Michael Lisby
  • Source: Scopus
1998 …2024

Research activity per year

Personal profile

Short presentation

The research of my laboratory is focused on the spatio-temporal organization and regulation of homologous recombination (HR) and its role in maintaining genome integrity. We take a cell biological and genetic approach to study HR in human cells and the yeast  Saccharomyces cerevisiae. Particular areas of interest are regulation of chromatin structure during HR, post-translational modification of HR proteins and the molecular architecture of HR complexes in living cells. We are particularly interested in understanding molecular mechanisms relevant to cancer predisposition, neurological disorders and premature ageing syndromes, and in utilizing homologous recombination in CRISPR-Cas9 gene-editing.

For more information visit http://www1.bio.ku.dk/english/research/fg/dnarepair/

Follow @lisby_michael

CV

Education

25/10/2000     

Ph.D. degree, Department of Molecular and Structural Biology, Aarhus University, Denmark. Field: Science.

Thesis: The molecular mechanism of type 1B topoisomerases and the catalytic inhibitor camptothecin.

 

1996-2000     

Graduate studies, Aarhus University, Department of Molecular and Structural Biology, Denmark.

Project: The catalytic mechanism of topoisomerase I and the action of topoisomerase I directed drugs.

 

1992-1996     

Undergraduate studies at the Department of Molecular and Structural Biology, Aarhus University, Denmark.

 

 

Professional / Work Experience

2014- 

Professor in Genome Integrity, Department of Biology, University of Copenhagen

2004-2014     

Associate Professor, Department of Biology, University of Copenhagen, Denmark

2000-2004        

Post doctoral fellow, Department of Genetics and Development, Columbia University, New York, USA

 

Grants and awards

2009                  

European Research Council, Starting Independent Researcher Grant

2019-2024

NNF Distinguished Investigator – Bioscience and Basic Biomedicine
2023-2028
Carlsberg Foundation Semper Ardens Advance Grant

Managerial experience

2015-                                                                                                                                                    

Vice-head of Department for research, Department of Biology, University of Copenhagen.

2010-2015                                                                                                                                            

Head of Section. I headed the Section of Functional Genomics at the Department of Biology, University of Copenhagen.

 

Keywords

  • Faculty of Science
  • Cancer
  • Genetics
  • Genetic stability
  • DNA damage response and repair
  • DNA replication
  • Cellular senescence

Collaborations and top research areas from the last five years

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