Research output per year
Research output per year
- 1 - 50 out of 256 results
Search results
-
2024
Absence of genotoxicity following pulmonary exposure to metal oxides of copper, tin, aluminum, zinc, and titanium in mice
Gutierrez, C. T., Hadrup, N., Loizides, C., Hafez, I., Biskos, G., Roursgaard, M., Saber, A. T., Møller, P. & Vogel, U., 2024, In: Environmental and Molecular Mutagenesis. 65, 8, p. 251-260 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile -
Comparison of DNA damage in fresh and frozen blood samples: implications for the comet assay in human biomonitoring studies
Matković, K., Gerić, M., Kazensky, L., Milić, M., Kašuba, V., Cvitković, A., Sanković, M., Šumanovac, A., Møller, P. & Gajski, G., 2024, In: Archives of Toxicology. 98, p. 3467–3476 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
-
Further development of CometChip technology to measure DNA damage in vitro and in vivo: Comparison with the 2 gels/slide format of the standard and enzyme-modified comet assay
Collia, M., Møller, P., Langie, S. A. S., Vettorazzi, A. & Azqueta, A., 2024, In: Toxicology. 501, 8 p., 153690.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)10 Downloads (Pure) -
Gastrointestinal tract exposure to particles and DNA damage in animals: A review of studies before, during and after the peak of nanotoxicology
Møller, P. & Roursgaard, M., 2024, In: Mutation Research - Reviews in Mutation Research. 793, 14 p., 108491.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile1 Citation (Scopus)9 Downloads (Pure) -
Residential greenspace and COVID-19 Severity: A cohort study of 313,657 individuals in Greater Manchester, United Kingdom
Hyman, S., Zhang, J., Lim, Y., Jovanovic Andersen, Z., Cole-hunter, T., Li, Y., Møller, P., Daras, K., Williams, R., Thomas, M. L., Labib, S. M. & Topping, D., 2024, In: Environment International. 190, 10 p., 108843.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile5 Downloads (Pure) -
The Comet Assay as a Tool in Human Biomonitoring Studies of Environmental and Occupational Exposure to Chemicals—A Systematic Scoping Review
Ladeira, C., Møller, P., Giovannelli, L., Gajski, G., Haveric, A., Bankoglu, E. E., Azqueta, A., Gerić, M., Stopper, H., Cabêda, J., Tonin, F. S. & Collins, A., 2024, In: Toxics. 12, 4, 121 p., 270.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile4 Citations (Scopus)5 Downloads (Pure) -
2023
Acute phase response following pulmonary exposure to soluble and insoluble metal oxide nanomaterials in mice
Gutierrez, C. T., Loizides, C., Hafez, I., Brostrøm, A., Wolff, H., Szarek, J., Berthing, T., Mortensen, A., Jensen, K. A., Roursgaard, M., Saber, A. T., Møller, P., Biskos, G. & Vogel, U., 2023, In: Particle and Fibre Toxicology. 20, 1, 25 p., 4.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile14 Citations (Scopus)29 Downloads (Pure) -
Airway and systemic biomarkers of health effects after short-term exposure to indoor ultrafine particles from cooking and candles – A randomized controlled double-blind crossover study among mild asthmatic subjects
Laursen, K. R., Christensen, N. V., Mulder, F. A., Schullehner, J., Hoffmann, H. J., Jensen, A., Møller, P., Loft, S., Olin, A. C., Rasmussen, B. B., Rosati, B., Strandberg, B., Glasius, M., Bilde, M., Sigsgaard, T. & The Climate Chamber Group, 2023, In: Particle and Fibre Toxicology. 20, 1, 18 p., 26.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)25 Downloads (Pure) -
Calibration of the comet assay using ionising radiation
Brunborg, G., Eide, D. M., Graupner, A., Gutzkow, K., Shaposhnikov, S., Kruszewski, M., Sirota, N., Jones, G. D. D., Koppen, G., Vanhavere, F., Møller, P., Stetina, R., Dahl, H. & Collins, A., 2023, In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 885, 11 p., 503560.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile13 Citations (Scopus)23 Downloads (Pure) -
DNA strand break levels in cryopreserved mononuclear blood cell lines measured by the alkaline comet assay: results from the hCOMET ring trial
Møller, P., Azqueta, A., Rodriguez-Garraus, A., Bakuradze, T., Richling, E., Bankoglu, E. E., Stopper, H., Bastos, V. C., Langie, S. A. S., Jensen, A., Ristori, S., Scavone, F., Giovannelli, L., Wojewódzka, M., Kruszewski, M., Valdiglesias, V., Laffon, B., Costa, C., Costa, S., Teixeira, J. P. & 6 others, , 2023, In: Mutagenesis. 38, 5, p. 273–282 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
-
Exposure to nanoplastic particles and DNA damage in mammalian cells
Møller, P. & Roursgaard, M., 2023, In: Mutation Research - Reviews in Mutation Research. 792, 15 p., 108468.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile2 Citations (Scopus)15 Downloads (Pure) -
Genotoxicity by rapeseed methyl ester and hydrogenated vegetable oil combustion exhaust products in lung epithelial (A549) cells
Rothmann, M. H., Møller, P., Essig, Y. J., Gren, L., Malmborg, V. B., Tunér, M., Pagels, J., Krais, A. M. & Roursgaard, M., 2023, In: Mutagenesis. 38, 4, p. 238–249 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
3 Citations (Scopus) -
Inter-laboratory variation in measurement of DNA damage by the alkaline comet assay in the hCOMET ring trial
Møller, P., Azqueta, A., Collia, M., Bakuradze, T., Richling, E., Bankoglu, E. E., Stopper, H., Bastos, V. C., Langie, S. A. S., Jensen, A., Ristori, S., Scavone, F., Giovannelli, L., Wojewódzka, M., Kruszewski, M., Valdiglesias, V., Laffon, B., Costa, C., Costa, S., Teixeira, J. P. & 6 others, , 2023, In: Mutagenesis. 38, 5, p. 283–294 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
-
Long-term cryopreservation of potassium bromate positive assay controls for measurement of oxidatively damaged DNA by the Fpg-modified comet assay: results from the hCOMET ring trial
Møller, P., Azqueta, A., Rodriguez-Garraus, A., Bakuradze, T., Richling, E., Bankoglu, E. E., Stopper, H., Bastos, V. C., Langie, S. A. S., Jensen, A., Ristori, S., Scavone, F., Giovannelli, L., Wojewódzka, M., Kruszewski, M., Valdiglesias, V., Laffon, B., Costa, C., Costa, S., Teixeira, J. P. & 6 others, , 2023, In: Mutagenesis. 38, 5, p. 264–272 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
-
Long-term exposure to air pollution and COVID-19 severity: A cohort study in Greater Manchester, United Kingdom
Hyman, S., Zhang, J., Andersen, Z. J., Cruickshank, S., Møller, P., Daras, K., Williams, R., Topping, D. & Lim, Y-H., 2023, In: Environmental Pollution. 327, 9 p., 121594.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile19 Citations (Scopus)25 Downloads (Pure) -
Measuring DNA modifications with the comet assay: a compendium of protocols
Collins, A., Moller, P., Gajski, G., Vodenkova, S., Abdulwahed, A., Anderson, D., Bankoglu, E. E., Bonassi, S., Boutet-Robinet, E., Brunborg, G., Chao, C., Cooke, M. S. S., Costa, C., Costa, S., Dhawan, A., de Lapuente, J., Del Bo, C., Dubus, J., Dusinska, M., Duthie, S. J. J. & 59 others, , 2023, In: Nature Protocols. 18, p. 929–989 61 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile138 Citations (Scopus)3 Downloads (Pure) -
Use of the single cell gel electrophoresis assay for the detection of DNA-protective dietary factors: Results of human intervention studies
Mišík, M., Staudinger, M., Kundi, M., Worel, N., Nersesyan, A., Ferk, F., Dusinska, M., Azqueta, A., Møller, P. & Knasmueller, S., 2023, In: Mutation Research - Reviews in Mutation Research. 791, 27 p., 108458.Research output: Contribution to journal › Review › Research › peer-review
6 Citations (Scopus) -
Visual comet scoring revisited: a guide to scoring comet assay slides and obtaining reliable results
Møller, P., Azqueta, A., Sanz-Serrano, J., Bakuradze, T., Richling, E., Bankoglu, E. E., Stopper, H., Bastos, V. C., Langie, S. A. S., Jensen, A., Scavone, F., Giovannelli, L., Wojewódzka, M., Kruszewski, M., Valdiglesias, V., Laffon, B., Costa, C. T., Costa, S., Teixeira, J. P., Marino, M. & 5 others, , 2023, In: Mutagenesis. 38, 5, p. 253–263 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
-
2022
A mix of chlorogenic and caffeic acid reduces C/EBPss and PPAR-gamma 1 levels and counteracts lipid accumulation in macrophages
Marino, M., Del Bo, C., Tucci, M., Venturi, S., Mantegazza, G., Taverniti, V., Møller, P., Riso, P. & Porrini, M., 2022, In: European Journal of Nutrition. 61, p. 1003–1014 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
14 Citations (Scopus) -
Assessment of primary and inflammation-driven genotoxicity of carbon black nanoparticles in vitro and in vivo
Di Ianni, E., Moller, P., Cholakova, T., Wolff, H., Jacobsen, N. R. & Vogel, U., 2022, In: Nanotoxicology. 16, 4, 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile11 Citations (Scopus)15 Downloads (Pure) -
Do cytotoxicity and cell death cause false positive results in the in vitro comet assay?
Azqueta, A., Stopper, H., Zegura, B., Dusinska, M. & Moller, P., 2022, In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 881, 9 p., 503520.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile29 Citations (Scopus)8 Downloads (Pure) -
Measurement of oxidatively damaged DNA in mammalian cells using the comet assay: Reflections on validity, reliability and variability
Møller, P., 2022, In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 873, 503423.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile19 Citations (Scopus)19 Downloads (Pure) -
Predicting nanomaterials pulmonary toxicity in animals by cell culture models: Achievements and perspectives
Di Ianni, E., Jacobsen, N. R., Vogel, U. & Møller, P., 2022, In: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 14, 6, 23 p., e1794.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile9 Citations (Scopus)14 Downloads (Pure) -
Systematic review on primary and secondary genotoxicity of carbon black nanoparticles in mammalian cells and animals
Di Ianni, E., Jacobsen, N. R., Vogel, U. B. & Moller, P., 2022, In: Mutation Research - Reviews. 790, 17 p., 108441.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile15 Citations (Scopus)15 Downloads (Pure) -
Vitamin D Counteracts Lipid Accumulation, Augments Free Fatty Acid-Induced ABCA1 and CPT-1A Expression While Reducing CD36 and C/EBPβ Protein Levels in Monocyte-Derived Macrophages
Marino, M., Venturi, S., Del Bo’, C., Møller, P., Riso, P. & Porrini, M., 2022, In: Biomedicines. 10, 4, 18 p., 775.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile13 Citations (Scopus)16 Downloads (Pure) -
2021
Accelerated atherosclerosis caused by serum amyloid A response in lungs of ApoE−/− mice
Christophersen, D. V., Møller, P., Thomsen, M. B., Lykkesfeldt, J., Loft, S., Wallin, H., Vogel, U. & Jacobsen, N. R., 2021, In: FASEB Journal. 35, 3, 14 p., e21307.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile10 Citations (Scopus)71 Downloads (Pure) -
A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges
Kermanizadeh, A., Jacobsen, N. R., Murphy, F., Powell, L., Parry, L., Zhang, H. & Møller, P., 2021, In: Advanced Therapeutics. 4, 2, 44 p., 2000186.Research output: Contribution to journal › Review › Research › peer-review
File9 Citations (Scopus)16 Downloads (Pure) -
Biomarkers of DNA Oxidation Products: Links to Exposure and Disease in Public Health Studies
Møller, P. & Roursgaard, M., 2021, In: Chemical Research in Toxicology. 34, p. 2235−2250 16 p.Research output: Contribution to journal › Review › Research › peer-review
10 Citations (Scopus) -
Biomarkers of nucleic acid oxidation: A summary state-of-the-art
Chao, M-R., Evans, M. D., Hu, C-W., Ji, Y., Møller, P., Rossner, P. & Cooke, M. S., 2021, In: Redox Biology. 42, 22 p., 101872.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile61 Citations (Scopus)26 Downloads (Pure) -
Collection and storage of human white blood cells for analysis of DNA damage and repair activity using the comet assay in molecular epidemiology studies
Møller, P., Bankoglu, E. E., Stopper, H., Giovannelli, L., Ladeira, C., Koppen, G., Gajski, G., Collins, A., Valdiglesias, V., Laffon, B., Boutet-Robinet, E., Perdry, H., Del Bo', C., Langie, S. A. S., Dusinska, M. & Azqueta, A., 2021, In: Mutagenesis. 36, 3, p. 193-212 20 p.Research output: Contribution to journal › Review › Research › peer-review
-
DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
Bonassi, S., Ceppi, M., Møller, P., Azqueta, A., Milic, M., Monica, N., Brunborg, G., Godschalk, R., Koppen, G., Langie, S. A. S., Teixeira, J. P., Bruzzone, M., Da Silva, J., Benedetti, D., Cavallo, D., Ursini, C. L., Giovannelli, L., Moretti, S., Riso, P., Del Bo', C. & 31 others, , 2021, In: Scientific Reports. 11, 1, 11 p., 16793.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile59 Citations (Scopus)20 Downloads (Pure) -
Genotoxicity of multi-walled carbon nanotube reference materials in mammalian cells and animals
Møller, P., Wils, R. S., Di Ianni, E., Gutierrez, C. A. T., Roursgaard, M. & Jacobsen, N. R., 2021, In: Mutation Research - Reviews. 788, 108393.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile14 Downloads (Pure) -
Impact of 12-month cryopreservation on endogenous DNA damage in whole blood and isolated mononuclear cells evaluated by the comet assay
Marino, M., Gigliotti, L., Møller, P., Riso, P., Porrini, M. & Del Bo, C., 2021, In: Scientific Reports. 11, 1, 11 p., 363.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile13 Citations (Scopus)26 Downloads (Pure) -
Inflammatory Response, Reactive Oxygen Species Production and DNA Damage in Mice After Intrapleural Exposure to Carbon Nanotubes
Wils, R. S., Jacobsen, N. R., Vogel, U., Roursgaard, M. & Møller, P., 2021, In: Toxicological Sciences. 183, 1, p. 184-194 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
11 Citations (Scopus) -
Inhalation of hydrogenated vegetable oil combustion exhaust and genotoxicity responses in humans
Scholten, R. H., Essig, Y. J., Roursgaard, M., Jensen, A., Krais, A. M., Gren, L., Dierschke, K., Gudmundsson, A., Wierzbicka, A. & Moller, P., 2021, In: Archives of Toxicology. 95, p. 3407–3416 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
9 Citations (Scopus) -
In vitro-in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT
Di Ianni, E., Erdem, J. S., Møller, P., Sahlgren, N. M., Poulsen, S. S., Knudsen, K. B., Zienolddiny, S., Saber, A. T., Wallin, H., Vogel, U. & Jacobsen, N. R., 2021, In: Particle and Fibre Toxicology. 18, 1, 16 p., 25.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile43 Citations (Scopus)37 Downloads (Pure) -
Occupational exposure and markers of genetic damage, systemic inflammation and lung function: a Danish cross-sectional study among air force personnel
Andersen, M. H. G., Saber, A. T., Frederiksen, M., Clausen, P. A., Sejbaek, C. S., Hemmingsen, C. H., Ebbehøj, N. E., Catalan, J., Aimonen, K., Koivisto, J., Loft, S., Møller, P. & Vogel, U., 2021, In: Scientific Reports. 11, 1, 14 p., 17998.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile12 Citations (Scopus)24 Downloads (Pure) -
Pro-inflammatory response and genotoxicity caused by clay and graphene nanomaterials in A549 and THP-1 cells
Di Ianni, E., Moller, P., Vogel, U. B. & Jacobsen, N. R., 2021, In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 872, 10 p., 503405.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile25 Citations (Scopus)19 Downloads (Pure) -
Reactive oxygen species production, genotoxicity and telomere length in FE1-Muta (TM) Mouse lung epithelial cells exposed to carbon nanotubes
Wils, R. S., Jacobsen, N. R., Di Ianni, E., Roursgaard, M. & Møller, P., 2021, In: Nanotoxicology. 15, 5, p. 661-672 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
21 Citations (Scopus) -
Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy
Harnung Scholten, R., Møller, P., Jovanovic Andersen, Z., Dehlendorff, C., Khan, J., Brandt, J., Ketzel, M., Knudsen, L. E. & Mathiesen, L., 2021, In: Environment International. 146, 11 p., 106202.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile36 Citations (Scopus)53 Downloads (Pure) -
The hCOMET project: International database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and effect of main confounders
Mili, M., Ceppi, M., Bruzzone, M., Azqueta, A., Brunborg, G., Godschalk, R., Koppen, G., Langie, S., Møller, P., Teixeira, J. P., Alija, A., Anderson, D., Andrade, V., Andreoli, C., Asllani, F., Bangkoglu, E. E., Barancokova, M., Basaran, N., Boutet-Robinet, E., Buschini, A. & 69 others, , 2021, In: Mutation Research - Reviews. 787, 13 p., 108371.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile60 Citations (Scopus)29 Downloads (Pure) -
Treatment intensity and survival trends among real-world elderly AML patients diagnosed in the period 2001-2016: a Danish nationwide cohort study
Naur, T. M. H., Jakobsen, L. H., Roug, A. S., El-Galaly, T. C., Marcher, C. W., Nørgaard, J. M., Theilgaard-Mönch, K., Møller, P., Schöllkopf, C. & Severinsen, M. T., 2021, In: Leukemia and Lymphoma. 62, 8, p. 2014-2017 4 p.Research output: Contribution to journal › Letter › Research › peer-review
3 Citations (Scopus) -
2020
An optimized comet-based in vitro DNA repair assay to assess base and nucleotide excision repair activity
Vodenkova, S., Azqueta, A., Collins, A., Dusinska, M., Gaivao, I., Møller, P., Opattova, A., Vodicka, P., Godschalk, R. W. L. & Langie, S. A. S., 2020, In: Nature Protocols. 15, p. 3844–3878 38 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile36 Citations (Scopus)24 Downloads (Pure) -
Application of the comet assay in human biomonitoring: An hCOMET perspective
Azqueta, A., Ladeira, C., Giovannelli, L., Boutet-Robinet, E., Bonassi, S., Neri, M., Gajski, G., Duthie, S., Del Bo’, C., Riso, P., Koppen, G., Basaran, N., Collins, A. & Møller, P., 2020, In: Mutation Research - Reviews in Mutation Research. 783, 20 p., 108288.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile110 Citations (Scopus)25 Downloads (Pure) -
Effect of combustion-derived particles on genotoxicity and telomere length: A study on human cells and exposed populations
Ma, Y., Bellini, N., Scholten, R. H., Andersen, M. H. G., Vogel, U., Saber, A. T., Loft, S., Moller, P. & Roursgaard, M., 2020, In: Toxicology Letters. 322, p. 20-31 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
13 Citations (Scopus) -
Hazard assessment of small-size plastic particles: is the conceptual framework of particle toxicology useful?
Heddagaard, F. E. & Møller, P., 2020, In: Food and Chemical Toxicology. 136, 14 p., 111106.Research output: Contribution to journal › Review › Research › peer-review
38 Citations (Scopus) -
Inflammation, oxidative stress and genotoxicity responses to biodiesel emissions in cultured mammalian cells and animals
Møller, P., Scholten, R. H., Roursgaard, M. & Krais, A. M., 2020, In: Critical Reviews in Toxicology. 50, 5, p. 383-401 19 p.Research output: Contribution to journal › Review › Research › peer-review
31 Citations (Scopus) -
Measurement of DNA damage with the comet assay in high-prevalence diseases: current status and future directions
Møller, P., Stopper, H. & Collins, A. R., 2020, In: Mutagenesis. 35, 1, p. 5-18 14 p.Research output: Contribution to journal › Review › Research › peer-review
58 Citations (Scopus) -
Minimum Information for Reporting on the Comet Assay (MIRCA): recommendations for describing comet assay procedures and results
Møller, P., Azqueta, A., Boutet-Robinet, E., Koppen, G., Bonassi, S., Milić, M., Gajski, G., Costa, S., Teixeira, J. P., Costa Pereira, C., Dusinska, M., Godschalk, R., Brunborg, G., Gutzkow, K. B., Giovannelli, L., Cooke, M. S., Richling, E., Laffon, B., Valdiglesias, V., Basaran, N. & 11 others, , 2020, In: Nature Protocols. 15, p. 3817-3826 10 p.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile234 Citations (Scopus)21 Downloads (Pure) -
Organomodified nanoclays induce less inflammation, acute phase response, and genotoxicity than pristine nanoclays in mice lungs
Di Ianni, E., Møller, P., Mortensen, A., Szarek, J., Clausen, P. A., Saber, A. T., Vogel, U. & Jacobsen, N. R., 2020, In: Nanotoxicology. 14, 7, p. 869-892 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile16 Citations (Scopus)41 Downloads (Pure)