Lennart Bunch

Search results

• 2024

  Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)-2-((S)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu₂ Receptor Agonist

  Liu, N., Eshak, F., Malhaire, F., Brabet, I., Prézeau, L., Renard, E., Pin, J. P., Acher, F. C., Staudt, M. & Bunch, L., 2024, In: Journal of Medicinal Chemistry. 67, 2, p. 1314–1326

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)

• Domoic Acid as a Lead for the Discovery of the First Selective Ligand for Kainate Receptor Subtype 5 (GluK5)

  Buschbom-Helmke, S., Wang, P., Alcaide, A., Miguez-Cabello, F., Carta, M., Viotti, J. S., Nielsen, B., Mulle, C., Bowie, D., Jørgensen, F. S., Pickering, D. S. & Bunch, L., 2024, In: Journal of Medicinal Chemistry. 67, 16, p. 14524–14542

  Research output: Contribution to journal › Journal article › Research › peer-review

• Synthesis and pharmacological characterization of conformationally restricted 2-amino-Adipic acid analogs and carboxycyclopropyl glycines as selective metabotropic glutamate 2 receptor agonists

  Staudt, M., Liu, N., Malhaire, F., Doroudian, Y., Prézeau, L., Renard, E., Hasanpour, Z., Pin, J. P. & Bunch, L., 2024, In: European Journal of Medicinal Chemistry. 266, 11 p., 116157.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  1 Citation (Scopus)

  14 Downloads (Pure)
• 2023

  Convenient access to β-substituted cysteines and β- and γ-mercapto prolines

  Hansen, J. C., Rabuffetti, M. & Bunch, L., 2023, In: Canadian Journal of Chemistry. 101, 5, p. 326-333

  Research output: Contribution to journal › Journal article › Research › peer-review

• In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs

  Bechthold, E., Grey, L., Diamant, E., Schmidt, J., Steigerwald, R., Zhao, F., Hansen, K. B., Bunch, L., Clausen, R. P. & Wünsch, B., 2023, In: Biological Chemistry. 404, 4, p. 255-265

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  2 Citations (Scopus)
• 2022

  (S)-2-Mercaptohistidine: A First Selective Orthosteric GluK3 Antagonist

  Poulie, C. B. M., Larsen, Y., Leteneur, C., Barthet, G., Bjorn-Yoshimoto, W. E., Malhaire, F., Nielsen, B., Pin, J. P., Mulle, C., Pickering, D. S. & Bunch, L., 2022, In: ACS Chemical Neuroscience. 13, 10, p. 1580–1587

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)

• Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

  Zhao, F., Atxabal, U., Mariottini, S., Yi, F., Lotti, J. S., Rouzbeh, N., Liu, N., Bunch, L., Hansen, K. B. & Clausen, R. P., 2022, In: Journal of Medicinal Chemistry. 65, 1, p. 734-746

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  6 Citations (Scopus)

• Discovery of (R)-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity

  Zhao, F., Mazis, G., Yi, F., Lotti, J. S., Layeux, M. S., Schultz, E. P., Bunch, L., Hansen, K. B. & Clausen, R. P., 2022, In: Frontiers in Chemistry. 10, 13 p., 1008233.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  3 Citations (Scopus)

  17 Downloads (Pure)

• Synthesis of phenol derivatives from cyclopentenones with arynes as key intermediates

  Telese, D., Staudt, M. & Bunch, L., 2022, In: Results in Chemistry. 4, 7 p., 100412.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  1 Citation (Scopus)

  30 Downloads (Pure)

• Transition Metal-Free Synthesis of meta-Bromo- and meta-Trifluoromethylanilines from Cyclopentanones by a Cascade Reaction

  Staudt, M., Cetin, A. & Bunch, L., 2022, In: Chemistry: A European Journal. 28, 10, 5 p., 202102998.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  4 Citations (Scopus)

  21 Downloads (Pure)
• 2021

  Semi-synthesis of novel buprenorphine derivatives and their anti-nociceptive properties and dependency potential

  Hasanpour, Z., Salehi, P., Bunch, L., Khoramjouy, M., Bararjanian, M., Stærk, D. & Faizi, M., 2021, In: Canadian Journal of Chemistry. 99, 11, p. 910-919

  Research output: Contribution to journal › Journal article › Research › peer-review

  File
  2 Citations (Scopus)

• Synthesis of Polysubstituted Meta-Halophenols by Anion-Accelerated 2π-Electrocyclic Ring-Opening

  Staudt, M., Sølling, T. I. & Bunch, L., 2021, In: Chemistry - A European Journal. 27, 42, p. 10941–10947 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)
• 2020

  A Diversity Oriented Synthesis Approach to New 2,3-trans-Substituted l-Proline Analogs as Potential Ligands for the Ionotropic Glutamate Receptors

  Kayser, S., Temperini, P., Poulie, C. B. M., Staudt, M., Nielsen, B., Pickering, D. S. & Bunch, L., 4 Mar 2020, In: ACS Chemical Neuroscience. 11, p. 702-714 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)

• Design, Synthesis, and Pharmacological Characterization of Heterobivalent Ligands for the Putative 5-HT_2A/mGlu₂ Receptor Complex

  Poulie, C. B. M., Liu, N., Jensen, A. A. & Bunch, L., 2020, In: Journal of Medicinal Chemistry. 63, 17, p. 9928-9949 22 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)

• From Methaqualone and Beyond: Structure-Activity Relationship of 6-, 7-, and 8-Substituted 2,3-Diphenyl-quinazolin-4(3H)-ones and in Silico Prediction of Putative Binding Modes of Quinazolin-4(3H)-ones as Positive Allosteric Modulators of GABAA Receptors

  Wang, P-F., Jensen, A. A. & Bunch, L., 2020, In: ACS Chemical Neuroscience. 11, 24, p. 4362-4375

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Stereoselective Synthesis of New (2S,3R)-3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid Analogues Utilizing a C(sp3)-H Activation Strategy and Structure-Activity Relationship Studies at the Ionotropic Glutamate Receptors

  Kayser, S., Hansen, J. C., Staudt, M., Moroz, A., Larsen, Y., Temperini, P., Yi, F., Syrenne, J. T., Krogsgaard-Larsen, N., Iliadis, S., Nielsen, B., Hansen, K. B., Pickering, D. S. & Bunch, L., 2020, In: ACS Chemical Neuroscience. 11, p. 674-701 28 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  8 Citations (Scopus)

• β-Indolyloxy Functionalized Aspartate Analogs as Inhibitors of the Excitatory Amino Acid Transporters (EAATs)

  Liu, N., Jensen, A. A. & Bunch, L., 2020, In: ACS Medicinal Chemistry Letters. 11, 11, p. 2212-2220 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  1 Citation (Scopus)
• 2019

  Design and Synthesis of 2,3-trans-Proline Analogs as Ligands for the Ionotropic Glutamate Receptors and the Excitatory Amino Acid Transporters

  Poulie, C. B. M., Alcaide Lopez, A., Krell-Jørgensen, M. P., Larsen, Y., Astier, E., Bjørn-Yoshimoto, W. E., Yi, F., Syrenne, J. T., Storgaard, M., Nielsen, B., Frydenvang, K. A., Jensen, A. A., Hansen, K. B., Pickering, D. S. & Bunch, L., 19 Jun 2019, In: A C S Chemical Neuroscience. 10, 6, p. 2989-3007 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  4 Citations (Scopus)

• Identification and Structure-Activity Relationship Study of Imidazo[1,2-a]pyridine-3-amines as First Selective Inhibitors of Excitatory Amino Acid Transporter Subtype 3 (EAAT3)

  Wu, P., Bjørn-Yoshimoto, W. E., Staudt, M., Jensen, A. A. & Bunch, L., 2019, In: ACS Chemical Neuroscience. 10, p. 4414-4429

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• The Screening and Design of Allosteric Kinase Inhibitors

  Wu, P., Dinér, P. & Bunch, L., 2019, Kinase Drug Discovery: Modern Approaches. 1. ed. Royal Society of Chemistry, p. 34-60

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  2 Citations (Scopus)
• 2018

  Chemoenzymatic synthesis and pharmacological characterization of functionalized aspartate analogues as novel excitatory amino acid transporter inhibitors

  Fu, H., Zhang, J., Tepper, P. G., Bunch, L., Jensen, A. A. & Poelarends, G. J., 13 Sep 2018, In: Journal of Medicinal Chemistry. 61, 17, p. 7741-7753

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  18 Citations (Scopus)

  224 Downloads (Pure)

• Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors

  Olander, E. R., Madjroh, N., Bunch, L., Söderhielm, P. C. & Jensen, A. A., 2018, In: Biochemical Pharmacology. 150, p. 305-319

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)

• Functionalization of Oxazolo[4,5-b]pyrazines by Deprotometallation

  Bisballe, N., Hedidi, M., Demmer, C. S., Chevallier, F., Roisnel, T., Dorcet, V., Halauko, Y. S., Ivashkevich, O. A., Matulis, V. E., Bentabed-Ababsa, G., Bunch, L. & Mongin, F., 7 Aug 2018, In: European Journal of Organic Chemistry. 29, p. 3904-3913

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)
• 2017

  Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist

  Gynther, M., Proietti Silvestri, I., Hansen, J. C., Hansen, K. B., Malm, T., Ishchenko, Y., Larsen, Y., Han, L., Kayser, S., Auriola, S., Petsalo, A., Nielsen, B., Pickering, D. S. & Bunch, L., 14 Dec 2017, In: Journal of Medicinal Chemistry. 60, 23, p. 9885-9904 20 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  28 Citations (Scopus)

• Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid

  Krogsgaard-Larsen, N., Delgar, C., Koch, K., Brown, P. M. G. E., Møller, C., Han, L., Huynh, T. H. V., Hansen, S. W., Nielsen, B., Bowie, D., Pickering, D. S., Kastrup, J. S. J., Frydenvang, K. A. & Bunch, L., 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 441-457 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• Revisiting the Quinoxalinedione scaffold in the Construction of New Ligands for the Ionotropic Glutamate Receptors.

  Demmer, C. S., Rombach, D., Liu, N., Nielsen, B., Pickering, D. S. & Bunch, L., 1 Dec 2017, In: A C S Chemical Neuroscience. 8, 11, p. 2477-2495 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• Tetrabutylammonium Fluoride (TBAF) as a Mild and Versatile Reagent for Cleaving Boroxazolidones to their Corresponding Free α-Amino Acids

  Poulie, C. B. M. & Bunch, L., Mar 2017, In: European Journal of Organic Chemistry. 11, p. 1475-1478

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)
• 2016

  Beta-Sulfonamido Functionalized Aspartate Analogs as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype-Selectivity Profiles Arising from Subtle Structural Differences

  Hansen, J. C., Bjørn-Yoshimoto, W. E., Bisballe, N., Nielsen, B., Jensen, A. A. & Bunch, L., 2016, In: Journal of Medicinal Chemistry. 59, p. 8771-8786 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Bioavailability studies and in vitro profiling of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor 2-amino-4-(4-methyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-102)

  Haym, I., Huynh, T. H. V., Hansen, S. W., Pedersen, M. H. F., Ruiz, J. A., Erichsen, M. N., Gynther, M., Bjørn-Yoshimoto, W. E., Abrahamsen, B., Bastlund, J. F., Bundgaard, C., Eriksen, A. L., Jensen, A. A. & Bunch, L., 2016, In: ChemMedChem. 11, 4, p. 403-419 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• Identification of a New Class of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors Followed by a Structure-Activity-Relationship Study

  Hansen, S. W., Erichsen, M. N., Fu, B., Bjørn-Yoshimoto, W. E., Abrahamsen, B., Hansen, J. C., Jensen, A. A. & Bunch, L., 2016, In: Journal of Medicinal Chemistry. 59, 19, p. 8757-8770 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)

• New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III

  Huynh, T. H. V., Erichsen, M. N., Tora, A. S., Goudet, C., Sagot, E., Assaf, Z., Thomsen, C., Brodbeck, R., Stensbol, T. B., Bjorn-Yoshimoto, W. E., Nielsen, B., Pin, J-P., Gefflaut, T. & Bunch, L., 2016, In: Journal of Medicinal Chemistry. 59, 3, p. 914-924 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• New insights into the structure-activity-relationship of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitors UCPH-101 and UCPH-102

  Hansen, S. W., Erichsen, M. N., Huynh, T. H. V., Ruiz, J. A., Haym, I., Bjørn-Yoshimoto, W. E., Abrahamsen, B., Hansen, J., Storgaard, M., Eriksen, A. L., Jensen, A. A. & Bunch, L., 2016, In: ChemMedChem. 11, 4, p. 382-402 21 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• Synthesis and Pharmacological Characterization of the Selective GluK1 Radioligand (S)-2-Amino-3-(6-[3H]-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)propanoic acid ([3H]-NF608)

  Alcaide, A., Marconi, L., Marek, A., Haym, I., Nielsen, B., Møllerud, S., Jensen, M., Conti, P., Pickering, D. S. & Bunch, L., 2016, In: MedChemComm. 7, p. 2136-2144 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)
• 2015

  A multifaceted GABAA receptor modulator: Functional properties and mechanism of action of the sedative-hypnotic and recreational drug methaqualone (Quaalude)

  Hammer, H., Bader, B. M., Ehnert, C., Bundgaard, C., Bunch, L., Hoestgaard-Jensen, K., Schroeder, O. H-U., Bastlund, J. F., Gramowski-Voß, A. & Jensen, A. A., 2015, In: Molecular Pharmacology. 88, 2, p. 401-420 20 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  48 Citations (Scopus)

• Benzoxazoles and oxazolopyridines in medicinal chemistry studies

  Demmer, C. S. & Bunch, L., 2015, In: European Journal of Medicinal Chemistry. 97, p. 778-785 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  133 Citations (Scopus)

• Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1

  Demmer, C. S., Møller, C., Brown, P. M. G. E., Han, L., Pickering, D. S., Nielsen, B., Bowie, D., Frydenvang, K., Kastrup, J. S. & Bunch, L., 9 Apr 2015, In: A C S Chemical Neuroscience. 6, p. 845-854 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• Blood-brain barrier permeability and brain uptake mechanism of kainic Acid and dihydrokainic Acid

  Gynther, M., Petsalo, A., Hansen, S. H., Bunch, L. & Pickering, D. S., Mar 2015, In: Neurochemical Research. 40, 3, p. 542-549 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities

  Jensen, A. A., Fahlke, C., Bjørn-Yoshimoto, W. E. & Bunch, L., 2015, In: Current Opinion in Pharmacology. 20, p. 116-123 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  78 Citations (Scopus)

• Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid

  Krogsgaard-Larsen, N., Storgaard, M., Møller, C., Demmer, C. S., Hansen, J., Han, L., Monrad, R. N., Nielsen, B., Tapken, D., Pickering, D. S., Kastrup, J. S., Frydenvang, K. & Bunch, L., 2015, In: Journal of Medicinal Chemistry. 58, 15, p. 6131-50 20 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)

• Synthesis and Selective Functionalization of [1,2,4]Triazolo[4,3-a]pyrazines

  Demmer, C. S., Jorgensen, M., Kehler, J., Bunch, L. & Rasmussen, L. K., 2015, In: SYNLETT: Accounts and Rapid Communications in Chemical Synthesis. 26, 4, p. 519-524 6 p.

  Research output: Contribution to journal › Letter › Research › peer-review
  10 Citations (Scopus)

• The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells

  Cuesta, E. P., Christensen, S., Jensen, A. A., Jensen, N. F., Bunch, L., Rømer, M. U. K., Brünner, N., Stenvang, J. & Pedersen, S. H. F., 2015, In: B M C Cancer. 15, 1, 17 p., 411.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  18 Citations (Scopus)

  394 Downloads (Pure)
• 2014

  Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain

  Venskutonyte, R., Larsen, A. P., Frydenvang, K. A., Gajhede, M., Gefflaut, T., Pickering, D. S., Bunch, L. & Kastrup, J. S. J., 2014, In: ChemMedChem. 9, 10, p. 2254-2259 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• New Palladium-Catalyzed Domino Reaction with Intramolecular Ring Closure of an N-(2-Chloro-3-heteroaryl) arylamide: First Synthesis of Oxazolo[4,5-b] pyrazines

  Demmer, C. S., Hansen, J. C., Kehler, J. & Bunch, L., 24 Mar 2014, In: Advanced Synthesis & Catalysis. 356, 5, p. 1047-1055 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• Probing for improved potency and in vivo bioavailability of excitatory amino acid transporter subtype 1 inhibitors UCPH-101 and UCPH-102: Design, synthesis and pharmacological evaluation of substituted 7-biphenyl analogs

  Erichsen, M. N., Hansen, J., Artacho Ruiz, J., Demmer, C. S., Abrahamsen, B., Bastlund, J. F., Bundgaard, C., Jensen, A. A. & Bunch, L., 2014, In: Neurochemical Research. 39, 10, p. 1964-1979 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• Profiling substrate specificity of two series of phenethylamine analogs at monoamine oxidase A and B

  Heuson, E., Storgaard, M., Huynh, T. H. V., Charmantray, F., Gefflaut, T. & Bunch, L., 2014, In: Organic & Biomolecular Chemistry. 12, 43, p. 8689-8695 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)

• Study of Oxidative Cyclization Using PhI(OAc)(2) in the Formation of Benzo[4,5]thiazolo[2,3-c][1,2,4]triazoles and Related Heterocycles - Scope and Limitations

  Demmer, C. S., Jorgensen, M., Kehler, J. & Bunch, L., Jun 2014, In: SYNLETT: Accounts and Rapid Communications in Chemical Synthesis. 25, 9, p. 1279-1282 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)

• Synthesis of (3-hydroxy-pyrazolin-5-yl)glycine based ligands interacting with ionotropic glutamate receptors

  Pinto, A., Tamborini, L., Mastronardi, F., Ettari, R., Safoz, Y., Bunch, L., Nielsen, B., Jensen, A. A., De Micheli, C. & Conti, P., 2014, In: European Journal of Medicinal Chemistry. 75, p. 151-158 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)
• 2013

  Allosteric modulation of an excitatory amino acid transporter: The subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain

  Abrahamsen, B., Schneider, N., Erichsen, M. N., Huynh, T. H. V., Fahlke, C., Bunch, L. & Jensen, A. A., 2013, In: Journal of Neuroscience. 33, 3, p. 1068-1087

  Research output: Contribution to journal › Journal article › Research › peer-review
  52 Citations (Scopus)

• Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

  Assaf, Z., Larsen, A. P., Venskutonyte, R., Han, L., Abrahamsen, B., Nielsen, B., Gajhede, M., Kastrup, J. S., Jensen, A. A., Pickering, D. S., Frydenvang, K., Gefflaut, T. & Bunch, L., 2013, In: Journal of Medicinal Chemistry. 56, 4, p. 1614-1628

  Research output: Contribution to journal › Journal article › Research › peer-review
  38 Citations (Scopus)

• Corrigendum to "Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate" [J. Struct. Biol. 176 (2011) 307-314]

  Venskutonyte, R., Frydenvang, K., Gajhede, M., Bunch, L., Pickering, D. S. & Kastrup, J. S., Nov 2013, In: Journal of Structural Biology. 184, 2, p. 381 1 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review
  1 Citation (Scopus)