Research output per year
Research output per year
Personal profile
Short presentation
- neuromedicinal chemistry
- biostructure based SAR studies
- organic synthesis
- development of NMDA receptor ligands
Education/Academic qualification
PhD, Organic Chemistry, Silicon in Organic Chemistry: New Tri- and Tetraalkoxysilanes, Aarhus University
Award Date: 28 Oct 1999
Cand. Scient., Chemistry - Cell Biology, University of Southern Denmark
Award Date: 19 Sept 1994
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain
Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K. & Teurlings, S. M. W. & 9 others, , 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access36 Citations (Scopus) -
Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity
Zhao, F., Atxabal, U., Mariottini, S., Yi, F., Lotti, J. S., Rouzbeh, N., Liu, N., Bunch, L., Hansen, K. B. & Clausen, R. P., 2022, In: Journal of Medicinal Chemistry. 65, 1, p. 734-746Research output: Contribution to journal › Journal article › Research › peer-review
Open Access9 Citations (Scopus) -
Stereoselective synthesis of novel 2′-(S)-CCG-IV analogues as potent NMDA receptor agonists
Maolanon, A., Papangelis, A., Kawiecki, D., Mou, T. C., Syrenne, J. T., Yi, F., Hansen, K. B. & Clausen, R. P., 2021, In: European Journal of Medicinal Chemistry. 212, 17 p., 113099.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)34 Downloads (Pure) -
Improved synthetic route for the GluN2-specific NMDA receptor glycine site agonist AICP
Zhao, F., Rouzbeh, N., Hansen, K. B. & Clausen, R. P., 31 Mar 2020, In: Tetrahedron Letters. 61, 12, 4 p., 151653.Research output: Contribution to journal › Letter › peer-review
6 Citations (Scopus) -
Design of (R)-3-(5-Thienyl)carboxamido-2-aminopropanoic Acid Derivatives as Novel NMDA Receptor Glycine Site Agonists: Variation in Molecular Geometry to Improve Potency and Augment GluN2 Subunit-Specific Activity
Zhao, F., Atxabal, U., Mariottini, S., Yi, F., Lotti, J. S., Layeux, M. S., Currier, C. C., Maderia, M. P., Cornelison, L. E., Anderson, C. M., Schultz, E. P., Zhang, Z., Jiang, L., Gao, Z., Liu, N., Woodahl, E. L., Bunch, L., Hansen, K. B. & Clausen, R. P., 2025, In: Journal of Medicinal Chemistry. 68, 3, p. 3572–3590Research output: Contribution to journal › Journal article › Research › peer-review
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Evaluation of allosteric NMDA receptor modulation by GluN2A-selective antagonists using pharmacological equilibrium modeling
Lotti, J. S., Jones, J., Farnsworth, J. C., Yi, F., Zhao, F., Menniti, F. S., Volkmann, R. A., Clausen, R. P. & Hansen, K. B., 2025, In: Molecular Pharmacology. 106, 5, 17 p., 100004.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)2 Downloads (Pure) -
In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs
Bechthold, E., Grey, L., Diamant, E., Schmidt, J., Steigerwald, R., Zhao, F., Hansen, K. B., Bunch, L., Clausen, R. P. & Wünsch, B., 2023, In: Biological Chemistry. 404, 4, p. 255-265Research output: Contribution to journal › Journal article › Research › peer-review
Open Access3 Citations (Scopus) -
Discovery of (R)-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity
Zhao, F., Mazis, G., Yi, F., Lotti, J. S., Layeux, M. S., Schultz, E. P., Bunch, L., Hansen, K. B. & Clausen, R. P., 2022, In: Frontiers in Chemistry. 10, 13 p., 1008233.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile5 Citations (Scopus)20 Downloads (Pure)