Pernille Tveden-Nyborg

Research output

Research output per year 2000 2014 2016 2018 2019 2021 2024

• 3361 Citations
• 58 Journal article
• 12 Review
• 3 Book chapter
• 2 Paper
• 6 More
  • 1 Doctoral thesis
  • 1 Ph.D. thesis
  • 1 Comment/debate
  • 1 Conference abstract in journal
  • 1 Editorial
  • 1 Net publication - Internet publication

Research output per year

Research output per year

Search results

• 2024

  CRISPR-Cas9 immune-evasive hESCs are rejected following transplantation into immunocompetent mice

  Frederiksen, H. R., Glantz, A., Vøls, K. K., Skov, S., Tveden-Nyborg, P., Freude, K. & Doehn, U., 2024, In: Frontiers in Genome Editing. 6, 17 p., 1403395.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Gender balance in the editorial room: BCPT as model journal?

  Wellendorph, P. & Tveden-Nyborg, P., 2024, In: Basic and Clinical Pharmacology and Toxicology. 134, 6, p. 767-769

  Research output: Contribution to journal › Editorial › Research › peer-review

• Novel traceable CRISPR-Cas9 engineered human embryonic stem cell line (E1C3 + hSEAP + 2xKO + pCD47), has potential to evade immune detection in pigs

  Frederiksen, H. R. S., Skov, S., Tveden-Nyborg, P., Freude, K. & Doehn, U., 2024, In: Stem Cell Research. 77, 7 p., 103438.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Validation of computed tomography as a diagnostic tool in guinea pigs with non-alcoholic fatty liver disease

  Lintrup, K., Ipsen, D. H., Skat-Rørdam, J., Lykkesfeldt, J., Tveden-Nyborg, P. & Buelund, L. E., 2024, In: Laboratory Animals. 58, 2, p. 127-137

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2023

  BCPT 2023 policy for experimental and clinical studies

  Tveden-Nyborg, P., Bergmann, T. K., Jessen, N., Simonsen, U. & Lykkesfeldt, J., 2023, In: Basic and Clinical Pharmacology and Toxicology. 133, 4, p. 391-396

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  80 Citations (Scopus)

  7 Downloads (Pure)

• Dietary Long-Chain Fatty Acids Accelerate Metabolic Dysfunction in Guinea Pigs with Non-Alcoholic Steatohepatitis

  Pedersen, K., Ipsen, D. H., Skat-Rørdam, J., Lykkesfeldt, J. & Tveden-Nyborg, P., 2023, In: Nutrients. 15, 2445.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  3 Citations (Scopus)

  23 Downloads (Pure)
• 2022

  A long‐term energy‐rich diet increases prefrontal bdnf in sprague‐dawley rats

  Virtuoso, A., Tveden‐nyborg, P., Schou‐pedersen, A. M. V., Lykkesfeldt, J., Müller, H. K., Elfving, B. & Sørensen, D. B., 2022, In: Nutrients. 14, 1, 126.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  7 Citations (Scopus)

  29 Downloads (Pure)

• A Role of Vitamin C in the Young Brain: Effects of deficiency in a model of human hypovitaminosis C

  Tveden-Nyborg, P., 2022, University of Copenhagen. 82 p.

  Research output: Book/Report › Doctoral thesis › Research

• Efficacy of fibroblast growth factor 21 in non-alcoholic fatty liver disease in guinea pigs

  Klaebel, J. H., Lykkesfeldt, J. & Tveden-Nyborg, P., 2022, In: Basic & Clinical Pharmacology & Toxicology. 130, 3, p. 385-393

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  4 Citations (Scopus)

  17 Downloads (Pure)

• Vitamin C Deficiency Exacerbates Dysfunction of Atherosclerotic Coronary Arteries in Guinea Pigs Fed a High-Fat Diet

  Skovsted, G. F., Skat-Rørdam, J., Frøkiær, A. P., Jensen, H. E., Tveden-Nyborg, P. & Lykkesfeldt, J., 2022, In: Antioxidants. 11, 11, 2226.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  5 Citations (Scopus)

  19 Downloads (Pure)

• Vitamin C deficiency may delay diet-induced NASH regression in the guinea pig

  Skat-Rørdam, J., Pedersen, K., Skovsted, G. F., Gregersen, I., Vangsgaard, S., Ipsen, D. H., Latta, M., Lykkesfeldt, J. & Tveden-Nyborg, P., 2022, In: Antioxidants. 11, 1, 69.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  8 Citations (Scopus)

  31 Downloads (Pure)
• 2021

  BCPT policy for experimental and clinical studies

  Tveden-Nyborg, P., Bergmann, T. K., Jessen, N., Simonsen, U. & Lykkesfeldt, J., 2021, In: Basic & Clinical Pharmacology & Toxicology. 128, 1, p. 4-8

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  255 Citations (Scopus)

  14 Downloads (Pure)

• Decreased expression of the GLP-1 receptor after segmental artery injury in mice

  Bjørnholm, K. D., Povlsen, G. K., Ougaard, M. E., Pyke, C., Rakipovski, G., Tveden-Nyborg, P., Lykkesfeldt, J. & Skovsted, G. F., 2021, In: The Journal of endocrinology. 248, 3, p. 289-301 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• Differential effects of dietary components on glucose intolerance and non‐alcoholic steatohepatitis

  Skat‐rørdam, J., Ipsen, D. H., Hardam, P. D., Latta, M., Lykkesfeldt, J. & Tveden‐nyborg, P., 2021, In: Nutrients. 13, 8, 2523.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  6 Citations (Scopus)

  30 Downloads (Pure)

• Extracellular vesicles as drivers of non-alcoholic fatty liver disease: Small particles with big impact

  Ipsen, D. H. & Tveden-Nyborg, P., 2021, In: Biomedicines. 9, 1, p. 1-13 13 p., 93.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  13 Citations (Scopus)

  35 Downloads (Pure)

• Hepatic Stellate Cell Activation and Inactivation in NASH-Fibrosis—Roles as Putative Treatment Targets?

  Zisser, A., Ipsen, D. H. & Tveden-Nyborg, P., 2021, In: Biomedicines. 9, 4, 365.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  57 Citations (Scopus)

  84 Downloads (Pure)

• Liraglutide treatment improves endothelial function in the Ldlr-/- mouse model of atherosclerosis, and affects genes involved in vascular remodelling and inflammation

  Bjørnholm, K. D., Skovsted, G. F., Mitgaard-Thomsen, A., Rakipovski, G., Tveden-Nyborg, P., Lykkesfeldt, J. & Povlsen, G. K., 2021, In: Basic & Clinical Pharmacology & Toxicology. 128, 1, p. 103-114

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)

• Modelling nonalcoholic steatohepatitis in vivo—a close transcriptomic similarity supports the guinea pig disease model

  Skat‐rørdam, J., Ipsen, D. H., Seemann, S. E., Latta, M., Lykkesfeldt, J. & Tveden‐nyborg, P., Sep 2021, In: Biomedicines. 9, 9, 1198.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  5 Citations (Scopus)

• Modelling Nonalcoholic Steatohepatitis In Vivo—A Close Transcriptomic Similarity Supports the Guinea Pig Disease Model

  Skat-rørdam, J., Ipsen, D. H., Seemann, S. E., Latta, M., Lykkesfeldt, J. & Tveden-nyborg, P., 2021, In: Biomedicines. 9, 9, 18 p., 1198.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  12 Downloads (Pure)

• Non-immunogenic Induced Pluripotent Stem Cells, a Promising Way Forward for Allogenic Transplantations for Neurological Disorders

  Frederiksen, H. R., Doehn, U., Tveden-nyborg, P. & Freude, K. K., 2021, In: Frontiers in Genome Editing. 2, 623717.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  12 Citations (Scopus)

  78 Downloads (Pure)

• The development of nonalcoholic steatohepatitis is subjected to breeder dependent variation in guinea pigs

  Ipsen, D. H., Agerskov, R. H., Klaebel, J. H., Lykkesfeldt, J. & Tveden-Nyborg, P., 2021, In: Scientific Reports. 11, 2955.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  4 Citations (Scopus)

  21 Downloads (Pure)

• The effect of acetylsalicylic acid and pentoxifylline in guinea pigs with non-alcoholic steatohepatitis

  Ipsen, D. H., Skat-Rørdam, J., Svenningsen, M., Andersen, M., Latta, M., Buelund, L. E., Lintrup, K., Skaarup, R., Lykkesfeldt, J. & Tveden-Nyborg, P., 2021, In: Basic & Clinical Pharmacology & Toxicology. 128, 4, p. 583-593

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• Vitamin c deficiency in the young brain—findings from experimental animal models

  Tveden-Nyborg, P., 2021, In: Nutrients. 13, 5, 1685.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  13 Citations (Scopus)

  17 Downloads (Pure)
• 2020

  Animal Models of Fibrosis in Nonalcoholic Steatohepatitis: Do They Reflect Human Disease?

  Ipsen, D. H., Lykkesfeldt, J. & Tveden-nyborg, P., 2020, In: Advances in Nutrition. 11, 6, p. 1696–1711

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access
  34 Citations (Scopus)

• Dietary Intervention Accelerates NASH Resolution Depending on Inflammatory Status with Minor Additive Effects on Hepatic Injury by Vitamin E Supplementation

  Klaebel, J. H., Rakipovski, G., Andersen, B., Lykkesfeldt, J. & Tveden-Nyborg, P., 2020, In: Antioxidants. 9, 9, 808.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  31 Citations (Scopus)

  60 Downloads (Pure)

• Inner histopathologic changes and disproportionate zone volumes in foetal growth plates following gestational hypoglycaemia in rats

  Jensen, V. F. H., Mølck, A-M., Bøgh, I. B., Nowak, J., Viuff, B. M., Rasmussen, C. L. M., Pedersen, L., Fels, J. J., Madsen, S. H., McGuigan, F. E., Tveden-Nyborg, P., Lykkesfeldt, J. & Akesson, K. E., 2020, In: Scientific Reports. 10, 1, 13 p., 5609.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  1 Citation (Scopus)

  62 Downloads (Pure)

• Variation in diagnostic NAFLD/NASH read-outs in paired liver samples from rodent models

  Jensen, V. S., Tveden-Nyborg, P., Zacho-Rasmussen, C., Quaade, M. L., Ipsen, D. H., Hvid, H., Fledelius, C., Wulff, E. M. & Lykkesfeldt, J., 2020, In: Journal of Pharmacological and Toxicological Methods. 101, 9 p., 106651.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  19 Citations (Scopus)

  190 Downloads (Pure)
• 2019

  A role of peroxisome proliferator-activated receptor gamma in non-alcoholic fatty liver disease

  Skat-Rordam, J., Ipsen, D. H., Lykkesfeldt, J. & Tveden-Nyborg, P., May 2019, In: Basic & Clinical Pharmacology & Toxicology. 124, 5, p. 528-537

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  139 Citations (Scopus)

  253 Downloads (Pure)

• Atorvastatin and vitamin e accelerates NASH resolution by dietary intervention in a preclinical guinea pig model

  Klaebel, J. H., Skjødt, M., Skat-Rørdam, J., Rakipovski, G., Ipsen, D. H., Schou-Pedersen, A. M. V., Lykkesfeldt, J. & Tveden-Nyborg, P., 2019, In: Nutrients. 11, 11, 20 p., 2834.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  15 Citations (Scopus)

  85 Downloads (Pure)

• Expression of endothelin type B receptors in uterine artery smooth muscle cells from pregnant Guinea pigs

  Skovsted, G. F., Tveden-Nyborg, P. & Lykkesfeldt, J., 2019, In: Placenta. 77, p. 8-15 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  1 Citation (Scopus)

• Molecular drivers of non-alcoholic steatohepatitis are sustained in mild-to-late fibrosis progression in a guinea pig model

  Ipsen, D. H., Skat-Rørdam, J., Tsamouri, M. M., Latta, M., Lykkesfeldt, J. & Tveden-Nyborg, P., 2019, In: Molecular Genetics and Genomics. 294, 3, p. 649–661

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)

• Når leveren bliver for fed

  Ipsen, D. H., Lykkesfeldt, J. & Tveden-Nyborg, P., 2019, In: Aktuel Naturvidenskab. 2019, 3, p. 28-31

  Research output: Contribution to journal › Journal article › Communication

  Open Access

• The Pharmacokinetics of Vitamin C

  Lykkesfeldt, J. & Tveden-Nyborg, P., 2019, In: Nutrients. 11, 10, 20 p., 2412.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  200 Citations (Scopus)

  100 Downloads (Pure)
• 2018

  A cafeteria diet alters the decision making strategy and metabolic markers in Sprague-Dawley male rats

  Virtuoso, A., Forkman, B., Sarruf, D. A., Tveden-Nyborg, P. & Sørensen, D. B., 2018, In: Applied Animal Behaviour Science. 199, p. 35-44 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)

• Basic & Clinical Pharmacology & Toxicology Policy for Experimental and Clinical studies

  Tveden-Nyborg, P., Bergmann, T. K. & Lykkesfeldt, J., 2018, In: Basic & Clinical Pharmacology & Toxicology. 123, 3, p. 233-235 3 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review
  265 Citations (Scopus)

• Early life vitamin C deficiency does not alter morphology of hippocampal CA1 pyramidal neurons or markers of synaptic plasticity in a Guinea pig model

  Hansen, S. N., Jørgensen, J. M. B., Nyengaard, J. R., Lykkesfeldt, J. & Tveden-Nyborg, P., 2018, In: Nutrients. 10, 6, 749.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  9 Citations (Scopus)

  187 Downloads (Pure)

• Holder C-vitamin dine blodkar sunde?

  Skovsted, G. F., Tveden-Nyborg, P. & Lykkesfeldt, J., 2018

  Research output: Other contribution › Net publication - Internet publication › Communication

  Open Access

• Liraglutide Decreases Hepatic Inflammation and Injury in Advanced Lean Non-Alcoholic Steatohepatitis

  Ipsen, D. H., Rolin, B., Rakipovski, G., Skovsted, G. F., Madsen, A., Kolstrup, S., Schou-Pedersen, A. M., Skat-Rørdam, J., Lykkesfeldt, J. & Tveden-Nyborg, P., 2018, In: Basic & Clinical Pharmacology & Toxicology. 123, 3, p. 704-713

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  43 Citations (Scopus)

  197 Downloads (Pure)

• Long term Westernized diet leads to region-specific changes in brain signaling mechanisms

  Hansen, S. N., Ipsen, D. H., Schou-Pedersen, A. M., Lykkesfeldt, J. & Tveden-Nyborg, P., 2018, In: Neuroscience Letters. 676, p. 85-91 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  16 Citations (Scopus)

  175 Downloads (Pure)

• Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

  Ipsen, D. H., Lykkesfeldt, J. & Tveden-Nyborg, P., 2018, In: Cellular and Molecular Life Sciences. 75, 18, p. 3313-3327 15 p.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  890 Citations (Scopus)

  271 Downloads (Pure)

• Spatial Memory Dysfunction Induced by Vitamin C Deficiency Is Associated with Changes in Monoaminergic Neurotransmitters and Aberrant Synapse Formation

  Hansen, S. N., Schou-Pedersen, A. M. V., Lykkesfeldt, J. & Tveden-Nyborg, P., 2018, In: Antioxidants. 7, 7, p. 11 82.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  10 Citations (Scopus)

  89 Downloads (Pure)
• 2017

  Vitamin C deficiency reduces muscarinic receptor coronary artery vasoconstriction and plasma tetrahydrobiopterin concentration in guinea pigs

  Skovsted, G. F., Tveden-Nyborg, P., Lindblad, M. M., Hansen, S. N. & Lykkesfeldt, J., 2017, In: Nutrients. 9, 7, 14 p., 691.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  7 Citations (Scopus)

  270 Downloads (Pure)
• 2016

  Diet-induced dyslipidemia leads to nonalcoholic fatty liver disease and oxidative stress in guinea pigs

  Tveden-Nyborg, P., Birck, M. M., Ipsen, D. H., Thiessen, T. S., Feldmann, L. D. B., Lindblad, M. M., Jensen, H. E. & Lykkesfeldt, J., 1 Feb 2016, In: Translational Research. 168, p. 146-160 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  40 Citations (Scopus)

• Dyslipidemia: Obese or Not Obese-That Is Not the Question

  Ipsen, D. H., Tveden-Nyborg, P. & Lykkesfeldt, J., Dec 2016, In: Current Obesity Reports. 5, 4, p. 405-412

  Research output: Contribution to journal › Review › Research › peer-review
  32 Citations (Scopus)

• High-fat but not sucrose intake is essential for induction of dyslipidemia and non-alcoholic steatohepatitis in guinea pigs

  Ipsen, D. H., Tveden-Nyborg, P., Rolin, B., Rakipovski, G., Beck, M., Mortensen, L. W., Færk, L., Heegaard, P. M. H., Møller, P. & Lykkesfeldt, J., 2016, In: Nutrition & Metabolism. 13, p. 51

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  32 Citations (Scopus)

  312 Downloads (Pure)

• _L-dehydroascorbic acid can substitute _L-ascorbic acid as dietary vitamin C source in guinea pigs

  Frikke-Schmidt, H. R., Tveden-Nyborg, P. & Lykkesfeldt, J., 2016, In: Redox Biology. 7, p. 8-13 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  27 Citations (Scopus)

  1130 Downloads (Pure)

• Maternal vitamin C deficiency does not reduce hippocampal volume and beta-tubulin III intensity in prenatal Guinea pigs

  Hansen, S. N., Schjoldager, J. G., Paidi, M. D., Lykkesfeldt, J. & Tveden-Nyborg, P., Jul 2016, In: Nutrition Research. 36, 7, p. 696-702

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)

• Modelling severe Staphylococcus aureus sepsis in conscious pigs: are implications for animal welfare justified?

  Olsen, H. G., Kjeldgaard-Hansen, M., Tveden-Nyborg, P., Birck, M. M., Hammelev, K. P., Vegge, A., Aalbæk, B., Leifsson, P. S., Jensen, H. E., Iburg, T., Heegaard, P. M. H. & Nielsen, O. L., 2016, In: BMC Research Notes. 9, p. 1-10 10 p., 99.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  10 Citations (Scopus)

  223 Downloads (Pure)

• Normal Weight Dyslipidemia: Is It All About the Liver?

  Ipsen, D. H., Tveden-Nyborg, P. & Lykkesfeldt, J., Mar 2016, In: Obesity. 24, 3, p. 556-567 12 p.

  Research output: Contribution to journal › Review › Research › peer-review
  41 Citations (Scopus)

• Simultaneous quantification of monoamine neurotransmitters and their biogenic metabolites intracellularly and extracellularly in primary neuronal cell cultures and in sub-regions of guinea pig brain

  Schou-Pedersen, A. M. V., Hansen, S. N., Tveden-Nyborg, P. & Lykkesfeldt, J., 15 Aug 2016, In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1028, p. 222-230 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)