Lise Arleth

Search results

• 2024

  Peripherally restricted PICK1 inhibitor mPD5 ameliorates pain behaviors in murine inflammatory and neuropathic pain models

  Jensen, K. L., Riis Christensen, N., Goddard, C. M., Jager, S. E., Noes-Holt, G., Kanneworff, I. B., Jakobsen, A., Jiménez-Fernández, L., Peck, E. G., Sivertsen, L., Baro, R. C., Houser, G. A., Mayer, F. P., Diaz-DelCastillo, M., Topp, M. L., Hopkins, C., Thomsen, C. D., Soltan, A. B. I., Tidemand, F. G. & Arleth, L. & 3 others, Heegaard, A. M., Sørensen, A. T. & Madsen, K. L., 2024, In: JCI insight. 9, 20, 19 p., e170976.

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• Structural characterisation of α-synuclein-membrane interactions and the resulting aggregation using small angle scattering

  Galvagnion, C., Barclay, A., Makasewicz, K., Marlet, F. R., Moulin, M., Devos, J. M., Linse, S., Martel, A., Porcar, L., Sparr, E., Pedersen, M. C., Roosen-Runge, F., Arleth, L. & Buell, A. K., 2024, In: Physical chemistry chemical physics : PCCP. 26, p. 10998-11013

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  3 Citations (Scopus)
• 2023

  Aggregative adherence fimbriae form compact structures as seen by SAXS

  Jønsson, R., Björling, A., Midtgaard, S. R., Jensen, G. V., Skar-gislinge, N., Arleth, L., Matthews, S., Krogfelt, K. A. & Jenssen, H., 2 Oct 2023, In: Scientific Reports. 13, 1, 7 p., 16516.

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• Anisotropic protein-protein interactions in dilute and concentrated solutions

  Pasquier, C., Midtgaard, S. R., Polimeni, M., Jorgensen, C. I., Arleth, L., Callisen, T. H. & Lund, M., Jan 2023, In: Journal of Colloid and Interface Science. 629, p. 794-804 11 p.

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  4 Citations (Scopus)

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• Modeling of flexible membrane-bound biomolecular complexes for solution small-angle scattering

  Barclay, A., Kragelund, B. B., Arleth, L. & Pedersen, M. C., Apr 2023, In: Journal of Colloid and Interface Science. 635, p. 611-621 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  1 Citation (Scopus)

• The effect of linker conformation on performance and stability of a two-domain lytic polysaccharide monooxygenase

  Forsberg, Z., Stepnov, A. A., Tesei, G., Wang, Y., Buchinger, E., Kristiansen, S. K., Aachmann, F. L., Arleth, L., Eijsink, V. G. H., Lindorff-Larsen, K. & Courtade, G., 2023, In: Journal of Biological Chemistry. 299, 11, 17 p., 105262.

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  8 Citations (Scopus)

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• The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate

  Araya-Secchi, R., Bugge, K., Seiffert, P., Petry, A., Haxholm, G. W., Lindorff-Larsen, K., Pedersen, S. F., Arleth, L. & Kragelund, B. B., 2023, In: eLife. 12, 27 p., e84645.

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  10 Citations (Scopus)

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• Travel light: Essential packing for membrane proteins with an active lifestyle

  Johansen, N. T., Tidemand, F. G., Pedersen, M. C. & Arleth, L., 2023, In: Biochimie. 205, p. 3-26 24 p.

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  7 Citations (Scopus)

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• 2022

  Dark peptide discs for the investigation of membrane proteins in supported lipid bilayers: the case of synaptobrevin 2 (VAMP2)

  Luchini, A., Tidemand, F. G., Johansen, N. T., Sebastiani, F., Corucci, G., Fragneto, G., Cardenas, M. & Arleth, L., 2022, In: Nanoscale Advances. 4, 21, p. 4526-4534 9 p.

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  3 Citations (Scopus)

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• Global fitting of multiple data frames from SEC-SAXS to investigate the structure of next-generation nanodiscs

  Barclay, A., Johansen, N. T., Tidemand, F. G., Arleth, L. & Pedersen, M. C., 2022, In: Acta Crystallographica Section D: Biological Crystallography. 78, p. 483-493 11 p.

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  5 Citations (Scopus)

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• Mg²⁺-dependent conformational equilibria in CorA and an integrated view on transport regulation

  Johansen, N. T., Bonaccorsi, M., Bengtsen, T., Larsen, A. H., Tidemand, F. G., Pedersen, M. C., Huda, P., Berndtsson, J., Darwish, T., Yepuri, N. R., Martel, A., Pomorski, T. G., Bertarello, A., Sansom, M., Rapp, M., Crehuet, R., Schubeis, T., Lindorff-Larsen, K., Pintacuda, G. & Arleth, L., 2022, In: eLife. 11, 35 p.

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  16 Citations (Scopus)

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• Non-ionic detergent assists formation of supercharged nanodiscs and insertion of membrane proteins

  Tidemand, F. G., Blemmer, S., Johansen, N. T., Arleth, L. & Pedersen, M. C., 1 Jun 2022, In: Biochimica et Biophysica Acta - Biomembranes. 1864, 6, 10 p., 183884.

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  2 Citations (Scopus)

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• Structural model of tissue factor (TF) and TF-factor VIIa complex in a lipid membrane: A combined experimental and computational study

  Luchini, A., Tidemand, F. G., Araya-Secchi, R., Campana, M., Cárdenas, M. & Arleth, L., 2022, In: Journal of Colloid and Interface Science. 623, p. 294-305 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)
• 2021

  Ab initio determination of the shape of membrane proteins in a nanodisc

  Orioli, S., Hansen, C. G. H. & Arleth, L., 2021, In: Acta crystallographica Section D: Structural biology . 77, p. 176-193 18 p.

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  6 Citations (Scopus)

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• Aescin - a natural soap for the formation of lipid nanodiscs with tunable size

  Geisler, R., Pedersen, M. C., Preisig, N., Hannappel, Y., Prevost, S., Dattani, R., Arleth, L. & Hellweg, T., 21 Feb 2021, In: Soft Matter. 17, 7, p. 1888-1900 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)

• Controlling the fractal dimension in self-assembly of terpyridine modified insulin by Fe²⁺ and Eu³+ to direct in vivo effects

  Mishra, N. K., Østergaard, M., Midtgaard, S. R., Strindberg, S. S., Winkler, S., Wu, S., Sørensen, T. J., Hassenkam, T., Poulsen, J. N., Lo Leggio, L., Nielsen, H. M., Arleth, L., Christensen, N. J., Thulstrup, P. W. & Jensen, K. J., 2021, In: Nanoscale. 13, 18, p. 8467–8473 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• Lipid-bound ApoE3 self-assemble into elliptical disc-shaped particles

  Larsen, A. H., Johansen, N. T., Gajhede, M., Arleth, L. & Midtgaard, S. R., 2021, In: B B A - Biomembranes. 1863, 1, 10 p., 183495.

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  3 Citations (Scopus)

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• Oligomerization of Pharmaceutically Relevant Insulin Analogues for Varying Concentration and Salinity Revealed by Small-Angle X-ray Scattering

  Jensen, G., Rosenmejer, K. R., Huda, P. & Arleth, L., 6 Sept 2021, In: Molecular Pharmaceutics. 18, 9, p. 3272-3280 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Order and disorder - An integrative structure of the full-length human growth hormone receptor

  Kassem, N., Araya-Secchi, R., Bugge, K., Barclay, A., Steinocher, H., Khondker, A., Wang, Y., Lenard, A. J., Bürck, J., Sahin, C., Ulrich, A. S., Landreh, M., Pedersen, M. C., Rheinstädter, M. C., Pedersen, P. A., Lindorff-Larsen, K., Arleth, L. & Kragelund, B. B., 2021, In: Science Advances. 7, 27, 20 p., eabh3805.

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  23 Citations (Scopus)

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• Peptide discs as precursors of biologically relevant supported lipid bilayers

  Luchini, A., Sebastiani, F., Tidemand, F. G., Batchu, K. C., Campana, M., Fragneto, G., Cárdenas, M. & Arleth, L., Mar 2021, In: Journal of Colloid and Interface Science. 585, p. 376-385 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering

  Lycksell, M., Rovsnik, U., Bergh, C., Johansen, N. T., Martel, A., Porcar, L., Arleth, L., Howard, R. J. & Lindahl, E., 14 Sep 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 37, 9 p., 2108006118.

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  6 Citations (Scopus)

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• Properdin oligomers adopt rigid extended conformations supporting function

  Pedersen, D. V., Pedersen, M. N., Mazarakis, S. M. M., Wang, Y., Lindorff-Larsen, K., Arleth, L. & Andersen, G. R., 2021, In: eLife. 10, 22 p., e63356.

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  9 Citations (Scopus)

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• Semi-empirical Analysis of Complex ITC Data from Protein-Surfactant Interactions

  Tidemand, F. G., Zunino, A., Johansen, N. T., Hansen, A. F., Westh, P., Mosegaard, K. & Arleth, L., 21 Sept 2021, In: Analytical Chemistry. 93, 37, p. 12698-12706 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)

• Solution Structure of the Gloeobacter Violaceus Ligand-Gated Ion Channel Probed by Small-Angle Neutron Scattering

  Lycksell, M., Rovsnik, U., Bergh, C. C., Johansen, N. T., Martel, A., Porcar, L., Arleth, L., Howard, R. & Lindahl, E., 2021, In: Biophysical Journal. 120, 3, Supp. 1, p. 56a-56a 1 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Structural and Biophysical Properties of Supercharged and Circularized Nanodiscs

  Johansen, N. T., Luchini, A., Tidemand, F. G., Orioli, S., Martel, A., Porcar, L., Arleth, L. & Pedersen, M. C., 2021, In: Langmuir. 37, 22, p. 6681-6690 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• The microscopic distribution of hydrophilic polymers in interpenetrating polymer networks (IPNs) of medical grade silicone

  Smith, G. N., Brok, E., Schmiele, M., Mortensen, K., Bouwman, W. G., Duif, C. P., Hassenkam, T., Alm, M., Thomsen, P. & Arleth, L., 22 Mar 2021, In: Polymer. 224, 9 p., 123671.

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  10 Citations (Scopus)

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• 2020

  A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain

  Christensen, N. R., De Luca, M., Lever, M. B., Richner, M., Hansen, A. B., Noes-Holt, G., Jensen, K. L., Rathje, M., Jensen, D. B., Erlendsson, S., Bartling, C. R. O., Ammendrup-Johnsen, I., Pedersen, S. E., Schönauer, M., Nissen, K. B., Midtgaard, S. R., Teilum, K., Arleth, L., Sørensen, A. T. & Bach, A. & 5 others, Strømgaard, K., Meehan, C. F., Vægter, C. B., Gether, U. & Madsen, K. L., 2020, In: EMBO Molecular Medicine. 12, 6, 25 p., e11248.

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  22 Citations (Scopus)

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• Assembly of Capsids from Hepatitis B Virus Core Protein Progresses through Highly Populated Intermediates in the Presence and Absence of RNA

  Oliver, R. C., Potrzebowski, W., Najibi, S. M., Pedersen, M. N., Arleth, L., Mahmoudi, N. & Andre, I., 25 Aug 2020, In: ACS Nano. 14, 8, p. 10226-10238 13 p.

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  16 Citations (Scopus)

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• Assessment of structure factors for analysis of small-angle scattering data from desired or undesired aggregates

  Larsen, A. H., Pedersen, J. S. & Arleth, L., Aug 2020, In: Journal of Applied Crystallography. 53, p. 991-1005 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  25 Citations (Scopus)

• Combining molecular dynamics simulations with small-angle X-ray and neutron scattering data to study multi-domain proteins in solution

  Larsen, A. H., Wang, Y., Bottaro, S., Grudinin, S., Arleth, L. & Lindorff-Larsen, K., 2020, In: P L o S Computational Biology. 16, 4, 29 p., e1007870.

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  62 Citations (Scopus)

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• Dispersion state of TiO2 pigment particles studied by ultra-small-angle X-ray scattering revealing dependence on dispersant but limited change during drying of paint coating

  Lof, D., Hamieau, G., Zalich, M., Ducher, P., Kynde, S., Midtgaard, S. R., Parasida, C. F., Arleth, L. & Jensen, G., 1 May 2020, In: Progress in Organic Coatings. 142, 8 p., 105590.

  Research output: Contribution to journal › Journal article › peer-review
  23 Citations (Scopus)

• Efficient refolding and reconstitution of tissue factor into nanodiscs facilitates structural investigation of a multicomponent system on a lipid bilayer

  Tidemand, F. G., Østergaard, H., Ploug, M., Kragelund, B. B. & Arleth, L., 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 10 p., 183214.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  3 Citations (Scopus)

• Exploring the Protein-Membrane Interactions on the Intracellular Side of PRLR

  Araya-Secchi, R., Bugge, K., Kragelund, B. B. & Arleth, L., 7 Feb 2020, In: Biophysical Journal. 118, 3, Suppl.1, p. 57A-57A 1 p.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• Orchestration of signaling by structural disorder in class 1 cytokine receptors

  Seiffert, P., Bugge, K., Nygaard, M., Haxholm, G. W., Martinsen, J. H., Pedersen, M. N., Arleth, L., Boomsma, W. & Kragelund, B. B., 24 Aug 2020, In: Cell Communication and Signaling. 18, 1, 30 p., 132.

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  18 Citations (Scopus)

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• Protocol for Investigating the Interactions Between Intrinsically Disordered Proteins and Membranes by Neutron Reflectometry

  Luchini, A. & Arleth, L., 22 Jul 2020, Intrinsically Disordered Proteins: Methods and Protocols. Kragelund, B. B. & Skriver, K. (eds.). Humana Press, p. 569-584 16 p. (Methods in Molecular Biology, Vol. 2141).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  2 Citations (Scopus)

• Small-angle Neutron Scattering Shows that the Solution Structures of the Bacterial Mg²⁺-Channel CorA are Overall Similar with and without Mg²⁺ Bound

  Arleth, L., Johansen, N. T., Bengtsen, T., Larsen, A. H., Tidemand, F., Pomorski, T. & Lindorff-Larsen, K., 7 Feb 2020, In: Biophysical Journal. 118, 3, Suppl. 1, p. 12A 1 p.

  Research output: Contribution to journal › Conference abstract in journal › Research

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• Structural Insight into the Self-Assembly of a Pharmaceutically Optimized Insulin Analogue Obtained by Small-Angle X-ray Scattering

  Dreyer, L. S., Nygaard, J., Malik, L., Hoeg-Jensen, T., Hoiberg-Nielsen, R. & Arleth, L., 3 Aug 2020, In: Molecular Pharmaceutics. 17, 8, p. 2809-2820 12 p.

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  4 Citations (Scopus)

• Structure and dynamics of a nanodisc by integrating NMR, SAXS and SANS experiments with molecular dynamics simulations.

  Bengtsen, T., Midtgaard, S. R., Holm, V. L., Kjølbye, L. R., Johansen, N. T., Tesei, G., Bottaro, S., Schiøtt, B., Arleth, L. & Lindorff-Larsen, K., 30 Jul 2020, In: eLife. 9, 24 p., e56518.

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  46 Citations (Scopus)

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• Supported Lipid Bilayers with Asymmetric Membrane Proteins: Controlling the Protein Orientation by using Peptide-Discs

  Luchini, A., Tidemand, F. G., Araya-Secchi, R. R. & Arleth, L., 7 Feb 2020, In: Biophysical Journal. 118, 3, Suppl.1, p. 17A-17A 1 p.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• The intracellular lipid-binding domain of human Na⁺/H⁺ exchanger 1 forms a lipid-protein co-structure essential for activity

  Hendus-Altenburger, R., Vogensen, J., Pedersen, E. S., Luchini, A., Araya-Secchi, R., Bendsoe, A. H., Prasad, N. S., Prestel, A., Cardenas, M., Pedraz-Cuesta, E., Arleth, L., Pedersen, S. H. F. & Kragelund, B. B., 3 Dec 2020, In: Communications Biology . 3, 1, 18 p., 731.

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  12 Citations (Scopus)

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• 2019

  Aescin-Induced Conversion of Gel-Phase Lipid Membranes into Bicelle-like Lipid Nanoparticles

  Geisler, R., Pedersen, M. C., Hannappel, Y., Schweins, R., Prevost, S., Dattani, R., Arleth, L. & Hellweg, T., 10 Dec 2019, In: Langmuir. 35, 49, p. 16244-16255

  Research output: Contribution to journal › Journal article › Research › peer-review
  22 Citations (Scopus)

• Circularized and solubility-enhanced MSPs facilitate simple and high-yield production of stable nanodiscs for studies of membrane proteins in solution

  Johansen, N. T., Tidemand, F. G., Nguyen, T. T. T. N., Rand, K. D., Pedersen, M. C. & Arleth, L., May 2019, In: F E B S Journal. 286, 9, p. 1734-1751

  Research output: Contribution to journal › Journal article › Research › peer-review
  32 Citations (Scopus)

• Distinct α-Synuclein:Lipid Co-Structure Complexes Affect Amyloid Nucleation through Fibril Mimetic Behavior

  Cholak, E., Bucciarelli, S., Bugge, K., Johansen, N. T., Vestergaard, B., Arleth, L., Kragelund, B. B. & Langkilde, A. E., Nov 2019, In: Biochemistry. 58, 50, p. 5052-5065

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Peptide disc mediated control of membrane protein orientation in supported lipid bilayers for surface-sensitive investigations

  Luchini, A., Tidemand, F. G., Johansen, N. T., Campana, M., Sotres, J., Ploug, M., Cárdenas, M. & Arleth, L., 2019, In: Analytical Chemistry. 92, 1, p. 1081-1088

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Probing Structural States of a Pentameric Ligand-Gated Ion Channel with Small Angle Neutron Scattering

  Lycksell, M., Johansen, N. T., Howard, R. J., Arleth, L. & Lindahl, E., 15 Feb 2019, In: Biophysical Journal. 116, 3, Supp. 1, p. 36A-37A

  Research output: Contribution to journal › Journal article › Research › peer-review

• PSX, Protein-Solvent Exchange: software for calculation of deuterium-exchange effects in small-angle neutron scattering measurements from protein coordinates

  Pedersen, M. C., Wang, Y., Tidemand, F. G., Martel, A., Lindorff-Larsen, K. & Arleth, L., 2019, In: Journal of Applied Crystallography. 52, 6, p. 1427-1436 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• SEC-SAXS on an in-house laboratory instrument

  Skou, S., Bucciarelli, S., Midtgaard, S. R., Pedersen, M. N., Arleth, L. & Vestergaard, B., 2019, p. A230-A230. 1 p.

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• Structure and Dynamics of the Central Lipid Pool and Proteins of the Bacterial Holo-Translocon

  Martin, R., Larsen, A. H., Corey, R. A., Midtgaard, S. R., Frielinghaus, H., Schaffitzel, C., Arleth, L. & Collinson, I., 21 May 2019, In: Biophysical Journal. 116, 10, p. 1931-1940 10 p.

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  16 Citations (Scopus)

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• The influence of pH, protein concentration and calcium ratio on the formation and structure of nanotubes from partially hydrolyzed bovine α-lactalbumin

  Geng, X., Kirkensgaard, J. J. K., Arleth, L., Otte, J. & Ipsen, R., 2019, In: Soft Matter. 15, 24, p. 4787-4796

  Research output: Contribution to journal › Journal article › Research › peer-review
  22 Citations (Scopus)

• Towards biomimics of cell membranes: Structural effect of phosphatidylinositol triphosphate (PIP3) on a lipid bilayer

  Luchini, A., Nzulumike, A. N. O., Lind, T. K., Nylander, T., Barker, R., Arleth, L., Mortensen, K. & Cardenas, M., 1 Jan 2019, In: Colloids and Surfaces B: Biointerfaces. 173, p. 202-209

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  22 Citations (Scopus)

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