Research output per year
Research output per year
PhD, Associate Professor, Senior Scientist, M.Sc.
Blegdamsvej 3, 2200 København N.
Research activity per year
The Almstrup group is mainly located at the Department of Growth and Reproduction, at Copenhagen University Hospital - Rigshospitalet but is also affiliated with the Department of Cellular and Molecular Medicine, at University of Copenhagen. Our research focus on studies that connect genetic and epigenetic variation to reproductive endpoints, testicular gene expression and functional studies of sperm cells.
Group homepage: https://www.rigshospitalet.dk/almstrup
Genetic and epigenetic variation in relation to reproductive endpoints, testicular gene expression and functional studies of sperm cells.
Medical genetics course (Medicine and Molecular Biomedicine)
PhD course in Genetics of Reproduction, May 16-17, 2022
Graduate programmes: Life Cycle in Medicine and Cellular & Genetic Medicine
None
The Almstrup group has been pioneering in describing genetic and epigenetic variation associated with several reproductive endpoints. This includes genetic variants causing non-obstructive azoospermia (GEMINI, IMIGC consortia), genetic variants associated with testicular germ cell cancer (TECAC consortia) as well as genetic variants and DNA methylation patterns that have a significant effect on the age of pubertal onset.
Small RNAs, like micro RNAs (miRNAs) and the PIWI-interacting RNAs (piRNAs), is an area of great interest to our group. We have shown that the piRNAs, which are nearly unique to male germ cell, are essential for human spermatogenesis and have identified piRNAs in seminal plasma and in circulation that may serve as markers of testicular function. However, also specific miRNAs show great promise as novel sensitive biomarker of testicular germ cell cancer.
The testis is a complex tissue with many different cell types and studies of testicular gene expression, therefore, needs to take into account the composition of cell types that are present in the analysis. The Almstrup group has been involved in studies of testicular gene expression since the pre-omics era, using differential display techniques, and are now working with single-cell/nuclei methods and spatial transcriptomics.
Sperm cells are unique because they have a tightly packed haploid genome, are extremely differentiated, and has the sole purpose of fertilising an egg. We have shown that the number of viable sperm cells with an intact acrosome is important for the fertility of men and that environmental chemicals can influence sperm cell function directly.
Senior Scientist, Department of Growth and Reproduction
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Review › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Review › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Kristian Almstrup (Editor)
Activity: Peer-review and editorial work types › Editor of Research journal › Communication
Kristian Almstrup (Editor)
Activity: Peer-review and editorial work types › Editor of Research journal › Research
Kristian Almstrup (Editor)
Activity: Peer-review and editorial work types › Editor of Research journal › Research
Kristian Almstrup (Other)
Activity: Talk or presentation types › Lecture and oral contribution
Kristian Almstrup (Participant)
Activity: Participating in an event - types › Organisation of and participation in conference
Kristian Almstrup (Other)
Activity: Talk or presentation types › Lecture and oral contribution
Kristian Almstrup (Other)
Activity: Talk or presentation types › Lecture and oral contribution
Kristian Almstrup (Other)
Activity: Talk or presentation types › Lecture and oral contribution
21/12/2022
1 item of Media coverage
Press/Media: Press / Media
05/08/2021
1 item of Media coverage
Press/Media: Press / Media
03/01/2018
1 item of Media coverage
Press/Media: Press / Media
05/08/2021
1 item of Media coverage
Press/Media: Press / Media
05/08/2021
1 item of Media coverage
Press/Media: Press / Media
05/08/2021
1 item of Media coverage
Press/Media: Press / Media