Morten Schak Nielsen

Search results

• 2023

  Mitochondrial pannexin1 controls cardiac sensitivity to ischaemia/reperfusion injury

  Rusiecka, O. M., Molica, F., Nielsen, M. S., Tollance, A., Morel, S., Frieden, M., Chanson, M., Boengler, K. & Kwak, B. R., 2023, In: Cardiovascular Research. 119, 13, p. 2342-2354

  Research output: Contribution to journal › Journal article › Research › peer-review

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  6 Citations (Scopus)

  18 Downloads (Pure)

• Phase-2 Re-Entry in Brugada Syndrome: More to Understand Than “Just” I_to

  Kanters, J. K. & Nielsen, M. S., 2023, In: JACC: Clinical Electrophysiology. 9, 12, p. 2475-2476

  Research output: Contribution to journal › Editorial › Research › peer-review

• The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes

  Nielsen, M. S., van Opbergen, C. J. M., van Veen, T. A. B. & Delmar, M., 2023, In: Physiological Reviews. 103, 3, p. 2271-2319

  Research output: Contribution to journal › Review › Research › peer-review

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  14 Citations (Scopus)
• 2021

  Connexins and Pannexins in Cardiovascular Disease

  Kwak, B. R. & Nielsen, M. S., 2021, Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside. Jalife, J. & Stevenson, W. G. (eds.). 8 ed. Philadelphia, PA, USA: Elsevier, p. 168-177 10 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
• 2020

  Pannexin 1 activation and inhibition is permeant-selective

  Nielsen, B. S., Toft-Bertelsen, T. L., Lolansen, S. D., Anderson, C. L., Nielsen, M. S., Thompson, R. J. & MacAulay, N., 2020, In: The Journal of Physiology. 598, 2, p. 361-379 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  31 Citations (Scopus)

• Quantitative proteomics characterization of acutely isolated primary adult rat cardiomyocytes and fibroblasts

  Poulsen, P. C., Schrölkamp, M., Bagwan, N., Leurs, U., Humphries, E. S. A., Bomholzt, S. H., Nielsen, M. S., Bentzen, B. H., Olsen, J. V. & Lundby, A., 2020, In: Journal of Molecular and Cellular Cardiology. 143, p. 63-70 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  9 Citations (Scopus)

  53 Downloads (Pure)
• 2019

  Acute intramyocardial lipid accumulation in rats does not slow cardiac conduction per se

  Jensen, C. F., Bartels, E. D., Braunstein, T. H., Nielsen, L. B., Holstein-Rathlou, N-H., Axelsen, L. N. & Nielsen, M. S., Apr 2019, In: Physiological Reports. 7, 7, 13 p., e14049.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  2 Citations (Scopus)

  62 Downloads (Pure)

• Modulating cardiac conduction during metabolic ischemia with perfusate sodium and calcium in guinea pig hearts

  George, S. A., Hoeker, G., Calhoun, P. J., Entz, M., Raisch, T. B., King, D. R., Khan, M., Baker, C., Gourdie, R. G., Smyth, J. W., Nielsen, M. S. & Poelzing, S., 1 Feb 2019, In: American Journal of Physiology: Heart and Circulatory Physiology. 316, 4, p. H849-H861

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  26 Citations (Scopus)

• Structural determinants underlying permeant discrimination of the Cx43 hemichannel

  Nielsen, B. S., Zonta, F., Farkas, T., Litman, T., Nielsen, M. S. & Macaulay, N., 2019, In: Journal of Biological Chemistry. 294, 45, p. 16789-16803 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  17 Citations (Scopus)

  46 Downloads (Pure)
• 2018

  Connexins and Disease

  Delmar, M., Laird, D. W., Naus, C. C., Nielsen, M. S., Verselis, V. K. & White, T. W., 2018, In: Cold Spring Harbor perspectives in biology. 10, 9, p. 1-18 a029348.

  Research output: Contribution to journal › Journal article › Research › peer-review
  76 Citations (Scopus)

• Genetically modified animals as tools to personalize the study of arrhythmia mechanisms and treatment

  Cerrone, M., Nielsen, M. S. & Delmar, M., 2018, ESC CardioMed. Camm, A. J., Lüscher, T. F., Maurer, G. & Serruys, P. W. (eds.). 3 ed. Oxford University Press

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

• Probenecid inhibits α-adrenergic receptor-mediated vasoconstriction in the human leg vasculature

  Nyberg, M. P., Piil, P. B., Kiehn, O. T., Maagaard, C., Jørgensen, T. S., Egelund, J., Isakson, B. E., Nielsen, M. S., Gliemann, L. & Hellsten, Y., 2018, In: Hypertension. 71, 1, p. 151-159 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  33 Citations (Scopus)

• Protein⁻Protein Interactions with Connexin 43: Regulation and Function

  Sorgen, P. L., Trease, A. J., Spagnol, G., Delmar, M. & Nielsen, M. S., 10 May 2018, In: International Journal of Molecular Sciences. 19, 5, 21 p., 1428.

  Research output: Contribution to journal › Review › Research › peer-review

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  74 Citations (Scopus)

  133 Downloads (Pure)

• Uremia increases QRS duration after β-adrenergic stimulation in mice

  Thomsen, M. B., Nielsen, M. S., Aarup, A., Bisgaard, L. S. & Pedersen, T. X., 1 Jul 2018, In: Physiological Reports. 6, 13, 13 p., e13720.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  7 Citations (Scopus)

  150 Downloads (Pure)
• 2017

  Astrocytic connexin hemichannels are regulated by PKC phosphorylation in an isoform-specific manner

  MacAulay, N., Alstrom, J. S., Hansen, D. B. & Nielsen, M. S., 2017, In: Glia. 65, S1, p. E64-E64 S17-01.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  Open Access

• Connexin Hemichannels in Astrocytes: An Assessment of Controversies Regarding Their Functional Characteristics

  Nielsen, B. S., Hansen, D. B., Ransom, B. R., Nielsen, M. S. & MacAulay, N., Sep 2017, In: Neurochemical Research. 42, 9, p. 2537–2550 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  29 Citations (Scopus)

• Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome

  Thorsen, K., Dam, V. S., Kjaer-Sorensen, K., Pedersen, L. N., Skeberdis, V. A., Jurevicius, J., Treinys, R., Petersen, I. M. B. S., Nielsen, M. S., Oxvig, C., Morth, J. P., Matchkov, V. V., Aalkjaer, C., Bundgaard, H. & Jensen, H. K., 22 Nov 2017, In: Nature Communications. 8, 10 p., 1696.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  77 Citations (Scopus)

  293 Downloads (Pure)

• Permeant-specific gating of connexin 30 hemichannels

  Nielsen, B. S., Alstrom, J. S., Nicholson, B., Nielsen, M. S. & Macaulay, N., 2017, In: Journal of Biological Chemistry. 292, 49, p. 19999-20009

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• T-type Ca(2+) channels and Autoregulation of Local Blood Flow

  Jensen, L. J., Nielsen, M. S., Salomonsson, M. & Sørensen, C. M., 2017, In: Channels (Austin). 11, 3, p. 183-195 13 p.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access
  12 Citations (Scopus)

• T-type Ca2+ channels and autoregulation of local blood flow

  Jensen, L. J., Nielsen, M. S., Salomonsson, M. & Sørensen, C. M., 4 May 2017, In: Channels (Austin). 11, 3, p. 183-195

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

• Unsupervised Idealization of Ion Channel Recordings by Minimum Description Length: Application to Human PIEZO1-Channels

  Gnanasambandam, R., Nielsen, M. S., Nicolai, C., Sachs, F., Hofgaard, J. P. & Dreyer, J. K., 2017, In: Frontiers in Neuroinformatics. 11, 16 p., 31.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  15 Citations (Scopus)

  254 Downloads (Pure)
• 2016

  Sphingosine-1-Phosphate reduces ischemia/reperfusion injury by phosphorylating the gap junction protein Connexin43

  Morel, S., Christoffersen, C., Axelsen, L. N., Montecucco, F., Rochemont, V., Frias, M. A., Mach, F., James, R. W., Naus, C. C., Chanson, M., Lampe, P. D., Nielsen, M. S., Nielsen, L. B. & Kwak, B. R., 13 Jan 2016, In: Cardiovascular Research. 109, p. 385-396 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  54 Citations (Scopus)
• 2015

  Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium

  Skibsbye, L., Wang, X., Axelsen, L. N., Bomholtz, S. H., Nielsen, M. S., Grunnet, M., Bentzen, B. H. & Jespersen, T., Aug 2015, In: Journal of Cardiovascular Pharmacology. 66, 2, p. 165-176 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  26 Citations (Scopus)

• Diet-induced pre-diabetes slows cardiac conductance and promotes arrhythmogenesis

  Axelsen, L. N., Callø, K., Braunstein, T. H., Riemann, M., Hofgaard, J. P., Liang, B., Jensen, C. F., Olsen, K. B., Bartels, E. D., Baandrup, U., Jespersen, T., Nielsen, L. B., von Holstein-Rathlou, N-H. & Nielsen, M. S., 14 Jul 2015, In: Cardiovascular Diabetology. 14, 14 p., 87.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  40 Citations (Scopus)

  391 Downloads (Pure)

• Gap junctions-guards of excitability

  Stroemlund, L. W., Jensen, C. F., Qvortrup, K., Delmar, M. & Nielsen, M. S., 1 Jun 2015, In: Biochemical Society Transactions. 43, 3, p. 508-12 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• Isoform-specific phosphorylation-dependent regulation of connexin hemichannels

  Alstrøm, J. S., Hansen, D. B., Nielsen, M. S. & MacAulay, N., 15 Nov 2015, In: Journal of Neurophysiology. 114, 5, p. 3014-22 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Protein kinase C-dependent regulation of connexin43 gap junctions and hemichannels

  Alstrøm, J. S., Stroemlund, L. W., Nielsen, M. S. & MacAulay, N., Jun 2015, In: Biochemical Society Transactions. 43, 3, p. 519-23 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  15 Citations (Scopus)

• Sympathetic vasoconstriction takes an unexpected pannexin detour

  Schak Nielsen, M., 17 Feb 2015, In: Science Signaling. 8, 364, p. 1-2 2 p., fs4.

  Research output: Contribution to journal › Comment/debate › Research › peer-review
  4 Citations (Scopus)
• 2014

  Activation, Permeability, and Inhibition of Astrocytic and Neuronal Large Pore (Hemi)channels

  Hansen, D. B., Ye, Z-C., Calloe, K., Braunstein, T. H., Hofgaard, J. P., Ransom, B. R., Nielsen, M. S. & MacAulay, N., 19 Sep 2014, In: The Journal of Biological Chemistry. 289, 38, p. 26058-73 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  45 Citations (Scopus)

• Distinct permeation profiles of the connexin 30 and 43 hemichannels

  Hansen, D. B., Braunstein, T. H., Nielsen, M. S. & Macaulay, N., 17 Apr 2014, In: FEBS Letters. 588, 8, p. 1446-57 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  57 Citations (Scopus)
• 2013

  Managing the complexity of communication: regulation of gap junctions by post-translational modification

  Axelsen, L. N., Callø, K., von Holstein-Rathlou, N-H. & Nielsen, M. S., Oct 2013, In: Frontiers in Pharmacology. 4, p. 1-18 18 p., 130.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Myocardial impulse propagation is impaired in right ventricular tissue of Zucker Diabetic Fatty (ZDF) rats

  Olsen, K. B., Axelsen, L. N., Braunstein, T. H., Sørensen, C. M., Andersen, C. B., Ploug, T., von Holstein-Rathlou, N-H. & Nielsen, M. S., 2013, In: Cardiovascular Diabetology. 12, p. 19 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  25 Citations (Scopus)
• 2012

  Estimation of the effective intercellular diffusion coefficient in cell monolayers coupled by gap junctions

  Olesen, N. E., Hofgaard, J. P., von Holstein-Rathlou, N-H., Nielsen, M. S. & Jacobsen, J. C. B., 2012, In: European Journal of Pharmaceutical Sciences. 46, 4, p. 222-32 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• Gap Junctions

  Nielsen, M. S., Axelsen, L. N., Sorgen, P., Verma, V., Mario, D. & von Holstein-Rathlou, N-H., 2012, In: Comprehensive Physiology. 2, p. 1981-2035

  Research output: Contribution to journal › Review › Research › peer-review
  347 Citations (Scopus)

• Lateralized gap junctions in pulmonary hypertension - lost but not alone

  Nielsen, M. S., 2012, In: Heart Rhythm. 9, 7, p. 1141-1142 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2011

  Angiotensin II does not acutely regulate conduction velocity in rat atrial tissue

  Olsen, K. B., Braunstein, T. H., Sørensen, C. M., Axelsen, L. N., Holstein-Rathlou, N-H. & Nielsen, M. S., 6 Jul 2011, In: Scandinavian Journal of Clinical and Laboratory Investigation. Supplement. 71, 6, p. 492 499 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• Norepinephrine inhibits intercellular coupling in rat cardiomyocytes by ubiquitination of connexin43 gap junctions

  Mollerup, S., Hofgaard, J. P., Braunstein, T. H., Kjenseth, A., Leithe, E., Rivedal, E., von Holstein-Rathlou, N-H. & Nielsen, M. S., 21 Sep 2011, In: Cell Communication & Adhesion (Print Edition). 18, 4, p. 57-65 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)

• The angiotensin II type 1 receptor antagonist Losartan binds and activates bradykinin B2 receptor signaling

  Bonde, M. M., Olsen, K. B., Erikstrup, N., Speerschneider, T., Lyngsø, C., Haunsø, S., Nielsen, M. S., Sheikh, S. P. & Hansen, J. L., 2011, In: Regulatory Peptides. 167, 1, p. 21-25 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)
• 2010

  Connexin mimetic peptides fail to inhibit vascular conducted calcium responses in renal arterioles (American Journal of Physiology - Regulatory Integrative and Comparative Physiology (2008) 295, (R840-R847) DOI:10.1152/ajpregu.00491.2007)

  Sorensen, C. M., Salomonsson, M., Braunstein, T. H., Nielsen, M. S. & Holstein-Rathlou, N. H., 1 Jan 2010, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 298, 1

  Research output: Contribution to journal › Comment/debate › Research › peer-review
  1 Citation (Scopus)
• 2009

  Myocyte-fibroblast interactions--risky connections

  Nielsen, M. S., 2009, In: Heart Rhythm. 6, 11, p. 1650-1 1 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  1 Citation (Scopus)

• Phosphorylation of connexin43 on serine 306 regulates electrical coupling

  Procida, K., Jørgensen, L., Schmitt, N., Delmar, M., Taffet, S. M., Holstein-Rathlou, N-H., Nielsen, M. S. & Braunstein, T. H., 2009, In: Heart Rhythm. 6, 11, p. 1632-8 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  49 Citations (Scopus)

• Quantification of gap junctional intercellular communication based on digital image analysis

  Hofgaard, J. P., Mollerup, S., Holstein-Rathlou, N-H. & Nielsen, M. S., 2009, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 297, 2, p. R243-7 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)
• 2008

  Connexin mimetic peptides fail to inhibit vascular conducted calcium responses in renal arterioles.

  Sørensen, C. M., Salomonsson, M., Braunstein, T. H., Nielsen, M. S. & Holstein-Rathlou, N-H., 2008, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 295, 3, p. R840-7

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)

• Phosphatidylinositol-bisphosphate regulates intercellular coupling in cardiac myocytes

  Hofgaard, J. P., Banach, K., Mollerup, S., Jørgensen, H. K., Olesen, S. P., Holstein-Rathlou, N-H. & Nielsen, M. S., 2008, In: Pflügers Archiv: European Journal of Physiology. 457, 2, p. 303-13 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• RXP-E: a connexin43-binding peptide that prevents action potential propagation block

  Lewandowski, R., Procida, K., Vaidyanathan, R., Coombs, W., Jalife, J., Nielsen, M. S., Taffet, S. M. & Delmar, M., 2008, In: Circulation Research. 103, 5, p. 519-26 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  35 Citations (Scopus)

• Synopsis of the International Gap Junction Conference in Elsinore, Denmark August 5-9, 2007.

  Willecke, K. & Nielsen, M. S., 2008, In: Cell Communication & Adhesion (Print Edition). 14, 6, p. 251-7 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2007

  Increasing gap junctional coupling: a tool for dissecting the role of gap junctions.

  Axelsen, L. N., Haugan, K., Stahlhut, M., Kjølbye, A-L., Hennan, J. K., Petersen, J. S., Nielsen, M. S. & Holstein-Rathlou, N-H., 2007, In: Journal of Membrane Biology. 216, 1, p. 23-35 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• KCNQ channels are involved in the regulatory volume decrease response in primary neonatal rat cardiomyocytes.

  Calloe, K., Nielsen, M. S., Grunnet, M., Schmitt, N. & Jorgensen, N. K., 2007, In: BBA General Subjects. 1773, 6, p. 764-73 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)
• 2006

  Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123).

  Axelsen, L. N., Stahlhut, M., Mohammed, S., Larsen, B. D., Nielsen, M. S., Andersen, S., Jensen, O. N., Hennan, J. K., Kjølbye, A. L. & Holstein-Rathlou, N-H., 2006, In: Journal of Molecular and Cellular Cardiology. 40, 6, p. 790-8 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  119 Citations (Scopus)

• Treatment with the gap junction modifier rotigaptide (ZP123) reduces infarct size in rats with chronic myocardial infarction.

  Haugan, K., Marcussen, N., Kjølbye, A. L., Nielsen, M. S., Hennan, J. K. & Petersen, J. S., 2006, In: Journal of Cardiovascular Pharmacology. 47, 2, p. 236-42 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  34 Citations (Scopus)