Research output per year
Research output per year
Personal profile
Short presentation
Palle Serup and his research group have during recent years focused on the role of cell to cell signalling in the control of pancreatic endocrine development and on the role of key transcription factors in the regulation of beta cell specification. Also, he has, as the principal investigator of both EU and NIH sponsored projects, together with teams of European and American scientists been instrumental in expanding our knowledge of intercellular signalling events and cell-autonomous transcription factors in pancreatic development.
For more information please visit the following webpage:
Keywords
- Faculty of Health and Medical Sciences
- Notch signalling
- pancreas
- embryonic stem cells
- endocrine development
- Diabetes
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting Wnt and BMP signaling
Funa, N. S., Mjoseng, H. K., Raineri, S., Esen, D., Egeskov-Madsen, A. L. R., Quaranta, R., Jørgensen, M. C., Hansen, M. S., van Cuyl Kuylenstierna, J., Jensen, K. B., Miao, Y., Garcia, K. C., Seymour, P. A. & Serup, P., 2024, In: Stem Cell Reports. 19, 7, p. 973–992Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)5 Downloads (Pure) -
Differential use of the Nkx2.2 NK2 domain in developing pancreatic islets and neurons
Seymour, P. A. & Serup, P., 2023, In: Genes & Development. 37, 11-12, p. 451-453 3 p.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile2 Citations (Scopus)9 Downloads (Pure) -
Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development
Xu, X., Seymour, P. A., Sneppen, K., Trusina, A., Egeskov-Madsen, A. L. R., Jørgensen, M. C., Jensen, M. H. & Serup, P., 2023, In: Nature Communications. 14, 17 p., 348.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile9 Citations (Scopus)83 Downloads (Pure) -
Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling
Maimets, M., Pedersen, M. T., Guiu, J., Dreier, J., Thodberg, M., Antoku, Y., Schweiger, P. J., Rib, L., Bressan, R. B., Miao, Y., Garcia, K. C., Sandelin, A., Serup, P. & Jensen, K. B., 2022, In: Nature Communications. 13, 12 p., 715.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile18 Citations (Scopus)51 Downloads (Pure) -
Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation
Cordero-Espinoza, L., Dowbaj, A. M., Kohler, T. N., Strauss, B., Sarlidou, O., Belenguer, G., Pacini, C., Martins, N. P., Dobie, R., Wilson-Kanamori, J. R., Butler, R., Prior, N., Serup, P., Jug, F., Henderson, N. C., Hollfelder, F. & Huch, M., 2021, In: Cell Stem Cell. 28, 11, p. 1907-1921.e8 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile37 Citations (Scopus)17 Downloads (Pure) -
Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network
Schreiber, V., Mercier, R., Jiménez, S., Ye, T., García-Sánchez, E., Klein, A., Meunier, A., Ghimire, S., Birck, C., Jost, B., de Lichtenberg, K. H., Honoré, C., Serup, P. & Gradwohl, G., 2021, In: Molecular Metabolism. 53, 15 p., 101313.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile21 Citations (Scopus)19 Downloads (Pure) -
Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development
Liu, D., Kousa, A. I., O'Neill, K. E., Rouse, P., Popis, M., Farley, A. M., Tomlinson, S. R., Ulyanchenko, S., Guillemot, F., Seymour, P. A., Jørgensen, M. C., Serup, P., Koch, U., Radtke, F. & Blackburn, C. C., 2020, In: Development (Cambridge, England). 147, p. 1-16 dev178582.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile28 Citations (Scopus)31 Downloads (Pure) -
Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors
Seymour, P. A., Collin, C. A., Egeskov-Madsen, A. L. R., Jørgensen, M. C., Shimojo, H., Imayoshi, I., de Lichtenberg, K. H., Kopan, R., Kageyama, R. & Serup, P., 2020, In: Developmental Cell. 52, 6, p. 731-747.e8 26 p.Research output: Contribution to journal › Journal article › Research › peer-review
47 Citations (Scopus)