Research output per year
Research output per year
Associate professor in forensic toxicology (50%) / Researcher at the Arctic University of Norway (50%)
Frederiksvej V's Vej 9-11
2100 København Ø
Research interests
- Computational mass spectrometry
- Forensic HRMS drug screening
- Metabolomics focused on coronary artery disease
I am interested in how we can use general-purpose programming languages to improve forensic services in general. We are constantly seeking to improve analytical strategies for the detection of new psychoactive substances through the sharing analytical intelligence and identifying analytical targets with drug metabolism studies. Furthermore, I am running a wastewater monitoring study for drugs of abuse in the greater Copenhagen area.
Ongoing projects
In forensic chemistry we are working on Principal investigator of the multi-disciplinary research project, TROMBOLOME (€1.4 mio funded by the Norwegian Research Council), with the objective to improve data workflows for large-scale untargeted, metabolome data. We aim to build a (structured query language) SQL database of untargeted metabolome data from population study biobank samples, and then combine the biochemical insights from metabolite profiles with health registry data for cardiovascular health. This will improve insight in pathophysiological mechanisms behind and personalized medicine for coronary artery disease.
Highlighted publications
Pan M, Rasmussen BS, Dalsgaard PW, Mollerup CB, Nielsen MKK, Nedahl M, Linnet K, Mardal M. A New Strategy for Efficient Retrospective Data Analyses for Designer Benzodiazepines in Large LC-HRMS Datasets, Frontiers in Chemistry 2022: https://doi.org/10.3389/fchem.2022.868532
Mardal M, Fuskevåg OM, Dalsgaard PW. Comprehensive UHPLC-HR-MSE screening workflow optimized for use in routine laboratory medicine: four workflows in one analytical method, Journal of Pharmaceutical and Biomedical Analysis 2021: https://doi.org/10.1016/j.jpba.2021.113936
Mardal M, Andreasen MF, Mollerup CB, Stockham P, Telving R, Thomaidis NS, Diamanti KS, Linnet K, Dalsgaard PW. HighResNPS.com: An Online Crowd-Sourced HR-MS Database for Suspect and Non-targeted Screening of New Psychoactive Substances. Journal of Analytical Toxicology 2019: https://doi.org/10.1093/jat/bkz030
Maries primary fields of research is drug metabolism, detectability, and disposition in various matrices.
In order to detect, and possibly quantify, drug consumption we need to know which analytical targets to measure, and in which matrices we can measure the targets. This information can be collected through studies involving post-mortem and/or in vitro analyses on drug disposition into the brain and bile together with drug metabolism studies. Additionally, Marie is currently involved in research projects involving analysis of drug consumption trends on community-level using wastewater-based epidemiology, in vitro metabolism studies on new psychoactive substances, and improvement of screening methods using high resolution mass spectrometry.
2020- : Associate professor, Department of Forensic Medicine, KU
2019- : Engineer/researcher, the Arctic University of Northern Norway
2018 - 2019: Tenure-track assistant professor, Section of forensic chemistry, UCPH
2016 - 2018: Scientific assistant/postdoctoral researcher, Section of forensic chemistry, UCPH
2013 - 2016: PhD, EU-funded MSCA ITN 'SEWPROF', Saarland University (Germany)
2012 - 2013: Scientific assistant, AAU BIO
2011 : ERASMUS student, Uppsala University (Sweden)
2010 - 2012: M.Sc. Pharmaceutical Sciences, UCPH
2006 - 2010: B.Sc. Pharmacy, UCPH
2016 - 2018: Management committee member in the EU-funded COST action SCORE-COST (ESSEM 1307)
Resarcher 50%, University of Tromsø – The Arctic University of Norway
1 Dec 2020 → 30 Nov 2025
Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research › peer-review
Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Review › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to conference › Poster › Research
Marie Mardal (Participant)
Activity: Participating in an event - types › Participation in workshop, seminar, course
Marie Mardal (Speaker)
Activity: Participating in an event - types › Participation in workshop, seminar, course
Marie Mardal (Board member)
Activity: Membership types › Membership in committee, council, board