Personal profile
Short presentation
How do plants integrate complex input signals, adapt and respond? Are we able to simulate these cellular circuits to control plant processes on command? Could these circuits be applied to achieve more efficient bioproduction? These questions drive my research.
My previous research was directed on genetic regulation developing switches that integrate one or more inputs like light or chemicals to get different types of responses in the plant. The development and successful implementation in planta of PULSE is one of my major achievements. PULSE is an optogenetic switch that turns on the gene expression of a gene while keeping it ‘off’ in ambient light. This foundational tool opens up the possibilities for the optogenetics plant field in basic and applied research.
My current research aims to understand how plants store high amounts of natural compounds in biocondensates while avoiding auto-toxicity. This will be key to expanding current green bio-production systems and removing current bottlenecks related to the storage of high-value compounds in the production host.
One of my career goals is to bring new technologies into the plant and microalgae field that may be applied to advance sustainable bioproduction of high-value compounds and facilitate a green transition in society.
Education/Academic qualification
Molecular and Synthetic Biology, PhD, Thesis: “Development of optogenetic tools for Plant Synthetic Biology”, Heinrich Heine University Düsseldorf
1 Jan 2015 → 7 Jul 2020
Award Date: 7 Jul 2020
B.Sc & M.Sc in Biotechnology , Thesis: “Development of modular and orthogonal logic gates for Plant Synthetic Biology by GoldenBraid Cloning system”, Polytechnic University of Valencia
1 Sept 2009 → 9 Jul 2014
Award Date: 9 Jul 2014
Keywords
- Faculty of Science
- Biochemistry
Collaborations and top research areas from the last five years
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Sorghum bicolor membrane steroid binding protein 1 can bind heme and remodel ER membranes
Ratanasopa, K., Ochoa-Fernandez, R., Mellor, S. B., Travaglia, V., Hinz, K., Tuelung, P. S. & Laursen, T., 2026, (E-pub ahead of print) In: Plant and Cell Physiology. 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access -
Biosynthesis of chlorophyll c in a dinoflagellate and heterologous production in planta
Jinkerson, R. E., Poveda-Huertes, D., Cooney, E. C., Cho, A., Ochoa-Fernandez, R., Keeling, P. J., Xiang, T. & Andersen-Ranberg, J., 2024, In: Current Biology. 34, 3, p. 594-605.e4 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile13 Citations (Scopus)22 Downloads (Pure) -
Ratiometric gibberellin biosensors for the analysis of signaling dynamics and metabolism in plant protoplasts
Andres, J., Schmunk, L. J., Grau-Enguix, F., Braguy, J., Samodelov, S. L., Blomeier, T., Ochoa-Fernandez, R., Weber, W., Al-Babili, S., Alabadí, D., Blázquez, M. A. & Zurbriggen, M. D., 2024, In: Plant Journal. 118, 4, p. 927-939 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile6 Citations (Scopus)10 Downloads (Pure) -
Sequence diversity in the monooxygenases involved in oxime production in plant defense and signaling: a conservative revision in the nomenclature of the highly complex CYP79 family
Koleva, D. T., Bengochea, A. W., Mellor, S. B., Ochoa-Fernandez, R., Nelson, D. R., Møller, B. L., Gillam, E. M. J. & Sørensen, M., 2024, In: Plant Journal. 120, 3, p. 1236-1256 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)13 Downloads (Pure) -
A Protoplast-Based Bioassay to Quantify Strigolactone Activity in Arabidopsis Using StrigoQuant
Braguy, J., Samodelov, S. L., Andres, J., Ochoa-Fernandez, R., Al-Babili, S. & Zurbriggen, M. D., 2021, Strigolactones. Springer, p. 201-218 (Methods in Molecular Biology, Vol. 2309).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
3 Citations (Scopus) -
Green Light-Controlled Gene Switch for Mammalian and Plant Cells
Schneider, N., Chatelle, C. V., Ochoa-Fernandez, R., Zurbriggen, M. D. & Weber, W., 2021, MAMMALIAN CELL ENGINEERING. Vol. 2312. p. 89-107 (Methods in Molecular Biology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
6 Citations (Scopus) -
GB3.0: a platform for plant bio-design that connects functional DNA elements with associated biological data
Vazquez-vilar, M., Quijano-rubio, A., Fernandez-del-carmen, A., Sarrion-perdigones, A., Ochoa-fernandez, R., Ziarsolo, P., Blanca, J., Granell, A. & Orzaez, D., 13 Mar 2020, In: Nucleic acids symposium series. p. gkw1326Research output: Contribution to journal › Journal article › Research › peer-review
Open Access81 Citations (Scopus) -
Optogenetic control of gene expression in plants in the presence of ambient white light
Ochoa-Fernandez, R., Abel, N. B., Wieland, F.-G., Schlegel, J., Koch, L.-A., Miller, J. B., Engesser, R., Giuriani, G., Brandl, S. M., Timmer, J., Weber, W., Ott, T., Simon, R. & Zurbriggen, M. D., 2020, In: Nature Methods. 17, 7, p. 717-725Research output: Contribution to journal › Journal article › Research › peer-review
124 Citations (Scopus)