Research output per year
Research output per year
Personal profile
Short presentation
My research is focused on the elucidation of the in vivo mechanism-of-action of GHB ligands. GHB (g-hydroxybutyric acid) is a proposed neuromodulator, but it is also known as the drug of abuse Fantasy and the clinically prescribed drug Xyrem for the treatment of narcolepsy. Pre-clinical studies showed a neuroprotective effect of GHB ligands in acute brain injury. Therefore, my project is focussing studying the neuroprotective potential of GHB ligands by employing the model of photothrombotic stroke.
CV
Academic degrees
2018: MSc in Pharmaceutical Science, University of Copenhagen.
2016: BSc in Life Science, Leibniz University (Hanover, Germany).
Employments
2018: Research assistent at Experimental Pharmacology, Deparment of Drug Design and Pharmacology, University of Copenhagen.
Education/Academic qualification
Molecular Pharmacology, PhD, University of Copenhagen
Award Date: 31 Aug 2022
Pharmaceutical Sciences, MSc, University of Copenhagen
Award Date: 31 Aug 2018
Life Science, BSc, Leibniz University Hannover
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Deletion of CaMKIIα disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex
Andersen, J. V., Westi, E. W., Griem-Krey, N., Skotte, N. H., Schousboe, A., Aldana, B. I. & Wellendorph, P., 2024, In: Journal of Neurochemistry. 168, 5, p. 704-718Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)8 Downloads (Pure) -
Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking, and modulation of kinase activity
Narayanan, D., Larsen, A. S. G., Gauger, S. J., Adafia, R., Hammershøi, R. B., Hamborg, L., Bruus-Jensen, J., Griem-Krey, N., Gee, C. L., Frølund, B., Stratton, M. M., Kuriyan, J., Kastrup, J. S., Langkilde, A. E., Wellendorph, P. & Solbak, S. M. Ø., 2024, In: Protein science : a publication of the Protein Society. 33, 10, 17 p., e5152.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Downloads (Pure) -
N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection
Ameen, S. S., Griem-Krey, N., Dufour, A., Hossain, M. I., Hoque, A., Sturgeon, S., Nandurkar, H., Draxler, D. F., Medcalf, R. L., Kamaruddin, M. A., Lucet, I. S., Leeming, M. G., Liu, D., Dhillon, A., Lim, J. P., Basheer, F., Zhu, H. J., Bokhari, L., Roulston, C. L., Paradkar, P. N. & 7 others, , 2023, In: Molecular & cellular proteomics : MCP. 22, 5, 100543.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Citations (Scopus)12 Downloads (Pure) -
The GHB analogue HOCPCA improves deficits in cognition and sensorimotor function after MCAO via CaMKIIα
Griem-Krey, N., Klein, A. B., Clausen, B. H., Namini, M. R. J., Nielsen, P. V., Bhuiyan, M., Nagaraja, R. Y., De Silva, T. M., Sobey, C. G., Cheng, H. C., Orset, C., Vivien, D., Lambertsen, K. L., Clarkson, A. N. & Wellendorph, P., 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 8, p. 1419-1434Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)19 Downloads (Pure) -
CaMKIIα as a Promising Drug Target for Ischemic Grey Matter
Griem-Krey, N., Clarkson, A. N. & Wellendorph, P., 2022, In: Brain Sciences. 12, 12, 21 p., 1639.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile4 Citations (Scopus)23 Downloads (Pure) -
The CaMKIIα hub ligand Ph-HTBA promotes neuroprotection after focal ischemic stroke by a distinct molecular interaction
Griem-Krey, N., Gauger, S. J., Gowing, E. K., Thiesen, L., Frølund, B., Clarkson, A. N. & Wellendorph, P., 2022, In: Biomedicine and Pharmacotherapy. 156, 10 p., 113895.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Citations (Scopus)33 Downloads (Pure) -
GABAA receptor β1-subunit knock-out mice show increased delta power in NREM sleep and decreased theta power in REM sleep
Lie, M. E. K., Falk-Petersen, C. B., Petersen, L. P., Griem-Krey, N., Wellendorph, P. & Kornum, B. R., 2021, In: European Journal of Neuroscience. 54, 2, p. 4445-4455 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
5 Citations (Scopus) -
GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain
Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, , 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access28 Citations (Scopus)