Research output per year
Research output per year
Personal profile
CV
Education
2004 Ph.D., Molecular Biology, University of Copenhagen
1997 M.Sc., Molecular Biology, University of Copenhagen
Career
2008 -
Postdoc, Biotech Research and Innovation Centre
2004 - 2008
Postdoc, Copenhagen University Hospital
2001 - 2004
Ph.D. student, Copenhagen University Hospital/EMBL-Monterotondo
1998 - 2001
Ass. researcher, Copenhagen University Hospital
Primary fields of research
C/EBPa in normal hematopoiesis and leukemia
Current research
Determinants of the pre-leukemic state in mice with Cebpa mutations
Secondary events in transformation of pre-malignant cells into leukemia
Post-translational regulation of C/EBPa in normal hematopoiesis and leukemia
Secondary events in transformation of pre-malignant cells into leukemia
Post-translational regulation of C/EBPa in normal hematopoiesis and leukemia
Fields of interest
Normal and malignant hematopoiesis
HSCs and cancer stem cells
HSCs and cancer stem cells
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
TET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression
Heyes, E., Wilhelmson, A. S., Wenzel, A., Manhart, G., Eder, T., Schuster, M. B., Rzepa, E., Pundhir, S., D’Altri, T., Frank, A. K., Gentil, C., Woessmann, J., Schoof, E. M., Meggendorfer, M., Schwaller, J., Haferlach, T., Grebien, F. & Porse, B. T., 2023, In: Nature Communications. 14, 18 p., 6185.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)18 Downloads (Pure) -
The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes
Trempenau, M. L., Schuster, M. B., Pundhir, S., Pereira, M. A., Kalvisa, A., Tapia, M., Su, J., Ge, Y., de Boer, B., Balhuizen, A., Bagger, F. O., Shliaha, P., Sroczynska, P., Walfridsson, J., Grønbæk, K., Theilgaard-Mönch, K., Jensen, O. N., Helin, K. & Porse, B. T., 2023, In: Leukemia. 37, 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile9 Citations (Scopus)33 Downloads (Pure) -
H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway
Hansen, A. M., Ge, Y., Schuster, M. B., Pundhir, S., Jakobsen, J. S., Kalvisa, A., Tapia, M. C., Gordon, S., Ambri, F., Bagger, F. O., Pandey, D., Helin, K. & Porse, B. T., 2022, In: Science Advances. 8, 11, eabf8627.Research output: Contribution to journal › Journal article › Research › peer-review
19 Citations (Scopus) -
PTBP1 promotes hematopoietic stem cell maintenance and red blood cell development by ensuring sufficient availability of ribosomal constituents
Rehn, M., Wenzel, A., Frank, A-K., Schuster, M. B., Pundhir, S., Jørgensen, N., Vitting-Seerup, K., Ge, Y., Jendholm, J., Michaut, M., Schoof, E. M., Jensen, T. L., Rapin, N., Sapio, R. T., Andersen, K. L., Lund, A. H., Solimena, M., Holzenberger, M., Pestov, D. G. & Porse, B. T., 2022, In: Cell Reports. 39, 6, 28 p., 110793.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)23 Downloads (Pure) -
Transcription factor-driven coordination of cell cycle exit and lineage-specification in vivo during granulocytic differentiation: In memoriam Professor Niels Borregaard
Theilgaard-Mönch, K., Pundhir, S., Reckzeh, K., Su, J., Tapia, M., Furtwängler, B., Jendholm, J., Jakobsen, J. S., Hasemann, M. S., Knudsen, K. J., Cowland, J. B., Fossum, A., Schoof, E., Schuster, M. B. & Porse, B. T., 2022, In: Nature Communications. 13, 1, 17 p., 3595.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile21 Downloads (Pure) -
The ASXL1-G643W variant accelerates the development of CEBPA mutant acute myeloid leukemia
D'Altri, T., Wilhelmson, A. S., Schuster, M. B., Wenzel, A., Kalvisa, A., Pundhir, S., Hansen, A. M. & Porse, B. T., 2021, In: Haematologica. 106, 4, p. 1000-1007 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access9 Citations (Scopus) -
Heterozygous loss of Srp72 in mice is not associated with major hematological phenotypes
D'Altri, T., Schuster, M. B., Wenzel, A. & Porse, B. T., 2019, In: European Journal of Haematology. 103, 4, p. 319-328 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
7 Citations (Scopus) -
Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML
Jakobsen, J. S., Laursen, L. G., Schuster, M. B., Pundhir, S., Schoof, E., Ge, Y., d'Altri, T., Vitting-Seerup, K., Rapin, N., Gentil, C., Jendholm, J., Theilgaard-Mönch, K., Reckzeh, K., Bullinger, L., Döhner, K., Hokland, P., Fitzgibbon, J. & Porse, B. T., 2019, In: Science Advances. 5, 7, p. 1-16 16 p., eaaw4304.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile33 Citations (Scopus)92 Downloads (Pure)