CV

Niels Bindslev, MD, Assoc Prof, Senior Lecturer in Physiology - April 2010 

Born January 20, 1944, Lemvig, Denmark

Married to Helle Brabrand. Two children: Thomas and Anne Kristine

Present position:
Associate Prof at Dept Biomed Sci, Panum Building, Copenhagen University

Education and positions:
Medical Doctor from Copenhagen University 1971
Course on Basic Medical Sciences at Copenhagen Univ (14 months) 1971-1972
Courses in Tropical Medicine 1972
Research fellow at Dept of Physiology, UCLA, Los Angeles 1972-1973
Course on Cell membranes, Tel Aviv, Israel 1974-1975
Clinical resident at Holbæk Central Hospital, Denmark 1975-1976
Assistant Prof at Dept of Medical Physiology, Copenhagen Univ 1976-1979
Research fellow at Dept of Physiology, UCLA, Los Angeles 1982-1984
Associate Prof at Dept of Medical Physiology, Copenhagen Univ 1979-2010
Research fellow at Dept of Physiology, UCLA, Los Angeles 1993-1994

Main research interests:
Epithelial transport and receptor characterization in human gut diseases.

Theoretical tools for dose-response analysis in enzymology, transportology, and pharmacodynamics.

Spent all my spare time from 2002 and on - writing a monograph (op cit) about model analyses of dose-response relationships.

Present Teaching:
I organize and teach a course in GI physiology for 4th semester medical students, incl labs on epithelial transport. Runs spring and autumn every year.

I organize and teach a Ph.D. course on Drug-Receptor Interaction based on my book (op cit).

I give 16 lectures. Runs spring and autumn every year.

Recent publications (international peer review indicated by * at the end of reference)
Kaltoft N, Tilotta MC, Witte AB, Osbak PS, Poulsen SS, Bindslev N, Hansen MB. Prostaglandin E2-induced colonic secretion in patients with and without colorectal neoplasia. BMC Gastroenterol. 2010; 10: 9 (pp 1-11)*

Bindslev N. New chapter for my book Drug-Acceptor Interactions. Plots, Fits and data interpretation. Co-Action Publishers, Stockholm, 2009, (pp 1-22).*

Available in Open Access April, 2009 at www.co-action.net

Mosa AS, Hansen MB, Tilotta CM, Bindslev N. EP4 and EP2 receptor subtypes involved in colonic secretion in rat. Basic Clin Pharmacol Toxicol. 2008; 103 (pp 214-221).*

Bindslev N. Drug-Acceptor Interactions. Co-Action Publishers, Stockholm, 2008 (pp 1-410).*

Available in Open Access May 15, 2008 at www.co-action.net

Osbak PS, Bindslev N, Poulsen SS, Kaltoft N, Tilotta MC, Hansen MB. Colonic epithelial ion transport is not affected in patients with diverticulosis. BMC Gastroenterol. 2007; 7:37 (pp 1-10).*

Engelmann BE, Bindslev N, Poulsen SS, Larsen R, Hansen MB. Functional characterization of serotonin receptor subtypes in human duodenal secretion. Basic Clin Pharmacol Toxicol. 2006; 98 (pp 142-149).*

Larsen R, Hansen MB, Bindslev N. Duodenal secretion in humans mediated by the EP4 receptor subtype. Acta Physiol Scand. 2005; 185 (pp 133-140).*

Bindslev N. A homotropic two-state model and auto-antagonism. BMC Pharmacol. 2004; 4:11 (pp 1-22).*

Larsen R, Hansen MB, Bindslev N, Mertz-Nielsen A. Functional characterization of muscarinic receptor subtypes in human duodenal secretion. Acta Physiol Scand. 2004; 182: (pp 63-68).*

Engelmann BE, Bindslev N, Poulsen SS, Hansen MB. Effects of cyclooxygenase and lipoxygenase inhibition on basal- and serotonin-induced ion transport in rat colon. Comp Biochem Physiol C Toxicol Pharmacol. 2002;132 (pp 37-52).*

Larsen R, Mertz-Nielsen A, Hansen MB, Poulsen SS, Bindslev N. Novel modified Ussing chamber for the study of absorption and secretion in human endoscopic biopsies. Acta Physiol Scand. 2001;173 (pp 213-222).*

Primary fields of research

Epithelial transport & Analysis of dose-response relations

Current research

I have recently written the book:
Drug-Acceptor Interactions 

This book on analysis of dose-response relationships at equilibrium will soon be available from Co-Action Publishing, Stockholm.