Pia Weikop

Search results

• 2025

  Anti-seizure effects of norepinephrine-induced free fatty acid release

  Li, B., Sun, Q., Ding, F., Xu, Q., Kang, N., Xue, Y., Ladron-de-Guevara, A., Hirase, H., Weikop, P., Gong, S., Smith, N. & Nedergaard, M., 2025, In: Cell Metabolism. 37, 1, p. 223-238.e5 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2024

  Anesthesia Blunts Carbon Dioxide Effects on Glymphatic Cerebrospinal Fluid Dynamics in Mechanically Ventilated Rats

  Persson, N. D. Å., Lohela, T. J., Mortensen, K. N., Rosenholm, M., Li, Q., Weikop, P., Nedergaard, M. & Lilius, T. O., 2024, In: Anesthesiology. 141, 2, p. 338-352 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  1 Citation (Scopus)

• Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration

  Ding, F., Sun, Q., Long, C., Rasmussen, R. N., Peng, S., Xu, Q., Kang, N., Song, W., Weikop, P., Goldman, S. A. & Nedergaard, M., 2024, In: Brain. 147, 5, p. 1726-1739 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)

• Enhancing glymphatic fluid transport by pan-adrenergic inhibition suppresses epileptogenesis in male mice

  Sun, Q., Peng, S., Xu, Q., Weikop, P., Hussain, R., Song, W., Nedergaard, M. & Ding, F., 2024, In: Nature Communications. 15, 1, 17 p., 9600.

  Research output: Contribution to journal › Journal article › Research › peer-review

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• Glymphatic clearance is enhanced during sleep

  Kroesbergen, E., Riesselmann, L. V., Gomolka, R. S., Plá, V., Esmail, T., Stenmo, V. H., Kovács, E. R., Nielsen, E. S., Goldman, S. A., Nedergaard, M., Weikop, P. & Mori, Y., 2024, 24 p. (bioRxiv).

  Research output: Working paper › Preprint

• Nutritional ketosis as treatment for alcohol withdrawal symptoms in female C57BL/6J mice

  Tonetto, S., Weikop, P. & Thomsen, M., 2024, In: Scientific Reports. 14, 1, 16 p., 5092.

  Research output: Contribution to journal › Journal article › Research › peer-review

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• Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model

  Cankar, N., Beschorner, N., Tsopanidou, A., Qvist, F. L., Colaço, A. R., Andersen, M., Kjaerby, C., Delle, C., Lambert, M., Mundt, F., Weikop, P., Jucker, M., Mann, M., Skotte, N. H. & Nedergaard, M., 2024, In: Cell Reports. 43, 11, 24 p., 114977.

  Research output: Contribution to journal › Journal article › Research › peer-review

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• Transient but not chronic hyperglycemia accelerates ocular glymphatic transport

  Delle, C., Wang, X., Giannetto, M., Newbold, E., Peng, W., Gomolka, R. S., Ladrón-de-Guevara, A., Cankar, N., Schiøler Nielsen, E., Kjaerby, C., Weikop, P., Mori, Y. & Nedergaard, M., 2024, In: Fluids and Barriers of the CNS. 21, 1, 13 p., 26.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  2 Citations (Scopus)

  7 Downloads (Pure)

• Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model

  Kaag Rasmussen, M., Møllgård, K., Bork, P. A. R., Weikop, P., Esmail, T., Drici, L., Wewer Albrechtsen, N. J., Carlsen, J. F., Huynh, N. P. T., Ghitani, N., Mann, M., Goldman, S. A., Mori, Y., Chesler, A. T. & Nedergaard, M., 2024, In: Science (New York, N.Y.). 385, 6704, p. 80-86 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)
• 2023

  Behavioral and biochemical effects of alcohol withdrawal in female C3H/HeNRj and C57BL/6JRj mice

  Tonetto, S., Weikop, P., Brudek, T. & Thomsen, M., 2023, In: Frontiers in Behavioral Neuroscience. 17, 18 p., 1143720.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  3 Citations (Scopus)

  17 Downloads (Pure)

• Local extracellular K⁺ in cortex regulates norepinephrine levels, network state, and behavioral output

  Dietz, A. G., Weikop, P., Hauglund, N., Andersen, M., Petersen, N. C., Rose, L., Hirase, H. & Nedergaard, M., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 40, 9 p., e2305071120.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  6 Citations (Scopus)

  40 Downloads (Pure)

• Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice

  Delle, C., Cankar, N., Digebjerg Holgersson, C., Hvorup Knudsen, H., Schiøler Nielsen, E., Kjaerby, C., Mori, Y., Nedergaard, M. & Weikop, P., 2023, In: Scientific Reports. 13, 1, 11 p., 4137.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  13 Citations (Scopus)

  34 Downloads (Pure)

• Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema

  Hussain, R., Tithof, J., Wang, W., Cheetham-West, A., Song, W., Peng, W., Sigurdsson, B., Kim, D., Sun, Q., Peng, S., Plá, V., Kelley, D. H., Hirase, H., Castorena-Gonzalez, J. A., Weikop, P., Goldman, S. A., Davis, M. J. & Nedergaard, M., 2023, In: Nature. 623, p. 992–1000 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  38 Citations (Scopus)

  5 Downloads (Pure)
• 2022

  An fMRI-compatible system for targeted electrical stimulation

  Jørgensen, L. M., Baandrup, A. O., Mandeville, J., Glud, A. N., Sørensen, J. C. H., Weikop, P., Jespersen, B., Hansen, A. E., Thomsen, C. & Knudsen, G. M., 2022, In: Journal of Neuroscience Methods. 378, 109659.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  1 Citation (Scopus)

  21 Downloads (Pure)

• Inactivation of the cholinergic M₄ receptor results in a disinhibited endophenotype predicting alcohol use

  Molander, A., Thorbek, D. D., Lysne, C., Weikop, P., Fink-Jensen, A. & Wörtwein, G., 2022, In: Behavioural Brain Research. 430, 10 p., 113921.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  1 Citation (Scopus)

  25 Downloads (Pure)

• Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation

  Wang, X., Delle, C., Asiminas, A., Akther, S., Vittani, M., Brøgger, P., Kusk, P., Vo, C. T., Radovanovic, T., Konno, A., Hirai, H., Fukuda, M., Weikop, P., Goldman, S. A., Nedergaard, M. & Hirase, H., 2022, In: Cell Reports Methods. 2, 10, 16 p., 100302.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  10 Citations (Scopus)

  19 Downloads (Pure)

• Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

  Kjaerby, C., Andersen, M., Hauglund, N., Untiet, V., Dall, C., Sigurdsson, B., Ding, F., Feng, J., Li, Y., Weikop, P., Hirase, H. & Nedergaard, M., 2022, In: Nature Neuroscience. 25, p. 1059–1070 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  94 Citations (Scopus)

  42 Downloads (Pure)

• The association of anxiety and other clinical features with CACNA1C rs1006737 in patients with depression

  Dam, H., Buch, J. O. D., Nielsen, A. B., Weikop, P. & Jørgensen, M. B., 2022, In: Translational Neuroscience. 13, 1, p. 320-326 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  17 Downloads (Pure)

• The role of central serotonergic markers and estradiol changes in perinatal mental health

  Borgsted, C., Høgh, S., Høgsted, E. S., Fonnesbech-Sandberg, L., Ekelund, K., Albrechtsen, C. K., Wiis, J. T., Hegaard, H., Cvetanovska, E., Juul, A., Frederiksen, H., Pinborg, A., Weikop, P. & Frokjaer, V., 2022, In: Acta Psychiatrica Scandinavica. 146, 4, p. 357-369 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  4 Citations (Scopus)

  22 Downloads (Pure)
• 2021

  Parkinson patients have a presynaptic serotonergic deficit: A dynamic deep brain stimulation PET study

  Jørgensen, L. M., Henriksen, T., Mardosiene, S., Keller, S. H., Stenbæk, D. S., Hansen, H. D., Jespersen, B., Thomsen, C., Weikop, P., Svarer, C. & Knudsen, G. M., 2021, In: Journal of Cerebral Blood Flow and Metabolism. 41, 8, p. 1954-1963 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  16 Citations (Scopus)

• The role of sex steroids and serotonin brain dynamics in perinatal mental health

  Borgsted, C., Høgh, S., Fonnesbech-Sandberg, L., Høgsted, E. S., Ekelund, K., Albrechtsen, C. K., Weikop, P., Wiis, J. T., Hegaard, H. K., Pinborg, A. & Frøkjær, V. G., 2021, In: European Neuropsychopharmacology. 53, p. S376-S377 2 p.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
• 2020

  Direct Measurement of Cerebrospinal Fluid Production in Mice

  Liu, G., Mestre, H., Sweeney, A. M., Sun, Q., Weikop, P., Du, T. & Nedergaard, M., 2020, In: Cell Reports. 33, 12, 13 p., 108524.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  66 Citations (Scopus)

  35 Downloads (Pure)

• Dynamic fluctuations of the locus coeruleus-norepinephrine system underlie sleep state transitions

  Kjaerby, C., Andersen, M., Hauglund, N., Ding, F., Wang, W., Xu, Q., Deng, S., Kang, N., Peng, S., Sun, Q., Dall, C., Jørgensen, P. K., Feng, J., Li, Y., Weikop, P., Hirase, H. & Nedergaard, M., 2 Sep 2020, 1 p.

  Research output: Other contribution › Research

  Open Access

• Effects of muscarinic M₁ receptor stimulation on reinforcing and neurochemical effects of cocaine in rats

  Weikop, P., Jensen, K. L. & Thomsen, M., 2020, In: Neuropsychopharmacology. 45, p. 1994–2002 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

  Plenge, P., Abramyan, A. M., Sørensen, G., Mork, A., Weikop, P., Gether, U., Bang-Andersen, B., Shi, L. & Loland, C. J., 2020, In: Nature Communications. 11, 1, 12 p., 1491.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  34 Citations (Scopus)

  88 Downloads (Pure)
• 2019

  Clinical association to FKBP5 rs1360780 in patients with depression

  Dam, H., Buch, J. O. D., Nielsen, A. B., Weikop, P., Werge, T. & Jørgensen, M. B., 2019, In: Psychiatric Genetics. 29, 6, p. 220-225 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)
• 2018

  Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β

  Xu, H., Rajsombath, M. M., Weikop, P. & Selkoe, D. J., 2018, In: EMBO Molecular Medicine. 10, 9, 17 p., e8931.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  55 Citations (Scopus)

  151 Downloads (Pure)

• Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons

  Runegaard, A. H., Sørensen, A. T., Fitzpatrick, C. M., Jørgensen, S. H., Petersen, A. V., Hansen, N. W., Weikop, P., Andreasen, J. T., Mikkelsen, J. D., Perrier, J-F., Woldbye, D., Rickhag, M., Wortwein, G. & Gether, U., 2018, In: eNeuro. 5, 3, 26 p., e0345.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  39 Citations (Scopus)

  294 Downloads (Pure)

• PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis

  Jensen, K. L., Sørensen, G., Dencker, D., Owens, W. A., Rahbek-Clemmensen, T., Brett Lever, M., Runegaard, A. H., Riis Christensen, N., Weikop, P., Wörtwein, G., Fink-Jensen, A., Madsen, K. L., Daws, L., Gether, U. & Rickhag, M., 2018, In: eNeuro. 5, 3

  Research output: Contribution to journal › Journal article › Research › peer-review

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  13 Citations (Scopus)

  190 Downloads (Pure)

• The circadian oscillator of the cerebral cortex: molecular, biochemical and behavioral effects of deleting the Arntl clock gene in cortical neurons

  Bering, T., Carstensen, M. B., Wörtwein, G., Weikop, P. & Rath, M. F., Feb 2018, In: Cerebral Cortex. 28, 2, p. 644–657

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)
• 2017

  Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake

  Jensen, K. L., Runegaard, A. H., Weikop, P., Gether, U. & Rickhag, M., Sep 2017, In: Journal of Visualized Experiments. 127, 10 p., e56093.

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)

• Cerebral 5-HT release correlates with [C-11]Cimbi36 PET measures of 5-HT2A receptor occupancy in the pig brain

  Jørgensen, L. M., Weikop, P., Villadsen, J., Visnapuu, T., Ettrup, A., Hansen, H. D., Baandrup, A. O., Andersen, F. L., Bjarkam, C. R., Thomsen, C., Jespersen, B. & Knudsen, G. M., Feb 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 2, p. 425-434

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  27 Citations (Scopus)

• Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice

  Thomsen, A. H. R., Jensen, K. L., Fitzpatrick, C. M., Dencker, D., Weikop, P., Gether, U. & Rickhag, K. M., Jan 2017, In: European Journal of Neuroscience. 45, 1, p. 121-128

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)
• 2016

  Decreased spontaneous activity in AMPK alpha 2 muscle specific kinase dead mice is not caused by changes in brain dopamine metabolism

  Møller, L. L. V., Sylow, L., Gøtzsche, C. R., Serup, A. K. L., Christiansen, S. H., Weikop, P., Kiens, B., Woldbye, D. P. D. & Richter, E. A., 2016, In: Physiology & Behavior. 164, Part A, p. 300-305 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels

  Reddy, I. A., Pino, J. A., Weikop, P., Osses, N., Sørensen, G., Bering, T., Valle, C., Bluett, R. J., Erreger, K., Wörtwein, G., Reyes, J. G., Graham, D., Stanwood, G. D., Hackett, T. A., Patel, S., Fink-Jensen, A., Torres, G. E. & Galli, A., 2016, In: Translational Psychiatry. 6, 11 p., e809.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  65 Citations (Scopus)

  188 Downloads (Pure)
• 2015

  Enhanced self-administration of alcohol in muscarinic acetylcholine M₄ receptor knockout mice

  de la Cour, C., Sørensen, G., Wörtwein, G., Weikop, P., Nielsen, D. D., Fink-Jensen, A. & Molander, A., 5 Jan 2015, In: European Journal of Pharmacology. 746, p. 1-5 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• INACTIVATION OF THE CHOLINERGIC M4 RECEPTOR RESULTS IN THE DEVELOPMENT OF A LOW ANXIETY ENDOPHENOTYPE PREDICTING FUTURE ALCOHOL CONSUMPTION

  Dencker, D., Woertwein, G., Lysne, C., Weikop, P., Fink-Jensen, A. & Molander, A., 2015, In: Alcohol and Alcoholism. 50, suppl 1, p. i57-i58 2 p., P-49.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• SUBCHRONIC LOW DOSE EXENDIN-4 PRETREATMENT INHIBITS RELAPSE TO ALCOHOL DRINKING IN HIGH ALCOHOL PREFERING C57BL6 MICE

  Dencker, D., Egecioglu, E., Jerlhag, E., Wörtwein, G., Weikop, P., Fink-Jensen, A. & Molander, A., 2015, In: Alcohol and Alcoholism. 50, suppl 1, p. i17-i18 2 p., SY15-2.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice

  Sorensen, G., Reddy, I. A., Weikop, P., Graham, D. L., Stanwood, G. D., Wörtwein, G., Galli, A. & Fink-Jensen, A., 1 Oct 2015, In: Physiology & Behavior. 149, p. 262-268 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  94 Citations (Scopus)
• 2013

  'In situ simulation' versus 'off site simulation' in obstetric emergencies and their effect on knowledge, safety attitudes, team performance, stress, and motivation: study protocol for a randomized controlled trial

  Sørensen, J. L., Van der Vleuten, C., Lindschou, J., Gluud, C., Ostergaard, D., Leblanc, V., Johansen, M., Ekelund, K., Albrechtsen, C. K., Pedersen, B. W., Kjærgaard, H., Weikop, P. & Ottesen, B., 2013, In: Trials. 14, p. 220

  Research output: Contribution to journal › Journal article › Research › peer-review
  32 Citations (Scopus)

• Low plasma arginine:asymmetric dimethyl arginine ratios predict mortality after intracranial aneurysm rupture

  Staalsø, J. M., Bergström, A., Edsen, T., Weikop, P., Romner, B. & Olsen, N. V., May 2013, In: Stroke. 44, 5, p. 1273-81 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  27 Citations (Scopus)

• Tesofensine induces appetite suppression and weight loss with reversal of low forebrain dopamine levels in the diet-induced obese rat

  Hansen, H. H., Jensen, M. M., Overgaard, A., Weikop, P. & Mikkelsen, J. D., 2013, In: Pharmacology, Biochemistry and Behavior. 110, p. 265-271 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  26 Citations (Scopus)
• 2012

  An allosteric enhancer of M₄ muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine

  Nielsen, D. D., Weikop, P., Sørensen, G., Woldbye, D. P. D., Wörtwein, G., Wess, J. & Fink-Jensen, A., 2012, In: Psychopharmacology. 224, 2, p. 277-87 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  43 Citations (Scopus)

• Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.

  Sørensen, G., Jensen, M., Weikop, P., Nielsen, D. D., Christiansen, S. H. O., Løland, C. J., Bengtsen, C. H., Petersen, J. H., Fink-Jensen, A., Wörtwein, G. & Woldbye, D. P. D., Feb 2012, In: Psychopharmacology. 222, p. 565-577 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  31 Citations (Scopus)
• 2011

  Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice.

  Schmidt, L. S., Thomsen, M., Weikop, P., Nielsen, D. D., Wess, J., Woldbye, D. P. D., Wörtwein, G. & Fink-Jensen, A., 2011, In: Psychopharmacology. 216, 3, p. 367-378 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  61 Citations (Scopus)

• Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist xanomeline

  Dencker, D., Wörtwein, G., Weikop, P., Jeon, J., Thomsen, M., Sager, T. N., Mørk, A., Woldbye, D. P. D., Wess, J. & Fink-Jensen, A., 2011, In: Journal of Neuroscience. 31, 16, p. 5905-8 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  48 Citations (Scopus)

• Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse and Parkinson's Disease

  Dencker, D., Thomsen, M., Wörtwein, G., Weikop, P., Cui, Y., Jeon, J., Wess, J. & Fink-Jensen, A., 22 Nov 2011, In: ACS Chemical Neuroscience. 3, 2, p. 80-89 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  57 Citations (Scopus)
• 2006

  Serotonin depletion results in a decrease of the neuronal activation caused by rivastigmine in the rat hippocampus

  Kornum, B. R., Weikop, P., Moller, A., Ronn, L. C. B., Knudsen, G. M. & Aznar, S., 16 Feb 2006, In: Brain Research. 1073-1074, p. 262-8 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)