Research output per year
Research output per year
Personal profile
Short presentation
Main research interests
I study drug compound permeation across biological barriers and the interplay with transport proteins to improve our understanding of these barriers and how they can be overcome through drug delivery.
My research is mainly focused on the blood-brain barrier and the role of efflux transporters. To this end, we develop cell culture models that mimick the human blood-brain barrier or over-express efflux transport proteins using human stem cells or immortalized cell lines. We use these cell models to study the dynamics of substrate-transporter interactions and explore new drug delivery concepts to improve brain delivery.
Education/Academic qualification
MSc Pharm.
2006 → 2008
Award Date: 20 Jun 2008
BSc. Pharm
2003 → 2006
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
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Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution
Langthaler, K., Jones, C. R., Saaby, L., Bundgaard, C. & Brodin, B., 2024, In: Fluids and Barriers of the CNS. 21, 1, 15 p., 11.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile24 Downloads (Pure) -
Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus
Nielsen, A. K. R., Lilieholm-Røngren, L., Schmid, B., Holst, B., Brodin, B. & Saaby, L., 2024, In: Stem Cell Research. 76, 5 p., 103348.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile20 Downloads (Pure) -
Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation
Mortensen, J. S., Bohr, S. S. R., Krog, L. S., Bøtker, J. P., Kapousidou, V., Saaby, L., Hatzakis, N. S., Mørck Nielsen, H., Nguyen, D. N. & Rønholt, S., 2024, In: Scientific Reports. 14, 1, 17 p., 7665.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile22 Downloads (Pure) -
The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells
Svane, N. I., Pedersen, A. B. V., Rodenberg, A., Ozgür, B., Saaby, L., Bundgaard, C., Kristensen, M., Tfelt-Hansen, P. & Larsen, B. B., 2024, In: Fluids and Barriers of the CNS. 21, 19 p., 39.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)13 Downloads (Pure) -
Barrier properties of ex vivo porcine intestinal mucus are highly independent of isolation and storage conditions
Støvring Mortensen, J., Saaby, L., Harloff-Helleberg, S. & Mørck Nielsen, H., 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 174, p. 106-110Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile6 Citations (Scopus)78 Downloads (Pure) -
Insight Into the Anti-staphylococcal Activity of JBC 1847 at Sub-Inhibitory Concentration
Ronco, T., Kappel, L. H., Aragao, M. F., Biagi, N., Svenningsen, S., Christensen, J. B., Permin, A., Saaby, L., Holmstrøm, K., Klitgaard, J. K., Sabat, A. J., Akkerboom, V., Monaco, M., Tinelli, M., Friedrich, A. W., Jana, B. & Olsen, R. H., 2022, In: Frontiers in Microbiology. 12, 786173.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)34 Downloads (Pure) -
Physical and barrier changes in gastrointestinal mucus induced by the permeation enhancer sodium 8-[(2-hydroxybenzoyl)amino]octanoate (SNAC)
Mortensen, J. S., Bohr, S. S. R., Harloff-Helleberg, S., Hatzakis, N. S., Saaby, L. & Nielsen, H. M., 2022, In: Journal of Controlled Release. 352, p. 163-178 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile11 Citations (Scopus)70 Downloads (Pure) -
A new phenothiazine derivate is active against Clostridioides difficile and shows low cytotoxicity
Ronco, T., Aragao, F. M., Saaby, L., Christensen, J. B., Permin, A., Williams, A. R., Thamsborg, S. M. & Olsen, R. H., 2021, In: PLoS ONE. 16, 10, 13 p., e0258207.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)32 Downloads (Pure)