Kristine Holgersen

Kristine Holgersen

PhD, MSc in Veterinary Medicine

  • Dyrlægevej 68

    1870 Frederiksberg C

Personal profile

Short presentation

My research concerns nutritional, metabolic and endocrine pathways in early life and how this impacts health and disease in the newborn. Of particular interest is the development and function of the gut. I work with specialized and clinically relevant experimental animal models of disease and utilize these to investigate mechanisms of action and clinical safety/efficacy of nutritional and pharmaceutical therapies.

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Education

PhD, 11 February 2015, Novo Nordisk A/S and University of Copenhagen

MSc in Veterinary Medicine (DVM), 22 August 2011, University of Copenhagen

BSc in Veterinary Medicine, 30 June 2008, University of Copenhagen

Positions

Jan 2024 – Jan 2025: Postdoc at Comparative Pediatric and Nutrition, Dept. of Veterinary and Animal Sciences, University of Copenhagen

  • Study responsible for in vivo studies in preterm pigs, e.g. investigating the effects of:
  • Different milk caseins on gut and immune maturation. Collaboration with Arla Food Ingredients and Aarhus University (the BMCIII and Casgut projects)
  • Absorption of extracellular vesicles in the intestine. Collaboration with Arla Food Ingredients and Aarhus University (GutBioMod project)

 

Jan 2021 – Dec 2023: Scientist at Odense University Hospital, Region of Southern Denmark

  • Human infant studies: Analyses of the metabolic profile, amino acids and early growth in very preterm infants fed fortified human breast milk from the FortiColos Trial.

 

Jan 2019 – Dec 2021: Postdoc at Comparative Pediatric and Nutrition, Dept. of Veterinary and Animal Sciences, University of Copenhagen

  • Study responsible for studies investigating the effects of exogenous systemic IGF-1 treatment on growth and organ development in preterm pigs. A collaboration with Takeda Pharmaceuticals.

 

May  2015 – Nov 2018: Compliance Consultant at Epista Life Science

  • Projects at CMC Development and Biopharm, Novo Nordisk A/S - testing and qualification of systems used in the GMP-regulated area for manufacturing drugs for clinical trials.

Nov. 2014 - April 2015: Scientific assistant at University of Southern Denmark

  • Establishment of an experimental mouse model of colitis with a humanized gut microbiota
  • DNA extraction and analysis of material from inflammatory bowel disease patients.

Sep 2011 – Oct 2014: PhD student at the Novo Nordisk – LIFE In Vivo Pharmacology Centre (LIFEPHARM). Dept. of Immunopharmacology, Novo Nordisk A/S and Dept. of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen.

  • Implementation and characterization of experimental mouse models of colitis and preclinical drug screening. PhD project entitled Piroxicam-accelerated colitis in interleukin-10 knockout mice; an in vivo model mimicking human inflammatory bowel disease.

 

Sep 2013- Dec 2013: Academic Visitor at the University of Oxford. Nuffield Department of Medicine, Translational Gastroenterology Unit, Powrie Laboratory.

  • Preclinical testing of a new Novo Nordisk lead compound in a mouse model of chronic colitis.

Teaching and supervision

  • Practical and theoretical courses in laboratory animal science for Bachelor-, Master- and PhD students.
  • Lecture on Bachelor course ‘Sygdomslære og farmakologi’ at University of Copenhagen
  • Co- supervising 5 veterinary master students during their master thesis project and 2 laboratory technician trainees in practical experimental work and during their final project.

Academic awards and honours:

  • Runner-up, Best poster presentation, IVP annual meeting, Marts 2014.

SHARE Young Scientist Research Award for outstanding achievement poster presentation, Nov 2011

Other scientific  skills

Poster and oral presentation; I have presented at several scientific congresses and academic meetings, incl.:

  • jENS Meeting, Rome 2023
  • ESPGHAN, Copenhagen 2022
  • Digestive Disease Week, Chicago 2014
  • Congress of the European Crohn’s and Colitis Organisation (ECCO), Barcelona 2012/Vienna 2013
  • European Medicines Research Training Network (EMTRAIN) PhD Workshop, Stevenage (GSK) 2013
  • European Congress of Immunology, Glasgow 2012.

 

Training courses:

  • Statistical methods for science (SmS), SCIENCE, University of Copenhagen
  • Data Integrity. Requirement for a GMP-compliant Data Life Cycle. European Compliance Academy
  • The 3-year In Vivo Pharmacology Research Training Programme. Faculty of Health and Medical sciences, University of Copenhagen as a collaboration with the pharmaceutical industry
  • In Vivo Pharmacology - Biologic variation, reproducibility and predictability in preclinical drug testing in lab. animals. Faculty of Health and Medical sciences, University of Copenhagen
  • Practical course in cellular immunology. Faculty of Health and Medical sciences, University of Copenhagen
  • Statistics for Veterinarians. Faculty of Health and Medical sciences, University of Copenhagen
  • Laboratory Animal Science - Cat. C Course. Faculty of Health and Medical sciences, University of Copenhagen.
  • Home Office, ANIMALS (SCIENTIFIC PROCEDURES) ACT 1986, personal licence, UK Government.

Excellent Microsoft Office Skills (Excel, Powerpoint, Word, Adobe Acrobat, Outlook etc.)

Language skills; Danish is native and English is fluent (written and spoken).

 

External positions

Scientist, Hans Christian Andersen Children's Hospital

1 Feb 202231 Dec 2023

Keywords

  • Laboratory animal
  • Development of new medicine
  • Former LIFE faculty

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or