Martin Willemoës

Search results

• 2024

  Carving out a Glycoside Hydrolase Active Site for Incorporation into a New Protein Scaffold Using Deep Network Hallucination

  Hansen, A. L., Theisen, F. F., Crehuet, R., Marcos, E., Aghajari, N. & Willemoës, M., 2024, In: ACS Synthetic Biology. 13, 3, p. 862-875 14 p.

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  1 Citation (Scopus)

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• 2022

  Co-evolution of drug resistance and broadened substrate recognition in HIV protease variants isolated from an Escherichia coli genetic selection system

  Koivisto, J. M., Poulsen, N. R., Larsen, B. S., Weibull, M. G. M., Stein, A., Doro, F., Winther, J. R., Lindorff-Larsen, K. & Willemoës, M., 2022, In: The Biochemical journal. 479, 4, p. 479-501

  Research output: Contribution to journal › Journal article › Research › peer-review
  1 Citation (Scopus)

• Engineering Bifidobacterium longum Endo-α-N-acetylgalactosaminidase for Neu5Acα2-3Ga1β1-3Ga1NAc reactivity on Fetuin

  Hansen, D. K., Hansen, A. L., Koivisto, J. M., Shuoker, B., Abou Hachem, M., Winther, J. R. & Willemoës, M., 2022, In: Archives of Biochemistry and Biophysics. 725, 8 p., 109280.

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  2 Citations (Scopus)

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• 2021

  Flash properties of Gaussia luciferase are the result of covalent inhibition after a limited number of cycles

  Dijkema, F. M., Nordentoft, M. K., Didriksen, A. K., Corneliussen, A. S., Willemoës, M. & Winther, J. R., 2021, In: Protein Science. 30, 3, p. 638-649 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  14 Citations (Scopus)

• Identification of a Catalytic Nucleophile-Activating Network in the endo-α-N-Acetylgalactosaminidase of Family GH101

  Hansen, A. L., Koivisto, J. M., Simonsen, S., Dong, Z., Crehuet, R., Hansen, D. K. & Willemoës, M., 2021, In: Biochemistry. 60, 45, p. 3398-3407 10 p.

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  1 Citation (Scopus)

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• Mapping the degradation pathway of a disease-linked aspartoacylase variant

  Gersing, S. K., Wang, Y., Grønbæk-Thygesen, M., Kampmeyer, C., Clausen, L., Willemoës, M., Andréasson, C., Stein, A., Lindorff-Larsen, K. & Hartmann-Petersen, R., 2021, In: PLOS Genetics. 17, 4, 28 p., e1009539.

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  13 Citations (Scopus)

  31 Downloads (Pure)

• Quantification of Conformational Entropy Unravels Effect of Disordered Flanking Region in Coupled Folding and Binding

  Theisen, F. F., Staby, L., Tidemand, F. G., O'Shea, C., Prestel, A., Willemoës, M., Kragelund, B. B. & Skriver, K., 2021, In: Journal of the American Chemical Society. 143, 36, p. 14540-14550 11 p.

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  24 Citations (Scopus)

  35 Downloads (Pure)
• 2020

  Global analysis of protein stability by temperature and chemical denaturation

  Hamborg, L., Horsted, E. W., Johansson, K. E., Willemoës, M., Lindorff-Larsen, K. & Teilum, K., 2020, In: Analytical Biochemistry. 605, 7 p., 113863.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)
• 2019

  Improving folding properties of computationally designed proteins

  Bjerre, B., Nissen, J., Madsen, M., Kamarauskaite, J., Norrild, R. K., Holm, P. C., Nordentoft, M. K., O'Shea, C., Willemoës, M., Johansson, K. E. & Winther, J. R., 13 Dec 2019, In: Protein Engineering Design and Selection (Print). 32, 3, p. 145-151 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses

  Hadrup, N., Knudsen, K. B., Berthing, T., Wolff, H., Bengtson, S., Kofoed, C., Espersen, R., Højgaard, C., Winther, J. R., Willemoës, M., Wedin, I., Nuopponen, M., Alenius, H., Norppa, H., Wallin, H. & Vogel, U., 2019, In: Environmental Toxicology and Pharmacology. 66, p. 116-125 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  43 Citations (Scopus)

• Steady state kinetic analysis of O-linked GalNAc glycan release catalyzed by endo-α-N-acetylgalactosaminidase

  Hansen, D. K., Winther, J. R. & Willemoës, M., 2019, In: Carbohydrate Research. 480, p. 54-60

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)

• The PCNA interaction motifs revisited: thinking outside the PIP-box

  Prestel, A., Wichmann, N., Martins, J. M., Marabini, R., Kassem, N., Broendum, S. S., Otterlei, M., Nielsen, O., Willemoës, M., Ploug, M., Boomsma, W. & Kragelund, B. B., 2019, In: Cellular and Molecular Life Sciences. 76, 24, p. 4923-4943

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  79 Citations (Scopus)

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• 2018

  A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton Channel

  Santner, P., Martins, J. M. D. S., Laursen, J. S., Behrendt, L., Riber, L., Olsen, C. A., Arkin, I. T., Winther, J. R., Willemoës, M. & Lindorff-Larsen, K., 2018, In: Biochemistry. 57, 41, p. 5949-5956

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)

• Nanofibrillated cellulose causes acute pulmonary inflammation that subsides within a month

  Ilves, M., Vilske, S., Aimonen, K., Lindberg, H. K., Pesonen, S., Wedin, I., Nuopponen, M., Vanhala, E., Højgaard, C., Winther, J. R., Willemoës, M., Vogel, U., Wolff, H., Norppa, H., Savolainen, K. & Alenius, H., 2018, In: Nanotoxicology. 12, 7, p. 729-746 18 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  36 Citations (Scopus)

• Random mutagenesis analysis of the Influenza A M2 proton channel reveals novel resistance mutants

  Santner, P., Martins, J. M. D. S., Kampmeyer, C., Hartmann-Petersen, R., Laursen, J. S., Stein, A., Olsen, C. A., Arkin, I. T., Winther, J. R., Willemoës, M. & Lindorff-Larsen, K., 2018, In: Biochemistry. 57, 41, p. 5957-5968

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)
• 2017

  Eukaryotic transcription factors: paradigms of protein intrinsic disorder

  Staby, L., O'Shea, C., Willemoës, M., Theisen, F., Kragelund, B. B. & Skriver, K., 12 Jul 2017, In: Biochemical Journal. 474, 15, p. 2509-2532 24 p.

  Research output: Contribution to journal › Review › Research › peer-review
  104 Citations (Scopus)

• Genotoxic and inflammatory effects of nanofibrillated cellulose in murine lungs

  Catalán, J., Rydman, E., Aimonen, K., Hannukainen, K-S., Suhonen, S., Vanhala, E., Moreno, C., Meyer, V., da Silva Perez, D., Sneck, A., Forsström, U., Højgaard, C., Willemoës, M., Winther, J. R., Vogel, U., Wolff, H., Alenius, H., Savolainen, K. M. & Norppa, H., Jan 2017, In: Mutagenesis. 32, 1, p. 23-31 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  63 Citations (Scopus)

• Phosphoribosyl diphosphate (PRPP): biosynthesis, enzymology, utilization, and metabolic significance

  Hove-Jensen, B., Andersen, K. R., Kilstrup, M., Martinussen, J., Switzer, R. L. & Willemoës, M., 1 Mar 2017, In: Microbiology and Molecular Biology Reviews. 81, 1, 83 p., e00040-16.

  Research output: Contribution to journal › Review › Research › peer-review

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  150 Citations (Scopus)

• Positive staining for cellulose in oral pulse granuloma

  Virkkunen, S., Wolff, H., Haglund, C., Højgaard, C., Winther, J. R., Willemoës, M., Vogel, U. & Hagström, J., Apr 2017, In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 123, 4, p. 464-467 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• Structures and short linear motif of disordered transcription factor regions provide clues to the interactome of the cellular hub radical-induced cell death1

  O'Shea, C., Staby, L., Bendsen, S. K., Tidemand, F. G., Redsted, A., Willemoës, M., Kragelund, B. B. & Skriver, K., 13 Jan 2017, In: Journal of Biological Chemistry. 292, 2, p. 512-527 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  50 Citations (Scopus)
• 2016

  A soluble, folded protein without charged amino acid residues

  Højgaard, C., Kofoed, C., Espersen, R., Johansson, K. E., Villa, M., Willemoës, M., Lindorff-Larsen, K., Teilum, K. & Winther, J. R., 2016, In: Biochemistry. 55, 28, p. 3949–3956 8 p.

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  29 Citations (Scopus)

  342 Downloads (Pure)

• Computational redesign of thioredoxin is hypersensitive towards minor conformational changes in the backbone template

  Johansson, K. E., Johansen, N. T., Christensen, S., Horowitz, S., Bardwell, J. C. A., Olsen, J. G., Willemoës, M., Lindorff-Larsen, K., Ferkinghoff-Borg, J., Hamelryck, T. W. & Winther, J. R., 2016, In: Journal of Molecular Biology. 428, 21, p. 4361-4377 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  17 Citations (Scopus)

  262 Downloads (Pure)
• 2015

  Bacillus halodurans strain C125 encodes and synthesizes enzymes from both known pathways to form dUMP directly from Cytosine Deoxyribonucleotides

  Oehlenschlæger, C. B., Løvgreen, M. N., Reinauer, E., Lehtinen, E., Pind, M-L. L., Harris, P., Martinussen, J. & Willemoës, M., 2015, In: Applied and Environmental Microbiology. 81, 10, p. 3395-3404 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• Mutational analysis of divalent metal ion binding in the active site of class II α-mannosidase from Sulfolobus solfataricus

  Hansen, D., Webb, H., Nielsen, J. W., Harris, P., Winther, J. R. & Willemoës, M., 2015, In: Biochemistry. 54, 11, p. 2032-2039 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• Protein intrinsic disorder in Arabidopsis NAC transcription factors: transcriptional activation by ANAC013 and ANAC046 and their interactions with RCD1

  O'Shea, C., Jensen, M. K., Stender, E. G. P., Kragelund, B. B., Willemoës, M. & Skriver, K., 2015, In: Biochemical Journal. 465, 2, p. 281-294 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  43 Citations (Scopus)

• Visualization of nanofibrillar cellulose in biological tissues using a biotinylated carbohydrate binding module of β-1,4-Glycanase

  Knudsen, K. B., Kofoed, C., Espersen, R., Højgaard, C., Winther, J. R., Willemoës, M., Wedin, I., Nuopponen, M., Vilske, S., Aimonen, K., Weydahl, I. E. K., Alenius, H., Norppa, H., Wolff, H., Wallin, E. H. R. & Vogel, U., 2015, In: Chemical Research in Toxicology. 28, 8, p. 1627-1635 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  19 Citations (Scopus)

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• 2014

  Analysis of surface binding sites (SBSs) in carbohydrate active enzymes with focus on glycoside hydrolase families 13 and 77 - a mini-review

  Cockburn, D., Wilkens, C., Ruzanski, C., Andersen, S., Nielsen, J. W., Smith, A. M., Field, R. A., Willemoës, M., Abou Hachem, M. & Svensson, B., 2014, In: Biologia. 69, 6, p. 705-712 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  50 Citations (Scopus)

• Catalytic site interactions in yeast OMP synthase

  Hansen, M. R., Barr, E. W., Jensen, K. F., Willemoës, M., Grubmeyer, C. & Winther, J. R., 2014, In: Archives of Biochemistry and Biophysics. 542, p. 28-38 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• In Silico prediction of mutant HIV-1 proteases cleaving a target sequence

  Jensen, J. H., Willemoës, M., Winther, J. R. & De Vico, L., 2014, In: P L o S One. 9, 5, 11 p., 5.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  11 Citations (Scopus)

  1673 Downloads (Pure)
• 2013

  Surface Binding Sites (SBSs), Mechanism and Regulation of Enzymes Degrading Amylopectin and α-Limit Dextrins

  S. Møller, M., Cockburn, D., W. Nielsen, J., M. Jensen, J., B. Vester-christensen, M., M. Nielsen, M., M. Andersen, J., Wilkens, C., Rannes, J., Hägglund, P., Henriksen, A., Abou Hachem, M., Willemoës, M. & Svensson, B., 1 Jan 2013, In: Journal of Applied Glycoscience. 60, 2, p. 101-109

  Research output: Contribution to journal › Review › Research › peer-review
• 2012

  Degradation of the starch components amylopectin and amylose by barley a-amylase 1: role of surface binding site 2

  Nielsen, J. W., Kramhøft, B., Bozonnet, S., Abou Hachem, M., Stipp, S. L. S., Svensson, B. & Willemoës, M., 2012, In: Archives of Biochemistry and Biophysics. 528, 1, p. 1-6 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  20 Citations (Scopus)

• Metal-ion dependent catalytic properties of Sulfolobus solfataricus class II α-mannosidase

  Nielsen, J. W., Poulsen, N. R., Johnsson, A. M. S., Winther, J. R., Stipp, S. L. S. & Willemoës, M., 2012, In: Biochemistry. 51, 40, p. 8039-8046 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  6 Citations (Scopus)

• Polysaccharide effects on calcite growth: the influence of composition and branching

  Nielsen, J. W., Sand, K. K., Pedersen, C. S., Lakshtanov, L. Z., Winther, J. R., Willemoës, M. & Stipp, S. L. S., 2012, In: Crystal Growth & Design. 12, 10, p. 4906-4910 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  32 Citations (Scopus)
• 2011

  Structure of the dimeric form of CTP synthase from Sulfolobus solfataricus

  Lauritsen, I. H., Willemoës, M., Jensen, K. F., Johansson, E. & Harris, P., 2011, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 67, 2, p. 201-208 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  22 Citations (Scopus)

• The Biochemical Basis | Nucleotide Metabolism

  Martinussen, J., Willemoës, M. & Kilstrup, M., 20 Jan 2011, Comprehensive Biotechnology. . Moo-Young, M., Butler, M., Webb, C., Moreira, A., Grodzinski, B., Cui, Z. F. & Agathos, S. (eds.). 2 ed. Elsevier, Vol. 1. p. 91-107 17 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  4 Citations (Scopus)
• 2010

  Accumulation of intermediates of the carbon-phosphorus lyase pathway for phosphonate degradation in phn mutants of Escherichia coli

  Hove-Jensen, B., Rosenkrantz, T. J., Zechel, D. L. & Willemoës, M., 2010, In: Journal of Bacteriology. 192, 1, p. 370-374

  Research output: Contribution to journal › Journal article › Research › peer-review
  28 Citations (Scopus)
• 2009

  Concerted bifunctionality of the dCTP deaminase-dUTPase from Methanocaldococcus jannaschii: a structural and pre-steady state kinetic analysis

  Siggaard, J. H. B., Johansson, E., Vognsen, T. R., Helt, S. S., Harris, P., Larsen, S. & Willemoës, M., 2009, In: Archives of Biochemistry and Biophysics. 490, 1, p. 42-9 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• Structural and kinetic studies of the allosteric transition in Sulfolobus solfataricus uracil phosphoribosyltransferase: Permanent activation by engineering of the C-terminus

  Christoffersen, S., Kadziola, A., Johansson, E., Rasmussen, M., Willemoës, M. & Jensen, K. F., 2009, In: Journal of Molecular Biology. 393, 2, p. 464-477

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)
• 2008

  Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis

  Helt, S. S., Thymark, M., Harris, P., Aagaard, C., Dietrich, J., Larsen, S. & Willemoes, M., 2008, In: Journal of Molecular Biology. 376, 2, p. 554-69 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  33 Citations (Scopus)

• Nucleotides, Nucleosides, and Nucleobases

  Jensen, K. F., Dandanell, G., Hove-Jensen, B. & Willemoës, M., 2008, EcoSal. Escherichia coli and Salmonella: cellular and molecular biology. Böck, A., Curtis III, R., Kaper, J. B., Karp, P. D., Neidhardt, F. C., Nyström, T., Slauch, J. M. & Squires, C. L. (eds.). Washington, D.C.: ASM International, Vol. Chapter 3.6.2.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  53 Citations (Scopus)

• Roles of multiple surface sites, long substrate binding clefts, and carbohydrate binding modules in the action of amylolytic enzymes on polysaccharide substrates

  Nielsen, M. M., Seo, E. S., Dilokpimol, A., Andersen, J., Hachem, M. A., Naested, H., Willemoës, M., Bozonnet, S., Kandra, L., Gymnt, G., Haser, R., Aghajari, N. & Svensson, B., 2008, In: Biocatalysis and Biotransformation. 26, 1 & 2, p. 59-67

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)
• 2007

  Forskningsbaseret undervisning- og hva' så!

  Willemoës, M. & Vogel, U. B., 2007, In: Biozoom. 3

  Research output: Contribution to journal › Comment/debate › Research

• Mutational analysis of the nucleotide binding site of Escherichia coli dCTP deaminase

  Thymark, M., Johansson, E., Larsen, S. & Willemoës, M., 2007, In: Archives of Biochemistry and Biophysics. 470, 1, p. 20-6 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)

• Regulation of dCTP deaminase from Escherichia coli by nonallosteric dTTP binding to an inactive form of the enzyme

  Johansson, E., Thymark, M., Bynck, J. H., Fanø, M., Larsen, S. & Willemoës, M., 2007, In: FEBS Journal. 274, 16, p. 4188-4198 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)

• The pair of sugar tongs site on the non-catalytic domain C of barley a-amylase participates in substrate binding and activity

  Bozonnet, S., Jensen, M. T., Nielsen, M. M., Aghajari, N., Jensen, M. H., Kramhøft, B., Willemoës, M., Tanier, S., Haser, R. & Svensson, B., 2007, In: FEBS Journal. 274, p. 5055-5067 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  59 Citations (Scopus)
• 2006

  Interactions between Barley a-Amylases, Substrates, Inhibitors and Regulatory Proteins

  Hachem, M. A., Bozonnet, S., Willemoës, M., Bønsager, B. C., Nielsen, M. M., Fukuda, K., Kramhøft, B., Maeda, K., Sigurskjold, B. W., Hägglund, P., Finnie, C., Mori, H., Robert, X., Jensen, M. H., Tranier, S., Aghajari, N., Haser, R. & Svensson, B., 2006, In: Journal of Applied Glycoscience. 53, 2, p. 163-169

  Research output: Contribution to journal › Journal article › Research › peer-review

• Interactions between Barley α-Amylases, Substrates, Inhibitors and Regulatory Proteins

  Abou Hachem, M., Bozonnet, S., Willemoës, M., C. Bønsager, B., Munch Nielsen, M., Fukuda, K., Kramhøft, B., Maeda, K., Sigurskjold, B. W., Hägglund, P., Finnie, C., Mori, H., Robert, X., H. Jensen, M., Tranier, S., Aghajari, N., Haser, R. & Svensson, B., 2006, In: Journal of Applied Glycoscience. 53, 2, p. 163-169

  Research output: Contribution to journal › Journal article › Research › peer-review

• Interactions of barley alpha-amylase isozymes with Ca2+, substrates and proteinaceous inhibitors

  Hachem, M. AB., Bozonnet, S., Willemoes, M., Kramhøft, B., Fukuda, K., Bønsager, B. C., Jensen, M. T., Nøhr, J., Tranier, N., Juge, N., Robert, X., Haser, R., Aghajari, N. & Svensson, B., 2006, In: Biocatalysis and Biotransformation. 24, 1-2, p. 83-93

  Research output: Contribution to journal › Journal article › Research › peer-review

• Niels Bohr – er det ikke noget med nogen antomer? Personer og kanoner i naturvidenskaben.

  Vogel, U. B. & Willemoës, M., 2006, In: Biozoom. 1

  Research output: Contribution to journal › Comment/debate › Research

• Structure of the Sulfolobus solfataricus alpha-glucosidase: Implications for domain conservation and substrate recognition in GH31

  Ernst, H. A., Lo Leggio, L., Willemoes, M., Leonard, G. A., Blum, P. & Larsen, S., 2006, In: Journal of Molecular Biology. 358, 4, p. 1106-24

  Research output: Contribution to journal › Journal article › Research › peer-review
  122 Citations (Scopus)