Personal profile
Short presentation
Primary fields of research
My primary focus is the toxicological effects of exposure to environmental factors. The research focuses is on mechanisms of action of environmental agents, using cell cultures, experimental laboratory models and controlled human exposures. The outcome aim to develop better models for understadning of the following:
- Molecular and functional assessment of exposure, susceptibility and effects
- Experimental in vitro and in vivo model systems
- Alternatives to animal experimentation
Current research
Use of in vitro models to investigate cell-cell interactions as well as cell exposure interactions. The primary use of the cell models are investigation of the effect of exposure to different types of particle such as air pollution and combustion particles as well as micro- and nanoplastic particles. Major focus is on cellular effects such as oxidative stress, inflammation and DNA damage.
Key word
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Particle toxicology
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Nanoparticles
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Nanoplastic
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Mikroplastic
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Nanomedicine
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co-cultures
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Oxidativ stress
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DNA damage
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Cell-cell interaction
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Cell-particle interaction
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Pulmonary effects
- Cardiovascular effects
Possible conflicts of interest
No conflicts of interest
Keywords
- Faculty of Health and Medical Sciences
- Air Pollution
- in vitro models
- Toxicology
- Nanotoxicology
- Particle Toxicology
- Microplastic
- Nanoplastic
Collaborations and top research areas from the last five years
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Effects of alcohol consumption on the allergen-specific immune response in mice
Linneberg, A., Roursgaard, M., Hersoug, L.-G. & Larsen, S. T., 2008, In: Alcoholism: Clinical and Experimental Research. 32, 3, p. 553-557 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
18 Citations (Scopus) -
Effect of vitamin C and iron chelation on diesel exhaust particle and carbon black induced oxidative damage and cell adhesion molecule expression in human endothelial cells
Frikke-Schmidt, H. R., Roursgaard, M., Lykkesfeldt, J., Loft, S., Nøjgaard, J. K. & Møller, P., 2011, In: Toxicology Letters. 203, 3, p. 181-189 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
83 Citations (Scopus) -
Oxidative stress, genotoxicity, and vascular cell adhesion molecule expression in cells exposed to particulate matter from combustion of conventional diesel and methyl ester biodiesel blends
Hemmingsen, J. G., Møller, P., Nøjgaard, J. K., Roursgaard, M. & Loft, S., 1 Oct 2011, In: Environmental Science & Technology (Washington). 45, 19, p. 8545-51 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
113 Citations (Scopus) -
Urinary excretion of 8-oxo-7,8-dihydroguanine as biomarker of oxidative damage to DNA
Loft, S., Danielsen, P. H., Løhr, M., Jantzen, K., Hemmingsen, J. G., Roursgaard, M., Karottki, D. G. & Møller, P., 2012, In: Archives of Biochemistry and Biophysics. 518, 2, p. 142-50 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
59 Citations (Scopus) -
Transport of SiO(2) Nanoparticles through Human Skin
Staronová, K., Nielsen, J. B., Roursgaard, M. & Knudsen, L. E., 2012, In: Basic & Clinical Pharmacology & Toxicology Online. 111, 2, p. 142-4 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
14 Citations (Scopus) -
Expression of adhesion molecules, monocyte interactions and oxidative stress in human endothelial cells exposed to wood smoke and diesel exhaust particulate matter
Forchhammer, L., Loft, S., Roursgaard, M., Cao, Y., Riddervold, I. S., Sigsgaard, T. & Møller, P., 2012, In: Toxicology Letters. 209, 2, p. 121-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
63 Citations (Scopus) -
Carbon black nanoparticles and vascular dysfunction in cultured endothelial cells and artery segments
Vesterdal, L. K., Mikkelsen, L., Folkmann, J. K., Sheykhzade, M., Cao, Y., Roursgaard, M., Loft, S. & Møller, P., 2012, In: Toxicology Letters. 214, 1, p. 19-26 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
62 Citations (Scopus) -
Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages
Jantzen, K., Roursgaard, M., Madsen, C. D., Loft, S., Rasmussen, L. J. & Møller, P., Nov 2012, In: Mutagenesis. 27, 6, p. 693-701 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
75 Citations (Scopus)