Research output per year
Research output per year
Personal profile
CV
ACADEMIC DEGREES
May 2015: PhD in Pharmaceutics, University of Copenhagen
May 2010: MSc in Biochemistry, University of Copenhagen
APPOINTMENTS
2022-: Associate Professor, CNS Drug Delivery & Barrier Modelling , Department of Pharmacy, University of Copenhagen (group leader as of October 2021)
2016-2021: Tenure Track Assistant Professor, CNS Drug Delivery & Barrier Modelling, Department of Pharmacy, University of Copenhagen (group leader: Professor Birger Brodin)
2015-2016: Postdoc, Peptide and Protein Drug Delivery, Department of Pharmacy, University of Copenhagen (mentor: Professor Hanne Mørck Nielsen)
2011-2015: PhD student, Biologics, Department of Pharmacy, University of Copenhagen (8 months maternity leave) (Supervisor: Professor Hanne Mørck Nielsen)
2011-2013: Visiting PhD student, The Novo Nordisk Foundation Center for Protein Research, Copenhagen (Supervisor: Associate Professor Jens Berthelsen)
2010-2011: Scientific Assistant, Developmental Neurobiology, Max Delbrück Center for Molecular Medicine, Berlin (mentor: Fritz G. Rathjen)
Primary fields of research
I investigate strategies to overcome key brain barriers, such as the blood-brain barrier and the nasal olfactory mucosa to enable effective drug delivery to the central nervous system. Using advanced cell models and animals, my work focuses on improving our mechanistic understanding of transport pathways and optimizing CNS drug delivery platforms.
A core area of my research is stroke, where I develop targeted delivery systems to bypass barriers and deliver neuroprotective therapies directly to the brain. The goal is to advance innovative treatments for stroke and other severe brain disorders.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Decanoate-induced permeation enhancement: Distinct membrane effects of micellar and vesicular colloids
Cunha, C., Heade, J., Raptis, K., Li, L., Duan, Y., Dietl, S., Kristensen, M., A.S. Bergström , C. & Nielsen, H. M., 2026, In: Pharmacological Research. 5, 12 p., 100079.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile22 Downloads (Pure) -
Elucidating the roles of TM7SF3 and LHFPL6 in the putative H +/OC antiporter function in the human brain capillary endothelial cell line, hCMEC/D3.
Svane, N., Kurosawa, T., Schmid, B., Saaby, L., Kristensen, M., Tabata, H., Kubo, Y., Terasaki, T., Brodin, B. & Deguchi, Y., 2026, In: European Journal of Pharmaceutical Sciences. 217, 10 p., 107409.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile17 Downloads (Pure) -
Evaluating sex as a biological variable in in vitro blood-brain barrier models: insights from primary mouse brain endothelial cells
Thaysen, M., Ørum, L. T., Pedersen, A. B. V., Svane, N., Frazier, S. E. D., Saaby, L., Brodin, B. & Kristensen, M., 2026, In: Fluids and Barriers of the CNS. 23, 12 p., 49.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile12 Downloads (Pure) -
Modifying the PSD-95 inhibitor NA-1 for brain delivery through proteolytic stabilization and conjugation to the potentially brain homing peptide BR1
Kolberg, H. G., Kjær Andresen, A., Thaysen, M., Jensen, C., Larsen, B. B., Gammelgaard, B. & Kristensen, M., 2026, In: International Journal of Pharmaceutics. 687, 11 p., 126434.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile30 Downloads (Pure) -
Sex-dependent investigations of the temporal development of infarct size and blood-brain barrier permeability after photothrombotic stroke in mice – a pilot study
Thaysen, M., Łopuszyńska, N., Westi, E. W., Wellendorph, P., Kellemann Kristensen, L. & Kristensen, M., 2026, In: Brain Research. 1893, 11 p., 150563.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Downloads (Pure) -
The PSD-95 inhibitor NA-1 is delivered to the brain upon nasal administration with uptake into the olfactory bulb improved by co-administration with the cell-penetrating peptides lowPro and Tat
Schmidt, S. E., Sandbjerg, C., Joensen, G., Thaysen, M., Gammelgaard, B., Schindowski, K. & Kristensen, M., 2026, In: Drug Delivery and Translational Research. 16, p. 3274–3285Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Downloads (Pure) -
Efficient Generation of Expandable Dorsal Forebrain Neural Rosette Stem Cell Lines
Frazier, S. E. D., Honnens de Lichtenberg, K., Jaberi, E., Bertelsen, C., Møller Jensen, S., Wrona, A., Strøyer Christophersen, N., Kristensen, M. & Villaescusa, J. C., 2025, In: eLife. 14, 37 p., RP107930.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile12 Downloads (Pure) -
Therapeutic Potential of Neural Rosette Stem Cell-Derived Small Extracellular Vesicles in the Management of Brain Edema
Frazier, S. E. D., Krickau Pedersen, S., Kryger Vøls, K., Lie, M., Quintana, C., Møller Nielsen, F., Wrona, A., Willenbrock, H., Chen, Q., Qu, X., Yang, J., Strøyer Christophersen , N., Kristensen, M. & Villaescusa, C., 2025, 51 p. (bioRxiv).Research output: Working paper › Preprint
File5 Downloads (Pure)
Activities
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Benzon Symposium 63 – New Paradigms of Protein Engineering
Kristensen, M. (Participant)
2017 → …Activity: Participating in an event - types › Participation in workshop, seminar, course
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20th Symposium on Signal Transduction at the Blood-Brain Barrier
Kristensen, M. (Participant)
2017 → …Activity: Participating in an event - types › Participation in workshop, seminar, course
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Cold Spring Harbor
Kristensen, M. (Participant)
2016 → …Activity: Participating in an event - types › Participation in workshop, seminar, course
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19th Symposium in Signal Transduction
Kristensen, M. (Participant)
2016 → …Activity: Participating in an event - types › Participation in workshop, seminar, course
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Crossing Biological Barriers
Kristensen, M. (Participant)
9 Nov 2015 → 11 Nov 2015Activity: Participating in an event - types › Organisation of and participation in conference
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Annual Controlled Release Society meeting
Kristensen, M. (Participant)
26 Jul 2015 → 29 Jul 2015Activity: Participating in an event - types › Organisation of and participation in conference
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From Cell-Penetrating Peptides to Nanoparticles for Cellular Delivery
Kristensen, M. (Participant)
1 Jul 2015 → 3 Jul 2015Activity: Participating in an event - types › Organisation of and participation in conference
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Globalization of Pharmaceutics Education Network Meeting 2014
Kristensen, M. (Speaker)
2014 → …Activity: Participating in an event - types › Organisation of and participation in conference