Research output per year
Research output per year
Personal profile
Primary fields of research
The research interests are centered around the DNA mimic PNA (peptide nucleic acid), and the chemical biology and medicinal chemistry properties and applications of derivatives of this molecule. This includes drug discovery (antisense antibiotics, muscular dystrophy, cystic fibrosis), gene targeting and antisense principles in general and cellular and in vivo delivery and administration of biopharmaceuticals. Additional interests cover origin of life prebiotic systems and the effects of oxidative stress on cellular RNA.
Current research
- Discovery of PNA and peptide based antibiotics against resistant Gram-negative bacterial infections
- Quorum sensing inhibitors as cystic fibrosis drugs
- Antisense drugs for Duchenne muscular dystrophy
- Antisense drug delivery and in vivo administration
Possible conflicts of interest
Member of the board of directors for Select Sport a/s, Copenhagen.
Member of Scientific Advisory Board for Neubase Inc. Pennsylvania, USA.
Keywords
- Faculty of Health and Medical Sciences
- Gene targeting
- PNA
- RNA interference
- Drug delivery
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Polymyxins with Potent Antibacterial Activity against Colistin-Resistant Pathogens: Fine-Tuning Hydrophobicity with Unnatural Amino Acids
Jørgensen, J. S., Mood, E. H., Knap, A. S. H., Nielsen, S. E., Nielsen, P. E., Żabicka, D., Matias, C., Domraceva, I., Björkling, F. & Franzyk, H., 2024, In: Journal of Medicinal Chemistry. 67, 2, p. 1370–1383Research output: Contribution to journal › Journal article › Research › peer-review
3 Citations (Scopus) -
Targeting synthesis of the Chromosome Replication Initiator Protein DnaA by antisense PNA-peptide conjugates in Escherichia coli
Campion, C., Charbon, G., Nielsen, P. E. & Løbner-Olesen, A., 2024, In: Frontiers in Antibiotics. 3, 10 p., 1384390.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)13 Downloads (Pure) -
Peptide nucleic acid-zirconium coordination nanoparticles
Öztürk, Ö., Lessl, A-L., Höhn, M., Wuttke, S., Nielsen, P. E., Wagner, E. & Lächelt, U., 2023, In: Scientific Reports. 13, 16 p., 14222.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)11 Downloads (Pure) -
Antisense Peptide Nucleic Acid-Diaminobutanoic Acid Dendron Conjugates with SbmA-Independent Antimicrobial Activity against Gram-Negative Bacteria
Iubatti, M., Gabas, I. M., Cavaco, L. M., Mood, E. H., Lim, E., Bonanno, F., Yavari, N., Brolin, C. & Nielsen, P. E., 2022, In: ACS Infectious Diseases. 8, 5, p. 1098–1106Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile13 Citations (Scopus)26 Downloads (Pure) -
Effects of LPS Composition in Escherichia coli on Antibacterial Activity and Bacterial Uptake of Antisense Peptide-PNA Conjugates
Goltermann, L., Zhang, M., Ebbensgaard, A. E., Fiodorovaite, M., Yavari, N., Løbner-Olesen, A. & Nielsen, P. E., 2022, In: Frontiers in Microbiology. 13, 877377.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile10 Citations (Scopus)28 Downloads (Pure) -
Translocation of non-lytic antimicrobial peptides and bacteria penetrating peptides across the inner membrane of the bacterial envelope
Frimodt-Møller, J., Campion, C., Nielsen, P. E. & Løbner-Olesen, A., 2022, In: Current Genetics. 68, 1, p. 83-90Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile16 Citations (Scopus)28 Downloads (Pure) -
Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli
Frimodt-Møller, J., Koulouktsis, A., Charbon, G., Otterlei, M., Nielsen, P. E. & Løbner-Olesen, A., 2021, In: Molecular Therapy - Nucleic Acids. 25, p. 444-454 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile46 Downloads (Pure) -
Antibiotic Potentiation in Multidrug-Resistant Gram-Negative Pathogenic Bacteria by a Synthetic Peptidomimetic
Mood, E. H., Goltermann, L., Brolin, C., Cavaco, L. M., Nejad, A. J., Yavari, N., Frederiksen, N., Franzyk, H. & Nielsen, P. E., 2021, In: ACS Infectious Diseases. 7, 8, p. 2152–2163Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile27 Citations (Scopus)28 Downloads (Pure)
Activities
- 2 Editor of Series
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Humana Press - Springer Verlag (Publisher)
Peter E. Nielsen (Editor)
2020Activity: Peer-review and editorial work types › Editor of Series › Research
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Humana Press - Springer Verlag (Publisher)
Peter E. Nielsen (Editor)
2014Activity: Peer-review and editorial work types › Editor of Series › Research