Research output per year
Research output per year
- 1 - 50 out of 141 results
Search results
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2024
Diversification of Pseudomonas aeruginosa Biofilm Populations under Repeated Phage Exposures Decreases the Efficacy of the Treatment
Martinet, M. G., Lohde, M., Higazy, D., Brandt, C., Pletz, M. W., Middelboe, M., Makarewicz, O. & Ciofu, O., 2024, In: Microorganisms. 12, 9, 20 p., 1880.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Downloads (Pure) -
2023
Hydrostatic pressure induces transformations in the organic matter and microbial community composition of marine snow particles
Stief, P., Schauberger, C., Becker, K. W., Elvert, M., Balmonte, J. P., Franco-Cisterna, B., Middelboe, M. & Glud, R. N., 2023, In: Communications Earth and Environment. 4, 1, 14 p., 377.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)15 Downloads (Pure) -
Staying below the Radar: Unraveling a New Family of Ubiquitous “Cryptic” Non-Tailed Temperate Vibriophages and Implications for Their Bacterial Hosts
Kalatzis, P. G., Mauritzen, J. J., Winther-Have, C. S., Michniewski, S., Millard, A., Tsertou, M. I., Katharios, P. & Middelboe, M., 2023, In: International Journal of Molecular Sciences. 24, 4, 23 p., 3937.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)19 Downloads (Pure) -
Strain-specific quorum-sensing responses determine virulence properties in Vibrio anguillarum
Mauritzen, J. J., Søndberg, E., Kalatzis, P. G., Roager, L., Gram, L., Svenningsen, S. L. & Middelboe, M., 2023, In: Environmental Microbiology. 25, 7, 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile6 Citations (Scopus)18 Downloads (Pure) -
2022
In Vitro Evolution of Specific Phages Infecting the Fish Pathogen Flavobacterium psychrophilum
Castillo, D., Højsting, A. R., Roosvall, A., Smyrlis, G., Jørgensen, J. & Middelboe, M., 2022, In: PHAGE: Therapy, Applications, and Research. 3, 1, p. 28-37 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)19 Downloads (Pure) -
On Single-Cell Enzyme Assays in Marine Microbial Ecology and Biogeochemistry
Traving, S. J., Balmonte, J. P., Seale, D., Arnosti, C., Glud, R. N., Hallam, S. J. & Middelboe, M., 2022, In: Frontiers in Marine Science. 9, 9 p., 846656.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)24 Downloads (Pure) -
Prevalence of genetically similar Flavobacterium columnare phages across aquaculture environments reveals a strong potential for pathogen control
Runtuvuori-Salmela, A., Kunttu, H. M. T., Laanto, E., Almeida, G. M. F., Mäkelä, K., Middelboe, M. & Sundberg, L-R., 2022, In: Environmental Microbiology. 24, 5, p. 2404-2420 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Citations (Scopus)21 Downloads (Pure) -
Reversible mutations in gliding motility and virulence genes: A flexible and efficient phage defence mechanism in Flavobacterium psychrophilum
Jørgensen, J., Sundell, K., Castillo, D., Dramshøj, L. S., Jørgensen, N. B., Madsen, S. B., Landor, L., Wiklund, T., Donati, V. L., Madsen, L., Dalsgaard, I. & Middelboe, M., 2022, In: Environmental Microbiology. 24, 10, p. 4915-4930Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile15 Downloads (Pure) -
The Gut Microbiota of Healthy and Flavobacterium psychrophilum-Infected Rainbow Trout Fry Is Shaped by Antibiotics and Phage Therapies
Donati, V. L., Madsen, L., Middelboe, M., Strube, M. L. & Dalsgaard, I., 2022, In: Frontiers in Microbiology. 13, 21 p., 771296.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile11 Citations (Scopus)20 Downloads (Pure) -
2021
Bacteriophage Resistance Affects Flavobacterium columnare Virulence Partly via Mutations in Genes Related to Gliding Motility and the Type IX Secretion System
Kunttu, H. M. T., Runtuvuori-Salmela, A., Sundell, K., Wiklund, T., Middelboe, M., Landor, L., Ashrafi, R., Hoikkala, V. & Sundberg, L-R., 2021, In: Applied and Environmental Microbiology. 87, 16, 19 p., e00812-21 .Research output: Contribution to journal › Journal article › Research › peer-review
Open Access11 Citations (Scopus) -
Comparative Genomic Analyses of Flavobacterium psychrophilum Isolates Reveals New Putative Genetic Determinants of Virulence Traits
Castillo, D., Donati, V. L., Jørgensen, J., Sundell, K., Dalsgaard, I., Madsen, L., Wiklund, T. & Middelboe, M., 2021, In: Microorganisms. 9, 8, 15 p., 1658.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile8 Citations (Scopus)33 Downloads (Pure) -
Comparison of Delivery Methods in Phage Therapy against Flavobacterium columnare Infections in Rainbow Trout
Kunttu, H. M. T., Runtuvuori-Salmela, A., Middelboe, M., Clark, J. & Sundberg, L. R., 2021, In: Antibiotics. 10, 8, 19 p., 914.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile7 Citations (Scopus)32 Downloads (Pure) -
Dynamics of Baltic Sea phages driven by environmental changes
Hoetzinger, M., Nilsson, E., Arabi, R., Osbeck, C. M. G., Pontiller, B., Hutinet, G., Bayfield, O. W., Traving, S., Kisand, V., Lundin, D., Pinhassi, J., Middelboe, M. & Holmfeldt, K., 2021, In: Environmental Microbiology. 23, 8, p. 4576-4594 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)34 Downloads (Pure) -
Genome-informed approach to identify genetic determinants of Flavobacterium psychrophilum phage susceptibility
Castillo, D., Jørgensen, J., Sundell, K., Madsen, L., Dalsgaard, I., Wiklund, T. & Middelboe, M., 2021, In: Environmental Microbiology. 23, 8, p. 4185-4199 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile8 Citations (Scopus)12 Downloads (Pure) -
Genomic Analysis of Pasteurella atlantica Provides Insight on Its Virulence Factors and Phylogeny and Highlights the Potential of Reverse Vaccinology in Aquaculture
Ellul, R. M., Kalatzis, P. G., Frantzen, C., Haugland, G. T., Gulla, S., Colquhoun, D. J., Middelboe, M., Wergeland, H. I. & Rønneseth, A., 2021, In: Microorganisms. 9, 6, 22 p., 1215.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile9 Citations (Scopus)31 Downloads (Pure) -
Interactions between Rainbow Trout Eyed Eggs and Flavobacterium spp. Using a Bath Challenge Model: Preliminary Evaluation of Bacteriophages as Pathogen Control Agents
Donati, V. L., Dalsgaard, I., Runtuvuori-Salmela, A., Kunttu, H., Jørgensen, J., Castillo, D., Sundberg, L-R., Middelboe, M. & Madsen, L., 2021, In: Microorganisms. 9, 5, 31 p., 971.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile6 Citations (Scopus)35 Downloads (Pure) -
Interactions between the Prophage 919TP and Its Vibrio cholerae Host: Implications of gmd Mutation for Phage Resistance, Cell Auto-Aggregation, and Motility
Li, N., Zeng, Y., Hu, B., Zhu, T., Svenningsen, S. L., Middelboe, M. & Tan, D., 2021, In: Viruses. 13, 12, 15 p., 2342.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)20 Downloads (Pure) -
Phage-Mediated Control of Flavobacterium psychrophilum in Aquaculture: In vivo Experiments to Compare Delivery Methods
Donati, V. L., Dalsgaard, I., Sundell, K., Castillo, D., Er-Rafik, M., Clark, J., Wiklund, T., Middelboe, M. & Madsen, L., 2021, In: Frontiers in Microbiology. 12, 16 p., 628309.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile22 Citations (Scopus)42 Downloads (Pure) -
Spatial variability of prokaryotic and viral abundances in the Kermadec and Atacama Trench regions
Schauberger, C., Middelboe, M., Larsen, M., Peoples, L. M., Bartlett, D. H., Kirpekar, F., Rowden, A. A., Wenzhöfer, F., Thamdrup, B. & Glud, R. N., 2021, In: Limnology and Oceanography. 66, 6, p. 2095-2109 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile17 Citations (Scopus)53 Downloads (Pure) -
2020
Bacteriophages: Emerging Applications in Medicine, Food, and Biotechnology
Sohail, H. A., Coffey, A., Debrowska, K., Meyer, I. M., Middelboe, M., Sohail, M. & Clokie, M. R. J., 2020, In: PHAGE: Therapy, Applications, and Research. 1, 2, p. 75-82 8 p.Research output: Contribution to journal › Conference article › Research › peer-review
7 Citations (Scopus) -
Bacteriophages as Biocontrol Agents for Flavobacterium psychrophilum Biofilms and Rainbow Trout Infections
Sundell, K., Landor, L., Castillo, D., Middelboe, M. & Wiklund, T., 2020, In: PHAGE: Therapy, Applications, and Research. 1, 4, p. 198-204 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile6 Citations (Scopus)32 Downloads (Pure) -
Beyond Cholera: Characterization of zot-Encoding Filamentous Phages in the Marine Fish Pathogen Vibrio anguillarum
Mauritzen, J. J., Castillo, D., Tan, D., Svenningsen, S. L. & Middelboe, M., 2020, In: Viruses. 12, 7, 17 p., 730.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile16 Citations (Scopus)91 Downloads (Pure) -
High cell densities favor lysogeny: induction of an H20 prophage is repressed by quorum sensing and enhances biofilm formation in Vibrio anguillarum
Tan, D., Hansen, M. F., de Carvalho, L. N., Røder, H. L., Burmølle, M., Middelboe, M. & Svenningsen, S. L., 2020, In: The ISME Journal. 14, 7, p. 1731-1742 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access50 Citations (Scopus) -
Sharp contrasts between freshwater and marine microbial enzymatic capabilities, community composition, and DOM pools in a NE Greenland fjord
Balmonte, J. P., Hasler-Sheetal, H., Glud, R. N., Andersen, T. J., Sejr, M. K., Middelboe, M., Teske, A. & Arnosti, C., 2020, In: Limnology and Oceanography. 65, 1, p. 77-95 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile19 Citations (Scopus)18 Downloads (Pure) -
2019
Big Impact of the Tiny: Bacteriophage–Bacteria Interactions in Biofilms
Hansen, M. F., Svenningsen, S. L., Røder, H. L., Middelboe, M. & Burmølle, M., 2019, In: Trends in Microbiology. 27, 9, p. 739-752 14 p.Research output: Contribution to journal › Review › Research › peer-review
91 Citations (Scopus) -
Biological transformation of Arctic dissolved organic matter in a NE Greenland fjord
Paulsen, M. L., Müller, O., Larsen, A., Møller, E. F., Middelboe, M., Sejr, M. K. & Stedmon, C., 2019, In: Limnology and Oceanography. 64, 3, p. 1014-1033Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile21 Citations (Scopus)134 Downloads (Pure) -
Combining probiotic Phaeobacter inhibens DSM17395 and broad-host-range vibriophage KVP40 against fish pathogenic vibrios
Rasmussen, B. B., Kalatzis, P. G., Middelboe, M. & Gram, L., 2019, In: Aquaculture. 513, 7 p., 734415.Research output: Contribution to journal › Journal article › Research › peer-review
13 Citations (Scopus) -
Complete Genome Sequence of Vibrio anguillarum Nontailed Bacteriophage NO16
Kalatzis, P. G., Carstens, A. B., Katharios, P., Castillo, D., Hansen, L. H. & Middelboe, M., 2019, In: Microbiology resource announcements. 8, 15, p. 1-2 e00020-19.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile6 Citations (Scopus)112 Downloads (Pure) -
Effects of allochthonous dissolved organic matter input on microbial composition and nitrogen-cycling genes at two contrasting estuarine sites
Happel, E. M., Markussen, T. M., Teikari, J. E., Huchaiah, V., Alneberg, J., Andersson, A. F., Sivonen, K., Middelboe, M., Kisand, V. & Riemann, L., 2019, In: F E M S Microbiology Ecology. 95, 9, 10 p., fiz123.Research output: Contribution to journal › Journal article › Research › peer-review
File4 Citations (Scopus)34 Downloads (Pure) -
Large Phenotypic and Genetic Diversity of Prophages Induced from the Fish Pathogen Vibrio anguillarum
Castillo, D., Andersen, N., Kalatzis, P. G. & Middelboe, M., 2019, In: Viruses. 11, 11, 15 p., 983.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile17 Citations (Scopus)113 Downloads (Pure) -
P. aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage-ciprofloxacin combination: —monitoring the phage–P. aeruginosa biofilms interactions
Henriksen, K., Rørbo, N., Rybtke, M. L., Martinet, M. G., Tolker-Nielsen, T., Høiby, N., Middelboe, M. & Ciofu, O., 2019, In: Pathogens and Disease. 77, 2, 11 p., ftz011.Research output: Contribution to journal › Journal article › Research › peer-review
53 Citations (Scopus) -
Phage defense mechanisms and their genomic and phenotypic implications in the fish pathogen Vibrio anguillarum
Castillo, D., Rørbo, N., Jørgensen, J., Lange, J., Tan, D., Kalatzis, P. G., Lo Svenningsen, S. & Middelboe, M., 2019, In: FEMS Microbiology Ecology. 95, 3, fiz004.Research output: Contribution to journal › Journal article › Research › peer-review
34 Citations (Scopus) -
Phenotypic and Genetic Predictors of Pathogenicity and Virulence in Flavobacterium psychrophilum
Sundell, K., Landor, L., Nicolas, P., Jørgensen, J., Castillo, D., Middelboe, M., Dalsgaard, I., Donati, V. L., Madsen, L. & Wiklund, T., 2019, In: Frontiers in Microbiology. 10, 14 p., 1711.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile79 Downloads (Pure) -
2018
Bacteriophage Interactions with Marine Pathogenic Vibrios: Implications for Phage Therapy
Kalatzis, P., Castillo Bermúdez, D. E., Katharios, P. & Middelboe, M., 2018, In: Antibiotics. 7, 1, 23 p., 15.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile75 Citations (Scopus)173 Downloads (Pure) -
Coupling biogeochemical process rates and metagenomic blueprints of coastal bacterial assemblages in the context of environmental change
Markussen, T. M., Happel, E. M., Teikari, J. E., Huchaiah, V., Alneberg, J., Andersson, A. F., Sivonen, K., Riemann, L., Middelboe, M. & Kisand, V., 2018, In: Environmental Microbiology. 20, 8, p. 3083-3099Research output: Contribution to journal › Journal article › Research › peer-review
10 Citations (Scopus) -
Draft Genome Sequences of Six Vibrio diazotrophicus Strains Isolated from Deep Subsurface Sediments of the Baltic Sea
Castillo, D., Vandieken, V., Engelen, B., Engelhardt, T. & Middelboe, M., 2018, In: Genome Announcements. 6, 10, p. 1-2 e00081-18.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile8 Citations (Scopus)111 Downloads (Pure) -
Exploring the Effect of Phage Therapy in Preventing Vibrio anguillarum Infections in Cod and Turbot Larvae
Rørbo, N. I., Rønneseth, A., Kalatzis, P., Rasmussen, B. B., Engell-Sørensen, K., Kleppen, H. P., Wergeland, H. I., Gram, L. & Middelboe, M., 2018, In: Antibiotics. 7, 2, 15 p., 42.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile34 Citations (Scopus)128 Downloads (Pure) -
Widespread distribution of prophage-encoded virulence factors in marine Vibrio communities
Castillo, D., Kauffman, K., Hussain, F., Kalatzis, P., Rørbo, N., Polz, M. F. & Middelboe, M., 2018, In: Scientific Reports. 8, p. 1-9 9973.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile75 Citations (Scopus)156 Downloads (Pure) -
2017
Carbon bioavailability in a high arctic fjord influenced by glacial meltwater, NE Greenland
Paulsen, M. L., Nielsen, S. E. B., Müller, O., Møller, E. F., Stedmon, C. A., Juul-Pedersen, T., Markager, S., Sejr, M. K., Delgado Huertas, A., Larsen, A. & Middelboe, M., 2017, In: Frontiers in Marine Science. 4, 19 p., 176.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile37 Citations (Scopus)239 Downloads (Pure) -
Comparative genome analyses of Vibrio anguillarum strains reveal a link with pathogenicity traits
Castillo Bermúdez, D. E., Alvise, P. D., Xu, R., Zhang, F., Middelboe, M. & Gram, L., 28 Feb 2017, In: mSystems. 2, 1, 14 p., e00001-17.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile49 Citations (Scopus)203 Downloads (Pure) -
Global occurrence and heterogeneity of the Roseobacter-clade species Ruegeria mobilis
Sonnenschein, E. C., Nielsen, K. F., D'Alvise, P., Porsby, C. H., Melchiorsen, J., Heilmann, J., Kalatzis, P., López-Pérez, M., Bunk, B., Spröer, C., Middelboe, M. & Gram, L., 2017, In: The ISME Journal. 11, p. 569-583 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access69 Citations (Scopus) -
Isolation and characterization of a N4-like lytic bacteriophage infecting Vibrio splendidus, a pathogen of fish and bivalves
Katharios, P., Kalatzis, P., Kokkari, C., Sarropoulou, E. & Middelboe, M., 28 Dec 2017, In: PLoS ONE. 12, 12, 14 p., e0190083.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile32 Citations (Scopus)215 Downloads (Pure) -
Marine viruses: key players in marine ecosystems
Middelboe, M. & Brussaard, C. P. D., Oct 2017, In: Viruses. 9, 10, 6 p., 302.Research output: Contribution to journal › Editorial › Research
Open AccessFile72 Citations (Scopus)134 Downloads (Pure) -
Stumbling across the same phage: comparative genomics of widespread temperate phages infecting the fish pathogen Vibrio anguillarum
Kalatzis, P., Rørbo, N. I., Castillo Bermúdez, D. E., Mauritzen, J. J., Jørgensen, J., Kokkari, C., Zhang, F., Katharios, P. & Middelboe, M., 20 May 2017, In: Viruses. 9, 5, 19 p., 122.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile35 Citations (Scopus)236 Downloads (Pure) -
2016
Benthic carbon mineralization in hadal trenches: assessment by in situ O2 microprofile measurements
Wenzhöfer, F., Oguri, K., Middelboe, M., Turnewitsch, R., Toyofuku, T., Kitazato, H. & Glud, R. N., 2016, In: Deep-Sea Research. Part 1: Oceanographic Research Papers. 116, p. 276-286 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile95 Citations (Scopus)328 Downloads (Pure) -
Comparative genome analysis provides Insights into the pathogenicity of Flavobacterium psychrophilum
Castillo Bermúdez, D. E., Christiansen, R. H., Dalsgaard, I., Madsen, L., Espejo, R. & Middelboe, M., 2016, In: P L o S One. 11, 4, 18 p., e0152515.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile36 Citations (Scopus)155 Downloads (Pure) -
Effect of bacteriophages on the growth of Favobacterium psychrophilum and development of phage-resistant strains
Christiansen, R. H., Madsen, L., Dalsgaard, I., Castillo Bermúdez, D. E., Kalatzis, P. G. & Middelboe, M., 2016, In: Microbial Ecology. 71, 4, p. 845-859 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
20 Citations (Scopus) -
Genomic diversity of bacteriophages infecting the fish pathogen Flavobacterium psychrophilum
Castillo Bermúdez, D. E. & Middelboe, M., 2016, In: F E M S Microbiology Letters. 363, 24, 6 p., fnw272.Research output: Contribution to journal › Journal article › Research › peer-review
19 Citations (Scopus) -
Predation and selection for antibiotic resistance in natural environments
Leisner, J., Jørgensen, N. O. G. & Middelboe, M., 2016, In: Evolutionary Applications (Online). 9, 3, p. 427-434 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
20 Citations (Scopus) -
Quantification of viral and prokaryotic production rates in benthic ecosystems: a methods comparison
Rastelli, E., Dell'Anno, A., Corinaldesi, C., Middelboe, M., Noble, R. T. & Danovaro, R., 2016, In: Frontiers in Microbiology. 7, 11 p., 1501.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile14 Citations (Scopus)137 Downloads (Pure)