Morten Frödin

Search results

• 2023

  Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells

  Green, A. C., Marttila, P., Kiweler, N., Chalkiadaki, C., Wiita, E., Cookson, V., Lesur, A., Eiden, K., Bernardin, F., Vallin, K. S. A., Borhade, S., Long, M., Ghahe, E. K., Jiménez-Alonso, J. J., Jemth, A-S., Loseva, O., Mortusewicz, O., Meyers, M., Viry, E., Johansson, A. I. & 14 others, Hodek, O., Homan, E., Bonagas, N., Ramos, L., Sandberg, L., Frödin, M., Moussay, E., Slipicevic, A., Letellier, E., Paggetti, J., Sørensen, C. S., Helleday, T., Henriksson, M. & Meiser, J., 2023, In: Nature Metabolism. 5, 4, p. 642-659

  Research output: Contribution to journal › Journal article › Research › peer-review

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  13 Citations (Scopus)

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• Frequency and Functional Characterization of RUNX1 Germline Variants in Myeloid Neoplasms

  Nitschke, N. J., Almosailleakh, M., Niu, Y., Hansen, J. W., Raaschou-Jensen, K., Jespersen, J. S., Severinsen, M. T., Roug, A. S., Frödin, M., Weischenfeldt, J. L., Andersen, M. K. & Grønbæk, K., 2023, In: Human Mutation. 2023, 11 p., 4738660.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  21 Downloads (Pure)
• 2022

  Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select

  Niu, Y., Azevedo, C. A. F., Li, X., Kamali, E., Nielsen, O. H., Sørensen, C. S. & Frödin, M., 2022, In: Nature Genetics. 54, 28 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  12 Citations (Scopus)

  53 Downloads (Pure)
• 2021

  CRISPR/Cas9-mediated knockout of clinically relevant alloantigenes in human primary T cells

  Kamali, E., Rahbarizadeh, F., Hojati, Z. & Frödin, M., 2021, In: BMC Biotechnology. 21, 1, 9.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  19 Citations (Scopus)

  34 Downloads (Pure)
• 2020

  INDEL detection, the 'Achilles heel' of precise genome editing: a survey of methods for accurate profiling of gene editing induced indels

  Bennett, E. P., Petersen, B. L., Johansen, I. E., Niu, Y., Yang, Z., Chamberlain, C. A., Met, Ö., Wandall, H. H. & Frödin, M., 2020, In: Nucleic Acids Research. 48, 21, p. 11958-11981 24 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  60 Citations (Scopus)

  43 Downloads (Pure)

• p190A RhoGAP induces CDH1 expression and cooperates with E-cadherin to activate LATS kinases and suppress tumor cell growth

  Ouyang, H., Luong, P., Frödin, M. & Hansen, S. H., 2020, In: Oncogene. 39, 33, p. 5570-5587

  Research output: Contribution to journal › Journal article › Research › peer-review

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  11 Citations (Scopus)

  26 Downloads (Pure)
• 2019

  In Vivo Editing of the Adult Mouse Liver Using CRISPR/Cas9 and Hydrodynamic Tail Vein Injection

  Niola, F., Dagnæs-Hansen, F. & Frödin, M., 2019, CRISPR Gene Editing: Methods and Protocols. Luo, Y. (ed.). New York, NY: Humana Press, Vol. 1961. p. 329-341 13 p. 20. (Methods in molecular biology (Clifton, N.J.)).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
  10 Citations (Scopus)
• 2018

  Correction: p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity

  Frank, S. R., Köllmann, C. P., Luong, P., Galli, G. G., Zou, L., Bernards, A., Getz, G., Calogero, R. A., Frödin, M. & Hansen, S. H., 2018, In: The Journal of Cell Biology. 217, 9, p. 3313 1 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review

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  91 Downloads (Pure)

• De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium

  Lavrsen, K., Dabelsteen, S., Vakhrushev, S. Y., Levann, A. M. R., Haue, A. D., Dylander, A., Mandel, U., Hansen, L., Frödin, M., Bennett, E. P. & Wandall, H. H., 2018, In: The Journal of Biological Chemistry. 293, p. 1298-1314

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  59 Citations (Scopus)

• p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity

  Frank, S. R., Köllmann, C. P., Luong, P., Galli, G. G., Zou, L., Bernards, A., Getz, G., Calogero, R. A., Frödin, M. & Hansen, S. H., 2018, In: The Journal of Cell Biology. 217, 9, p. 3183-3201 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  16 Citations (Scopus)

  132 Downloads (Pure)
• 2017

  CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1–Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma

  Engelholm, L. H., Riaz, A., Serra, D., Dagnæs-Hansen, F., Johansen, J. V., Santoni-Rugiu, E., Hansen, S. H., Niola, F. & Frödin, M., 1 Dec 2017, In: Gastroenterology. 153, 6, p. 1662-1673.e10

  Research output: Contribution to journal › Journal article › Research › peer-review

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  84 Citations (Scopus)

  354 Downloads (Pure)

• Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysis

  Lonowski, L. A., Narimatsu, Y., Riaz, A., Delay, C. M. E., Yang, Z., Niola, F., Duda, K., Ober, E. A., Clausen, H., Wandall, H. H., Hansen, S. H., Bennett, E. P. & Frödin, M., Mar 2017, In: Nature Protocols. 12, 3, p. 581-603 23 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  87 Citations (Scopus)

• The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion

  Frank, S. R., Köllmann, C. P., van Lidth de Jeude, J. F., Thiagarajah, J. R., Engelholm, L. H., Frödin, M. & Hansen, S. H., 30 Mar 2017, In: Oncogene. 36, 13, p. 1816-1828 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  25 Citations (Scopus)

  348 Downloads (Pure)
• 2015

  A Novel Locus Harbouring a Functional CD164 Nonsense Mutation Identified in a Large Danish Family with Nonsyndromic Hearing Impairment

  Nyegaard, M., Rendtorff, N. D., Nielsen, M. S., Corydon, T. J., Demontis, D., Starnawska, A., Hedemand, A., Buniello, A., Niola, F., Overgaard, M. T., Leal, S. M., Ahmad, W., Wikman, F. P., Petersen, K. B., Crueger, D. G., Oostrik, J., Kremer, H., Tommerup, N., Froedin, M., Steel, K. P. & 2 others, Tranebjaerg, L. & Borglum, A. D., Jul 2015, In: P L o S Genetics. 11, 7, p. 1-25 25 p., e1005386.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  19 Citations (Scopus)

• Engineered CHO cells for production of diverse, homogeneous glycoproteins

  Yang, Z., Wang, S., Halim, A., Schulz, M. A., Frödin, M., Rahman, S. H., Vester-Christensen, M. B., Behrens, C., Kristensen, C., Vakhrushev, S. Y., Bennett, E. P., Wandall, H. H. & Clausen, H., 20 Jul 2015, In: Nature Biotechnology. 33, 8, p. 842-844 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  197 Citations (Scopus)

• Fast and sensitive detection of indels induced by precise gene targeting

  Yang, Z., Steentoft, C., Hauge, C., Hansen, L., Thomsen, A. L., Niola, F., Vester-Christensen, M. B., Frödin, M., Clausen, H., Wandall, H. H. & Bennett, E. P., 2015, In: Nucleic Acids Research. 43, 9, p. 1-8 8 p., e59.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  140 Citations (Scopus)

  54 Downloads (Pure)
• 2014

  High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairs

  Duda, K., Lonowski, L. A., Kofoed-Nielsen, M., Ibarra, A., Delay, C. M., Kang, Q., Yang, Z., Pruett-Miller, S. M., Bennett, E. P., Wandall, H. H., Davis, G. D., Hansen, S. H. & Frödin, M., 21 Apr 2014, In: Nucleic Acids Research. 42, 10, p. 1-16 16 p., e84.

  Research output: Contribution to journal › Journal article › Research › peer-review
  70 Citations (Scopus)
• 2012

  A βPIX-PAK2 complex confers protection against Scrib-dependent and cadherin-mediated apoptosis

  Frank, S. R., Bell, J. H., Frödin, M. & Hansen, S. H., 9 Oct 2012, In: Current biology : CB. 22, 19, p. 1747-54 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  22 Citations (Scopus)

• Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

  Serafimova, I. M., Pufall, M. A., Krishnan, S., Duda, K., Cohen, M. S., Maglathlin, R. L., McFarland, J. M., Miller, R. M., Frödin, M. & Taunton, J., May 2012, In: Nature Chemical Biology. 8, 5, p. 471-6 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  407 Citations (Scopus)
• 2011

  High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases

  Chen, F., Pruett-Miller, S. M., Huang, Y., Gjoka, M., Duda, K., Taunton, J., Collingwood, T. N., Frödin, M. & Davis, G. D., Sep 2011, In: Nature Methods. 8, 9, p. 753-5 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  385 Citations (Scopus)
• 2009

  Regulation of the interaction between protein kinase C-related protein kinase 2 (PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1)

  Dettori, R., Sonzogni, S., Meyer, L., Lopez-Garcia, L. A., Morrice, N. A., Zeuzem, S., Engel, M., Piiper, A., Neimanis, S., Frödin, M. & Biondi, R. M., 2009, In: Journal of Biological Chemistry. 284, 44, p. 30318-27 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  28 Citations (Scopus)

• RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells

  Doehn, U., Hauge, C., Frank, S. R., Jensen, C. A. J., Duda, K., Nielsen, J. V., Cohen, M. S., Johansen, J. V., Winther, B. R., Lund, L. R., Winther, O., Taunton, J., Hansen, S. H. & Frödin, M., 2009, In: Molecular Cell. 35, 4, p. 511-22 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  184 Citations (Scopus)
• 2007

  A RSK kinase inhibitor reporting its selectivity in vivo.

  Frödin, M., 2007, In: Nature Chemical Biology. 3, 3, p. 138-9 1 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.

  Sapkota, G. P., Cummings, L., Newell, F. S., Armstrong, C., Bain, J., Frödin, M., Grauert, M., Hoffmann, M., Schnapp, G., Steegmaier, M., Cohen, P. & Alessi, D. R., 2007, In: Biochemical Journal. 401, 1, p. 29-38 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  250 Citations (Scopus)

• Heregulin-induced epigenetic regulation of the utrophin-A promoter.

  Basu, U., Gyrd-Hansen, M., Baby, S. M., Lozynska, O., Krag, T. O. B., Jensen, C. J., Frödin, M. & Khurana, T. S., 2007, In: FEBS Letters. 581, 22, p. 4153-8 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation.

  Hauge, C., Antal, T. L., Hirschberg, D., Doehn, U., Thorup, K., Idrissova, L., Hansen, K., Jensen, O. N., Jørgensen, T. J., Biondi, R. M. & Frödin, M., 2007, In: EMBO Journal. 26, 9, p. 2251-61 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  88 Citations (Scopus)
• 2006

  RSK and MSK in MAP kinase signalling.

  Hauge, C. & Frödin, M., 2006, In: Journal of Cell Science. 119, Pt 15, p. 3021-3 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  162 Citations (Scopus)
• 2005

  Analysis of 65 tuberous sclerosis complex (TSC) patients by TSC2 DGGE, TSC1/RSC2 MLPA, and TSC1 long-range PCR sequencing, and report of 28 novel mutations

  Rendtorff, N. D., Bjerregaard, B., Frödin, M., Kjaergaard, S., Hove, H., Skovby, F., Brøndum-Nielsen, T. D. T. S. G. K. & Schwartz, M., 2005, In: Human Mutation. 26, 4, p. 374-383 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  44 Citations (Scopus)

• Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types.

  Dümmler, B. A., Hauge, C., Silber, J., Yntema, H. G., Kruse, L. S., Kofoed, B., Hemmings, B. A., Alessi, D. R. & Frödin, M., 2005, In: Journal of Biological Chemistry. 280, 14, p. 13304-14 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  104 Citations (Scopus)

• Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear protein.

  Artus, J., Vandormael-Pournin, S., Frödin, M., Nacerddine, K., Babinet, C. & Cohen-Tannoudji, M., 2005, In: Molecular and Cellular Biology. 25, 14, p. 6289-302 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)
• 2004

  Activation of p90 Rsk1 is sufficient for differentiation of PC12 cells.

  Silverman, E., Frödin, M., Gammeltoft, S. & Maller, J. L., 2004, In: Molecular and Cellular Biology. 24, 24, p. 10573-83 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  35 Citations (Scopus)
• 2003

  ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.

  Zhao, J., Yuan, X., Frödin, M. & Grummt, I., 2003, In: Molecular Cell. 11, 2, p. 405-13 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  225 Citations (Scopus)

• Xp38gamma/SAPK3 promotes meiotic G(2)/M transition in Xenopus oocytes and activates Cdc25C.

  Perdiguero, E., Pillaire, M-J., Bodart, J-F., Hennersdorf, F., Frödin, M., Duesbery, N. S., Alonso, G. & Nebreda, A. R., 2003, In: EMBO Journal. 22, 21, p. 5746-56 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  44 Citations (Scopus)
• 2002

  A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.

  Frödin, M., Antal, T. L., Dümmler, B. A., Jensen, C. J., Deak, M., Gammeltoft, S. & Biondi, R. M., 2002, In: EMBO Journal. 21, 20, p. 5396-407 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  233 Citations (Scopus)
• 2001

  Identification and characterization of an inner ear-expressed human melanoma inhibitory activity (MIA)-like gene (MIAL) with a frequent polymorphism that abolishes translation.

  Rendtorff, N. D., Frödin, M., Attié-Bitach, T., Vekemans, M. & Tommerup, N., 2001, In: Genomics. 71, 1, p. 40-52 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)
• 2000

  A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

  Frödin, M., Jensen, C. A. J., Merienne, K. & Gammeltoft, S., 2000, In: EMBO Journal. 19, 12, p. 2924-34 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  265 Citations (Scopus)
• 1999

  90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

  Jensen, C. A. J., Buch, M. B., Krag, T. O., Hemmings, B. A., Gammeltoft, S. & Frödin, M., 1999, In: Journal of Biological Chemistry. 274, 38, p. 27168-76 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  224 Citations (Scopus)

• Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.

  Frödin, M. & Gammeltoft, S., 1999, In: Molecular and Cellular Endocrinology. 151, 1-2, p. 65-77 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  633 Citations (Scopus)

• Transforming growth factor-beta, but not ciliary neurotrophic factor, inhibits DNA synthesis of adrenal medullary cells in vitro.

  Wolf, N., Krohn, K., Bieger, S., Frödin, M., Gammeltoft, S., Krieglstein, K. & Unsicker, K., 1999, In: Neuroscience. 90, 2, p. 629-41 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  16 Citations (Scopus)
• 1995

  Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1.

  Frödin, M., Sekine, N., Roche, E., Filloux, C., Prentki, M., Wollheim, C. B. & Van Obberghen, E., 1995, In: Journal of Biological Chemistry. 270, 14, p. 7882-9 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  203 Citations (Scopus)

• Neuronal localization of pituitary adenylate cyclase-activating polypeptide 38 in the adrenal medulla and growth-inhibitory effect on chromaffin cells.

  Frödin, M., Hannibal, J., Wulff, B. S., Gammeltoft, S. & Fahrenkrug, J., 1995, In: Neuroscience. 65, 2, p. 599-608 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  66 Citations (Scopus)

• Regulation of the MAP kinase cascade in PC12 cells: B-Raf activates MEK-1 (MAP kinase or ERK kinase) and is inhibited by cAMP.

  Peraldi, P., Frödin, M., Barnier, J. V., Calleja, V., Scimeca, J. C., Filloux, C., Calothy, G. & Van Obberghen, E., 1995, In: FEBS Letters. 357, 3, p. 290-6 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  78 Citations (Scopus)
• 1994

  Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells.

  Frödin, M., Peraldi, P. & Van Obberghen, E., 1994, In: Journal of Biological Chemistry. 269, 8, p. 6207-14 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  326 Citations (Scopus)

• Insulin-like growth factors act synergistically with basic fibroblast growth factor and nerve growth factor to promote chromaffin cell proliferation.

  Frödin, M. & Gammeltoft, S., 1994, In: Proceedings of the National Academy of Science of the United States of America. 91, 5, p. 1771-5 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  68 Citations (Scopus)