Nils Billestrup

Research output

Research output per year 1984 1990 1994 1995 1996 1998 2003 2005 2008 2009 2010 2011 2014 2015 2016 2024

• 6947 Citations
• 115 Journal article
• 1 Book chapter
• 1 Conference abstract for conference
• 1 Conference abstract in journal
• 1 More
  • 1 Review

Research output per year

Research output per year

Search results

• 2024

  Butyrate functions as a histone deacetylase inhibitor to protect pancreatic beta cells from IL-1β-induced dysfunction

  Pedersen, S. S., Ingerslev, L. R., Olsen, M., Prause, M. & Billestrup, N., 2024, In: FEBS Journal. 291, 3, p. 566-583

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  9 Citations (Scopus)

• Protection of beta cells against cytokine-induced apoptosis by the gut microbial metabolite butyrate

  Jørgensen, K. S., Pedersen, S. S., Hjorth, S. A., Billestrup, N. & Prause, M., 2024, (E-pub ahead of print) In: FEBS Journal.

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2023

  Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding

  Urizar, A. I., Prause, M., Ingerslev, L. R., Wortham, M., Sui, Y., Sander, M., Williams, K., Barrès, R., Larsen, M. R., Christensen, G. L. & Billestrup, N., 2023, In: Cell Death and Disease. 14, 7, 16 p., 399.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  3 Citations (Scopus)

  32 Downloads (Pure)

• Targeted Delivery of Butyrate Improves Glucose Homeostasis, Reduces Hepatic Lipid Accumulation and Inflammation in db/db Mice

  Pedersen, S. S., Prause, M., Sørensen, C., Størling, J., Moritz, T., Mariño, E. & Billestrup, N., 2023, In: International Journal of Molecular Sciences. 24, 5, 17 p., 4533.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  9 Citations (Scopus)

  34 Downloads (Pure)
• 2022

  Butyrate inhibits IL-1β-induced inflammatory gene expression by suppression of NF-κB activity in pancreatic beta cells

  Pedersen, S. S., Prause, M., Williams, K., Barrès, R. & Billestrup, N., 2022, In: Journal of Biological Chemistry. 298, 9, 14 p., 102312.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  24 Citations (Scopus)

  40 Downloads (Pure)
• 2021

  Butyrate protects pancreatic beta cells from cytokine-induced dysfunction

  Prause, M., Pedersen, S. S., Tsonkova, V., Qiao, M. & Billestrup, N., 2021, In: International Journal of Molecular Sciences. 22, 19, 18 p., 10427.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  23 Citations (Scopus)

  49 Downloads (Pure)
• 2019

  Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1 beta is associated with changes in expression of beta-cell maturity genes and associated histone modifications

  Urizar, A. I., Prause, M., Wortham, M., Sui, Y., Thams, P., Sander, M., Christensen, G. L. & Billestrup, N., 2019, In: Molecular and Cellular Endocrinology. 496, 12 p., 110524 .

  Research output: Contribution to journal › Review › Research › peer-review
  19 Citations (Scopus)
• 2018

  Characterization of the Molecular Mechanisms Underlying Glucose Stimulated Insulin Secretion from Isolated Pancreatic β-cells Using Post-translational Modification Specific Proteomics (PTMomics)

  Kang, T., Jensen, P., Huang, H., Lund Christensen, G., Billestrup, N. & Larsen, M. R., Jan 2018, In: Molecular and Cellular Proteomics. 17, 1, p. 95-110 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  31 Citations (Scopus)
• 2017

  In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes

  Skarbaliene, J., Rigbolt, K. T., Fosgerau, K. & Billestrup, N., 15 Nov 2017, In: European Journal of Pharmacology. 815, p. 181-189 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• Pannexin-2-deficiency sensitizes pancreatic beta-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo

  Berchtold, L. A., Miani, M., Diep, T. A., Madsen, A. N., Cigliola, V., Colli, M., Krivokapic, J. M., Pociot, F., Eizirik, D. L., Meda, P., Hoist, B., Billestrup, N. & Storling, J., 2017, In: Molecular and Cellular Endocrinology. 448, p. 108-121 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)
• 2016

  Aberrant accumulation of the diabetes autoantigen GAD65 in Golgi membranes in conditions of ER stress and autoimmunity

  Phelps, E. A., Cianciaruso, C., Michael, I. P., Pasquier, M., Kanaani, J., Nano, R., Lavallard, V., Billestrup, N., Hubbell, J. A. & Baekkeskov, S., Sep 2016, In: Diabetes. 65, 9, p. 2686-2699

  Research output: Contribution to journal › Journal article › Research › peer-review
  27 Citations (Scopus)

• Inflammatory Cytokines Stimulate Bone Morphogenetic Protein-2 Expression and Release from Pancreatic Beta Cells

  Urizar, A. I., Friberg, J., Christensen, D. P., Christensen, G. L. & Billestrup, N., 1 Jan 2016, In: Journal of Interferon & Cytokine Research. 36, 1, p. 20-29

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)

• JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1 beta-Induced Apoptosis Associated with Abrogated Myc Expression

  Prause, M., Mayer, C. M., Brorsson, C., Frederiksen, K. S., Billestrup, N., Storling, J. & Mandrup-Poulsen, T., 2016, In: Journal of Diabetes Research. 2016, 15 p., 1312705.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  10 Citations (Scopus)

  259 Downloads (Pure)

• Regulation of Pancreatic Alpha Cell Function and Proliferation by Bone Morphogenetic Protein 4 (BMP4) in vitro.

  Nielsen, S. S., Christensen, G. L., Holst, J. J. & Billestrup, N., Oct 2016, In: Endocrinology. 157, 10, p. 3809-3820 12 p., 27479530 .

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• Regulation of Pancreatic α-Cell Function and Proliferation by Bone Morphogenetic Protein 4 (BMP4) In Vitro

  Nielsen, S. S., Christensen, G. L., Holst, J. J. & Billestrup, N., Oct 2016, In: Endocrinology. 157, 10, p. 3809-3820 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells

  Prause, M., Berchtold, L. A., Urizar, A. I., Trauelsen, M., Billestrup, N., Mandrup-Poulsen, T. & Størling, J., 15 Jan 2016, In: Molecular and Cellular Endocrinology. 420, p. 24-36 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)
• 2015

  Bone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currents

  Christensen, G. L., Jacobsen, M. L. B., Wendt, A., Mollet, I. G., Friberg, J., Frederiksen, K. S., Meyer, M., Bruun, C., Eliasson, L. & Billestrup, N., Jun 2015, In: Diabetologia. 58, 6, p. 1282-1290 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)

• Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons

  Kanaani, J., Cianciaruso, C., Phelps, E. A., Pasquier, M., Brioudes, E., Billestrup, N. & Baekkeskov, S., 2015, In: PLOS ONE. 10, 2, p. 1-24 24 p., e0117130.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  28 Citations (Scopus)

• Surface-expressed insulin receptors as well as IGF-I receptors both contribute to the mitogenic effects of human insulin and its analogues

  Lundby, A., Bolvig, P., Hegelund, A. C., Hansen, B. F., Worm, J., Lützen, A., Billestrup, N., Bonnesen, C. & Oleksiewicz, M. B., Jul 2015, In: Journal of Applied Toxicology. 35, 7, p. 842-850 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)

• The Anti-diabetic Effects of GLP-1-gastrin Dual Agonist ZP3022 in ZDF rats

  Skarbaliene, J., Secher, T., Jelsing, J., Ansarullah, Neerup, T. S. R., Billestrup, N. & Fosgerau, K., Jul 2015, In: Peptides. 69, p. 47-55 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  23 Citations (Scopus)
• 2014

  Co-ordinated regulation of neurogenin-3 expression in the maternal and fetal pancreas during pregnancy

  Søstrup, B., Gaarn, L. W., Nalla, A., Billestrup, N. & Nielsen, J. H., Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1190-7 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• CRFR1 activation protects against cytokine-induced beta cell death

  Blaabjerg, L., Christensen, G. L., Matsumoto, M., van der Meulen, T., Huising, M. O., Billestrup, N. & Vale, W., 16 Oct 2014, In: Journal of Molecular Endocrinology. 53, p. 417-427 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• Impact of fetal and neonatal environment on beta cell function and development of diabetes

  Nielsen, J. H., Haase, T. N., Jaksch, C., Nalla, A., Søstrup, B., Nalla, A. A., Larsen, L., Rasmussen, M., Dalgaard, L. T., Gaarn, L. W., Thams, P., Kofod, H. & Billestrup, N., Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1109-22 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  71 Citations (Scopus)

• Implications for the offspring of circulating factors involved in beta cell adaptation in pregnancy

  Nalla, A., Ringholm, L., Søstrup, B., Højrup, P., Thim, L., Levery, S. B., Vakhrushev, S. Y., Billestrup, N., Mathiesen, E. R., Damm, P. & Nielsen, J. H., Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1181-9 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)

• Inhibition of beta cell growth and function by bone morphogenetic proteins

  Bruun, C., Christensen, G. L., Jacobsen, M. L. B., Kanstrup, M. B., Jensen, P. R., Fjordvang, H., Mandrup-Poulsen, T. & Billestrup, N., 27 Sep 2014, In: Diabetologia. 57, 12, p. 2546-54 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  32 Citations (Scopus)

• JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis

  Prause, M., Christensen, D. P., Billestrup, N. & Mandrup-Poulsen, T., 2014, In: PLOS ONE. 9, 1, p. 1-11 11 p., e87067.

  Research output: Contribution to journal › Journal article › Research › peer-review
  35 Citations (Scopus)

• Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

  Christensen, D. P., Gysemans, C., Lundh, M., Dahllöf, M. S., Noesgaard, D., Schmidt, S. F., Mandrup, S., Birkbak, N., Workman, C., Piemonti, L., Blaabjerg, L., Monzani, V., Fossati, G., Mascagni, P., Paraskevas, S., Aikin, R. A., Billestrup, N., Grunnet, L. G., Dinarello, C. A., Mathieu, C. & 1 others, Mandrup-Poulsen, T., 6 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. 1055-9 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  59 Citations (Scopus)

• The mitogenic effect of Gas6 on pancreatic beta cells is mediated via the receptor tyrosine kinase Axl

  Haase, T. N., Gustafsson, A., Nalla, A., Ringholm, L., Damm, P., Mathiesen, E. R., Dahlback, B., Billestrup, N. & Nielsen, J. H., Sep 2014, In: Diabetologia. 57, 1 Suppl, p. S173-S174 408.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
• 2013

  Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell

  Haase, T. N., Rasmussen, M., Jaksch, C. A. M., Gaarn, L. W., Petersen, C. K., Billestrup, N. & Nielsen, J. H., Apr 2013, In: Diabetologia. 56, 4, p. 763-773 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)
• 2012

  Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ß cell fate in response to cytokines

  Hansen, J. B., Tonnesen, M. F., Madsen, A. N., Hagedorn, P., Friberg, J., Grunnet, L. G., Heller, R. S., Nielsen, A. Ø., Størling, J., Baeyens, L., Anker-Kitai, L., Qvortrup, K., Bouwens, L., Efrat, S., Aalund, M., Andrews, N. C., Billestrup, N., Karlsen, A. E., Holst, B., Pociot, F. & 1 others, Mandrup-Poulsen, T., 2012, In: Cell Metabolism. 16, 4, p. 449-61 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  135 Citations (Scopus)
• 2011

  Direct demonstration of NCAM cis-dimerization and inhibitory effect of palmitoylation using the BRET2 technique

  Kulahin, N., Grunnet, L. G., Lundh, M., Christensen, D. P., Jorgensen, R., Heding, A., Billestrup, N., Berezin, V., Bock, E. & Mandrup-Poulsen, T., 3 Jan 2011, In: FEBS Letters. 585, 1, p. 58-64 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• Endothelial Progenitor Cells in Long-Standing Asymptomatic Type 1 Diabetic Patients with or without Diabetic Nephropathy

  Reinhard, H., Jacobsen, P. K., Lajer, M., Tarnow, L., Astrup, A. S., Kim, W. Y., Pedersen, N., Billestrup, N., Mandrup-Poulsen, T., Parving, H-H. & Rossing, P., 2011, In: Nephron Clinical Practice. 118, 3, p. c309-c314 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus

  Christensen, D. P., Dahllöf, M. S., Lundh, M., Rasmussen, D. N., Nielsen, M. D., Billestrup, N., Grunnet, L. G. & Mandrup-Poulsen, T., 2011, In: Molecular Medicine. 17, 5-6, p. 378-90 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  211 Citations (Scopus)

• ID'ing a novel inhibitor of β-cell function, Id1

  Billestrup, N., Oct 2011, In: Diabetes. 60, 10, p. 2455-6 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• ß-cell specific overexpression of suppressor of cytokine signalling-3 does not protect against multiple low dose streptozotocin induced type 1 diabetes in mice

  Börjesson, A., Rønn, S. G., Karlsen, A. E., Billestrup, N. & Sandler, S., 30 Apr 2011, In: Immunology Letters. 136, 1, p. 74-9 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)
• 2010

  Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells

  Eriksen, K. W., Woetmann, A., Skov, L., Krejsgaard, T., Bovin, L. F., Hansen, M. L., Grønbæk, K., Billestrup, N., Nissen, M. H., Geisler, C., Wasik, M. A. & Odum, N., 2010, In: Journal of Investigative Dermatology. 130, 6, p. 1590-7 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  39 Citations (Scopus)

• Dissociation between skeletal muscle inhibitor-{kappa}B kinase/nuclear factor-{kappa}B pathway activity and insulin sensitivity in nondiabetic twins

  Friedrichsen, M., Ribel-Madsen, R., Wojtaszewski, J., Grunnet, L., Richter, E. A., Billestrup, N., Ploug, T., Vaag, A. & Poulsen, P., 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 1, p. 414-421 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)

• Genetic deficiency of tissue inhibitor of metalloproteinase (TIMP) 1 does not affect apoptosis in cytokine-exposed mouse islets in vitro.

  Hansen, J. B., Tonnesen, M. F., Rømer, M. U. K., Billestrup, N., Brunner, N. & Mandrup-Poulsen, T., 2010, (Accepted/In press).

  Research output: Contribution to conference › Conference abstract for conference › Research

• Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines

  Lundh, M., Christensen, D. P., Rasmussen, D. N., Mascagni, P., Dinarello, C. A., Billestrup, N., Grunnet, L. G. & Mandrup-Poulsen, T., 1 Dec 2010, In: Diabetologia. 53, 12, p. 2569-78 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  67 Citations (Scopus)

• Multifactorial treatment increases endothelial progenitor cells in patients with type 2 diabetes

  Reinhard, H., Jacobsen, P. K., Lajer, M., Pedersen, N., Billestrup, N., Mandrup-Poulsen, T., Parving, H-H. & Rossing, P., 1 Oct 2010, In: Diabetologica. 53, 10, p. 2129-33 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  35 Citations (Scopus)
• 2009

  CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner

  Huising, M. O., van der Meulen, T., Vaughan, J. M., Matsumoto, M., Donaldson, C. J., Park, H., Billestrup, N. & Vale, W. W., 2009, In: Proceedings of the National Academy of Science of the United States of America. 107, 2, p. 912-7 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  67 Citations (Scopus)

• IL-1 beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells

  Jacobsen, M. L. B., Ronn, S. G., Bruun, C., Larsen, C. M., Eizirik, D. L., Mandrup-Poulsen, T. & Billestrup, N., 2009, In: Diabetologia. 52, 2, p. 281-288 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells

  Tonnesen, M. F., Grunnet, L. G., Friberg, J., Cardozo, A. K., Billestrup, N., Eizirik, D. L., Størling, J. & Mandrup-Poulsen, T., Sep 2009, In: Endocrinology. 150, 9, p. 4094-103 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  33 Citations (Scopus)

• Inhibition of Nuclear Factor-kappa B or Bax Prevents Endoplasmic Reticulum Stress-But Not Nitric Oxide-Mediated Apoptosis in INS-1E Cells

  Tonnesen, M. F., Grunnet, L. G., Friberg, J., Cardozo, A. K., Billestrup, N., Eizirik, D. L., Storling, J. & Mandrup-Poulsen, T., 2009, In: Endocrinology. 150, 9, p. 4094-4103 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells

  Grunnet, L. G., Aikin, R., Tonnesen, M. F., Paraskevas, S., Blaabjerg, L., Størling, J., Rosenberg, L., Billestrup, N., Maysinger, D. & Mandrup-Poulsen, T., 2009, In: Diabetes. 58, 8, p. 1807-15 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  181 Citations (Scopus)

• Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells

  Bruun, C., Heding, P. E., Rønn, S. G., Frobøse, H., Rhodes, C. J., Mandrup-Poulsen, T. & Billestrup, N., 2009, In: Molecular and Cellular Endocrinology. 311, 1-2, p. 32-8 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  29 Citations (Scopus)

• The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells

  Collombat, P., Xu, X., Ravassard, P., Sosa-Pineda, B., Dussaud, S., Billestrup, N., Madsen, O. D., Serup, P., Heimberg, H. & Mansouri, A., 2009, In: Cell. 138, 3, p. 449-62 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  464 Citations (Scopus)
• 2008

  Dedifferentiation for replication of human beta-cells: a division between mice and men?

  Billestrup, N. & Otonkoski, T., 2008, In: Diabetes. 57, 6, p. 1457-8 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)

• IL-1beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells

  Jacobsen, M. L. B., Rønn, S. G., Bruun, C., Larsen, C. M., Eizirik, D. L., Mandrup-Poulsen, T. & Billestrup, N., 2008, In: Diabetologia. 52, 2, p. 281-8 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• Impact of fasting on growth hormone signaling and action in muscle and fat

  Moller, L., Dalman, L., Norrelund, H., Billestrup, N., Frystyk, J., Moller, N. & Jorgensen, J. O. L., 2008, In: Journal of Clinical Endocrinology and Metabolism. 94, 3, p. 965-72 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  39 Citations (Scopus)