Personal profile
Primary fields of research
- Computational chemical design of tool compounds for the evaluation of the pharmacological potential of lactate and ketone metabolite receptors
- Virtual ligand screening for novel allosteric modulators for the free fatty-acid receptor GPR40
Teaching
MSc course for human biologists "Molecular Pharmacology"
Education/Academic qualification
Computational Chemistry, PhD, In Silico-Guided Discovery and Development of Novel Tool Compounds for Metabolite and Viral GPCRs, University of Copenhagen
1 Aug 2015 → 1 Nov 2018
Award Date: 4 Dec 2018
Biochemistry, Master of Science, Investigation of Structure-Function Relationships Within the Ghrelin Receptor Family, University of Copenhagen
3 Sept 2012 → 15 Aug 2014
Award Date: 15 Aug 2014
Keywords
- Faculty of Health and Medical Sciences
Collaborations and top research areas from the last five years
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Molecular dynamics-based identification of binding pathways and two distinct high-affinity sites for succinate in succinate receptor 1/GPR91
Shenol, A., Lückmann, M., Trauelsen, M., Lambrughi, M., Tiberti, M., Papaleo, E., Frimurer, T. M. & Schwartz, T. W., 2024, In: Molecular Cell. 84, 5, p. 955-966.e4 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile15 Citations (Scopus)40 Downloads (Pure) -
Multiple recent HCAR2 structures demonstrate a highly dynamic ligand binding and G protein activation mode
Shenol, A., Tenente, R., Lückmann, M., Frimurer, T. M. & Schwartz, T. W., 2024, In: Nature Communications. 15, 10 p., 5364.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile11 Citations (Scopus)45 Downloads (Pure) -
Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action
Lückmann, M., Shenol, A., Nissen, T. A. D., Petersen, J. E., Kouvchinov, D., Schwartz, T. W. & Frimurer, T. M., 2022, In: ACS Medicinal Chemistry Letters. 13, 12, p. 1839-1847Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Citations (Scopus)97 Downloads (Pure) -
Discovery of GPR183 Agonists Based on an Antagonist Scaffold
Kjær, V. M. S., Ieremias, L., Daugvilaite, V., Lückmann, M., Frimurer, T. M., Ulven, T., Rosenkilde, M. M. & Våbenø, J., 2021, In: ChemMedChem. 16, 17, p. 2623-2627Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile9 Citations (Scopus)73 Downloads (Pure) -
Investigating GIPR (ant)agonism: A structural analysis of GIP and its receptor
Smit, F. X., van der Velden, W. J. C., Kizilkaya, H. S., Nørskov, A., Lückmann, M., Hansen, T. N., Sparre-Ulrich, A. H., Qvotrup, K., Frimurer, T. M. & Rosenkilde, M. M., 2021, In: Structure. 29, 7, p. 679-693.e6 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
22 Citations (Scopus) -
Molecular mechanism of ligand binding pathways and activation of the succinate receptor
Iliyaz, A. S., Luckmann, M., Trauelsen, M., Frimurer, T. M. & Schwartz, T. W., 2021, In: European Biophysics Journal. 50, Suppl. 1, p. 160 1 p., P-234.Research output: Contribution to journal › Conference abstract in journal › Research
File -
Structural basis for GPCR signaling by small polar versus large lipid metabolites-discovery of non-metabolite ligands
Luckmann, M., Trauelsen, M., Frimurer, T. M. & Schwartz, T. W., 2020, In: Current Opinion in Cell Biology. 63, p. 38-48Research output: Contribution to journal › Review › peer-review
20 Citations (Scopus) -
Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7
Jorgensen, A. S., Larsen, O., Uetz-von Allmen, E., Lückmann, M., Legler, D. F., Frimurer, T. M., Veldkamp, C. T., Hjortø, G. M. & Rosenkilde, M. M., 2019, In: Frontiers in Immunology. 10, 14 p., 2156.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile26 Citations (Scopus)191 Downloads (Pure)