Research output per year
Research output per year
- 29 results
Search results
-
2024
High efficacytreatment of murine Pseudomonas aeruginosa catheter-associated urinary tract infections using the c-di-GMP modulating anti-biofilmcompound Disperazol in combination with ciprofloxacin
Hultqvist, L. D., Andersen, J. B., Nilsson, C. M., Jansen, C. U., Rybtke, M., Jakobsen, T. H., Nielsen, T. E., Qvortrup, K., Moser, C., Graz, M., Qvortrup, K., Tolker-Nielsen, T. & Givskov, M., 2024, In: Antimicrobial Agents and Chemotherapy. 68, 6, 16 p., e01481-23.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus) -
Upscaling and Risk Evaluation of the Synthesis of the 3,5-Diamino-1H-Pyrazole, Disperazol
Jansen, C. U., Grier, K. E., Andersen, J. B., Hultqvist, L. D., Nilsson, M., Moser, C., Graz, M., Tolker-Nielsen, T., Givskov, M. & Qvortrup, K., 2024, In: International Journal of Molecular Sciences. 25, 12, 8 p., 6737.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Downloads (Pure) -
2021
Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms
Andersen, J. B., Hultqvist, L. D., Jansen, C. U., Jakobsen, T. H., Nilsson, M., Rybtke, M., Uhd, J., Fritz, B. G., Seifert, R., Berthelsen, J., Nielsen, T. E., Qvortrup, K., Givskov, M. & Tolker-Nielsen, T., 2021, In: npj Biofilms and Microbiomes. 7, 13 p., 59.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile45 Citations (Scopus)49 Downloads (Pure) -
Induction of native c-di-GMP phosphodiesterases leads to dispersal of Pseudomonas aeruginosa biofilms
Andersen, J. B., Kragh, K. N., Hultqvist, L. D., Rybtke, M., Nilsson, M., Jakobsen, T. H., Givskov, M. & Tolker-Nielsen, T., 2021, In: Antimicrobial Agents and Chemotherapy. 65, 4, e02431-20.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access28 Citations (Scopus) -
SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms
Jansen, C. U., Uhd, J., Andersen, J. B., Hultqvist, L. D., Jakobsen, T. H., Nilsson, M., Nielsen, T. E., Givskov, M., Tolker-Nielsen, T. & Qvortrup, K. M., 2021, In: RSC Medicinal Chemistry. 12, 11, p. 1868-1878 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
7 Citations (Scopus) -
2019
Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation
Qvortrup, K., Hultqvist, L. D., Nilsson, M., Jakobsen, T. H., Jansen, C. U., Uhd, J., Andersen, J. B., Nielsen, T. E., Givskov, M. & Tolker-Nielsen, T., 2019, In: Frontiers in Chemistry. 7, 27 p., 742.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile81 Citations (Scopus)213 Downloads (Pure) -
Visualizing biofilm by targeting eDNA with long wavelength probe CDr15
Kwon, H. Y., Kim, J. Y., Liu, X., Lee, J. Y., Yam, J. K. H., Dahl Hultqvist, L., Xu, W., Rybtke, M., Tolker-Nielsen, T., Heo, W., Kim, J. J., Kang, N. Y., Joo, T., Yang, L., Park, S. J., Givskov, M. & Chang, Y. T., 2019, In: Biomaterials Science. 7, 9, p. 3594-3598 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
11 Citations (Scopus) -
2018
CDy14: A novel biofilm probe targeting exopolysaccharide Psl
Kwon, H. Y., Kim, J. Y., Lee, J. Y., Yam, J. K. H., Hultqvist, L. D., Xu, W., Rybtke, M., Tolker-Nielsen, T., Kim, J. J., Kang, N. Y., Yang, L., Park, S. J., Givskov, M. & Chang, Y. T., 2018, In: Chemical Communications. 54, 84, p. 11865-11868 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
8 Citations (Scopus) -
Imaging N-acyl homoserine lactone quorum sensing in vivo
Hultqvist, L. D., Alhede, M., Jakobsen, T. H., Givskov, M. & Bjarnsholt, T., 2018, Quorum Sensing: Methods and Protocols. Leoni, L. & Rampion, G. (eds.). Humana Press, Vol. 1673. p. 203-212 10 p. (Methods in Molecular Biology; No. 1673).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
3 Citations (Scopus) -
Qualitative and Quantitative Determination of Quorum Sensing Inhibition In Vitro
Jakobsen, T. H., Alhede, M., Hultqvist, L. D., Bjarnsholt, T. & Givskov, M., 2018, Quorum Sensing: Methods and Protocols. Springer, Vol. 1673. p. 275-285 11 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
3 Citations (Scopus) -
2015
In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm-dispersed cells via c-di-GMP manipulation
Chua, S. L., Hultqvist, L. D., Yuan, M., Rybtke, M., Nielsen, T. E., Givskov, M., Tolker-Nielsen, T. & Yang, L., Aug 2015, In: Nature Protocols (Print). 10, 8, p. 1165-80 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
55 Citations (Scopus) -
Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response
Rybtke, M., Hultqvist, L. D., Givskov, M. & Tolker-Nielsen, T., 2015, In: Journal of Molecular Biology. 427, 23, p. 3628-3645Research output: Contribution to journal › Review › Research › peer-review
189 Citations (Scopus) -
2014
Bacterial biofilm formation and treatment in soft tissue fillers
Alhede, M., Er, O., Eickhardt, S., Kragh, K., Alhede, M., Hultqvist, L. D., Poulsen, S. S., Givskov, M., Christensen, L. H., Høiby, N., Tvede, M. & Bjarnsholt, T., 30 Jan 2014, In: Pathogens and Disease. 70, p. 339-346 8 p.Research output: Contribution to journal › Journal article › Research
58 Citations (Scopus) -
2013
Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria
Hultqvist, L. D., van Gennip, M., Rybtke, M. T., Wu, H., Chiang, W-C., Alhede, M., Høiby, N., Nielsen, T., Givskov, M. & Tolker-Nielsen, T., Aug 2013, In: Infection and Immunity. 81, 8, p. 2705-13 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
78 Citations (Scopus) -
2012
Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing
Jakobsen, T. H., van Gennip, M., Phipps, R. K., Shanmugham, M. S., Hultqvist, L. D., Alhede, M., Skindersoe, M. E., Rasmussen, T. B., Friedrich, K., Uthe, F., Jensen, P. Ø., Moser, C., Nielsen, K. F., Eberl, L., Larsen, T. O., Tanner, D. A., Høiby, N., Bjarnsholt, T., Givskov, M. & Alhede, M., May 2012, In: Antimicrobial Agents and Chemotherapy. 56, 5, p. 2314-25 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
374 Citations (Scopus) -
Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa
Jakobsen, T. H., Bragason, S. K., Phipps, R. K., Christensen, L. D., van Gennip, M., Alhede, M., Skindersoe, M., Larsen, T. O., Høiby, N., Bjarnsholt, T. & Givskov, M., 2012, In: Applied and Environmental Microbiology. 78, 7, p. 2410-2421 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
175 Citations (Scopus) -
Interactions between polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilms on silicone implants in vivo
van Gennip, M., Hultqvist, L. D., Alhede, M., Qvortrup, K., Jensen, P. Ø., Høiby, N., Givskov, M. & Bjarnsholt, T., Aug 2012, In: Infection and Immunity. 80, 8, p. 2601-2607 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
65 Citations (Scopus) -
Process for the manufacture of ajoene derivatives
Bjarnsholt, T., Hoeiby, N., Jensen, P. Ø., Phipps, R., Shanmugham, Meenakshi, S., Alhede, M., Hultqvist, L. D., Jakobsen, T. H., Tanner, D., Larsen, Thomas, O. & Givskov, M., 14 Jun 2012, IPC No. C07C 323/ 65 A I, Patent No. WO2012076016, Priority date 8 Dec 2010, Priority No. EP20100194154Research output: Patent
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Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorom sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model.
Hultqvist, L. D., van Gennip, M., Jakobsen, T. H., Alhede, M., Hougen, H. P., Høiby, N., Bjarnsholt, T. & Givskov, M., 2012, In: Journal of Antimicrobial Chemotherapy. 67, 5, p. 1198-1206 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
152 Citations (Scopus) -
Treatment of Pseudomonas Aeruginosa Biofilm Infections: An Experimental Study
Hultqvist, L. D., 2012Research output: Book/Report › Ph.D. thesis › Research
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2011
Imaging N-acyl homoserine lactone quorum sensing in vivo
Christensen, L. D., van Gennip, M., Jakobsen, T. H., Givskov, M. & Bjarnsholt, T., 1 Jan 2011, In: Methods in Molecular Biology. 692, 2, p. 147-157 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
6 Citations (Scopus) -
Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm
Alhede, M., Kragh, K. N., Qvortrup, K., Allesen-Holm, M., van Gennip, M., Christensen, L. D., Jensen, P. Ø., Nielsen, A. K., Parsek, M., Wozniak, D., Molin, S., Tolker-Nielsen, T., Høiby, N., Givskov, M. & Bjarnsholt, T., 2011, In: P L o S One. 6, 11, p. e27943Research output: Contribution to journal › Journal article › Research › peer-review
223 Citations (Scopus) -
Qualitative and quantitative determination of quorum sensing inhibition in vitro
Jakobsen, T. H., van Gennip, M., Christensen, L. D., Bjarnsholt, T. & Givskov, M., 1 Jan 2011, In: Methods in Molecular Biology. 692, 3, p. 253-263 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
6 Citations (Scopus) -
2010
In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect
Bjarnsholt, T., van Gennip, M., Jakobsen, T. H., Christensen, L. D., Jensen, P. Ø. & Givskov, M., 2010, In: Nature Protocols (Print Edition). 5, 2, p. 282-93 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
64 Citations (Scopus) -
Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis
Kolpen, M., Hansen, C. R., Bjarnsholt, T., Moser, C., Hultqvist, L. D., van Gennip, M., Ciofu, O., Mandsberg, L., Kharazmi, A., Döring, G., Givskov, M., Høiby, N. & Jensen, P. Ø., 1 Jan 2010, In: Thorax. 65, 1, p. 57-62 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
154 Citations (Scopus) -
2009
Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa
van Gennip, M., Moser, C., Christensen, L. D., Bjarnsholt, T., Calum, H., Jensen, P. Ø., Christophersen, L., Hougen, H. P., Ciofu, O., Molin, S., Givskov, M. & Høiby, N., 1 Dec 2009, In: Journal of Antimicrobial Chemotherapy. 64, 6, p. 1241-50 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
22 Citations (Scopus) -
Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes
Van Gennip, M., Christensen, L. D., Alhede, M., Phipps, R., Jensen, P. Ø., Christophersen, L., Pamp, S. J., Moser, C., Mikkelsen, P. J., Koh, A. Y., Tolker-Nielsen, T., Pier, G. B., Høiby, N., Givskov, M. & Bjarnsholt, T., 1 Jul 2009, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 7, p. 537-46 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
159 Citations (Scopus) -
Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes
Alhede, M., Bjarnsholt, T., Jensen, P. Ø., Phipps, R. K., Moser, C., Christophersen, L., Hultqvist, L. D., van Gennip, M., Parsek, M., Høiby, N., Rasmussen, T. B. & Givskov, M., 2009, In: Microbiology. 155, 11, p. 3500-3508 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
186 Citations (Scopus) -
2007
Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model
Christensen, L. D., Moser, C., Jensen, P. Ø., Rasmussen, T. B., Christophersen, L., Kjelleberg, S., Kumar, N., Høiby, N., Givskov, M. & Bjarnsholt, T., 2007, In: Microbiology. 153, Pt 7, p. 2312-20 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
115 Citations (Scopus)