Ole Jannik Bjerrum

Research output

Research output per year 1979 2011 2013 2022

• 979 Citations
• 51 Journal article
• 28 Poster
• 3 Review
• 2 Book chapter
• 8 More
  • 2 Encyclopedia chapter
  • 2 Comment/debate
  • 2 Conference abstract in journal
  • 1 Conference abstract for conference
  • 1 Letter

Research output per year

Research output per year

Search results

• 2022

  Dorsal horn volume loss and pain pathway changes in Cavalier King Charles Spaniels with syringomyelia, signs of pain, and phantom scratching

  Mortensen, D., Thoefner, M. S., Agerholm, J. S., Slumstrup, L., Jensen, T. S., Bjerrum, O. J., Berendt, M. & Nyengaard, J. R., 2022, In: Pain. 163, 12, p. 2365-2379

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)
• 2020

  Analysis of the Authorized Target Populations for Fixed Dose Combination Products Between 2000 and 2017 Reveals Discrepancies Between EMA's and FDA's Views on Initial Dual-Therapy

  Bjerrum, O. J., Eichendorff, S. & Alkis, N. B., Mar 2020, In: Therapeutic Innovation & Regulatory Science. 54, 2, p. 297-302 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Demonstrating Contribution of Components of Fixed-Dose Drug Combinations Through Longitudinal Exposure-Response Analysis

  Nøhr-Nielsen, A., Lange, T., Forman, J. L., Papathanasiou, T., Foster, D. J. R., Upton, R. N., Bjerrum, O. J. & Lund, T. M., 2020, In: The AAPS Journal. 22, 2, 32.

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• Pregabalin alleviates clinical signs of syringomyelia-related central neuropathic pain in Cavalier King Charles Spaniel dogs: a randomized controlled trial

  Thoefner, M. S., Skovgaard, L. T., McEvoy, F. J., Berendt, M. & Bjerrum, O. J., 2020, In: Veterinary Anaesthesia and Analgesia. 47, 2, p. 238–248

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  8 Citations (Scopus)

  240 Downloads (Pure)
• 2019

  Analysis of the Authorized Target Populations for Fixed Dose Combination Products Between 2000 and 2017 Reveals Discrepancies Between EMA’s and FDA’s Views on Initial Dual-Therapy

  Bjerrum, O. J., Eichendorff, S. & Alkis, N. B., 2019, In: Therapeutic Innovation & Regulatory Science. 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Body of evidence and approaches applied in the clinical development programme of fixed-dose combinations in the European Union from 2010 to 2016

  Nøhr-Nielsen, A., De Bruin, M. L., Thomsen, M., Pipper, C. B., Lange, T., Bjerrum, O. J. & Lund, T. M., 2019, In: British Journal of Clinical Pharmacology. 85, 8, p. 1829-1840 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  6 Citations (Scopus)

• Community pharmacies as platform for collection of real-world evidence of medicines usage explored through a pilot study: From standard T2D medication to treatment with the injectable combination product Xultophy

  Alkis, N., Nørgaard, L. S. & Bjerrum, O. J., 2019.

  Research output: Contribution to conference › Poster › Research › peer-review

• Glutamate transport system as a key constituent of glutamosome: Molecular pathology and pharmacological modulation in chronic pain

  Gegelashvili, G. & Bjerrum, O. J., 2019, In: Neuropharmacology. 161, 107623.

  Research output: Contribution to journal › Review › Research › peer-review
  19 Citations (Scopus)

• Mechanical sensory threshold in Cavalier King Charles spaniels with syringomyelia-associated scratching and control dogs

  Thoefner, M. S., Westrup, U., Toft, N., Bjerrum, O. J. & Berendt, M., 2019, In: Veterinary Journal. 246, p. 92-97 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  8 Citations (Scopus)

  37 Downloads (Pure)
• 2018

  Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity

  Nasser, A., Møller, A. T., Hellmund, V., Thorborg, S. S., Jespersgaard, C., Bjerrum, O. J., Dupontd, E., Nachman, G., Lykkesfeldt, J., Jensen, T. S. & Møller, L. B., 2018, In: Pain. 159, 6, p. 1012-1024 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• Identifying Off-label Prescriptions trough Data Mining in Danish Community Pharmacy Servers: An exploratory Study on Desmopressin, Diclofenac, Fucidin, Mirtazapine and Quetiapine

  Bjerrum, O. J. & Androlyte, M., Aug 2018, In: Basic & Clinical Pharmacology & Toxicology. 123 , 2, p. 155–160 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• The β-lactam clavulanic acid mediates glutamate transport-sensitive pain relief in a rat model of neuropathic pain

  Kristensen, P. J., Gegelashvili, G., Munro, G., Heegaard, A. M. & Bjerrum, O. J., Feb 2018, In: European Journal of Pain. 22, 2, p. 282-294

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)
• 2017

  From Face-to-fase training to blended learning in the postgraduate program SafeSciMet - a case study

  Bjerrum, O. J., Vos, C., Dragovic, S., Jochimsen, M., Dirac, J., Foth, H. & Wiese, J., 2017, In: European Journal of Pharmaceutical Sciences. 96, p. III-VIII 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Glutamate Transport System as a Novel Therapeutic Target in Chronic Pain: Molecular Mechanisms and Pharmacology

  Gegelashvili, G. & Bjerrum, O. J., 2017, Glial Amino Acid Transporters. Springer, Vol. 16. p. 225-253 29 p. (Advances in Neurobiology).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  15 Citations (Scopus)

• Vendor-derived differences in injury-induced pain phenotype and pharmacology of Sprague-Dawley rats: Does it matter?

  Kristensen, P. J., Heegaard, A. M., Kristensen, S. H., Jeggo, R. D., Bjerrum, O. J. & Munro, G., Apr 2017, In: European Journal of Pain. 21, 4, p. 692-704 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)
• 2016

  A Paradigm Shift Towards Patient Involvement in Medicines Development and Regulatory Science: Workshop Proceedings and Commentary

  Borup, G., Bach, K. F., Schmiegelow, M., Kildemoes, H. W., Bjerrum, O. J. & Westergaard, N., May 2016, In: Therapeutic Innovation & Regulatory Science. 50, 3, p. 304-311 8 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review
  19 Citations (Scopus)
• 2015

  An analysis of the fixed-dose combinations authorized by the European Union, 2009-14: A Focus on benefit-risk and clinial development condition

  Sawicki-Wrzask, D., Thomsen, M. & Bjerrum, O. J., 2015, In: Therapeutic Innovation & Regulatory Science. 49, 4, p. 553-559 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• High-affinity Glutamate Transporters in Pain: An Emerging and Therapeutic Target

  Gegelashvili, G. & Bjerrum, O. J., 2015, In: Journal of Neurochemistry. 6, p. 712-30 18 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Intraplantar injection of tetrahydrobiopterin induces nociception in mice

  Nasser, A., Ali, S., Wilsbech, S., Bjerrum, O. J. & Birk Møller, L., 2015, In: Neuroscience Letters. 584, p. 247-252 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• The wider use of fixed-dose combinations emphasizes the need for a global approach to regulatory guideline development

  Gautam, Y., Bjerrum, O. J. & Schmiegelow, M., 2015, In: Therapeutic Innovation & Regulatory Science. 49, 1, p. 197-204 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)
• 2014

  Drug-drug combinations revisited

  Bjerrum, O. J., Gautam, Y., Honoré, P. G. H. & Vana, V., 15 Jan 2014, In: European Journal of Hospital Pharmacy - Science and Practice. 21, 1, p. 8-12 5 p.

  Research output: Contribution to journal › Review › Research › peer-review
  1 Citation (Scopus)
• 2013

  Donepezil anvendt ved neuropatisk smerte

  Bjerrum, O. J. & Bjerrum, H. J., 2013, In: Ugesskrift for læger. 175, 42, p. 2493-2494 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  1 Citation (Scopus)

• Donepezil as add-on to gabapentin for post-traumatic neuropathic pain: an exploratory study

  Basnet, A., Butler, S., Honoré, P. G. H., Butler, M., Gordh, T. E., Kristensen, K. K. & Bjerrum, O. J., 2013, In: Acta Anaesthesiologica Scandinavica. 58, 1, p. 61-73 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Dose and administration-period play a key role in the effect of ceftriaxone on neuropathic pain in CCi-operated rats

  Bjerrum, O. J., Honoré, P. G. H., Frederiksen, K. K., Kristensen, P., Abrahamsen, B. & Gegelashvili, G., 2013.

  Research output: Contribution to conference › Poster › Research › peer-review

• Dose-dependent effect of ceftriaxone (A beta-lactam) on mechanical pain hypersensitivity in the CCI nerve rat model

  Bjerrum, O. J., Frederiksen, K. K., Kristensen, P., Abrahamsen, B. & Honoré, P. G. H., 2013.

  Research output: Contribution to conference › Poster › Research › peer-review

• Fixed Dose Combinations. The Physician attitude to the wider use. A pilot study

  Bjerrum, O. J. & Vana, V., 2013.

  Research output: Contribution to conference › Poster › Research › peer-review

• Fixed drug combinations: are current regulatory guidelines in the EU and US adequate for effectively guiding Development?

  Bjerrum, O. J., Gautam, Y. & Schmiegelow, M., 2013.

  Research output: Contribution to conference › Poster › Research › peer-review

• Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain

  Nasser, A., Bjerrum, O. J., Heegaard, A-M., Møller, A. T., Larsen, M., Dalbøge, L. S., Dupont, E., Jensen, T. S. & Møller, L. B., 19 Feb 2013, In: Molecular Pain. 9, p. 5

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• Measurement of sedation in rats. Comparison of the locomotor activity test, open field test and the rotarod test

  Bjerrum, O. J., Nasser, A., Basnet, A., Merry, A. & Kristensen, P., Nov 2013.

  Research output: Contribution to conference › Poster › Research › peer-review

• Medicines combinations options and regulatory hurdles

  Bjerrum, O. J., Gautam, Y., Bjerrum, E. J., Schmiegelow, M. & Boonen, H. C. M., 16 Jul 2013, In: European Journal of Pharmaceutical Sciences. 49, 4, p. 659-63 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Orphan disease council - A new interdiciplinary private/public partnership promoting the Development of orphan medicinal products

  Bjerrum, O. J., Hove, H. B., Dali, C., Callesen, L., Ludvig, G. & Thyregod, L., 2013.

  Research output: Contribution to conference › Poster › Research › peer-review

• Pain perception and Dopa Responsive Dystonia

  Bjerrum, O. J., Nasser, A., Møller, A. T., Møller, B. & Jensen, T. S., 2013.

  Research output: Contribution to conference › Poster › Research › peer-review

• Promising effects of donepezil when added to patients treated with gabapentin for neuropathic pain

  Basnet, A., Butler, S., Honoré, P. G. H., Butler, M., Gordh, T. E., Kristensen, K. & Bjerrum, O. J., 2013.

  Research output: Contribution to conference › Poster › Research › peer-review

• Why medicines Combinations? Friend or Foe?

  Bjerrum, O. J., Gautam, Y., Boonen, H. C. M., Schmiegelow, M. & Honoré, P. G. H., 2013.

  Research output: Contribution to conference › Poster › Research › peer-review
• 2012

  Blå medicin mod smerter

  Boulakou, A., Bjerrum, O. J. & Honoré, P. G. H., 2012, In: Lægemiddelforskning. 2012, p. 18-19 2 p.

  Research output: Contribution to journal › Journal article › Communication

• Kombinationslægemiddel reducerer bivirkningerne ved smertebehandling

  Bjerrum, O. J., Basnet, A., Honoré, P. G. H. & Gautam, Y., 2012, In: Lægemiddelforskning. 1, p. 15-17 3 p.

  Research output: Contribution to journal › Journal article › Communication

• Sortilins in neuropathic pain

  Richner, M., Bjerrum, O. J., Koninck, Y. D., Nykjaer, A. & Vaegter, C. B., 29 Dec 2012, In: Scandinavian Journal of Pain. 3, 3, p. 183-184 2 p.

  Research output: Contribution to journal › Conference abstract in journal › Research
• 2011

  Alleviation of nociception in rats by treatment with ceftriaxone, a ß-lactam that promote the expression of the excitatory amino acid transporter 2

  Bjerrum, O. J., Abrahamsen, B. & Honoré, P. G. H., Nov 2011.

  Research output: Contribution to conference › Poster › Communication

• Beta-lactam antibiotic as dose dependent analgesic treatment of neuropathic pain

  Bjerrum, O. J., Abrahamsen, B. & Honoré, P. G. H., 2011.

  Research output: Contribution to conference › Poster › Research › peer-review

• Ceftriaxone, an EAAT-2 transporter inducer, shows antinociceptive effects in acute and neuropathic pain models

  Bjerrum, O. J., Abrahamsen, B. & Honoré, P. G. H., 2011.

  Research output: Contribution to conference › Poster › Research › peer-review

• Characterization of drug combination effects in a rat model of neuropathic pain ny population modelling and simulation of response-time profiles

  Bjerrum, O. J. & Honoré, P. G. H., 2011.

  Research output: Contribution to conference › Poster › Research › peer-review

• Combination therapy for neuropathic pain: Donepezil improves gabapentins antinoceptive effect in SNI rats

  Bjerrum, O. J. & Honoré, P. G. H., 2011.

  Research output: Contribution to conference › Poster › Research › peer-review

• Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen) and phenobarbital in human volunteers

  Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Houston, J. B., Oosterhuis, B., Bjerrum, O. J., Grynkiewicz, G., Alder, J., Rowland, M. & Garner, C., 20 Apr 2011, In: European Journal of Pharmaceutical Sciences. 43, 3, p. 141-150 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  52 Citations (Scopus)

• Decrease in nocifensive behaviour in rats after treatment with the EAAT-2 transporter inducer cetriaxone

  Bjerrum, O. J., Honoré, P. G. H. & Abrahamsen, B., 2011.

  Research output: Contribution to conference › Poster › Research › peer-review

• Development of quantitative Pharmacology Pharmacometrics in Denmark

  Bjerrum, O. J. & Honoré, P. G. H., 2011.

  Research output: Contribution to conference › Poster › Research › peer-review

• Development of quantitative pharmacology-pharmacometrics in Denmark

  Honoré, P. G. H., Bjerrum, O. J., Lund, T. M., Angelo, H., Ingwersen, S. H., Thygesen, P., Kristensen, K. & Larsen, F., 2011.

  Research output: Contribution to conference › Poster › Research

• Effects of the excitatory amino acid transporter subtype 2(EAAT-2) inducer ceftriaxone on different pain modalities in rat

  Eljaja, L., Bjerrum, O. J., Honoré, P. G. H. & Abrahamsen, B., 2011, In: Scandinavian Journal of Pain. 2, 3, p. 132-136 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)

• European new safe and innovative medicines initiatives: history and progress (through December 2009)

  Bjerrum, O. J. & H. Linden, H., Mar 2011, Translational medicine and drug discovery. Cambridge: Cambridge University Press, p. 265-288 23 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

  6 Citations (Scopus)

• Excellence in education and training advances competitiveness of the pharmaceutical industry in Europe

  Bjerrum, O. J., 2011, In: European Journal of Pharmaceutical Sciences. 44, 2, p. 174-175 2 p.

  Research output: Contribution to journal › Comment/debate › Research
  2 Citations (Scopus)

• Neuropathic pain models in the development of analgesic drugs

  Honoré, P. G. H., Basnet, A., Eljaja, L., Kristensen, P., Neustrup, L. M., Møllgaard, P. & Bjerrum, O. J., 2011, In: Scandinavian Journal of Pain. 2, 4, p. 172-177 5 p.

  Research output: Contribution to journal › Review › Research › peer-review
  16 Citations (Scopus)