Mads Gyrd-Hansen

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• 2024

  Advancements in pathogen immunity and signaling

  Gyrd-Hansen, M., Kajaste-Rudnitski, A., Manel, N., Rehwinkel, J., van der Veen, A. G. & Iannacone, M., 2024, In: Nature Immunology. 25, p. 1322–1325

  Research output: Contribution to journal › Journal article › Research
  2 Citations (Scopus)

• A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

  Mannion, J., Gifford, V., Bellenie, B., Fernando, W., Ramos Garcia, L., Wilson, R., John, S. W., Udainiya, S., Patin, E. C., Tiu, C., Smith, A., Goicoechea, M., Craxton, A., Moraes de Vasconcelos, N., Guppy, N., Cheung, K. M. J., Cundy, N. J., Pierrat, O., Brennan, A. & Roumeliotis, T. I. & 25 others, Benstead-Hume, G., Alexander, J., Muirhead, G., Layzell, S., Lyu, W., Roulstone, V., Allen, M., Baldock, H., Legrand, A., Gabel, F., Serrano-Aparicio, N., Starling, C., Guo, H., Upton, J., Gyrd-Hansen, M., MacFarlane, M., Seddon, B., Raynaud, F., Roxanis, I., Harrington, K., Haider, S., Choudhary, J. S., Hoelder, S., Tenev, T. & Meier, P., 2024, In: Immunity. 57, 7, p. 1514-1532.e15

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  10 Citations (Scopus)

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• Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response

  Vringer, E., Heilig, R., Riley, J. S., Black, A., Cloix, C., Skalka, G., Montes-Gómez, A. E., Aguado, A., Lilla, S., Walczak, H., Gyrd-Hansen, M., Murphy, D. J., Huang, D. T., Zanivan, S. & Tait, S. W., 2024, In: The EMBO Journal. 43, 6, p. 904–930

  Research output: Contribution to journal › Journal article › Research › peer-review

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  14 Citations (Scopus)

  3 Downloads (Pure)

• The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo

  Vind, A. C., Wu, Z., Firdaus, M. J., Snieckute, G., Toh, G. A., Jessen, M., Martínez, J. F., Haahr, P., Andersen, T. L., Blasius, M., Koh, L. F., Maartensson, N. L., Common, J. E. A., Gyrd-Hansen, M., Zhong, F. L. & Bekker-Jensen, S., 25 Nov 2024, In: Molecular Cell. 84, 24, p. 4774-4789

  Research output: Contribution to journal › Journal article › Research › peer-review

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  4 Citations (Scopus)

  3 Downloads (Pure)
• 2022

  Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1

  Peng, R., Wang, C. K., Wang-Kan, X., Idorn, M., Kjær, M., Zhou, F. Y., Fiil, B. K., Timmermann, F., Orozco, S. L., McCarthy, J., Leung, C. S., Lu, X., Bagola, K., Rehwinkel, J., Oberst, A., Maelfait, J., Paludan, S. R. & Gyrd-Hansen, M., 2022, In: EMBO Reports. 2022, 23, e55839.

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  35 Citations (Scopus)

  26 Downloads (Pure)
• 2021

  Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling

  Nikhar, S., Siokas, I., Schlicher, L., Lee, S., Gyrd-Hansen, M., Degterev, A. & Cuny, G. D., 2021, In: European Journal of Medicinal Chemistry. 215, 113252.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains

  Elliott, P. R., Leske, D., Wagstaff, J., Schlicher, L., Berridge, G., Maslen, S., Timmermann, F., Ma, B., Fischer, R., Freund, S. M. V., Komander, D. & Gyrd-Hansen, M., 2021, In: Cell Reports. 37, 1, 25 p., 109777.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  23 Citations (Scopus)

  36 Downloads (Pure)

• Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase

  Klaessens, S., Stroobant, V., Hoffmann, D., Gyrd-Hansen, M., Pilotte, L., Vigneron, N., De Plaen, E. & Van den Eynde, B. J., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 23, p. e2022447118

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)
• 2020

  HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection

  Bodda, C., Reinert, L. S., Fruhwürth, S., Richardo, T., Sun, C., Zhang, B.-C., Kalamvoki, M., Pohlmann, A., Mogensen, T. H., Bergström, P., Agholme, L., O'Hare, P., Sodeik, B., Gyrd-Hansen, M., Zetterberg, H. & Paludan, S. R., 2020, In: The Journal of Experimental Medicine. 217, 7

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  66 Citations (Scopus)

• Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

  Fenech, E. J., Lari, F., Charles, P. D., Fischer, R., Laétitia-Thézénas, M., Bagola, K., Paton, A. W., Paton, J. C., Gyrd-Hansen, M., Kessler, B. M. & Christianson, J. C., 2 Jul 2020, In: eLife. 9

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  60 Citations (Scopus)

• Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold

  Suebsuwong, C., Dai, B., Pinkas, D. M., Duddupudi, A. L., Li, L., Bufton, J. C., Schlicher, L., Gyrd-Hansen, M., Hu, M., Bullock, A. N., Degterev, A. & Cuny, G. D., 2020, In: European Journal of Medicinal Chemistry. 200, 21 p., 112417.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  15 Citations (Scopus)

  11 Downloads (Pure)
• 2018

  Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1

  Prabakaran, T., Bodda, C., Krapp, C., Zhang, B.-C., Christensen, M. H., Sun, C., Reinert, L., Cai, Y., Jensen, S. B., Skouboe, M. K., Nyengaard, J. R., Thompson, C. B., Lebbink, R. J., Sen, G. C., van Loo, G., Nielsen, R., Komatsu, M., Nejsum, L. N., Jakobsen, M. R. & Gyrd-Hansen, M. & 1 others, Paludan, S. R., 13 Apr 2018, In: The EMBO Journal. 37, 8, e97858.

  Research output: Contribution to journal › Journal article › Research › peer-review
  318 Citations (Scopus)

• Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling

  Hrdinka, M., Schlicher, L., Dai, B., Pinkas, D. M., Bufton, J. C., Picaud, S., Ward, J. A., Rogers, C., Suebsuwong, C., Nikhar, S., Cuny, G. D., Huber, K. V., Filippakopoulos, P., Bullock, A. N., Degterev, A. & Gyrd-Hansen, M., 3 Sept 2018, In: The EMBO Journal. 37, 17

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  54 Citations (Scopus)
• 2017

  Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease

  Schwerd, T., Pandey, S., Yang, H.-T., Bagola, K., Jameson, E., Jung, J., Lachmann, R. H., Shah, N., Patel, S. Y., Booth, C., Runz, H., Düker, G., Bettels, R., Rohrbach, M., Kugathasan, S., Chapel, H., Keshav, S., Elkadri, A., Platt, N. & Muise, A. M. & 8 others, Koletzko, S., Xavier, R. J., Marquardt, T., Powrie, F., Wraith, J. E., Gyrd-Hansen, M., Platt, F. M. & Uhlig, H. H., Jun 2017, In: Gut. 66, 6, p. 1060-1073 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  124 Citations (Scopus)
• 2016

  CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

  Hrdinka, M., Fiil, B. K., Zucca, M., Leske, D., Bagola, K., Yabal, M., Elliott, P. R., Damgaard, R. B., Komander, D., Jost, P. J. & Gyrd-Hansen, M., 29 Mar 2016, In: Cell Reports. 14, 12, p. 2846-58 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  122 Citations (Scopus)

• OTULIN deficiency causes auto-inflammatory syndrome

  Fiil, B. K. & Gyrd-Hansen, M., Nov 2016, In: Cell Research. 26, 11, p. 1176-1177 2 p.

  Research output: Contribution to journal › Journal article › Commissioned
  12 Citations (Scopus)

• SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

  Elliott, P. R., Leske, D., Hrdinka, M., Bagola, K., Fiil, B. K., McLaughlin, S. H., Wagstaff, J., Volkmar, N., Christianson, J. C., Kessler, B. M., Freund, S. M. V., Komander, D. & Gyrd-Hansen, M., 15 Sept 2016, In: Molecular Cell. 63, 6, p. 990-1005 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  130 Citations (Scopus)
• 2015

  A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

  Nachbur, U., Stafford, C. A., Bankovacki, A., Zhan, Y., Lindqvist, L. M., Fiil, B. K., Khakham, Y., Ko, H.-J., Sandow, J. J., Falk, H., Holien, J. K., Chau, D., Hildebrand, J., Vince, J. E., Sharp, P. P., Webb, A. I., Jackman, K. A., Mühlen, S., Kennedy, C. L. & Lowes, K. N. & 8 others, Murphy, J. M., Gyrd-Hansen, M., Parker, M. W., Hartland, E. L., Lew, A. M., Huang, D. C. S., Lessene, G. & Silke, J., 17 Mar 2015, In: Nature Communications. 6, 13 p., 6442.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  103 Citations (Scopus)

• Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors

  Canning, P., Ruan, Q., Schwerd, T., Hrdinka, M., Maki, J. L., Saleh, D., Suebsuwong, C., Ray, S., Brennan, P. E., Cuny, G. D., Uhlig, H. H., Gyrd-Hansen, M., Degterev, A. & Bullock, A. N., 17 Sept 2015, In: Cell Chemical Biology. 22, 9, p. 1174-84 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  93 Citations (Scopus)

• Symptomatic Males and Female Carriers in a Large Caucasian Kindred with XIAP Deficiency

  Dziadzio, M., Ammann, S., Canning, C., Boyle, F., Hassan, A., Cale, C., Elawad, M., Fiil, B. K., Gyrd-Hansen, M., Salzer, U., Speckmann, C. & Grimbacher, B., 25 Jul 2015, In: Journal of Clinical Immunology. 35, 5, p. 439-444 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  28 Citations (Scopus)
• 2014

  A new functional assay for the diagnosis of X-linked inhibitor of apoptosis (XIAP) deficiency

  Ammann, S., Elling, R., Gyrd-Hansen, M., Dückers, G., Bredius, R., Burns, S. O., Edgar, J. D. M., Worth, A., Brandau, H., Warnatz, K., zur Stadt, U., Hasselblatt, P., Schwarz, K., Ehl, S. & Speckmann, C., 2014, In: Clinical and Experimental Immunology. 176, 3, p. 394-400 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  76 Citations (Scopus)

• Molecular basis and regulation of OTULIN-LUBAC interaction

  Elliott, P. R., Al-Saoudi, S. V., Marco-Casanova, P., Fiil, B. K., Keusekotten, K., Mailand, N., Freund, S. M. V., Gyrd-Hansen, M. & Komander, D., 2014, In: Molecular Cell. 54, 3, p. 335-348 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  158 Citations (Scopus)

  1920 Downloads (Pure)

• XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

  Yabal, M., Müller, N., Adler, H., Knies, N., Groß, C. J., Damgaard, R. B., Kanegane, H., Ringelhan, M., Kaufmann, T., Heikenwälder, M., Strasser, A., Groß, O., Ruland, J., Peschel, C., Gyrd-Hansen, M. & Jost, P. J., 26 Jun 2014, In: Cell Reports. 7, 6, p. 1796-1808

  Research output: Contribution to journal › Journal article › Research › peer-review
  212 Citations (Scopus)
• 2013

  Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

  Damgaard, R. B., Fiil, B. K., Speckmann, C., Yabal, M., Stadt, U. Z., Bekker-Jensen, S., Jost, P. J., Ehl, S., Mailand, N. & Gyrd-Hansen, M., 1 Jul 2013, In: E M B O Journal. 5, p. 1278-1295 18 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  133 Citations (Scopus)

• OTULIN antagonizes LUBAC signaling by specifically hydrolyzing met1-linked polyubiquitin

  Keusekotten, K., Elliott, P. R., Kulathu, Y., Wauer, T., Hospenthal, M. K., Komander, D., Glockner, L., Krappmann, D., Fiil, B. K., Damgaard, R. B., Gyrd-Hansen, M. & Hofmann, K., 6 Jun 2013, In: Cell. 153, 6, p. 1312-1326 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  386 Citations (Scopus)

• OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

  Fiil, B. K., Damgaard, R. B., Wagner, S. A., Keusekotten, K., Fritsch, M., Bekker-Jensen, S., Mailand, N., Choudhary, C. R., Komander, D. & Gyrd-Hansen, M., 27 Jun 2013, In: Molecular Cell. 50, 6, p. 818-30 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  206 Citations (Scopus)

• X-linked inhibitor of apoptosis (XIAP) deficiency: The spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis

  Speckmann, C., Lehmberg, K., Albert, M. H., Damgaard, R. B., Fritsch, M., Gyrd-Hansen, M., Rensing-Ehl, A., Vraetz, T., Grimbacher, B., Salzer, U., Fuchs, I., Ufheil, H., Belohradsky, B. H., Hassan, A., Cale, C. M., Elawad, M., Strahm, B., Schibli, S., Lauten, M. & Kohl, M. & 10 others, Meerpohl, J. J., Rodeck, B., Kolb, R., Eberl, W., Soerensen, J., von Bernuth, H., Lorenz, M., Schwarz, K.-U., zur Stadt, U. & Ehl, S., 1 Oct 2013, In: Clinical Immunology. 149, 1, p. 133-141 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  145 Citations (Scopus)
• 2012

  The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

  Damgaard, R. B., Nachbur, U., Yabal, M., Wong, W.W.-L., Fiil, B. K., Kastirr, M., Rieser, E., Rickard, J. A., Bankovacki, A., Peschel, C., Ruland, J., Bekker-Jensen, S., Mailand, N., Kaufmann, T., Strasser, A., Walczak, H., Silke, J., Jost, P. J. & Gyrd-Hansen, M., 2012, In: Molecular Cell. 46, 6, p. 746-58 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  321 Citations (Scopus)
• 2010

  IAPs: From caspase inhibitors to modulators of NF-κB, inflammation and cancer

  Gyrd-Hansen, M. & Meier, P., 2010, In: Nature Reviews Cancer.

  Research output: Contribution to journal › Journal article › Commissioned › peer-review
  703 Citations (Scopus)
• 2008

  IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

  Gyrd-Hansen, M., Darding, M., Miasari, M., Santoro, M. M., Zender, L., Xue, W., Tenev, T., da Fonseca, P. C. A., Zvelebil, M., Bujnicki, J. M., Lowe, S., Silke, J. & Meier, P., 2008, In: Nature Cell Biology. 10, 11, p. 1309-17 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  214 Citations (Scopus)
• 2007

  Breast cancer cells with acquired antiestrogen resistance are sensitized to cisplatin-induced cell death

  Yde, C. W., Gyrd-Hansen, M., Lykkesfeldt, A. E., Issinger, O.-G. & Stenvang, J., Jun 2007, In: Molecular Cancer Therapeutics. 6, 6, p. 1869-1876 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  25 Citations (Scopus)

• Heregulin-induced epigenetic regulation of the utrophin-A promoter.

  Basu, U., Gyrd-Hansen, M., Baby, S. M., Lozynska, O., Krag, T. O. B., Jensen, C. J., Frödin, M. & Khurana, T. S., 2007, In: FEBS Letters. 581, 22, p. 4153-8 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)
• 2006

  Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9

  Gyrd-Hansen, M., Farkas, T., Fehrenbacher, N., Bastholm, L., Høyer-Hansen, M., Elling, F., Wallach, D., Flavell, R., Kroemer, G., Nylandsted, J. & Jäättelä, M., 2006, In: Molecular and Cellular Biology. 26, 21, p. 7880-7891

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  98 Citations (Scopus)
• 2004

  Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity.

  Gyrd-Hansen, M., Nylandsted, J. & Jäättelä, M., 2004, In: Cell Cycle. 3, 12, p. 1484-5 1 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  101 Citations (Scopus)

• Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.

  Nylandsted, J., Gyrd-Hansen, M., Danielewicz, A., Fehrenbacher, N., Lademann, U., Høyer-Hansen, M., Weber, E., Multhoff, G., Rohde, M. & Jäättelä, M., 2004, In: Journal of Experimental Medicine. 200, 4, p. 425-435 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  482 Citations (Scopus)

• JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways

  Dietrich, N., Thastrup, J., Holmberg, C. H., Gyrd-Hansen, M., Fehrenbacher, N., Lademann, U., Lerdrup, M., Herdegen, T., Jäättelä, M. & Kallunki, T., 2004, In: Cell Death and Differentiation. 11, 3, p. 301-313 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  55 Citations (Scopus)

• Sensitization to the lysosomal cell death pathway upon immortalization and transformation.

  Fehrenbacher, N., Gyrd-Hansen, M., Poulsen, B., Felbor, U., Kallunki, T., Boes, M., Weber, E., Leist, M. & Jäättelä, M., 2004, In: Cancer Research. 64, 15, p. 5301–5310

  Research output: Contribution to journal › Journal article › Research › peer-review
  134 Citations (Scopus)
• 2003

  Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex.

  Lademann, U., Cain, K., Gyrd-Hansen, M., Brown, D., Peters, D. & Jäättelä, M., 2003, In: Molecular and Cellular Biology. 23, 21, p. 7829-37 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  48 Citations (Scopus)
• 2002

  Sp1 and the ets-related transcription factor complex GABP alpha/beta functionally cooperate to activate the utrophin promoter.

  Gyrd-Hansen, M., Krag, T. O. B., Rosmarin, A. G. & Khurana, T. S., 2002, In: Journal of the Neurological Sciences. 197, 1-2, p. 27-35 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  21 Citations (Scopus)
• 2001

  Harnessing the potential of dystrophin-related proteins for ameliorating Duchenne's muscular dystrophy.

  Krag, T. O., Gyrd-Hansen, M. & Khurana, T. S., 2001, In: Acta Physiologica (Print Edition). 171, 3, p. 349-58 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  20 Citations (Scopus)