Rasmus Kjøbsted

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• 2025

  Effects of seven days’ fasting on physical performance and metabolic adaptation during exercise in humans

  Kolnes, K. J., Nilsen, E. T. F., Brufladt, S., Meadows, A. M., Jeppesen, P. B., Skattebo, Ø., Johansen, E. I., Birk, J. B., Højlund, K., Hingst, J., Skålhegg, B. S., Kjøbsted, R., Griffin, J. L., Kolnes, A. J., O’Rahilly, S., Wojtaszewski, J. F. P. & Jensen, J., 2025, In: Nature Communications. 16, 1, 14 p., 122.

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• Pantothenate kinase 4 controls skeletal muscle substrate metabolism

  Miranda-Cervantes, A., Fritzen, A. M., Raun, S. H., Hodek, O., Møller, L. L. V., Johann, K., Deisen, L., Gregorevic, P., Gudiksen, A., Artati, A., Adamski, J., Andersen, N. R., Sigvardsen, C. M., Carl, C. S., Voldstedlund, C. T., Kjøbsted, R., Hauck, S. M., Schjerling, P., Jensen, T. E., Cebrian-Serrano, A. & 13 others, Jähnert, M., Gottmann, P., Burtscher, I., Lickert, H., Pilegaard, H., Schürmann, A., Tschöp, M. H., Moritz, T., Müller, T. D., Sylow, L., Kiens, B., Richter, E. A. & Kleinert, M., 2025, In: Nature Communications. 16, 15 p., 345.

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• 2024

  In-depth phosphoproteomic profiling of the insulin signaling response in heart tissue and cardiomyocytes unveils canonical and specialized regulation

  Achter, J. S., Vega, E. T., Sorrentino, A., Kahnert, K., Galsgaard, K. D., Hernandez-Varas, P., Wierer, M., Holst, J. J., Wojtaszewski, J. F. P., Mills, R. W., Kjøbsted, R. & Lundby, A., 2024, In: Cardiovascular Diabetology. 23, 1, 16 p., 258.

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• Pharmacological activation of PDC flux reverses lipid-induced inhibition of insulin action in muscle during recovery from exercise

  Carl, C. S., Jensen, M. M., Sjøberg, K. A., Constantin-Teodosiu, D., Hill, I. R., Kjøbsted, R., Greenhaff, P. L., Wojtaszewski, J. F. P., Richter, E. A., Fritzen, A. M. & Kiens, B., 2024, In: Diabetes. 73, 7, p. 1072–1083

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• The human AMPKγ3 R225W mutation negatively impacts site-1 nucleotide binding and does not enhance basal AMPKγ3-associated activity nor glycogen production in human or mouse skeletal muscle

  Eskesen, N. O., Kjøbsted, R., Birk, J. B., Henriksen, N. S., Andersen, N. R., Ringholm, S., Pilegaard, H. & Wojtaszewski, J. F. P., 2024, In: Acta Physiologica. 240, 10, e14213.

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• 2023

  AMPKγ3 Controls Muscle Glucose Uptake in Recovery From Exercise to Recapture Energy Stores

  Kido, K., Eskesen, N. O., Henriksen, N. S., Onslev, J., Kristensen, J. M., Larsen, M. R., Hingst, J. R., Knudsen, J. R., Birk, J. B., Andersen, N. R., Jensen, T. E., Pehmoller, C., Wojtaszewski, J. F. P. & Kjøbsted, R., 2023, In: Diabetes. 72, 10, p. 1397-1408 12 p.

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  6 Citations (Scopus)

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• TBC1D4-S711 controls skeletal muscle insulin sensitization after exercise and contraction

  Kjøbsted, R., Kristensen, J. M., Eskesen, N. O., Kido, K., Fjorder, K., Damgaard, D. F., Larsen, J. K., Andersen, N. R., Birk, J. B., Gudiksen, A., Treebak, J. T., Schjerling, P., Pilegaard, H. & Wojtaszewski, J., 2023, In: Diabetes. 72, 7, p. 857-871 15 p.

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• 2022

  Illumination of the endogenous insulin-regulated TBC1D4 interactome in human skeletal muscle

  Larsen, J. K., Larsen, M. R., Birk, J. B., Steenberg, D. E., Hingst, J. R., Højlund, K., Chadt, A., Al-Hasani, H., Deshmukh, A. S., Wojtaszewski, J. & Kjøbsted, R., 2022, In: Diabetes. 71, 5, p. 906-920

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  5 Citations (Scopus)

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• Insulin sensitization following a single exercise bout is uncoupled to glycogen in human skeletal muscle: A meta-analysis of 13 single-center human studies

  Hingst, J. R., Onslev, J. D., Holm, S., Kjøbsted, R., Frøsig, C., Kido, K., Steenberg, D. E., Larsen, M. R., Kristensen, J. M., Carl, C. S., Sjøberg, K., Thong, F. S. L., Derave, W., Pehmøller, C., Brandt, N., McConell, G., Jensen, J., Kiens, B., Richter, E. A. & Wojtaszewski, J., 2022, In: Diabetes. 71, 11, p. 2237-2250 14 p.

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  8 Citations (Scopus)

• ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle

  Nordgaard, C., Vind, A. C., Stonadge, A., Kjøbsted, R., Snieckute, G., Antas, P., Blasius, M., Reinert, M. S., Del Val, A. M., Bekker-Jensen, D. B., Haahr, P., Miroshnikova, Y. A., Mazouzi, A., Falk, S., Perrier-Groult, E., Tiedje, C., Li, X., Jakobsen, J. R., Jørgensen, N. O., Wojtaszewski, J. & 12 others, Mallein-Gerin, F., Andersen, J. L., Pennisi, C. P., Clemmensen, C., Kassem, M., Jafari, A., Brummelkamp, T., Li, V. S., Wickström, S. A., Olsen, J. V., Blanco, G. & Bekker-Jensen, S., 2022, In: E M B O Journal. 41, 17, 19 p., e111650.

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  17 Citations (Scopus)

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• 2021

  Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training

  Deshmukh, A. S., Steenberg, D. E., Hostrup, M., Birk, J. B., Larsen, J. K., Santos, A., Kjøbsted, R., Hingst, J. R., Schéele, C. C., Murgia, M., Kiens, B., Richter, E. A., Mann, M. & Wojtaszewski, J., 2021, In: Nature Communications. 12, 15 p., 304.

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  101 Citations (Scopus)

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• Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering

  Jørgensen, N. O., Kjøbsted, R., Larsen, M. R., Birk, J. B., Andersen, N. R., Albuquerque, B., Schjerling, P., Miller, R., Carling, D., Pehmøller, C. K. & Wojtaszewski, J., 2021, In: Molecular Metabolism. 51, 13 p., 101259.

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• Effect of exercise training on skeletal muscle protein expression in relation to insulin sensitivity: Per-protocol analysis of a randomized controlled trial (GO-ACTIWE)

  Bruhn, L., Kjøbsted, R., Quist, J. S., Gram, A. S., Rosenkilde, M., Færch, K., Wojtaszewski, J., Stallknecht, B. & Blond, M. B., 2021, In: Physiological Reports. 9, 10, 14 p., e14850.

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  2 Citations (Scopus)

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• Measurement of insulin- and contraction-stimulated glucose uptake in isolated and incubated mature skeletal muscle from mice

  Kjøbsted, R., Kido, K., Larsen, J. K., Jørgensen, N. O., Birk, J. B., Hellsten, Y. & Wojtaszewski, J., 2021, In: Journal of Visualized Experiments. 171, 22 p., e61398.

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• Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution

  Martinez-Val, A., Bekker-Jensen, D. B., Steigerwald, S., Koenig, C., Østergaard, O., Mehta, A., Tran, T., Sikorski, K., Torres-Vega, E., Kwasniewicz, E., Brynjólfsdóttir, S. H., Frankel, L. B., Kjøbsted, R., Krogh, N., Lundby, A., Bekker-Jensen, S., Lund-Johansen, F. & Olsen, J. V., 2021, In: Nature Communications. 12, 1, 17 p., 7113.

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  42 Citations (Scopus)

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• 2020

  ApoA-1 improves glucose tolerance by increasing glucose uptake into heart and skeletal muscle independently of AMPKα₂

  Fritzen, A. M., Domingo-Espín, J., Lundsgaard, A., Kleinert, M., Israelsen, I., Carl, C. S., Nicolaisen, T. S., Kjøbsted, R., Jeppesen, J. F., Wojtaszewski, J., Lagerstedt, J. O. & Kiens, B., 2020, In: Molecular Metabolism. 35, 11 p., 100949.

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  27 Citations (Scopus)

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• Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner

  Buch, B. T., Halling, J. F., Ringholm, S., Gudiksen, A., Kjøbsted, R., Olsen, M. A., Wojtaszewski, J. & Pilegaard, H., 2020, In: F A S E B Journal. 34, 6, p. 8653-8670

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  15 Citations (Scopus)

• Inducible deletion of skeletal muscle AMPKα 1 reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise

  Hingst, J. R., Kjøbsted, R., Birk, J. B., Jørgensen, N. O., Larsen, M. R., Kido, K., Larsen, J. K., Kjeldsen, S. A. S., Fentz, J., Frøsig, C., Holm, S., Fritzen, A. M., Dohlmann, T. L., Larsen, S., Foretz, M., Viollet, B., Schjerling, P., Overby, P., Halling, J. F., Pilegaard, H. & 2 others, Hellsten, Y. & Wojtaszewski, J., 2020, In: Molecular Metabolism. 40, 17 p., 101028.

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  34 Citations (Scopus)

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• Insulin-stimulated glucose uptake partly relies on p21-activated kinase (PAK)2, but not PAK1, in mouse skeletal muscle

  Møller, L. L. V., Jaurji, M., Kjøbsted, R., Joseph, G. A., Madsen, A. B., Knudsen, J. R., Lundsgaard, A., Andersen, N. R., Schjerling, P., Jensen, T. E., Krauss, R. S., Richter, E. A. & Sylow, L., 2020, In: Journal of Physiology. 598, 23, p. 5351-5377 27 p.

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  16 Citations (Scopus)
• 2019

  AMPK and TBC1D1 regulate muscle glucose uptake after, but not during, exercise and contraction

  Kjøbsted, R., Roll, J. L. W., Jørgensen, N. O., Birk, J. B., Foretz, M., Viollet, B., Chadt, A., Al-Hasani, H. & Wojtaszewski, J., 2019, In: Diabetes. 68, 7, p. 1427-1440 14 p.

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  72 Citations (Scopus)

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• Metformin does not compromise energy status in human skeletal muscle at rest or during acute exercise: A randomised, crossover trial

  Kristensen, J. M., Lillelund, C., Kjøbsted, R., Birk, J. B., Andersen, N. R., Nybo, L., Mellberg, K., Balendran, A., Richter, E. A. & Wojtaszewski, J., 2019, In: Physiological Reports. 7, 23, 17 p., e14307.

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  18 Citations (Scopus)

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• TBC1D4 is necessary for enhancing muscle insulin sensitivity in response to AICAR and contraction

  Kjøbsted, R., Chadt, A., Jørgensen, N. O., Kido, K., Larsen, J. K., de Wendt, C., Al-Hasani, H. & Wojtaszewski, J., 2019, In: Diabetes. 68, 9, p. 1756-1766 11 p.

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  45 Citations (Scopus)
• 2018

  Differential effects of high-fat diet and exercise training on bone and energy metabolism

  Picke, A-K., Sylow, L., Møller, L. L. V., Kjøbsted, R., Schmidt, F. N., Steejn, M. W., Salbach-Hirsch, J., Hofbauer, C., Blüher, M., Saalbach, A., Busse, B., Rauner, M. & Hofbauer, L. C., 2018, In: Bone. 116, p. 120-134 15 p.

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  39 Citations (Scopus)

• Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt

  Raun, S. H., Ali, M. S., Kjøbsted, R., Møller, L. L. V., Federspiel, M. A., Richter, E. A., Jensen, T. E. & Sylow, L., 2018, In: Journal of Physiology. 596, 12, p. 2283-2299 17 p.

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  39 Citations (Scopus)

• Serum is not necessary for prior pharmacological activation of AMPK to increase insulin sensitivity of mouse skeletal muscle

  Jørgensen, N. O., Wojtaszewski, J. & Kjøbsted, R., 2018, In: International Journal of Molecular Sciences (Online). 19, 4, 11 p., 1201.

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  4 Citations (Scopus)

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• Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity

  Shi, H., Munk, A., Nielsen, T. S., Daughtry, M. R., Larsson, L., Li, S., Høyer, K. F., Geisler, H. W., Sulek, K., Kjøbsted, R., Fisher, T., Andersen, M. M., Shen, Z., Hansen, U. K., England, E. M., Cheng, Z., Højlund, K., Wojtaszewski, J., Yang, X., Hulver, M. W. & 3 others, Helm, R. F., Treebak, J. T. & Gerrard, D. E., 2018, In: Molecular Metabolism. 11, p. 160-177 18 p.

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• 2017

  Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects

  Davegårdh, C., Broholm, C., Perfilyev, A., Henriksen, T., García-Calzón, S., Peijs, L., Hansen, N. S., Volkov, P., Kjøbsted, R., Wojtaszewski, J., Pedersen, M., Pedersen, B. K., Ballak, D. B., Dinarello, C. A., Heinhuis, B., Joosten, L. A. B., Nilsson, E., Vaag, A., Scheele, C. & Ling, C., 2017, In: BMC Medicine. 15, 27 p., 39.

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  48 Citations (Scopus)

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• Activation of skeletal muscle AMPK promotes glucose disposal and glucose lowering in non-human primates and mice

  Cokorinos, E. C., Delmore, J., Reyes, A. R., Albuquerque, B., Kjøbsted, R., Jørgensen, N. O., Tran, J-L., Jatkar, A., Cialdea, K., Esquejo, R. M., Meissen, J., Calabrese, M. F., Cordes, J., Moccia, R., Tess, D., Salatto, C. T., Coskran, T. M., Opsahl, A. C., Flynn, D., Blatnik, M. & 10 others, Li, W., Kindt, E., Foretz, M., Viollet, B., Ward, J., Kurumbail, R. G., Kalgutkar, A. S., Wojtaszewski, J., Cameron, K. O. & Miller, R. A., 2017, In: Cell Metabolism. 25, 5, p. 1147-1159, e1-e10 23 p.

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  211 Citations (Scopus)

• Enhanced muscle insulin sensitivity after contraction/exercise is mediated by AMPK

  Kjøbsted, R., Munk-Hansen, N., Birk, J. B., Foretz, M., Viollet, B., Björnholm, M., Zierath, J. R., Treebak, J. T. & Wojtaszewski, J., 2017, In: Diabetes. 66, 3, p. 598-612 15 p.

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  139 Citations (Scopus)

• Exercise increases human skeletal muscle insulin sensitivity via coordinated increases in microvascular perfusion and molecular signaling

  Sjøberg, K. A., Frøsig, C., Kjøbsted, R., Sylow, L., Kleinert, M., Betik, A. C., Shaw, C. S., Kiens, B., Wojtaszewski, J., Rattigan, S., Richter, E. A. & McConell, G. K., 2017, In: Diabetes. 66, 6, p. 1501-1510 10 p.

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  127 Citations (Scopus)

• Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice

  Kleinert, M., Parker, B. L., Fritzen, A. M., Knudsen, J. R., Jensen, T. E., Kjøbsted, R., Sylow, L., Ruegg, M. A., James, D. E. & Richter, E. A., 2017, In: Journal of Physiology. 595, 14, p. 4845-4855 11 p.

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  41 Citations (Scopus)
• 2016

  Intact regulation of the AMPK signaling network in response to exercise and insulin in skeletal muscle of male patients with type 2 diabetes: Illumination of AMPK activation in recovery from exercise

  Kjøbsted, R., Pedersen, A. J. T., Hingst, J. R., Sabaratnam, R., Birk, J. B., Kristensen, J. M., Højlund, K. & Wojtaszewski, J., 2016, In: Diabetes. 65, 5, p. 1219-1230 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  64 Citations (Scopus)

• α-MSH stimulates glucose uptake in mouse muscle and phosphorylates Rab-GTPase-activating protein TBC1D1 independently of AMPK

  Møller, C. L., Kjøbsted, R., Enriori, P. J., Jensen, T. E., Garcia-Rudaz, C., Litwak, S. A., Raun, K., Wojtaszewski, J., Wulff, B. S. & Cowley, M. A., 2016, In: P L o S One. 11, 7, 18 p., e0157027.

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  9 Citations (Scopus)

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• 2015

  AMPKα is critical for enhancing skeletal muscle fatty acid utilization during in vivo exercise in mice

  Fentz, J., Kjøbsted, R., Birk, J. B., Jordy, A. B., Jeppesen, J. F., Thorsen, K., Schjerling, P., Kiens, B., Jessen, N., Viollet, B. & Wojtaszewski, J., 2015, In: F A S E B Journal. 29, 5, p. 1725-1738 14 p.

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  67 Citations (Scopus)

• AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle

  Fentz, J., Kjøbsted, R., Maag Kristensen, C., Hingst, J. R., Birk, J. B., Gudiksen, A., Foretz, M., Schjerling, P., Viollet, B., Pilegaard, H. & Wojtaszewski, J., 2015, In: American Journal of Physiology: Endocrinology and Metabolism. 309, 11, p. E900-E914 15 p.

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  31 Citations (Scopus)

• Prior AICAR stimulation increases insulin sensitivity in mouse skeletal muscle in an AMPK-dependent manner

  Kjøbsted, R., Treebak, J. T., Fentz, J., Lantier, L., Viollet, B., Birk, J. B., Schjerling, P., Björnholm, M., Zierath, J. R. & Wojtaszewski, J., 2015, In: Diabetes. 64, 6, p. 2042-2055 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  110 Citations (Scopus)
• 2014

  Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 in human skeletal muscle

  Treebak, J. T., Pehmøller, C., Kristensen, J. M., Kjøbsted, R., Birk, J. B., Schjerling, P., Richter, E. A., Goodyear, L. J. & Wojtaszewski, J., 2014, In: Journal of Physiology. 592, 2, p. 351-375 25 p.

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  94 Citations (Scopus)