Research output per year
Research output per year
Universitetsparken 2
2100 København Ø
Research activity per year
Designing and developing in vitro models to evaluate drug performance after oral administration.
Mette Klitgaard is a PhD student associated with the Physiological Pharmaceutics group at the Department of Pharmacy, University of Copenhagen. The PhD project is entitled "Is intestinal mucus an important factor in solubilization and absorption of poorly soluble drugs?" and is funded by Lundbeckfonden.
Currently, the mucus lining the small intestine is considered a barrier for absorption, especially for protein drugs. We are taking an orthogonal approach to this, by hypothesizing that the mucus layer also has very good drug solubilizing properties, which is important for absorption of poorly soluble drugs. Thus, for the first time, we will include the mucus in the simulation of dissolution and absorption studies of drugs, to improve the understanding and simulation of the absorption process.
Predictive in vitro models, simulating the human gastro-intestinal tract, are needed for a rational development of new effective oral drugs and bioactives. Existing in vitro models are hampered by lack of a complete understanding of drug absorption mechanisms and especially the role mucus is playing in the process. The development of predictive in vitro models will reduce the need for animal studies and will also enable a more rational design of clinical studies.
2018 - present PhD Student, Department of Pharmacy, UCPH
2018 - 2018 Research Assistant (primarily focussed on teaching), Department of Pharmacy, UCPH
2016 - 2018 MSc Pharmaceutical Sciences, UCPH
2015 - 2016 Undergraduate research assistant at the Department of Pharmacy, UCPH
2011 - 2015 BSc in Pharmacy, UCPH
MSc Pharmaceutical Sciences
Award Date: 28 Aug 2018
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Review › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review