Michael Givskov

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• 2024

  High efficacytreatment of murine Pseudomonas aeruginosa catheter-associated urinary tract infections using the c-di-GMP modulating anti-biofilmcompound Disperazol in combination with ciprofloxacin

  Hultqvist, L. D., Andersen, J. B., Nilsson, C. M., Jansen, C. U., Rybtke, M., Jakobsen, T. H., Nielsen, T. E., Qvortrup, K., Moser, C., Graz, M., Qvortrup, K., Tolker-Nielsen, T. & Givskov, M., 2024, In: Antimicrobial Agents and Chemotherapy. 68, 6, 16 p., e01481-23.

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• Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF-oprN efflux pump

  Kristensen, R., Andersen, J. B., Rybtke, M., Jansen, C. U., Fritz, B. G., Kiilerich, R. O., Uhd, J., Bjarnsholt, T., Qvortrup, K., Tolker-Nielsen, T., Givskov, M. & Jakobsen, T. H., 2024, In: Antimicrobial Agents and Chemotherapy. 68, 2

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• The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture

  Eilers, K., Hoong Yam, J. K., Liu, X., Goh, Y. F., To, K. N., Paracuellos, P., Morton, R., Brizuela, J., Hui Yong, A. M., Givskov, M., Freibert, S. A., Bange, G., Rice, S. A., Steinchen, W. & Filloux, A., 2024, In: Journal of Biological Chemistry. 300, 2, 105659.

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• Upscaling and Risk Evaluation of the Synthesis of the 3,5-Diamino-1H-Pyrazole, Disperazol

  Jansen, C. U., Grier, K. E., Andersen, J. B., Hultqvist, L. D., Nilsson, M., Moser, C., Graz, M., Tolker-Nielsen, T., Givskov, M. & Qvortrup, K., 2024, In: International Journal of Molecular Sciences. 25, 12, 8 p., 6737.

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• 2023

  A genetic switch controls Pseudomonas aeruginosa surface colonization

  Manner, C., Dias Teixeira, R., Saha, D., Kaczmarczyk, A., Zemp, R., Wyss, F., Jaeger, T., Laventie, B. J., Boyer, S., Malone, J. G., Qvortrup, K., Andersen, J. B., Givskov, M., Tolker-Nielsen, T., Hiller, S., Drescher, K. & Jenal, U., 2023, In: Nature Microbiology. 8, p. 1520–1533

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  19 Citations (Scopus)

• Associational Resistance to Predation by Protists in a Mixed Species Biofilm

  Goh, Y. F., Røder, H. L., Chan, S. H., Ismail, M. H., Madsen, J. S., Lee, K. W. K., Sørensen, S. J., Givskov, M., Burmølle, M., Rice, S. A. & McDougald, D., 2023, In: Applied and Environmental Microbiology. 89, 2, 16 p., e0174122.

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• Auranofin inhibits virulence pathways in Pseudomonas aeruginosa

  Yam, J. K. H., Tan, L. Z. W., Hong, Z., Salido, M. M. S., Woo, B. Y., Yong, A. M. H., Tan, C. A. Z., Li, S. F. Y., Yang, L., Givskov, M. & Chng, S. S., 2023, In: Bioorganic and Medicinal Chemistry. 79, 12 p., 117167.

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• Characterization of TelE, a T7SS LXG Effector Exhibiting a Conserved C-Terminal Glycine Zipper Motif Required for Toxicity

  Teh, W. K., Ding, Y., Gubellini, F., Filloux, A., Poyart, C., Givskov, M. & Dramsi, S., 2023, In: Microbiology Spectrum. 11, 4, e0148123.

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• 2022

  Adaptation to an Amoeba Host Leads to Pseudomonas aeruginosa Isolates with Attenuated Virulence

  Leong, W., Poh, W. H., Williams, J., Lutz, C., Mozammel Hoque, M., Poh, Y. H., Yee, B. Y. K., Chua, C., Givskov, M., Sanderson-Smith, M., Rice, S. A. & McDougald, D., 2022, In: Applied and Environmental Microbiology. 88, 5, e02322.

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• A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination

  Miettinen, K., Leelahakorn, N., Almeida Robles, A. R., Zhao, Y., Hansen, L. R., Nikolajsen, I. E., Andersen, J. B., Givskov, M., Stærk, D., Bak, S. & Kampranis, S., 2022, In: Nature Communications. 13, 16 p., 3664.

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• Effects of antibiotic treatment and phagocyte infiltration on development of Pseudomonas aeruginosa biofilm—Insights from the application of a novel PF hydrogel model in vitro and in vivo

  Wu, H., Song, L., Yam, J. K. H., Plotkin, M., Wang, H., Rybtke, M., Seliktar, D., Kofidis, T., Høiby, N., Tolker-Nielsen, T., Song, Z. & Givskov, M., 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 826450.

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• Elevated c-di-GMP Levels and Expression of the Type III Secretion System Promote Corneal Infection by Pseudomonas aeruginosa

  Yam, J. K. H., Aung, T. T., Chua, S. L., Cheng, Y., Kohli, G. S., Zhou, J., Constancias, F., Liu, Y., Cai, Z., Salido, M. M. S., Drautz-Moses, D. I., Rice, S. A., Schuster, S. C., Boo, Z. Z., Wu, B., Kjelleberg, S., Tolker-Nielsen, T., Lakshminarayanan, R., Beuerman, R. W., Yang, L. & 1 others, Givskov, M., 2022, In: Infection and Immunity. 90, 8

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• Phenotypic and integrated analysis of a comprehensive Pseudomonas aeruginosa PAO1 library of mutants lacking cyclic-di-GMP-related genes

  Eilers, K., Kuok Hoong Yam, J., Morton, R., Mei Hui Yong, A., Brizuela, J., Hadjicharalambous, C., Liu, X., Givskov, M., Rice, S. A. & Filloux, A., 2022, In: Frontiers in Microbiology. 13, 949597.

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• Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors

  Flagstad, T., Pedersen, M. T., Jakobsen, T. H., Felding, J., Tolker-Nielsen, T., Givskov, M., Qvortrup, K. & Nielsen, T. E., 2022, In: Bioorganic and Medicinal Chemistry Letters. 57, 128499.

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• 2021

  Bacterial genotoxins induce T cell senescence

  Mathiasen, S. L., Gall-Mas, L., Pateras, I. S., Theodorou, S. D. P., Namini, M. R. J., Hansen, M. B., Martin, O. C. B., Vadivel, C. K., Ntostoglou, K., Butter, D., Givskov, M., Geisler, C., Akbar, A. N., Gorgoulis, V. G., Frisan, T., Ødum, N. & Krejsgaard, T., 2021, In: Cell Reports. 35, 10, 109220.

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• Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants

  Nair, H. A. S., Subramoni, S., Poh, W. H., Hasnuddin, N. T. B., Tay, M., Givskov, M., Tolker-Nielsen, T., Kjelleberg, S., McDougald, D. & Rice, S. A., 2021, In: BMC Microbiology. 21, 10 p., 255.

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  8 Citations (Scopus)

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• Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc₁sub-unit

  Soh, E. Y. C., Smith, F., Gimenez, M. R., Yang, L., Vejborg, R. M., Fletcher, M., Halliday, N., Bleves, S., Heeb, S., Cámara, M., Givskov, M., Hardie, K. R., Tolker-Nielsen, T., Ize, B. & Williams, P., 2021, In: PLOS Pathogens. 17, 8, 25 p., e1009425.

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• Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through loss of the Rieske cytochrome bc1 sub-unit

  Soh, EY-C., Smith, F., Gimenez, M. R., Yang, L., Vejborg, R. M., Fletcher, M., Halliday, N., Bleves, S., Heeb, S., Camara, M., Givskov, M., Hardie, K. R., Tolker-Nielsen, T., Ize, B. & Williams, P., 2021, bioRxiv, 43 p.

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• Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

  Andersen, J. B., Hultqvist, L. D., Jansen, C. U., Jakobsen, T. H., Nilsson, M., Rybtke, M., Uhd, J., Fritz, B. G., Seifert, R., Berthelsen, J., Nielsen, T. E., Qvortrup, K., Givskov, M. & Tolker-Nielsen, T., 2021, In: npj Biofilms and Microbiomes. 7, 13 p., 59.

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• Induction of native c-di-GMP phosphodiesterases leads to dispersal of Pseudomonas aeruginosa biofilms

  Andersen, J. B., Kragh, K. N., Hultqvist, L. D., Rybtke, M., Nilsson, M., Jakobsen, T. H., Givskov, M. & Tolker-Nielsen, T., 2021, In: Antimicrobial Agents and Chemotherapy. 65, 4, e02431-20.

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  29 Citations (Scopus)

• Periodontitis associates with species-specific gene expression of the oral microbiota

  Belstrøm, D., Constancias, F., Drautz-Moses, D. I., Schuster, S. C., Veleba, M., Mahé, F. & Givskov, M., 2021, In: npj Biofilms and Microbiomes. 7, 76.

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  26 Citations (Scopus)

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• SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms

  Jansen, C. U., Uhd, J., Andersen, J. B., Hultqvist, L. D., Jakobsen, T. H., Nilsson, M., Nielsen, T. E., Givskov, M., Tolker-Nielsen, T. & Qvortrup, K. M., 2021, In: RSC Medicinal Chemistry. 12, 11, p. 1868-1878 11 p.

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  8 Citations (Scopus)

• Transcriptional Activity of Predominant Streptococcus Species at Multiple Oral Sites Associate With Periodontal Status

  Belstrøm, D., Constancias, F., Markvart, M., Sikora, M., Sørensen, C. E. & Givskov, M., 2021, In: Frontiers in Cellular and Infection Microbiology. 11, 13 p., 752664.

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• 2020

  A mouse ear skin model to study the dynamics of innate immune responses against Staphylococcus aureus biofilms

  Abdul Hamid, A. I., Nakusi, L., Givskov, M., Chang, Y. T., Marquès, C. & Gueirard, P., 2020, In: BMC Microbiology. 20, 1, 12 p., 22.

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  10 Citations (Scopus)

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• Early IL-2 treatment of mice with Pseudomonas aeruginosa pneumonia induced PMN-dominating response and reduced lung pathology

  Calum, H. P., Moser, C., Jensen, P. O., Bjarnsholt, T., Givskov, M. & Høiby, N., 2020, In: APMIS - Journal of Pathology, Microbiology and Immunology. 128, 12, p. 647-653

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  2 Citations (Scopus)

• Pseudomonas aeruginosa isolates co-incubated with Acanthamoeba castellanii exhibit phenotypes similar to chronic cystic fibrosis isolates

  Leong, W., Lutz, C., Williams, J., Poh, Y. H., Ken Yee, B. Y., Chua, C., Rice, S. A., Givskov, M., Sanderson-Smith, M. & McDougald, D., 2020, bioRxiv, 49 p.

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• 2019

  Antibiotics inhibit tumor and disease activity in cutaneous T cell lymphoma

  Lindahl, L. M., Willerslev-Olsen, A., Gjerdrum, L. M. R., Nielsen, P. R., Blümel, E., Rittig, A. H., Celis, P., Herpers, B., Becker, J. C., Stausbøl-Grøn, B., Wasik, M. A., Gluud, M., Fredholm, S., Buus, T. B., Johansen, C., Nastasi, C., Peiffer, L., Kubat, L., Bzorek, M., Eriksen, J. O. & 11 others, Krejsgaard, T., Bonefeld, C. M., Geisler, C., Mustelin, T., Langhoff, E., Givskov, M., Woetmann, A., Kilian, M., Litman, T., Iversen, L. & Odum, N., 26 Sep 2019, In: Blood. 134, 13, p. 1072-1083

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  111 Citations (Scopus)

• High levels of cAMP inhibit Pseudomonas aeruginosa biofilm formation through reduction of the c-di-GMP content

  Almblad, H., Rybtke, M., Hendiani, S., Andersen, J. B., Givskov, M. & Tolker-Nielsen, T., Mar 2019, In: Microbiology. 165, 3, p. 324-333 10 p.

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  32 Citations (Scopus)

• Inactivation of the pgmA Gene in Streptococcus mutans Significantly Decreases Biofilm-Associated Antimicrobial Tolerance

  Nilsson, M., Givskov, M., Twetman, S. & Tolker-Nielsen, T., 2019, In: Microorganisms. 7, 9, 12 p., 310.

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• Increased Intracellular Cyclic di-AMP Levels Sensitize Streptococcus gallolyticus subsp. gallolyticus to Osmotic Stress and Reduce Biofilm Formation and Adherence on Intestinal Cells

  Teh, W. K., Dramsi, S., Tolker-Nielsen, T., Yang, L. & Givskov, M., 2019, In: Journal of Bacteriology. 201, 6, p. 1-16 16 p.

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• Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

  Fong, J., Mortensen, K. T., Nørskov, A., Qvortrup, K., Yang, L., Tan, C. H., Nielsen, T. E. & Givskov, M., 2019, In: Frontiers in Cellular and Infection Microbiology. 11, 11 p., 433.

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• Key Players and Individualists of Cyclic-di-GMP Signaling in Burkholderia cenocepacia

  Richter, A. M., Fazli, M., Schmid, N., Shilling, R., Suppiger, A., Givskov, M., Eberl, L. & Tolker-Nielsen, T., 2019, In: Frontiers in Microbiology. 9, 15 p., 3286.

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  14 Citations (Scopus)

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• Oxidative stress response plays a role in antibiotic tolerance of Streptococcus mutans biofilms

  Nilsson, M., Jakobsen, T. H., Givskov, M., Twetman, S. & Tolker-Nielsen, T., 2019, In: Microbiology. 165, 3, p. 334-342

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  24 Citations (Scopus)

• Reactivity and Synthetic Applications of Multicomponent Petasis Reactions

  Wu, P., Givskov, M. & Nielsen, T. E., 2019, In: Chemical Reviews. 119, 20, p. 11245-11290 46 p.

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• Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation

  Qvortrup, K., Hultqvist, L. D., Nilsson, M., Jakobsen, T. H., Jansen, C. U., Uhd, J., Andersen, J. B., Nielsen, T. E., Givskov, M. & Tolker-Nielsen, T., 2019, In: Frontiers in Chemistry. 7, 27 p., 742.

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  83 Citations (Scopus)

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• Transposon Mutagenesis in Streptococcus Species

  Nilsson, M., Givskov, M. & Tolker-Nielsen, T., 2019, Microbial Transposon Mutagenesis: Protocols and Applications. Humana Press, p. 39-49 11 p. (Methods in Molecular Biology, Vol. 2016).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  2 Citations (Scopus)

• Visualizing biofilm by targeting eDNA with long wavelength probe CDr15

  Kwon, H. Y., Kim, J. Y., Liu, X., Lee, J. Y., Yam, J. K. H., Dahl Hultqvist, L., Xu, W., Rybtke, M., Tolker-Nielsen, T., Heo, W., Kim, J. J., Kang, N. Y., Joo, T., Yang, L., Park, S. J., Givskov, M. & Chang, Y. T., 2019, In: Biomaterials Science. 7, 9, p. 3594-3598 5 p.

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  11 Citations (Scopus)
• 2018

  Acquisition of resistance to carbapenem and macrolide-mediated quorum sensing inhibition by Pseudomonas aeruginosa via ICE_Tn4371 6385

  Ding, Y., Teo, J. W. P., Drautz-Moses, D. I., Schuster, S. C., Givskov, M. & Yang, L., 2018, In: Communications Biology. 1, 10 p., 57.

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• CDy14: A novel biofilm probe targeting exopolysaccharide Psl

  Kwon, H. Y., Kim, J. Y., Lee, J. Y., Yam, J. K. H., Hultqvist, L. D., Xu, W., Rybtke, M., Tolker-Nielsen, T., Kim, J. J., Kang, N. Y., Yang, L., Park, S. J., Givskov, M. & Chang, Y. T., 2018, In: Chemical Communications. 54, 84, p. 11865-11868 4 p.

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  9 Citations (Scopus)

• Characterization of a novel multidrug resistance plasmid pSGB23 isolated from Salmonella enterica subspecies enterica serovar Saintpaul

  Ding, Y., Zwe, Y. H., Chin, S. F., Kohli, G. S., Drautz-Moses, D. I., Givskov, M., Schlundt, J., Schuster, S. C., Yuk, H. G. & Yang, L., 2018, In: Gut Pathogens. 10, 5 p., 20.

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• Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. aeruginosa

  Fong, J., Zhang, C., Yang, R., Boo, Z. Z., Tan, S. K., Nielsen, T. E., Givskov, M., Liu, X-W., Bin, W., Su, H. & Yang, L., 1 Dec 2018, In: Scientific Reports. 8, 11 p., 1155.

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• Imaging N-acyl homoserine lactone quorum sensing in vivo

  Hultqvist, L. D., Alhede, M., Jakobsen, T. H., Givskov, M. & Bjarnsholt, T., 2018, Quorum Sensing: Methods and Protocols. Leoni, L. & Rampion, G. (eds.). Humana Press, Vol. 1673. p. 203-212 10 p. (Methods in Molecular Biology; No. 1673).

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  3 Citations (Scopus)

• Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin

  Woetmann, A., Alhede, M., Dabelsteen, S., Bjarnsholt, T., Rybtke, M., Nastasi, C., Krejsgaard, T., Andersen, M. H., Bonefeld, C. M., Geisler, C., Givskov, M. & Odum, N., 2018, In: OncoTarget. 9, 28, p. 19481-19489 9 p.

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• Matrix Polysaccharides and SiaD Diguanylate Cyclase Alter Community Structure and Competitiveness of Pseudomonas aeruginosa during Dual-Species Biofilm Development with Staphylococcus aureus

  Chew, S. C., Yam, J. K. H., Matysik, A., Seng, Z. J., Klebensberger, J., Givskov, M., Doyle, P., Rice, S. A., Yang, L. & Kjelleberg, S., 2018, In: mBio. 9, 6, 16 p., e00585-18.

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• Qualitative and Quantitative Determination of Quorum Sensing Inhibition In Vitro

  Jakobsen, T. H., Alhede, M., Hultqvist, L. D., Bjarnsholt, T. & Givskov, M., 2018, Quorum Sensing: Methods and Protocols. Springer, Vol. 1673. p. 275-285 11 p. (Methods in molecular biology (Clifton, N.J.)).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  3 Citations (Scopus)

• Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents

  Yuan, M., Chua, S. L., Liu, Y., Drautz-Moses, D. I., Hoong Yam, J. K., Aung, T. T., Beuerman, R. W., Santillan Salido, M. M., Schuster, S. C., Tan, C. H., Givskov, M., Yang, L. & Nielsen, T. E., 2018, In: Beilstein Journal of Organic Chemistry. 14, p. 3059-3069 11 p.

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• The Bacterial Toxin CNF1 Induces Activation and Maturation of Human Monocyte-Derived Dendritic Cells

  Gall-Mas, L., Fabbri, A., Namini, M. R. J., Givskov, M., Fiorentini, C. & Krejsgaard, T., 2018, In: International Journal of Molecular Sciences . 19, 5, 11 p., 1408.

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• 2017

  A broad range quorum sensing inhibitor working through sRNA inhibition

  Jakobsen, T. H., Warming, A. N., Vejborg, R. M., Moscoso, J. A., Stegger, M., Lorenzen, F., Rybtke, M., Andersen, J. B., Petersen, R., Andersen, P. S., Nielsen, T. E., Tolker-Nielsen, T., Filloux, A., Ingmer, H. & Givskov, M., 2017, In: Scientific Reports. 7, 1, 12 p., 9857.

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• A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors

  Bang, C. G., Jensen, J. F., O'Hanlon Cohrt, E., Olsen, L. B., Siyum, S. G., Mortensen, K. T., Skovgaard, T., Berthelsen, J., Yang, L., Givskov, M., Qvortrup, K. & Nielsen, T. E., Oct 2017, In: ACS Combinatorial Science. 19, 10, p. 657-669 13 p.

  Research output: Contribution to journal › Journal article › peer-review
  7 Citations (Scopus)

• Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes

  Jakobsen, T. H., Tolker-Nielsen, T. & Givskov, M., Sep 2017, In: International Journal of Molecular Sciences. 18, 9, 27 p., 1970.

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