, J. M., Wennerberg, K. & Aittokallio, T., 2024, In: Nature Protocols. 19, p. 60-82

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)
• 2023

  A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids

  Senkowski, W., Gall-Mas, L., Falco, M. M., Li, Y., Lavikka, K., Kriegbaum, M. C., Oikkonen, J., Bulanova, D., Pietras, E. J., Voßgröne, K., Chen, Y. J., Erkan, E. P., Dai, J., Lundgren, A., Grønning Høg, M. K., Larsen, I. M., Lamminen, T., Kaipio, K., Huvila, J., Virtanen, A. & 9 others, Engelholm, L., Christiansen, P., Santoni-Rugiu, E., Huhtinen, K., Carpén, O., Hynninen, J., Hautaniemi, S., Vähärautio, A. & Wennerberg, K., 2023, In: Developmental Cell. 58, 12, p. 1106-1121.e7 24 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  26 Citations (Scopus)

  87 Downloads (Pure)

• Breeze 2.0: an interactive web-tool for visual analysis and comparison of drug response data

  Potdar, S., Ianevski, F., Ianevski, A., Tanoli, Z., Wennerberg, K., Seashore-Ludlow, B., Kallioniemi, O., Ostling, P., Aittokallio, T. & Saarela, J., 2023, In: Nucleic Acids Research. 51, W1, p. W57-W61 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  3 Citations (Scopus)

  17 Downloads (Pure)

• Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

  Kuusanmäki, H., Dufva, O., Vähä-Koskela, M., Leppä, A-M., Huuhtanen, J., Vänttinen, I. M., Nygren, P. J., Klievink, J., Bouhlal, J. O. V., Pölönen, P., Zhang, Q., Adnan Awad, S., Mancebo-Pérez, C., Saad, J., Miettinen, J. J., Javarappa, K. K., Aakko, S., Ruokoranta, T., Eldfors, S., Heinäniemi, M. & 9 others, Theilgaard-Mönch, K., Wartiovaara-Kautto, U., Keränen, M. A. I., Porkka, K., Konopleva, M., Wennerberg, K., Kontro, M., Heckman, C. A. & Mustjoki, S., 2023, In: Blood. 141, 13, p. 1610-1625

  Research output: Contribution to journal › Journal article › Research › peer-review

• Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia

  Kuusanmäki, H., Kytölä, S., Vänttinen, I., Ruokoranta, T., Ranta, A., Huuhtanen, J., Suvela, M., Parsons, A., Holopainen, A., Partanen, A., Kuusisto, M. E. L., Koskela, S., Räty, R., Itälä-Remes, M., Västrik, I., Dufva, O., Siitonen, S., Porkka, K., Wennerberg, K., Heckman, C. A. & 5 others, Ettala, P., Pyörälä, M., Rimpiläinen, J., Siitonen, T. & Kontro, M., 2023, In: Haematologica. 108, 7, p. 1768-1781 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• PI3Kβ inhibition enhances ALK-inhibitor sensitivity in ALK-rearranged lung cancer

  Talwelkar, S. S., Mayranpaa, M. I., Schuler, J., Linnavirta, N., Hemmes, A., Adinolfi, S., Kankainen, M., Sommergruber, W., Levonen, A-L., Rasanen, J., Knuuttila, A., Verschuren, E. W. & Wennerberg, K., 2023, In: Molecular Oncology. 17, 5, p. 747-764 18 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  5 Citations (Scopus)

  15 Downloads (Pure)

• PP2A-based triple-strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells

  Denisova, O. V., Merisaari, J., Huhtaniemi, R., Qiao, X., Yetukuri, L., Jumppanen, M., Kaur, A., Pääkkönen, M., von Schantz-Fant, С., Ohlmeyer, M., Wennerberg, K., Kauko, O., Koch, R., Aittokallio, T., Taipale, M. & Westermarck, J., 2023, In: Molecular Oncology. 17, 9, p. 1803-1820 18 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  3 Citations (Scopus)

  11 Downloads (Pure)

• Standardized assays to monitor drug sensitivity in hematologic cancers

  Ayuda-Durán, P., Hermansen, J. U., Giliberto, M., Yin, Y., Hanes, R., Gordon, S., Kuusanmäki, H., Brodersen, A. M., Andersen, A. N., Taskén, K., Wennerberg, K., Enserink, J. M. & Skånland, S. S., 2023, In: Cell Death Discovery. 9, 13 p., 435.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  2 Citations (Scopus)

  10 Downloads (Pure)

• Synthetic lethal interaction between WEE1 and PKMYT1 is a target for multiple low-dose treatment of high-grade serous ovarian carcinoma

  Benada, J., Bulanova, D., Azzoni, V., Petrosius, V., Ghazanfar, S., Wennerberg, K. & Sørensen, C. S., 2023, In: NAR Cancer. 5, 3, 13 p., zcad029.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  8 Citations (Scopus)

  21 Downloads (Pure)
• 2022

  Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models

  Chalabi Hajkarim, M., Karjalainen, E., Osipovitch, M., Dimopoulos, K., Gordon, S. L., Ambri, F., Rasmussen, K. D., Grønbæk, K., Helin, K., Wennerberg, K. & Won, K-J., 2022, In: eLife. 11, e73760.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  3 Citations (Scopus)

  62 Downloads (Pure)

• Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors

  Stalnecker, C. A., Grover, K. R., Edwards, A. C., Coleman, M. F., Yang, R., DeLiberty, J. M., Papke, B., Goodwin, C. M., Pierobon, M., Petricoin, E. F., Gautam, P., Wennerberg, K., Cox, A. D., Der, C. J., Hursting, S. D. & Bryant, K. L., 2022, In: Cancer Research. 82, 4, p. 586-598 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  29 Citations (Scopus)

• Development of actionable targets of multi-kinase inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells

  Denisova, O. V., Merisaari, J., Kaur, A., Yetukuri, L., Jumppanen, M., von Schantz-Fant, C., Ohlmeyer, M., Wennerberg, K., Aittokallio, T., Taipale, M. & Westermarck, J., 2022, In: Scientific Reports. 12, 9 p., 13796.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  1 Citation (Scopus)

  15 Downloads (Pure)

• Effects of Wee1 inhibitor adavosertib on patient-derived high-grade serous ovarian cancer cells are multiple and independent of homologous recombination status

  Roering, P., Siddiqui, A., Heuser, V. D., Potdar, S., Mikkonen, P., Oikkonen, J., Li, Y., Pikkusaari, S., Wennerberg, K., Hynninen, J., Grenman, S., Huhtinen, K., Auranen, A., Carpén, O. & Kaipio, K., 2022, In: Frontiers in Oncology. 12, 14 p., 954430.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  2 Citations (Scopus)

  17 Downloads (Pure)

• Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia

  Malani, D., Kumar, A., Brück, O., Kontro, M., Yadav, B., Hellesøy, M., Kuusanmäki, H., Dufva, O., Kankainen, M., Eldfors, S., Potdar, S., Saarela, J., Turunen, L., Parsons, A., Västrik, I., Kivinen, K., Saarela, J., Räty, R., Lehto, M., Wolf, M. & 7 others, Gjertsen, B. T., Mustjoki, S., Aittokallio, T., Wennerberg, K., Heckman, C. A., Kallioniemi, O. & Porkka, K., 2022, In: Cancer Discovery. 12, 2, p. 388-401 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  77 Citations (Scopus)

  19 Downloads (Pure)

• Minimal information for chemosensitivity assays (MICHA): a next-generation pipeline to enable the FAIRification of drug screening experiments

  Tanoli, Z., Aldahdooh, J., Alam, F., Wang, Y., Seemab, U., Fratelli, M., Pavlis, P., Hajduch, M., Bietrix, F., Gribbon, P., Zaliani, A., Hall, M. D., Shen, M., Brimacombe, K., Kulesskiy, E., Saarela, J., Wennerberg, K., Vähä-Koskela, M. & Tang, J., 2022, In: Briefings in Bioinformatics. 23, 1, 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  10 Citations (Scopus)

  19 Downloads (Pure)

• Protocol to utilize fresh uncultured human lung tumor cells for personalized functional diagnostics

  Talwelkar, S. S., Lähdeniemi, I. A. K., Mäyränpää, M. I., Hemmes, A., Linnavirta, N., Räsänen, J., Knuuttila, A., Wennerberg, K. & Verschuren, E. W., 2022, In: STAR Protocols. 3, 4, 19 p., 101720.

  Research output: Contribution to journal › Journal article › Research › peer-review

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• 2021

  Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia

  White, B. S., Khan, S. A., Mason, M. J., Ammad-ud-din, M., Potdar, S., Malani, D., Kuusanmäki, H., Druker, B. J., Heckman, C., Kallioniemi, O., Kurtz, S. E., Porkka, K., Tognon, C. E., Tyner, J. W., Aittokallio, T., Wennerberg, K. & Guinney, J., 2021, In: n p j Precision Oncology. 5, 1, 11 p., 71.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  18 Citations (Scopus)

  44 Downloads (Pure)

• Crowdsourced mapping of unexplored target space of kinase inhibitors

  Cichonska, A., Ravikumar, B., Allaway, R. J., Wan, F., Isayev, O., Li, S., Mason, M., Lamb, A., Tanoli, Z., Jeon, M., Kim, S., Popova, M., Capuzzi, S., Zeng, J., Dang, K., Koytiger, G., Kang, J., Wells, C. I., Willson, T. M., Oprea, T. I. & 6 others, Schlessinger, A., Drewry, D. H., Stolovitzky, G., Wennerberg, K., Guinney, J. & Aittokallio, T., 2021, In: Nature Communications. 12, 1, 18 p., 3307.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  44 Citations (Scopus)

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• Exploration of databases and methods supporting drug repurposing: A comprehensive survey

  Tanoli, Z., Seemab, U., Scherer, A., Wennerberg, K., Tang, J. & Vähä-Koskela, M., 2021, In: Briefings in Bioinformatics. 22, 2, p. 1656-1678 23 p.

  Research output: Contribution to journal › Review › Research › peer-review

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  68 Citations (Scopus)

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• Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments

  Talwelkar, S. S., Mäyränpää, M. I., Søraas, L., Potdar, S., Bao, J., Hemmes, A., Linnavirta, N., Lømo, J., Räsänen, J., Knuuttila, A., Wennerberg, K. & Verschuren, E. W., 2021, In: Cell Reports Medicine. 2, 8, 21 p., 100373.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  5 Citations (Scopus)

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• Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor

  Jaiswal, A., Gautam, P., Pietilä, E. A., Timonen, S., Nordström, N., Akimov, Y., Sipari, N., Tanoli, Z., Fleischer, T., Lehti, K., Wennerberg, K. & Aittokallio, T., 2021, In: Molecular Systems Biology. 17, 3, p. 1-25 e9526.

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  6 Citations (Scopus)

  36 Downloads (Pure)

• Network-guided identification of cancer-selective combinatorial therapies in ovarian cancer

  He, L., Bulanova, D., Oikkonen, J., Häkkinen, A., Zhang, K., Zheng, S., Wang, W., Erkan, E. P., Carpén, O., Joutsiniemi, T., Hietanen, S., Hynninen, J., Huhtinen, K., Hautaniemi, S., Vähärautio, A., Tang, J., Wennerberg, K. & Aittokallio, T., 2021, In: Briefings in Bioinformatics. 22, 6, 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  12 Citations (Scopus)

  17 Downloads (Pure)

• Patient-tailored design for selective co-inhibition of leukemic cell subpopulations

  Ianevski, A., Lahtela, J., Javarappa, K. K., Sergeev, P., Ghimire, B. R., Gautam, P., Vähä-Koskela, M., Turunen, L., Linnavirta, N., Kuusanmäki, H., Kontro, M., Porkka, K., Heckman, C. A., Mattila, P., Wennerberg, K., Giri, A. K. & Aittokallio, T., 2021, In: Science Advances. 7, 8, eabe4038.

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  19 Citations (Scopus)

  25 Downloads (Pure)

• Selective drug combination vulnerabilities in STAT3- And TP53-mutant malignant NK cells

  Parri, E., Kuusanmäki, H., Bulanova, D., Mustjoki, S. & Wennerberg, K., 2021, In: Blood advances. 5, 7, p. 1862-1875

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  6 Citations (Scopus)

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• 2020

  Abstract P6-10-28: Therapeutic stratification of triple negative breast cancer by integrating chemosensitivity & phospho-proteome profiles

  Gautam, P., Qin, X., Vainonen, J., Nagelli, S., Lampe, J., Klefström, J., Westermarck, J., Wennerberg, K. & Aittokallio, T., 2020.

  Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

• ALDH1A1‐related stemness in high‐grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR‐PI3K/aurora kinase inhibitors

  Kaipio, K., Chen, P., Roering, P., Huhtinen, K., Mikkonen, P., Östling, P., Lehtinen, L., Mansuri, N., Korpela, T., Potdar, S., Hynninen, J., Auranen, A., Grénman, S., Wennerberg, K., Hautaniemi, S. & Carpén, O., 2020, In: Journal of Pathology. 250, 2, p. 159-169 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  37 Citations (Scopus)

  18 Downloads (Pure)

• A normalized drug response metric improves accuracy and consistency of anticancer drug sensitivity quantification in cell-based screening

  Gupta, A., Gautam, P., Wennerberg, K. & Aittokallio, T., 2020, In: Communications Biology. 3, 1, p. 1-12

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  23 Citations (Scopus)

  71 Downloads (Pure)

• Atypical KRAS^G12R mutant is impaired in PI3K signaling and macropinocytosis in pancreatic cancer

  Hobbs, G. A., Baker, N. M., Miermont, A. M., Thurman, R. D., Pierobon, M., Tran, T. H., Anderson, A. O., Waters, A. M., Diehl, J. N., Papke, B., Hodge, R. G., Klomp, J. E., Goodwin, C. M., DeLiberty, J. M., Wang, J., Ng, R. W. S., Gautam, P., Bryant, K. L., Esposito, D., Campbell, S. L. & 8 others, Petricoin, E. F., Simanshu, D. K., Aguirre, A. J., Wolpin, B. M., Wennerberg, K., Rudloff, U., Cox, A. D. & Der, C. J., 2020, In: Cancer Discovery. 10, 1, p. 104-123 20 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  124 Citations (Scopus)

• Breeze: an integrated quality control and data analysis application for high-throughput drug screening

  Potdar, S., Ianevski, A., Mpindi, J., Bychkov, D., Fiere, C., Ianevski, P., Yadav, B., Wennerberg, K., Aittokallio, T., Kallioniemi, O., Saarela, J. & Östling, P., 2020, In: Bioinformatics. 36, 11, p. 3602-3604

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  60 Citations (Scopus)

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• Human Tumor–Derived Matrix Improves the Predictability of Head and Neck Cancer Drug Testing

  Tuomainen, K., Al-samadi, A., Potdar, S., Turunen, L., Turunen, M., Karhemo, P., Bergman, P., Risteli, M., Åström, P., Tiikkaja, R., Grenman, R., Wennerberg, K., Monni, O. & Salo, T., 2020, In: Cancers. 12, 1, 92.

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  24 Citations (Scopus)

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• Identification of novel regulators of STAT3 activity

  Parri, E., Kuusanmäki, H., Van Adrichem, A. J., Kaustio, M. & Wennerberg, K., 2020, In: PLoS ONE. 15, 3, p. 1-18 e0230819.

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  14 Citations (Scopus)

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• Improved detection of differentially represented DNA barcodes for high-throughput clonal phenomics

  Akimov, Y., Bulanova, D., Timonen, S., Wennerberg, K. & Aittokallio, T., 2020, In: Molecular Systems Biology. 16, 3, p. 1-18 e9195.

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  11 Citations (Scopus)

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• Interactive visual analysis of drug–target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing

  Tanoli, Z., Alam, Z., Ianevski, A., Wennerberg, K., Vähä-koskela, M. & Aittokallio, T., 2020, In: Briefings in Bioinformatics. 21, 1, p. 211-220

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  30 Citations (Scopus)

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• KIT pathway upregulation predicts dasatinib efficacy in acute myeloid leukemia

  Malani, D., Yadav, B., Kumar, A., Potdar, S., Kontro, M., Kankainen, M., Javarappa, K. K., Porkka, K., Wolf, M., Aittokallio, T., Wennerberg, K., Heckman, C. A., Murumägi, A. & Kallioniemi, O., 2020, In: Leukemia. 34, p. 2780-2784

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  8 Citations (Scopus)

  15 Downloads (Pure)

• Mitochondria in Their Prime Drive Venetoclax Response in Acute Myeloid Leukemia

  Kriegbaum, M. C. & Wennerberg, K., 2020, In: Cancer Cell. 38, 6, p. 776-778 3 p.

  Research output: Contribution to journal › Journal article › Research
  1 Citation (Scopus)

• Multi-parametric single cell evaluation defines distinct drug responses in healthy hematologic cells that are retained in corresponding malignant cell types

  Majumder, M. M., Leppä, A., Hellesøy, M., Dowling, P., Malyutina, A., Kopperud, R., Bazou, D., Andersson, E., Parsons, A., Tang, J., Kallioniemi, O., Mustjoki, S., O’gorman, P., Wennerberg, K., Porkka, K., Gjertsen, B. T. & Heckman, C. A., 2020, In: Haematologica. 105, 6, p. 1527-1538

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  19 Citations (Scopus)

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• Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition

  Tambe, M., Karjalainen, E., Vähä-Koskela, M., Bulanova, D., Gjertsen, B. T., Kontro, M., Porkka, K., Heckman, C. A. & Wennerberg, K., 2020, In: Leukemia. 34, p. 3186-3196

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)

• Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1

  Kauko, O., Imanishi, S. Y., Kulesskiy, E., Yetukuri, L., Laajala, T. D., Sharma, M., Pavic, K., Aakula, A., Rupp, C., Jumppanen, M., Haapaniemi, P., Ruan, L., Yadav, B., Suni, V., Varila, T., Corthals, G. L., Reimand, J., Wennerberg, K., Aittokallio, T. & Westermarck, J., 2020, In: Journal of Biological Chemistry. 295, 13, p. 4194-4211

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  43 Citations (Scopus)

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• Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma

  Hansson, K., Radke, K., Aaltonen, K., Saarela, J., Mañas, A., Sjölund, J., Smith, E. M., Pietras, K., Påhlman, S., Wennerberg, K., Gisselsson, D. & Bexell, D., 2020, In: Science Translational Medicine. 12, 562, p. 1-17 eaba4434.

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  19 Citations (Scopus)

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• 2019

  Abstract P2-06-25: A phenotypic screening and machine learning platform efficiently identifies triple negative breast cancer-selective and readily druggable targets

  Gautam, P., Jaiswal, A., Aittokallio, T., Hassan, A. & Wennerberg, K., 2019, In: Cancer Research. p. P2-06-25-P2-06-25

  Research output: Contribution to journal › Conference abstract in journal › Research

• Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies

  Ravikumar, B., Timonen, S., Alam, Z., Parri, E., Wennerberg, K. & Aittokallio, T., 2019, In: Cell Chemical Biology. 26, 11, p. 1608-1622

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)

• Drug screening and molecular profiling identifies INKA1 as a predictive biomarker for sensitivity to MAPK inhibition-antimitotic combination treatment in pancreatic ductal adenocarcinoma

  Gautam, P., Vaha-Koskela, M., Tomlinson, M., Cox, A. D., Der, C. J., Aittokallio, T. & Wennerberg, K., 2019, In: Molecular Cancer Therapeutics. 18, 12, A137.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• Drug sensitivity testing on patient-derived sarcoma cells predicts patient response to treatment and identifies c-Sarc inhibitors as active drugs for translocation sarcomas

  Brodin, B. A., Wennerberg, K., Lidbrink, E., Brosjö, O., Potdar, S., Wilson, J. N., Ma, L., Moens, L. N., Hesla, A., Porovic, E., Bernhardsson, E., Papakonstantinou, A., Bauer, H., Tsagkozis, P., Von Sivers, K., Wejde, J., Östling, P., Kallioniemi, O. & Stragliotto, C. L., 2019, In: British Journal of Cancer. 120, 4, p. 435-443 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  23 Citations (Scopus)

  85 Downloads (Pure)

• Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer

  Tang, J., Gautam, P., Gupta, A., He, L., Timonen, S., Akimov, Y., Wang, W., Szwajda, A., Jaiswal, A., Turei, D., Yadav, B., Kankainen, M., Saarela, J., Saez-rodriguez, J., Wennerberg, K. & Aittokallio, T., 2019, In: npj Systems Biology and Applications. 5, 1, 5.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  26 Citations (Scopus)

  61 Downloads (Pure)

• Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets

  Gautam, P., Jaiswal, A., Aittokallio, T., Al-ali, H. & Wennerberg, K., 2019, In: Cell Chemical Biology. 26, 7, p. 970-979

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  31 Citations (Scopus)

• Prediction of drug combination effects with a minimal set of experiments

  Ianevski, A., Giri, A. K., Gautam, P., Kononov, A., Potdar, S., Saarela, J., Wennerberg, K. & Aittokallio, T., 2019, In: Nature Machine Intelligence. 1, 12, p. 568-577

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access