Morten Grunnet

Research output

Research output per year 2001 2003 2004 2005 2006 2007 2008 2009 2011 2017 2024

• 5495 Citations
• 105 Journal article
• 1 Conference abstract in journal
• 1 Conference article
• 1 Review
• 1 More
  • 1 Other contribution

Research output per year

Research output per year

Search results

• 2024

  A phase 1 trial of AP30663, a K_Ca2 channel inhibitor in development for conversion of atrial fibrillation

  Yfanti, C., Vestbjerg, B., van't Westende, J., Edvardsson, N., Monfort, L. M., Olesen, M. S., Bentzen, B. H., Grunnet, M., Eveleens Maarse, B. C., Diness, J. G., Kemme, M. J. B., Sørensen, U., Moerland, M., van Esdonk, M. J., Klaassen, E. S., Gal, P. & Holst, A. G., 2024, In: British Journal of Clinical Pharmacology. 90, 4, p. 1027-1035

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  13 Downloads (Pure)
• 2020

  Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing

  Citerni, C., Kirchhoff, J., Olsen, L. H., Sattler, S. M., Gentilini, F., Forni, M., Zannoni, A., Grunnet, M., Edvardsson, N., Bentzen, B. H. & Diness, J. G., 2020, In: Frontiers in Veterinary Science. 7, 12 p., 179.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  12 Citations (Scopus)

  115 Downloads (Pure)

• Inhibition of KCa2 and Kv11.1 Channels in Pigs With Left Ventricular Dysfunction

  Citerni, C., Kirchhoff, J., Olsen, L. H., Sattler, S. M., Grunnet, M., Edvardsson, N., Bentzen, B. H. & Diness, J. G., 2020, In: Frontiers in Pharmacology. 11, 11 p., 556.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  2 Citations (Scopus)

  70 Downloads (Pure)

• The K_Ca2 Channel Inhibitor AP30663 Selectively Increases Atrial Refractoriness, Converts Vernakalant-Resistant Atrial Fibrillation and Prevents Its Reinduction in Conscious Pigs

  Diness, J. G., Kirchhoff, J. E., Speerschneider, T., Abildgaard, L., Edvardsson, N., Sorensen, U. S., Grunnet, M. & Bentzen, B. H., 2020, In: Frontiers in Pharmacology. 11, 9 p., 159.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  28 Citations (Scopus)

  64 Downloads (Pure)
• 2019

  Arrhythmia development during inhibition of small-conductance calcium-activated potassium channels in acute myocardial infarction in a porcine model

  Lubberding, A. F., Sattler, S. M., Grunnet, M., Sørensen, U. S., Tfelt-Hansen, J. & Jespersen, T., Oct 2019, In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 21, 10, p. 1584–1593

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Impact of arrhythmogenic calmodulin variants on small conductance Ca²⁺-activated K⁺ (SK3) channels

  Saljic, A., Muthukumarasamy, K. M., la Cour, J. M., Boddum, K., Grunnet, M., Berchtold, M. W. & Jespersen, T., 2019, In: Physiological Reports. 7, 19, 13 p., e14210.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  8 Citations (Scopus)

  81 Downloads (Pure)

• The K_Ca2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts

  Kirchhoff, J. E., Skarsfeldt, M., Muthukumarasamy, K. M., Simó-Vicens, R., Bomholtz, S. H., Abildgaard, L., Jespersen, T., Sørensen, U. S., Grunnet, M., Bentzen, B. H. & Diness, J. G., 2019, In: Frontiers in Pharmacology. 10, 13 p., 668.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  8 Citations (Scopus)

  163 Downloads (Pure)
• 2018

  Pharmacological rescue of mutated K(v)3.1 ion-channel linked to progressive myoclonus epilepsies

  Munch, A. S., Saljic, A., Boddum, K., Grunnet, M., Hougaard, C. & Jespersen, T., 2018, In: European Journal of Pharmacology. 833, p. 255-262

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Selective Na V 1.1 activation rescues Dravet syndrome mice from seizures and premature death

  Richards, K. L., Milligan, C. J., Richardson, R. J., Jancovski, N., Grunnet, M., Jacobson, L. H., Undheim, E. A. B., Mobli, M., Chow, C. Y., Herzig, V., Csoti, A., Panyi, G., Reid, C. A., King, G. F. & Petrou, S., 21 Aug 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 34, p. E8077-E8085

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  102 Citations (Scopus)
• 2017

  A New Negative Allosteric Modulator AP14145 for the Study of Small Conductance Calcium-Activated Potassium Channels

  Simo Vicens, R., Kirchhoff, J. E., Dolce, B., Abildgaard, L., Speerschneider, T., Sørensen, U. S., Grunnet, M., Diness, J. G. & Bentzen, B. H., 5 Dec 2017, In: British Journal of Pharmacology. 174, 23, p. 4396-4408 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  23 Citations (Scopus)

  161 Downloads (Pure)

• Effect of antiarrhythmic drugs on small conductance calcium –activated potassium channels

  Simo Vicens, R., Sauter, D. R. P., Grunnet, M., Diness, J. G. & Bentzen, B. H., 15 May 2017, In: European Journal of Pharmacology. 803, p. 118-123 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  10 Citations (Scopus)

  406 Downloads (Pure)

• Novel negative allosteric modulator inhibits small conductance calcium-activated potassium channels and selectively prolongs atrial refractoriness in conscious pigs

  Simó-Vicens, R., Citerni, C., Edvardsson, N. G., Sørensen, U. S., Grunnet, M., Diness, J. G. & Bentzen, B. H., 11 May 2017, In: Heart Rhythm. 14, 5 suppl., p. S149-S150 P-PO02-15.

  Research output: Contribution to journal › Conference abstract in journal › Research

  Open Access

  File
  169 Downloads (Pure)

• Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats

  Laursen, M., Beck, L., Kehler, J., Christoffersen, C. T., Bundgaard, C., Mogensen, S., Mow, T. J., Pinilla, E., Knudsen, J. S., Hedegaard, E. R., Grunnet, M. & Simonsen, U., Aug 2017, In: British Journal of Pharmacology. 174, 15, p. 2563-2575 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  25 Citations (Scopus)

• Phosphodiesterase 1a inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries

  Khammy, M. M., Dalsgaard, T., Larsen, P. H., Christoffersen, C. T., Clausen, D., Rasmussen, L. K., Folkersen, L., Grunnet, M., Kehler, J., Aalkjaer, C. & Nielsen, J., Nov 2017, In: British Journal of Pharmacology. 174, 22, p. 4186-4198 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs

  Diness, J. G., Skibsbye, L., Simó-Vicens, R., Louro Larupa dos Santos, J., Lundegaard, P. R., Citerni, C., Sauter, D. R. P., Bomholtz, S. H., Svendsen, J. H., Olesen, S-P., Sørensen, U. S., Jespersen, T., Grunnet, M. & Bentzen, B. H., 10 Oct 2017, In: Circulation: Arrhythmia and Electrophysiology. 10, 19 p., e005125.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  59 Citations (Scopus)

  401 Downloads (Pure)
• 2016

  Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation

  Kirchhoff, J. E., Diness, J. G., Abildgaard, L., Sheykhzade, M., Grunnet, M. & Jespersen, T., 8 Oct 2016, In: Pfluegers Archiv. 468, 11, p. 1853–1863 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  13 Citations (Scopus)

  329 Downloads (Pure)
• 2015

  Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium

  Skibsbye, L., Wang, X., Axelsen, L. N., Bomholtz, S. H., Nielsen, M. S., Grunnet, M., Bentzen, B. H. & Jespersen, T., Aug 2015, In: Journal of Cardiovascular Pharmacology. 66, 2, p. 165-176 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  26 Citations (Scopus)

• Combined gating and trafficking defect in Kv11.1 manifests as a malignant long QT syndrome phenotype in a large Danish p.F29L founder family

  Kanters, J. K., Skibsbye, L., Hedley, P. L., Dembic, M., Liang, B., Hagen, C. M., Eschen, O., Grunnet, M., Christiansen, M. & Jespersen, T., 2015, In: Scandinavian Journal of Clinical & Laboratory Investigation. 75, 8, p. 699-709 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• Common and rare variants in SCN10A modulate the risk of atrial fibrillation.

  Jabbari, J., Olesen, M. S., Yuan, L., Nielsen, J. B., Liang, B., Macri, V., Christophersen, I. E., Nielsen, N., Sajadieh, A., Ellinor, P. T., Grunnet, M., Haunsø, S., Holst, A. G., Svendsen, J. H. & Jespersen, T., 2015, In: Circulation: Cardiovascular Genetics. 8, 1, p. 64-73 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  67 Citations (Scopus)

• Late Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial Fibrillation

  Poulet, C., Wettwer, E., Grunnet, M., Jespersen, T., Fabritz, L., Matschke, K., Knaut, M. & Ravens, U., 29 Jun 2015, In: PLOS ONE. 10, 6, p. 1-19 19 p., e0131432.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  61 Citations (Scopus)

• Role of calcium activated potassium channels in atrial fibrillation pathophysiology and therapy

  Diness, J. G., Bentzen, B. H., S. Sørensen, U. & Grunnet, M., Nov 2015, In: Journal of Cardiovascular Pharmacology. 66, 5, p. 441-448 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  36 Citations (Scopus)
• 2014

  BK channel activators and their therapeutic perspectives

  Bentzen, B. H., Olesen, S-P., Rønn, L. C. B. & Grunnet, M., 2014, In: Frontiers in Physiology. 5, p. 1-12 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  130 Citations (Scopus)

  196 Downloads (Pure)

• Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia

  Schmitt, N., Grunnet, M. & Olesen, S-P., Apr 2014, In: Physiological Reviews. 94, 2, p. 609-53 45 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  186 Citations (Scopus)

• Flecainide provocation reveals concealed brugada syndrome in a long QT syndrome family with a novel L1786Q mutation in SCN5A. SCN5A mutations associated with overlap phenotype of long QT syndrome type 3 and Brugada syndrome.

  Kanters, J. K., Yuan, L., Hedley, P. L., Stoevring, B., Jons, C., Bloch Thomsen, P. E., Grunnet, M., Christiansen, M. & Jespersen, T., 6 Mar 2014, In: Circulation Journal. 78, 5, p. 1136-43 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  26 Citations (Scopus)

• G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization

  Liang, B., Nissen, J. D., Laursen, M., Wang, X., Skibsbye, L., Hearing, M. C., Andersen, M. N., Rasmussen, H. B., Wickman, K., Grunnet, M., Olesen, S-P. & Jespersen, T., 1 Jan 2014, In: Cardiovascular Research. 101, 1, p. 175-84 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  34 Citations (Scopus)
• 2013

  Benzimidazolyl-acetamide derivatives useful as potassium channel modulators

  SØRENSEN, U. S., Grunnet, M., BENTZEN, B. H., Christophersen, P., Diness, J. G., SKIBSBYE, L. & Strøbæk, D., 7 Jan 2013

  Research output: Other contribution › Research

• GIRK channel activation via adenosine or muscarinic receptors has similar effects on rat atrial electrophysiology

  Wang, X., Liang, B., Skibsbye, L., Olesen, S-P., Grunnet, M. & Jespersen, T., Aug 2013, In: Journal of Cardiovascular Pharmacology. 62, 2, p. 192-8 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)
• 2012

  Anti-hypertensive treatment preserves appetite suppression while preventing cardiovascular adverse effects of tesofensine in rats

  Bentzen, B. H., Grunnet, M., Hyveled-Nielsen, L., Sundgreen, C., lassen, J. B. & Hansen, H. H., 2012, In: Obesity.

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)

• Attenuated ventricular β-adrenergic response and reduced repolarization reserve in a rabbit model of chronic heart failure

  Nissen, J. D., Thomsen, M. B., Bentzen, B. H., Diness, J. G., Diness, T. G., Jespersen, T. & Grunnet, M., 2012, In: Journal of Cardiovascular Pharmacology. 59, 2, p. 142-150 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels

  Krzystanek, K., Rasmussen, H. B., Grunnet, M., Staub, O., Olesen, S-P., Abriel, H. & Jespersen, T., 2012, In: Heart Rhythm. 9, 3, p. 440-8 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  26 Citations (Scopus)

• Functionally Selective AT(1) Receptor Activation Reduces Ischemia Reperfusion Injury

  Hostrup, A., Christensen, G. L., Bentzen, B. H., Liang, B., Aplin, M., Grunnet, M., Hansen, J. L. & Jespersen, T., 30 Jul 2012, In: Cellular Physiology and Biochemistry. 30, 3, p. 642-652 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  File
  17 Citations (Scopus)

• Keeping the rhythm -- pro-arrhythmic investigations in isolated Göttingen minipig hearts

  Laursen, M., Grunnet, M., Olesen, S-P., Jespersen, T. & Mow, T., 2012, In: Journal of Pharmacological and Toxicological Methods. 64, 2, p. 134-44 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)
• 2011

  Cardiac channelopathies and sudden infant death syndrome

  Tfelt-Hansen, J., Winkel, B. G., Grunnet, M. & Jespersen, T., 2011, In: The Cardiology. 119, 1, p. 21-33 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  33 Citations (Scopus)

• Cardiac ion channels and mechanisms for protection against atrial fibrillation.

  Grunnet, M., Bentzen, B. H., Sørensen, U. S. & Diness, J. G., 2011, In: Reviews of Physiology, Biochemistry and Pharmacology. 162, p. 1-58 59 p.

  Research output: Contribution to journal › Review › Research › peer-review

  35 Citations (Scopus)

• Central and Peripheral GABA(A) Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal

  Bentzen, B. H. & Grunnet, M., 2011, In: Advances in Pharmacological Sciences. 2011, 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  22 Citations (Scopus)

• Characterization of cardiac repolarization in the Göttingen minipig

  Laursen, M., Olesen, S-P., Grunnet, M., Mow, T., Jespersen, T. & Jespersen, T., 2011, In: Journal of Pharmacological and Toxicological Methods. 63, 2, p. 186-95 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  26 Citations (Scopus)

• Effects on atrial fibrillation in aged hypertensive rats by Ca(2+)-activated K(+) channel inhibition

  Diness, J. G., Skibsbye, L., Jespersen, T., Bartels, E. D., Sørensen, U. S., Hansen, R. S. & Grunnet, M., 2011, In: Hypertension. 57, 6, p. 1129-35 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  96 Citations (Scopus)

• Extracellular potassium inhibits Kv7.1 potassium channels by stabilizing an inactivated state

  Larsen, A. P., Steffensen, A. B., Grunnet, M. & Olesen, S-P., 2011, In: Biophysical Journal. 101, 4, p. 818-27 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)

• Pharmacological activation of Kv11.1 in transgenic long QT-1 rabbits

  Bentzen, B. H., Bahrke, S., Wu, K., Larsen, A. P., Odening, K. E., Franke, G., Storm vans Gravesande, K., Biermann, J., Peng, X., Koren, G., Zehender, M., Bode, C., Grunnet, M. & Brunner, M., Feb 2011, In: Journal of Cardiovascular Pharmacology. 57, 2, p. 223-30 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  36 Citations (Scopus)

• The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na⁺/H⁺ exchanger NHE1

  Andersen, A-D., Bentzen, B. H., Salling, H., Klingberg, H., Kanneworff, M., Grunnet, M. & Pedersen, S. H. F., 2011, In: Cellular Physiology and Biochemistry. 28, 1, p. 13-24 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)

• The duration of pacing-induced atrial fibrillation is reduced in vivo by inhibition of small conductance Ca²⁺-activated K⁺ channels.

  Skibsbye, L., Diness, J., Sørensen, U. S., Hansen, R. S. & Grunnet, M., 2011, In: Journal of Cardiovascular Pharmacology. 57, 6, p. 672-681

  Research output: Contribution to journal › Journal article › Research › peer-review
  82 Citations (Scopus)
• 2010

  Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels

  Larsen, A. P., Bentzen, B. H. & Grunnet, M., Oct 2010, In: British Journal of Pharmacology. 161, 3, p. 614-28 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• Identification of a Kir3.4 Mutation in Congenital Long QT Syndrome

  Yang, Y., Yang, Y., Liang, B., Liu, J., Li, J., Grunnet, M., Olesen, S-P., Rasmussen, H. B., Ellinor, P. T., Gao, L., Lin, X., Li, L., Wang, L., Xiao, J., Liu, Y., Liu, Y., Zhang, S., Liang, D., Peng, L., Jespersen, T. & 1 others, Chen, Y-H., 2010, In: American Journal of Human Genetics. 86, 6, p. 872-80 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  File
  174 Citations (Scopus)

  1 Downloads (Pure)

• Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation

  Diness, J. G., Sørensen, U. S., Nissen, J. D., Al-Shahib, B., Jespersen, T., Grunnet, M., Hansen, R. S. & Jespersen, T., Aug 2010, In: Circulation. Arrhythmia and electrophysiology. 3, 4, p. 380-90 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  165 Citations (Scopus)
• 2009

  Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury

  Bentzen, B. H., Osadchii, O., Jespersen, T., Hansen, R. S., Olesen, S-P. & Grunnet, M., 2009, In: Pflügers Archiv: European Journal of Physiology. 457, 5, p. 979-88 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  84 Citations (Scopus)

• Bevacizumab plus irinotecan in the treatment patients with progressive recurrent malignant brain tumours

  Poulsen, H. S., Grunnet, K., Sorensen, M., Olsen, P., Hasselbalch, B., Nelausen, K., Kosteljanetz, M. & Lassen, U., 2009, In: Acta Oncologica. 48, 1, p. 52-58 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  101 Citations (Scopus)

• Energetic performance is improved by specific activation of K+ fluxes through K(Ca) channels in heart mitochondria

  Aon, M. A., Cortassa, S., Wei, A-C., Grunnet, M. & O'Rourke, B., 2009, In: BBA General Subjects. 1797, 1, p. 71-80 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  77 Citations (Scopus)

• Functional properties of human neuronal Kv11 channels

  Einarsen, K., Calloe, K., Grunnet, M., Olesen, S-P. & Schmitt, N., 2009, In: Pflügers Archiv: European Journal of Physiology. 458, 4, p. 689-700 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)

• Inherited Cardiac Diseases Caused by Mutations in the Nav1.5 Sodium Channel

  Tfelt-Hansen, J., Winkel, B. G., Grunnet, M. & Jespersen, T., 2009, In: Cardiovascular Electrophysiology.

  Research output: Contribution to journal › Journal article › Research › peer-review
  69 Citations (Scopus)

• Inherited cardiac diseases caused by mutations in the Nav1.5 sodium channel.

  Tfelt-Hansen, J., Winkel, BG., Grunnet, M. & Jespersen, T., Oct 2009, In: Journal of Cardiovascular Electrophysiology.

  Research output: Contribution to journal › Journal article › Research › peer-review