Research output per year
Research output per year
- 1 - 50 out of 366 results
Search results
-
2024
A Multi-Center Randomized, Double-Blind, Placebo Controlled, Parallel Group, Phase IIa Study to Evaluate the Efficacy, Safety and Tolerability of an Anthocyanin Rich Extract (ACRE) in Patients with Ulcerative Colitis
Biedermann, L., Doulberis, M., Schreiner, P., Nielsen, O. H., The, F. O., Brand, S., Burk, S., Hurz, P., Juillerat, P., Krieger-Gruebel, C., Leu, K., Leventhal, G., Misselwitz, B., Scharl, S., Schoepfer, A., Seibold, F., Herfarth, H., Rogler, G. & Rogler, G., 2024.Research output: Working paper › Preprint › Research
-
Deep Visual Proteomics advances human colon organoid models by revealing a switch to an in vivo-like phenotype upon xenotransplantation
Post, F., Hausmann, A., Kabatnik, S., Steigerwald, S., Jønsson, A. B., Clement, D. L., Skov, J., Boye, T. L., Sato, T., Mund, A., Nielsen, O. H., Jensen, K. B. & Mann, M., 2024, 45 p.Research output: Working paper › Preprint › Research
File4 Downloads (Pure) -
Diagnosis and Pharmacological Management of Microscopic Colitis in Geriatric Care
Nielsen, O. H. & Pardi, D. S., 2024, In: Drugs and Aging. 41, p. 113-123 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)5 Downloads (Pure) -
Effects of smoking on clinical treatment outcomes amongst patients with chronic inflammatory diseases initiating biologics: secondary analyses of the prospective BELIEVE cohort study
Larsen, M. G. R., Overgaard, S. H., Petersen, S. R., Møllegaard, K. M., Munk, H. L., Nexøe, A. B., Glerup, H., Guldmann, T., Pedersen, N., Saboori, S., Dahlerup, J. F., Hvas, C. L., Andersen, K. W., Jawhara, M., Nielsen, O. H., Bergenheim, F. O., Brodersen, J. B., Bygum, A., Ellingsen, T., Kjeldsen, J. & 2 others, , 2024, In: Scandinavian Journal of Immunology. 100, 3, 15 p., e13395.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Downloads (Pure) -
Gut Microbiome and Disorders of the Gastrointestinal Tract
Hammerhøj, A., Gubatan, J. M. & Nielsen, O. H., 2024, In: Microorganisms. 12, 3, 2 p., 576.Research output: Contribution to journal › Editorial › Research › peer-review
Open AccessFile2 Citations (Scopus)3 Downloads (Pure) -
High-dimensional profiling demonstrates complexity, tissue imprinting, and lineage-specific precursors within the mononuclear phagocyte compartment of the human intestine
Fenton, T. M., Wulff, L., Jones, G-R., Vandamme, J., Jørgensen, P. B., Bain, C. C., Lee, J., Izarzugaza, J. M., Belling, K. G., Ho, G-T., Nielsen, O. H., Riis, L. B., Pers, T. H., Jakobsen, H. L., Mowat, A. M., Brunak, S. & Agace, W. W., 2024, 123 p.Research output: Working paper › Preprint › Research
File -
IAPs and RIPK1 mediate LPS-induced cytokine production in healthy subjects and Crohn's disease
Seidelin, J. B., Jensen, S., Hansen, M., Bronze, M. R. D. C., Cuchet-Lourenҫo, D., Nejentsev, S., LaCasse, E. C. & Nielsen, O. H., 2024, In: Clinical and Experimental Immunology. 215, 3, p. 291–301 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
-
Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation
Hausmann, A., Steenholdt, C., Nielsen, O. H. & Jensen, K. B., 2024, In: Trends in Molecular Medicine. 30, 3, p. 239-251Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile3 Citations (Scopus)14 Downloads (Pure) -
Immune Checkpoint Inhibitor-Induced Cardiotoxicity: A Systematic Review and Meta-Analysis
Nielsen, D. L., Juhl, C. B., Nielsen, O. H., Chen, I. M. & Herrmann, J., 22 Aug 2024, (E-pub ahead of print) In: JAMA Oncology.Research output: Contribution to journal › Journal article › Research › peer-review
-
Immunogenicity of Therapeutic Antibodies Used for Inflammatory Bowel Disease: Treatment and Clinical Considerations
Nielsen, O. H., Hammerhøj, A., Ainsworth, M. A., Gubatan, J. & D'Haens, G., 13 Nov 2024, (E-pub ahead of print) In: Drugs. 19 p.Research output: Contribution to journal › Review › Research › peer-review
-
Impact of gluten intake on clinical outcomes in patients with chronic inflammatory diseases initiating biologics: Secondary analysis of the prospective multicentre BELIEVE cohort study
Gregersen, L., Jessen, P. D., Lund, H. W., Overgaard, S. H., Hikmat, Z., Ellingsen, T., Kjeldsen, J., Pedersen, A. K., Petersen, S. R., Jawhara, M., Nexøe, A. B., Bygum, A., Hvas, C. L., Dahlerup, J. F., Bergenheim, F. O., Glerup, H., Henriksen, R. H., Guldmann, T., Hvid, L., Brodersen, J. & 8 others, , 2024, (Accepted/In press) In: Scandinavian Journal of Immunology.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access -
Influence of vitamin D receptor signalling and vitamin D on colonic epithelial cell fate decisions in ulcerative colitis
Kellermann, L., Hansen, S. L., Maciag, G., Granau, A. M., Johansen, J. V., Teves, J. M., Bressan, R. B., Pedersen, M. T., Soendergaard, C., Baattrup, A. M., Hammerhøj, A., Riis, L. B., Gubatan, J., Jensen, K. B. & Nielsen, O. H., 2024, In: Journal of Crohn's & colitis. 18, 10, p. 1672–1689 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile -
In Severe Inflammatory Bowel Disease, the Onset of Effectiveness of Biologics and Small Molecules Depends More on the Medication Than on the Diagnosis
Attauabi, M., Burisch, J., Nielsen, O. H. & Seidelin, J. B., 2024, In: Inflammatory Bowel Diseases. 30, 10, p. 1931-1932 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
-
JAK/STAT signaling promotes the emergence of unique cell states in ulcerative colitis
Maciag, G., Hansen, S. L., Krizic, K., Kellermann, L., Zøylner, M. J. I., Ulyanchenko, S., Maimets, M., Baattrup, A. M., Riis, L. B., Khodosevich, K., Sato, T., Bardini Bressan, R., Nielsen, O. H. & Jensen, K. B., 2024, In: Stem Cell Reports. 19, 8, p. 1172–1188 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Downloads (Pure) -
Metabolomics for enhanced clinical understanding of inflammatory bowel disease
Boye, T. L., Hammerhøj, A., Nielsen, O. H. & Wang, Y., 2024, In: Life Sciences. 359, 14 p., 123238.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile -
Microfibrillar-associated protein 4 as a predictive biomarker of treatment response in patients with chronic inflammatory diseases initiating biologics: secondary analyses based on the prospective BELIEVE cohort study
Sofíudóttir, B. K., Munk, H. L., Christensen, R., Möller, S., Overgaard, S. H., Sorensen, G. L., Møllegaard, K. M., Pingel, J., Nexøe, A. B., Glerup, H., Guldmann, T., Pedersen, N., Dahlerup, J. F., Hvas, C. L., Andersen, K. W., Jawhara, M., Nielsen, O. H., Bergenheim, F. O., Bygum, A., Davidsen, J. R. & 5 others, , 28 Oct 2024, (E-pub ahead of print) In: Rheumatology International. 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access -
Mirikizumab (Omvoh™) for ulcerative colitis
Hammerhøj, A., Boye, T. L., Langholz, E. & Nielsen, O. H., 2024, In: Trends in Pharmacological Sciences. 45, 3, p. 281-282 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
-
Network meta-analysis: Comparative onset of early effect of biologics and small molecules in moderately to severely active luminal Crohn's disease
Attauabi, M., Steenholdt, C., Poulsen, A., Gubatan, J., Burisch, J., Haagen Nielsen, O. & Seidelin, J. B., 2024, In: Alimentary Pharmacology and Therapeutics. 60, 2, p. 124-143Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
Organoids as regenerative medicine for inflammatory bowel disease
Hammerhøj, A., Chakravarti, D., Sato, T., Jensen, K. B. & Nielsen, O. H., 2024, In: iScience. 27, 6, 12 p., 110118.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile2 Citations (Scopus)8 Downloads (Pure) -
Updates on the management of inflammatory bowel disease from periconception to pregnancy and lactation
Nielsen, O. H., Gubatan, J. M., Kolho, K-L., Streett, S. E. & Maxwell, C., 30 Mar 2024, In: The Lancet. 403, 10433, p. 1291-1303 13 p.Research output: Contribution to journal › Review › Research › peer-review
6 Citations (Scopus) -
2023
Comparative onset of effect of biologics and small molecules in moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis
Attauabi, M., Dahl, E. K., Burisch, J., Gubatan, J., Nielsen, O. H. & Seidelin, J. B., 2023, In: EClinicalMedicine. 57, 3, 101866.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile11 Citations (Scopus)16 Downloads (Pure) -
Deucravacitinib (Sotyktu™) for plaque psoriasis
Granau, A. M., Boye, T. L., Jensen, K. B. & Nielsen, O. H., 2023, In: Trends in Pharmacological Sciences. 44, 4, p. 252-253Research output: Contribution to journal › Letter › Research › peer-review
Open AccessFile2 Citations (Scopus)11 Downloads (Pure) -
Effectiveness of Non-Budesonide Therapies in Management of Microscopic Colitis: A Systematic Review and Meta-analysis
Rehde, A., Hendel, S. K., Juhl, C. B., Gubatan, J. & Nielsen, O. H., 2023, In: Drugs. 83, 11, p. 1027-1038 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Citations (Scopus)4 Downloads (Pure) -
Investigating the Crime Scene—Molecular Signatures in Inflammatory Bowel Disease
Andersen, V., Bennike, T. B., Bang, C., Rioux, J. D., Hébert-Milette, I., Sato, T., Hansen, A. K. & Nielsen, O. H., 2023, In: International Journal of Molecular Sciences. 24, 13, 11217.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile3 Citations (Scopus)17 Downloads (Pure) -
Kinase Signaling in Colitis-Associated Colon Cancer and Inflammatory Bowel Disease
Temby, M., Boye, T. L., Hoang, J., Nielsen, O. H. & Gubatan, J., Nov 2023, In: Biomolecules. 13, 11, 14 p., 1620.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile2 Citations (Scopus)7 Downloads (Pure) -
Paternal Medications in Inflammatory Bowel Disease and Male Fertility and Reproductive Outcomes: A Systematic Review and Meta-analysis
Gubatan, J., Barber, G. E., Nielsen, O. H., Juhl, C. B., Maxwell, C., Eisenberg, M. L. & Streett, S. E., 2023, In: Clinical Gastroenterology and Hepatology. 21, 9, p. 2222-2238 17 p.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile6 Citations (Scopus)2 Downloads (Pure) -
Selective JAK1 inhibitors for the treatment of inflammatory bowel disease
Nielsen, O. H., Boye, T. L., Gubatan, J., Chakravarti, D., Jaquith, J. B. & LaCasse, E. C., 2023, In: Pharmacology and Therapeutics. 245, 108402.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile11 Citations (Scopus)10 Downloads (Pure) -
2022
Biologics for Inflammatory Bowel Disease and their Safety in Pregnancy: A Systematic Review and Meta-analysis
Nielsen, O. H., Gubatan, J. M., Juhl, C. B., Streett, S. E. & Maxwell, C., 2022, In: Clinical Gastroenterology and Hepatology. 20, 1, p. 74-87.e3Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile66 Citations (Scopus)16 Downloads (Pure) -
COLAR: open-label clinical study of IL-6 blockade with tocilizumab for the treatment of immune checkpoint inhibitor-induced colitis and arthritis
Holmstroem, R. B., Nielsen, O. H., Jacobsen, S., Riis, L. B., Theile, S., Bjerrum, J. T., Vilmann, P., Johansen, J. S., Boisen, M. K., Eefsen, R. H. L., Marie Svane, I., Nielsen, D. L. & Chen, I. M., 2022, In: Journal for ImmunoTherapy of Cancer. 10, 9Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile28 Citations (Scopus)20 Downloads (Pure) -
Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer
Gubatan, J., Boye, T. L., Temby, M., Sojwal, R. S., Holman, D. R., Sinha, S. R., Rogalla, S. R. & Nielsen, O. H., 2022, In: Microorganisms. 10, 7, 1371.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile26 Citations (Scopus)17 Downloads (Pure) -
Impact of fibre and red/processed meat intake on treatment outcomes among patients with chronic inflammatory diseases initiating biological therapy: A prospective cohort study
Overgaard, S. H., Sørensen, S. B., Munk, H. L., Nexøe, A. B., Glerup, H., Henriksen, R. H., Guldmann, T., Pedersen, N., Saboori, S., Hvid, L., Dahlerup, J. F., Hvas, C. L., Jawhara, M., Andersen, K. W., Pedersen, A. K., Nielsen, O. H., Bergenheim, F., Brodersen, J. B., Heitmann, B. L., Halldorsson, T. I. & 6 others, , 2022, In: Frontiers in Nutrition. 9, 13 p., 985732.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile11 Citations (Scopus)24 Downloads (Pure) -
Lipidomic Trajectories Characterize Delayed Mucosal Wound Healing in Quiescent Ulcerative Colitis and Identify Potential Novel Therapeutic Targets
Bjerrum, J. T., Wang, Y., Zhang, J., Riis, L. B., Nielsen, O. H. & Seidelin, J. B., 2022, In: International Journal of Biological Sciences. 18, 5, p. 1813-1828 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile5 Citations (Scopus)18 Downloads (Pure) -
Microscopic colitis: Etiopathology, diagnosis, and rational management
Nielsen, O. H., Fernandez-Banares, F., Sato, T. & Pardi, D. S., 1 Aug 2022, In: eLife. 11, 21 p., e79397.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile24 Citations (Scopus)9 Downloads (Pure) -
Molecular Manipulations and Intestinal Stem Cell-Derived Organoids in Inflammatory Bowel Disease
Boye, T. L., Steenholdt, C., Jensen, K. B. & Nielsen, O. H., 2022, In: Stem Cells. 40, 5, p. 447-457Research output: Contribution to journal › Journal article › Research › peer-review
7 Citations (Scopus) -
Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select
Niu, Y., Azevedo, C. A. F., Li, X., Kamali, E., Nielsen, O. H., Sørensen, C. S. & Frödin, M., 2022, In: Nature Genetics. 54, 28 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile10 Citations (Scopus)53 Downloads (Pure) -
Reply
Nielsen, O. H., Gubatan, J. & Juhl, C. B., 2022, In: Clinical Gastroenterology and Hepatology. 20, 4, p. 963-964Research output: Contribution to journal › Comment/debate › Research › peer-review
-
Selective tyrosine kinase 2 inhibitors in inflammatory bowel disease
Nielsen, O. H., Boye, T. L., Chakravarti, D. & Gubatan, J., 2022, In: Trends in Pharmacological Sciences. 43, 5, p. 424-436Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile14 Citations (Scopus)9 Downloads (Pure) -
Tuft Cells and Their Role in Intestinal Diseases
Hendel, S. K., Kellermann, L., Hausmann, A., Bindslev, N., Jensen, K. B. & Nielsen, O. H., 2022, In: Frontiers in Immunology. 13, 13 p., 822867.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile21 Downloads (Pure) -
2021
Biologics During Pregnancy in Women With Inflammatory Bowel Disease and Risk of Infantile Infections: A Systematic Review and Meta-Analysis
Gubatan, J. M., Nielsen, O. H., Levitte, S., Juhl, C. B., Maxwell, C., Streett, S. E. & Habtezion, A., 2021, In: Am J Gastroenterol. 116, 2, p. 243-253Research output: Contribution to journal › Journal article › Research › peer-review
Open Access20 Citations (Scopus) -
IBD metabonomics predicts phenotype, disease course, and treatment response
Bjerrum, J. T., Wang, Y. L., Seidelin, J. B. & Nielsen, O. H., 2021, In: EBioMedicine. 71, 103551.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile21 Citations (Scopus)12 Downloads (Pure) -
Identification, isolation and analysis of human gut-associated lymphoid tissues
Jørgensen, P. B., Fenton, T. M., Mörbe, U. M., Riis, L. B., Jakobsen, H. L., Nielsen, O. H. & Agace, W. W., 22 Feb 2021, In: Nature Protocols. 16, p. 2051–2067Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile31 Citations (Scopus)12 Downloads (Pure) -
Telomere dysfunction instigates inflammation in inflammatory bowel disease
Chakravarti, D., Lee, R., Multani, A. S., Santoni, A., Keith, Z., Hsu, W. H., Chang, K., Reyes, L., Rashid, A., Wu, C. J., Li, J., Zhang, J., Shim, H. S., Chandra, K., Deng, P., Spring, D. J., Nielsen, O. H., Riis, L. B., Mayigegowda, K. K., Blutt, S. E. & 9 others, , 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 29, e2024853118.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access32 Citations (Scopus) -
2020
A fully defined 3D matrix for ex vivo expansion of human colonic organoids from biopsy tissue
Bergenheim, F., Fregni, G., Buchanan, C. F., Riis, L. B., Heulot, M., Touati, J., Seidelin, J. B., Rizzi, S. C. & Nielsen, O. H., 2020, In: Biomaterials. 262, 11 p., 120248.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile19 Citations (Scopus)34 Downloads (Pure) -
Efficacy and safety of methotrexate in the management of inflammatory bowel disease: A systematic review and meta-analysis of randomized, controlled trials
Nielsen, O. H., Steenholdt, C., Juhl, C. B. & Rogler, G., Mar 2020, In: EClinicalMedicine. 20, 10 p., 100271.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile35 Citations (Scopus)23 Downloads (Pure) -
Immune Profiling of Human Gut-Associated Lymphoid Tissue Identifies a Role for Isolated Lymphoid Follicles in Priming of Region-Specific Immunity
Fenton, T. M., Jørgensen, P. B., Niss, K., Rubin, S. J. S., Mörbe, U. M., Riis, L. B., Da Silva, C., Plumb, A., Vandamme, J., Jakobsen, H. L., Brunak, S., Habtezion, A., Nielsen, O. H., Johansson-Lindbom, B. & Agace, W. W., 2020, In: Immunity. 52, 3, p. 557-570, e1-e6Research output: Contribution to journal › Journal article › Research › peer-review
Open Access83 Citations (Scopus) -
Mucosal vitamin D signaling in inflammatory bowel disease
Kellermann, L., Jensen, K. B., Bergenheim, F., Gubatan, J., Chou, N. D., Moss, A. & Nielsen, O. H., 2020, In: Autoimmunity Reviews. 19, 11, 102672.Research output: Contribution to journal › Review › Research › peer-review
37 Citations (Scopus) -
SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory diseases
Jensen, S., Seidelin, J. B., LaCasse, E. C. & Nielsen, O. H., 2020, In: Science Signaling. 13, 619, 18 p., eaax8295.Research output: Contribution to journal › Review › Research › peer-review
42 Citations (Scopus) -
Telomere dysfunction activates YAP1 to drive tissue inflammation
Chakravarti, D., Hu, B., Mao, X., Rashid, A., Li, J., Li, J., Liao, W. T., Whitley, E. M., Dey, P., Hou, P., LaBella, K. A., Chang, A., Wang, G., Spring, D. J., Deng, P., Zhao, D., Liang, X., Lan, Z., Lin, Y., Sarkar, S. & 16 others, , 2020, In: Nature Communications. 11, 13 p., 4766.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile51 Citations (Scopus)17 Downloads (Pure) -
2019
Biosimilars for management of Crohn disease
Nielsen, O. H. & Ainsworth, M. A., 2019, In: Annals of Internal Medicine. 170, 2, p. 129-130 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
4 Citations (Scopus) -
Fluorescence-based tracing of transplanted intestinal epithelial cells using confocal laser endomicroscopy
Bergenheim, F., Seidelin, J. B., Pedersen, M. T., Mead, B. E., Jensen, K. B., Karp, J. M. & Nielsen, O. H., 2019, In: Stem Cell Research & Therapy. 10, 1, p. 1-12 12 p., 148.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile12 Citations (Scopus)98 Downloads (Pure)