Mathias Middelboe

Research output

Research output per year 1992 2006 2008 2014 2015 2016 2019 2021 2024

• 6242 Citations
• 128 Journal article
• 6 Book chapter
• 2 Letter
• 2 Review
• 3 More
  • 1 Paper
  • 1 Conference article
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2024

  Diversification of Pseudomonas aeruginosa Biofilm Populations under Repeated Phage Exposures Decreases the Efficacy of the Treatment

  Martinet, M. G., Lohde, M., Higazy, D., Brandt, C., Pletz, M. W., Middelboe, M., Makarewicz, O. & Ciofu, O., 2024, In: Microorganisms. 12, 9, 20 p., 1880.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
• 2023

  Hydrostatic pressure induces transformations in the organic matter and microbial community composition of marine snow particles

  Stief, P., Schauberger, C., Becker, K. W., Elvert, M., Balmonte, J. P., Franco-Cisterna, B., Middelboe, M. & Glud, R. N., 2023, In: Communications Earth and Environment. 4, 1, 14 p., 377.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  3 Citations (Scopus)

  14 Downloads (Pure)

• Staying below the Radar: Unraveling a New Family of Ubiquitous “Cryptic” Non-Tailed Temperate Vibriophages and Implications for Their Bacterial Hosts

  Kalatzis, P. G., Mauritzen, J. J., Winther-Have, C. S., Michniewski, S., Millard, A., Tsertou, M. I., Katharios, P. & Middelboe, M., 2023, In: International Journal of Molecular Sciences. 24, 4, 23 p., 3937.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  1 Citation (Scopus)

  19 Downloads (Pure)

• Strain-specific quorum-sensing responses determine virulence properties in Vibrio anguillarum

  Mauritzen, J. J., Søndberg, E., Kalatzis, P. G., Roager, L., Gram, L., Svenningsen, S. L. & Middelboe, M., 2023, In: Environmental Microbiology. 25, 7, 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  6 Citations (Scopus)

  17 Downloads (Pure)
• 2022

  In Vitro Evolution of Specific Phages Infecting the Fish Pathogen Flavobacterium psychrophilum

  Castillo, D., Højsting, A. R., Roosvall, A., Smyrlis, G., Jørgensen, J. & Middelboe, M., 2022, In: PHAGE: Therapy, Applications, and Research. 3, 1, p. 28-37 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  1 Citation (Scopus)

  18 Downloads (Pure)

• On Single-Cell Enzyme Assays in Marine Microbial Ecology and Biogeochemistry

  Traving, S. J., Balmonte, J. P., Seale, D., Arnosti, C., Glud, R. N., Hallam, S. J. & Middelboe, M., 2022, In: Frontiers in Marine Science. 9, 9 p., 846656.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  1 Citation (Scopus)

  23 Downloads (Pure)

• Prevalence of genetically similar Flavobacterium columnare phages across aquaculture environments reveals a strong potential for pathogen control

  Runtuvuori-Salmela, A., Kunttu, H. M. T., Laanto, E., Almeida, G. M. F., Mäkelä, K., Middelboe, M. & Sundberg, L-R., 2022, In: Environmental Microbiology. 24, 5, p. 2404-2420 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  21 Downloads (Pure)

• Reversible mutations in gliding motility and virulence genes: A flexible and efficient phage defence mechanism in Flavobacterium psychrophilum

  Jørgensen, J., Sundell, K., Castillo, D., Dramshøj, L. S., Jørgensen, N. B., Madsen, S. B., Landor, L., Wiklund, T., Donati, V. L., Madsen, L., Dalsgaard, I. & Middelboe, M., 2022, In: Environmental Microbiology. 24, 10, p. 4915-4930

  Research output: Contribution to journal › Journal article › Research › peer-review

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  14 Downloads (Pure)

• The Gut Microbiota of Healthy and Flavobacterium psychrophilum-Infected Rainbow Trout Fry Is Shaped by Antibiotics and Phage Therapies

  Donati, V. L., Madsen, L., Middelboe, M., Strube, M. L. & Dalsgaard, I., 2022, In: Frontiers in Microbiology. 13, 21 p., 771296.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  11 Citations (Scopus)

  19 Downloads (Pure)
• 2021

  Bacteriophage Resistance Affects Flavobacterium columnare Virulence Partly via Mutations in Genes Related to Gliding Motility and the Type IX Secretion System

  Kunttu, H. M. T., Runtuvuori-Salmela, A., Sundell, K., Wiklund, T., Middelboe, M., Landor, L., Ashrafi, R., Hoikkala, V. & Sundberg, L-R., 2021, In: Applied and Environmental Microbiology. 87, 16, 19 p., e00812-21 .

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  11 Citations (Scopus)

• Comparative Genomic Analyses of Flavobacterium psychrophilum Isolates Reveals New Putative Genetic Determinants of Virulence Traits

  Castillo, D., Donati, V. L., Jørgensen, J., Sundell, K., Dalsgaard, I., Madsen, L., Wiklund, T. & Middelboe, M., 2021, In: Microorganisms. 9, 8, 15 p., 1658.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  8 Citations (Scopus)

  32 Downloads (Pure)

• Comparison of Delivery Methods in Phage Therapy against Flavobacterium columnare Infections in Rainbow Trout

  Kunttu, H. M. T., Runtuvuori-Salmela, A., Middelboe, M., Clark, J. & Sundberg, L. R., 2021, In: Antibiotics. 10, 8, 19 p., 914.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  7 Citations (Scopus)

  32 Downloads (Pure)

• Dynamics of Baltic Sea phages driven by environmental changes

  Hoetzinger, M., Nilsson, E., Arabi, R., Osbeck, C. M. G., Pontiller, B., Hutinet, G., Bayfield, O. W., Traving, S., Kisand, V., Lundin, D., Pinhassi, J., Middelboe, M. & Holmfeldt, K., 2021, In: Environmental Microbiology. 23, 8, p. 4576-4594 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  3 Citations (Scopus)

  34 Downloads (Pure)

• Genome-informed approach to identify genetic determinants of Flavobacterium psychrophilum phage susceptibility

  Castillo, D., Jørgensen, J., Sundell, K., Madsen, L., Dalsgaard, I., Wiklund, T. & Middelboe, M., 2021, In: Environmental Microbiology. 23, 8, p. 4185-4199 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  8 Citations (Scopus)

  11 Downloads (Pure)

• Genomic Analysis of Pasteurella atlantica Provides Insight on Its Virulence Factors and Phylogeny and Highlights the Potential of Reverse Vaccinology in Aquaculture

  Ellul, R. M., Kalatzis, P. G., Frantzen, C., Haugland, G. T., Gulla, S., Colquhoun, D. J., Middelboe, M., Wergeland, H. I. & Rønneseth, A., 2021, In: Microorganisms. 9, 6, 22 p., 1215.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  31 Downloads (Pure)

• Interactions between Rainbow Trout Eyed Eggs and Flavobacterium spp. Using a Bath Challenge Model: Preliminary Evaluation of Bacteriophages as Pathogen Control Agents

  Donati, V. L., Dalsgaard, I., Runtuvuori-Salmela, A., Kunttu, H., Jørgensen, J., Castillo, D., Sundberg, L-R., Middelboe, M. & Madsen, L., 2021, In: Microorganisms. 9, 5, 31 p., 971.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  35 Downloads (Pure)

• Interactions between the Prophage 919TP and Its Vibrio cholerae Host: Implications of gmd Mutation for Phage Resistance, Cell Auto-Aggregation, and Motility

  Li, N., Zeng, Y., Hu, B., Zhu, T., Svenningsen, S. L., Middelboe, M. & Tan, D., 2021, In: Viruses. 13, 12, 15 p., 2342.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  1 Citation (Scopus)

  20 Downloads (Pure)

• Phage-Mediated Control of Flavobacterium psychrophilum in Aquaculture: In vivo Experiments to Compare Delivery Methods

  Donati, V. L., Dalsgaard, I., Sundell, K., Castillo, D., Er-Rafik, M., Clark, J., Wiklund, T., Middelboe, M. & Madsen, L., 2021, In: Frontiers in Microbiology. 12, 16 p., 628309.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  22 Citations (Scopus)

  41 Downloads (Pure)

• Spatial variability of prokaryotic and viral abundances in the Kermadec and Atacama Trench regions

  Schauberger, C., Middelboe, M., Larsen, M., Peoples, L. M., Bartlett, D. H., Kirpekar, F., Rowden, A. A., Wenzhöfer, F., Thamdrup, B. & Glud, R. N., 2021, In: Limnology and Oceanography. 66, 6, p. 2095-2109 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  17 Citations (Scopus)

  53 Downloads (Pure)
• 2020

  Bacteriophages: Emerging Applications in Medicine, Food, and Biotechnology

  Sohail, H. A., Coffey, A., Debrowska, K., Meyer, I. M., Middelboe, M., Sohail, M. & Clokie, M. R. J., 2020, In: PHAGE: Therapy, Applications, and Research. 1, 2, p. 75-82 8 p.

  Research output: Contribution to journal › Conference article › Research › peer-review
  7 Citations (Scopus)

• Bacteriophages as Biocontrol Agents for Flavobacterium psychrophilum Biofilms and Rainbow Trout Infections

  Sundell, K., Landor, L., Castillo, D., Middelboe, M. & Wiklund, T., 2020, In: PHAGE: Therapy, Applications, and Research. 1, 4, p. 198-204 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  6 Citations (Scopus)

  32 Downloads (Pure)

• Beyond Cholera: Characterization of zot-Encoding Filamentous Phages in the Marine Fish Pathogen Vibrio anguillarum

  Mauritzen, J. J., Castillo, D., Tan, D., Svenningsen, S. L. & Middelboe, M., 2020, In: Viruses. 12, 7, 17 p., 730.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  16 Citations (Scopus)

  91 Downloads (Pure)

• High cell densities favor lysogeny: induction of an H20 prophage is repressed by quorum sensing and enhances biofilm formation in Vibrio anguillarum

  Tan, D., Hansen, M. F., de Carvalho, L. N., Røder, H. L., Burmølle, M., Middelboe, M. & Svenningsen, S. L., 2020, In: The ISME Journal. 14, 7, p. 1731-1742 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  50 Citations (Scopus)

• Sharp contrasts between freshwater and marine microbial enzymatic capabilities, community composition, and DOM pools in a NE Greenland fjord

  Balmonte, J. P., Hasler-Sheetal, H., Glud, R. N., Andersen, T. J., Sejr, M. K., Middelboe, M., Teske, A. & Arnosti, C., 2020, In: Limnology and Oceanography. 65, 1, p. 77-95 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  19 Citations (Scopus)

  17 Downloads (Pure)
• 2019

  Big Impact of the Tiny: Bacteriophage–Bacteria Interactions in Biofilms

  Hansen, M. F., Svenningsen, S. L., Røder, H. L., Middelboe, M. & Burmølle, M., 2019, In: Trends in Microbiology. 27, 9, p. 739-752 14 p.

  Research output: Contribution to journal › Review › Research › peer-review
  91 Citations (Scopus)

• Biological transformation of Arctic dissolved organic matter in a NE Greenland fjord

  Paulsen, M. L., Müller, O., Larsen, A., Møller, E. F., Middelboe, M., Sejr, M. K. & Stedmon, C., 2019, In: Limnology and Oceanography. 64, 3, p. 1014-1033

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  21 Citations (Scopus)

  133 Downloads (Pure)

• Combining probiotic Phaeobacter inhibens DSM17395 and broad-host-range vibriophage KVP40 against fish pathogenic vibrios

  Rasmussen, B. B., Kalatzis, P. G., Middelboe, M. & Gram, L., 2019, In: Aquaculture. 513, 7 p., 734415.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Complete Genome Sequence of Vibrio anguillarum Nontailed Bacteriophage NO16

  Kalatzis, P. G., Carstens, A. B., Katharios, P., Castillo, D., Hansen, L. H. & Middelboe, M., 2019, In: Microbiology resource announcements. 8, 15, p. 1-2 e00020-19.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  6 Citations (Scopus)

  111 Downloads (Pure)

• Effects of allochthonous dissolved organic matter input on microbial composition and nitrogen-cycling genes at two contrasting estuarine sites

  Happel, E. M., Markussen, T. M., Teikari, J. E., Huchaiah, V., Alneberg, J., Andersson, A. F., Sivonen, K., Middelboe, M., Kisand, V. & Riemann, L., 2019, In: F E M S Microbiology Ecology. 95, 9, 10 p., fiz123.

  Research output: Contribution to journal › Journal article › Research › peer-review

  File
  4 Citations (Scopus)

  34 Downloads (Pure)

• Large Phenotypic and Genetic Diversity of Prophages Induced from the Fish Pathogen Vibrio anguillarum

  Castillo, D., Andersen, N., Kalatzis, P. G. & Middelboe, M., 2019, In: Viruses. 11, 11, 15 p., 983.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  17 Citations (Scopus)

  113 Downloads (Pure)

• P. aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage-ciprofloxacin combination: —monitoring the phage–P. aeruginosa biofilms interactions

  Henriksen, K., Rørbo, N., Rybtke, M. L., Martinet, M. G., Tolker-Nielsen, T., Høiby, N., Middelboe, M. & Ciofu, O., 2019, In: Pathogens and Disease. 77, 2, 11 p., ftz011.

  Research output: Contribution to journal › Journal article › Research › peer-review
  53 Citations (Scopus)

• Phage defense mechanisms and their genomic and phenotypic implications in the fish pathogen Vibrio anguillarum

  Castillo, D., Rørbo, N., Jørgensen, J., Lange, J., Tan, D., Kalatzis, P. G., Lo Svenningsen, S. & Middelboe, M., 2019, In: FEMS Microbiology Ecology. 95, 3, fiz004.

  Research output: Contribution to journal › Journal article › Research › peer-review
  34 Citations (Scopus)

• Phenotypic and Genetic Predictors of Pathogenicity and Virulence in Flavobacterium psychrophilum

  Sundell, K., Landor, L., Nicolas, P., Jørgensen, J., Castillo, D., Middelboe, M., Dalsgaard, I., Donati, V. L., Madsen, L. & Wiklund, T., 2019, In: Frontiers in Microbiology. 10, 14 p., 1711.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  79 Downloads (Pure)
• 2018

  Bacteriophage Interactions with Marine Pathogenic Vibrios: Implications for Phage Therapy

  Kalatzis, P., Castillo Bermúdez, D. E., Katharios, P. & Middelboe, M., 2018, In: Antibiotics. 7, 1, 23 p., 15.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

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  75 Citations (Scopus)

  173 Downloads (Pure)

• Coupling biogeochemical process rates and metagenomic blueprints of coastal bacterial assemblages in the context of environmental change

  Markussen, T. M., Happel, E. M., Teikari, J. E., Huchaiah, V., Alneberg, J., Andersson, A. F., Sivonen, K., Riemann, L., Middelboe, M. & Kisand, V., 2018, In: Environmental Microbiology. 20, 8, p. 3083-3099

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Draft Genome Sequences of Six Vibrio diazotrophicus Strains Isolated from Deep Subsurface Sediments of the Baltic Sea

  Castillo, D., Vandieken, V., Engelen, B., Engelhardt, T. & Middelboe, M., 2018, In: Genome Announcements. 6, 10, p. 1-2 e00081-18.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  8 Citations (Scopus)

  111 Downloads (Pure)

• Exploring the Effect of Phage Therapy in Preventing Vibrio anguillarum Infections in Cod and Turbot Larvae

  Rørbo, N. I., Rønneseth, A., Kalatzis, P., Rasmussen, B. B., Engell-Sørensen, K., Kleppen, H. P., Wergeland, H. I., Gram, L. & Middelboe, M., 2018, In: Antibiotics. 7, 2, 15 p., 42.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  34 Citations (Scopus)

  126 Downloads (Pure)

• Widespread distribution of prophage-encoded virulence factors in marine Vibrio communities

  Castillo, D., Kauffman, K., Hussain, F., Kalatzis, P., Rørbo, N., Polz, M. F. & Middelboe, M., 2018, In: Scientific Reports. 8, p. 1-9 9973.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  75 Citations (Scopus)

  155 Downloads (Pure)
• 2017

  Carbon bioavailability in a high arctic fjord influenced by glacial meltwater, NE Greenland

  Paulsen, M. L., Nielsen, S. E. B., Müller, O., Møller, E. F., Stedmon, C. A., Juul-Pedersen, T., Markager, S., Sejr, M. K., Delgado Huertas, A., Larsen, A. & Middelboe, M., 2017, In: Frontiers in Marine Science. 4, 19 p., 176.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  37 Citations (Scopus)

  236 Downloads (Pure)

• Comparative genome analyses of Vibrio anguillarum strains reveal a link with pathogenicity traits

  Castillo Bermúdez, D. E., Alvise, P. D., Xu, R., Zhang, F., Middelboe, M. & Gram, L., 28 Feb 2017, In: mSystems. 2, 1, 14 p., e00001-17.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  49 Citations (Scopus)

  203 Downloads (Pure)

• Global occurrence and heterogeneity of the Roseobacter-clade species Ruegeria mobilis

  Sonnenschein, E. C., Nielsen, K. F., D'Alvise, P., Porsby, C. H., Melchiorsen, J., Heilmann, J., Kalatzis, P., López-Pérez, M., Bunk, B., Spröer, C., Middelboe, M. & Gram, L., 2017, In: The ISME Journal. 11, p. 569-583 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  69 Citations (Scopus)

• Isolation and characterization of a N4-like lytic bacteriophage infecting Vibrio splendidus, a pathogen of fish and bivalves

  Katharios, P., Kalatzis, P., Kokkari, C., Sarropoulou, E. & Middelboe, M., 28 Dec 2017, In: PLoS ONE. 12, 12, 14 p., e0190083.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  32 Citations (Scopus)

  215 Downloads (Pure)

• Marine viruses: key players in marine ecosystems

  Middelboe, M. & Brussaard, C. P. D., Oct 2017, In: Viruses. 9, 10, 6 p., 302.

  Research output: Contribution to journal › Editorial › Research

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  72 Citations (Scopus)

  134 Downloads (Pure)

• Stumbling across the same phage: comparative genomics of widespread temperate phages infecting the fish pathogen Vibrio anguillarum

  Kalatzis, P., Rørbo, N. I., Castillo Bermúdez, D. E., Mauritzen, J. J., Jørgensen, J., Kokkari, C., Zhang, F., Katharios, P. & Middelboe, M., 20 May 2017, In: Viruses. 9, 5, 19 p., 122.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  35 Citations (Scopus)

  236 Downloads (Pure)
• 2016

  Benthic carbon mineralization in hadal trenches: assessment by in situ O₂ microprofile measurements

  Wenzhöfer, F., Oguri, K., Middelboe, M., Turnewitsch, R., Toyofuku, T., Kitazato, H. & Glud, R. N., 2016, In: Deep-Sea Research. Part 1: Oceanographic Research Papers. 116, p. 276-286 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  95 Citations (Scopus)

  327 Downloads (Pure)

• Comparative genome analysis provides Insights into the pathogenicity of Flavobacterium psychrophilum

  Castillo Bermúdez, D. E., Christiansen, R. H., Dalsgaard, I., Madsen, L., Espejo, R. & Middelboe, M., 2016, In: P L o S One. 11, 4, 18 p., e0152515.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  36 Citations (Scopus)

  154 Downloads (Pure)

• Effect of bacteriophages on the growth of Favobacterium psychrophilum and development of phage-resistant strains

  Christiansen, R. H., Madsen, L., Dalsgaard, I., Castillo Bermúdez, D. E., Kalatzis, P. G. & Middelboe, M., 2016, In: Microbial Ecology. 71, 4, p. 845-859 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)

• Genomic diversity of bacteriophages infecting the fish pathogen Flavobacterium psychrophilum

  Castillo Bermúdez, D. E. & Middelboe, M., 2016, In: F E M S Microbiology Letters. 363, 24, 6 p., fnw272.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• Predation and selection for antibiotic resistance in natural environments

  Leisner, J., Jørgensen, N. O. G. & Middelboe, M., 2016, In: Evolutionary Applications (Online). 9, 3, p. 427-434 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)

• Quantification of viral and prokaryotic production rates in benthic ecosystems: a methods comparison

  Rastelli, E., Dell'Anno, A., Corinaldesi, C., Middelboe, M., Noble, R. T. & Danovaro, R., 2016, In: Frontiers in Microbiology. 7, 11 p., 1501.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  14 Citations (Scopus)

  136 Downloads (Pure)