Søren Bak

Search results

• 2024

  Site-directed genotype screening for elimination of antinutritional saponins in quinoa seeds identifies TSARL1 as a master controller of saponin biosynthesis selectively in seeds

  Trinh, M. D. L., Visintainer, D., Günther, J., Østerberg, J. T., Rodrigues da Fonseca, R. A., Fondevilla, S., Moog, M. W., Luo, G., Nørrevang, A. F., Crocoll, C., Nielsen, P. V., Jacobsen, S.-E., Wendt, T., Bak, S., López-Marqués, R. L. & Palmgren, M., 2024, In: Plant Biotechnology Journal. 22, 8, p. 2216-2234 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  1 Citation (Scopus)

  12 Downloads (Pure)
• 2023

  Biosynthesis and biotechnological production of the anti-obesity agent celastrol

  Zhao, Y., Hansen, N. L., Duan, Y., Prasad, M., Motawia, M. S., Møller, B. L., Pateraki, I., Staerk, D., Bak, S., Miettinen, K. & Kampranis, S. C., 2023, In: Nature Chemistry. 15, p. 1236–1246

  Research output: Contribution to journal › Journal article › Research › peer-review
  31 Citations (Scopus)

• Lessons learned from metabolic engineering in hairy roots: Transcriptome and metabolic profile changes caused by Rhizobium-mediated plant transformation in Cucurbitaceae species

  Almeida, A., Favero, B. T., Dong, L., Cárdenas, P. D., Saenz-Mata, J., Lütken, H. & Bak, S., Aug 2023, In: Plant Physiology and Biochemistry. 201, 8 p., 107797.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  3 Citations (Scopus)

  44 Downloads (Pure)

• Phytoalexins of the crucifer Barbarea vulgaris: Structural profile and correlation with glucosinolate turnover

  Cárdenas, P. D., Landtved, J. P., Larsen, S. H., Lindegaard, N., Wøhlk, S., Jensen, K. R., Pattison, D. I., Burow, M., Bak, S., Crocoll, C. & Agerbirk, N., 2023, In: Phytochemistry. 213, 17 p., 113742.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  4 Citations (Scopus)

  39 Downloads (Pure)

• Pollen-feeding delays reproductive senescence and maintains toxicity of Heliconius erato

  Castro, E. C. P. D., McPherson, J., Jullian, G., Mattila, A. L. K., Bak, S., Montgomery, S. H. & Jiggins, C., 2023, bioRxiv, 18 p.

  Research output: Working paper › Preprint

  Open Access

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  8 Downloads (Pure)

• The saponin bomb: a nucleolar-localized β-glucosidase hydrolyzes triterpene saponins in Medicago truncatula

  Lacchini, E., Erffelinck, M.-L., Mertens, J., Marcou, S., Molina-Hidalgo, F. J., Tzfadia, O., Venegas-Molina, J., Cárdenas, P. D., Pollier, J., Tava, A., Bak, S., Höfte, M. & Goossens, A., 2023, In: New Phytologist. 239, 2, 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  13 Citations (Scopus)

  17 Downloads (Pure)
• 2022

  A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination

  Miettinen, K., Leelahakorn, N., Almeida Robles, A. R., Zhao, Y., Hansen, L. R., Nikolajsen, I. E., Andersen, J. B., Givskov, M., Stærk, D., Bak, S. & Kampranis, S., 2022, In: Nature Communications. 13, 16 p., 3664.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  30 Citations (Scopus)

  135 Downloads (Pure)

• Metabolic engineering of cucurbitacins in Cucurbita pepo hairy roots

  Almeida, A., Dong, L., Thorsen, T. H., Raadam, M. H., Khakimov, B., Carreno-Quintero, N., Kampranis, S. C. & Bak, S., 2022, In: Frontiers in Plant Science. 13, 18 p., 1021907.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  4 Citations (Scopus)

  22 Downloads (Pure)

• Reciprocal mutations of two multifunctional β-amyrin synthases from Barbarea vulgaris shift α/β-amyrin ratios

  Günther, J., Erthmann, P. O., Khakimov, B. & Bak, S., 2022, In: Plant Physiology. 188, 3, p. 1483-1495

  Research output: Contribution to journal › Journal article › Research › peer-review

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  10 Citations (Scopus)

  34 Downloads (Pure)

• The saponin bomb

  Erffelinck, M.-L., Mertens, J., Lacchini, E., Molina-Hidalgo, F. J., Tzfadia, O., Cárdenas, P., Pollier, J., Tava, A., Bak, S. & Goossens, A., 2022, Research Square, 33 p.

  Research output: Working paper › Preprint

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  26 Downloads (Pure)
• 2021

  An independent evolutionary origin for insect deterrent cucurbitacins in Iberis amara

  Dong, L., Almeida Robles, A. R., Pollier, J., Khakimov, B., Bassard, J.-É. A., Miettinen, K., Stærk, D., Mehran, R., Olsen, C. E., Motawie, M. S., Goossens, A. & Bak, S., 2021, In: Molecular Biology and Evolution. 38, 11, p. 4659-4673 15 p., msab213.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  11 Citations (Scopus)

  33 Downloads (Pure)

• Cascading effects of root microbial symbiosis on the development and metabolome of the insect herbivore Manduca sexta L.

  Papantoniou, D., Vergara, F., Weinhold, A., Quijano, T., Khakimov, B., Pattison, D. I., Bak, S., van Dam, N. M. & Martínez-Medina, A., 2021, In: Metabolites. 11, 11, 23 p., 731.

  Research output: Contribution to journal › Review › peer-review

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  18 Citations (Scopus)

  16 Downloads (Pure)

• Effects of a saponin-based insect resistance and a systemic pathogen resistance on field performance of the wild crucifer Barbarea vulgaris

  Hauser, T. P., Christensen, S., Kuzina, V., Thines, M., Ploch, S. & Bak, S., 2021, In: Arthropod-Plant Interactions. 15, p. 683-698

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• Phenotypic plasticity in chemical defence of butterflies allows usage of diverse host plants

  De Castro, É. C. P., Musgrove, J., Bak, S., McMillan, W. O. & Jiggins, C. D., 2021, In: Biology Letters. 17, 3, 6 p., 20200863.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  13 Citations (Scopus)

  34 Downloads (Pure)
• 2020

  Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol

  Hansen, N. L., Miettinen, K., Zhao, Y., Ignea, C., Andreadeli, A., Raadam, M. H., Makris, A. M., Møller, B. L., Stærk, D., Bak, S. & Kampranis, S., 2020, In: Microbial Cell Factories. 19, 17 p., 15.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  39 Citations (Scopus)

  190 Downloads (Pure)

• Phenotypic plasticity in chemical defence allows butterflies to diversify host use strategies

  Castro, É. C. P. D., Musgrove, J., Bak, S., McMillan, W. O. & Jiggins, C. D., 2020, bioRxiv, 14 p.

  Research output: Working paper › Preprint

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  8 Downloads (Pure)

• Plant triterpenoids with bond-missing skeletons: biogenesis, distribution and bioactivity

  Almeida, A., Dong, L., Appendino, G. & Bak, S., 2020, In: Natural Product Reports. 37, 22 p.

  Research output: Contribution to journal › Review › peer-review
  31 Citations (Scopus)

• The dynamics of cyanide defences in the life cycle of an aposematic butterfly: Biosynthesis versus sequestration

  Pinheiro de Castro, É. C., Demirtas, R., Orteu, A., Olsen, C. E., Motawie, M. S., Zikan Cardoso, M., Zagrobelny, M. & Bak, S., Jan 2020, In: Insect Biochemistry and Molecular Biology. 116, p. 1-9 103259.

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)

• Variation of chemical compounds in wild Heliconiini reveals ecological factors involved in the evolution of chemical defenses in mimetic butterflies

  Sculfort, O., de Castro, E. C. P., Kozak, K. M., Bak, S., Elias, M., Nay, B. & Llaurens, V., 2020, In: Ecology and Evolution. 10, 5, p. 2677-2694 18 p.

  Research output: Contribution to journal › Review › peer-review

  Open Access

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  16 Citations (Scopus)

  27 Downloads (Pure)
• 2019

  Evolution of Structural Diversity of Triterpenoids

  Cárdenas, P. D., Almeida, A. & Bak, S., 2019, In: Frontiers in Plant Science. 10, p. 1-10 1523.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  104 Citations (Scopus)

  131 Downloads (Pure)

• Sequestration and biosynthesis of cyanogenic glucosides in passion vine butterflies and consequences for the diversification of their host plants

  Pinheiro de Castro, É. C., Zagrobelny, M., Zurano, J. P., Zikan Cardoso, M., Feyereisen, R. & Bak, S., 1 May 2019, In: Ecology and Evolution. 9, 9, p. 5079-5093

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  25 Citations (Scopus)

  122 Downloads (Pure)

• Sequestration and functional diversification of cyanogenic glucosides in the life cycle of Heliconius melpomene

  Castro, É. C. P. D., Demirtas, R., Orteu, A., Olsen, C. E., Motawie, M. S., Cardoso, M. Z., Zagrobelny, M. & Bak, S., 2019, bioRxiv, 31 p.

  Research output: Working paper › Preprint

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  9 Downloads (Pure)

• The cytochrome P450 CYP72A552 is key to production of hederagenin‐based saponins that mediate plant defense against herbivores

  Liu, Q., Khakimov, B., Cárdenas, P. D., Cozzi, F., Olsen, C. E., Jensen, K. R., Hauser, T. P. & Bak, S., May 2019, In: New Phytologist (Online). 222, 3, p. 1599-1609

  Research output: Contribution to journal › Journal article › Research › peer-review

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  44 Citations (Scopus)

  392 Downloads (Pure)
• 2018

  A Single Oxidosqualene Cyclase Produces the Seco-Triterpenoid α-Onocerin

  Almeida, A., Dong, L., Khakimov, B., Bassard, J.-É. A., Moses, T., Lota, F., Goossens, A., Appendino, G. & Bak, S., Feb 2018, In: Plant Physiology. 176, 2, p. 1469-1484 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  23 Citations (Scopus)

  108 Downloads (Pure)

• A tandem array of UDP-glycosyltransferases from the UGT73C subfamily glycosylate sapogenins, forming a spectrum of mono- and bisdesmosidic saponins

  Erthmann, P. Ø., Agerbirk, N. & Bak, S., 2018, In: Plant Molecular Biology. 97, 1-2, p. 37-55 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  38 Citations (Scopus)

• Co-expression of squalene epoxidases with triterpene cyclases boosts production of triterpenoids in plants and yeast

  Dong, L., Pollier, J., Bassard, J.-E., Ntallas, G., Almeida, A., Lazaridi, E., Khakimov, B., Arendt, P., de Oliveira, L. S., Lota, F., Goossens, A., Michoux, F. & Bak, S., Sept 2018, In: Metabolic Engineering. 49, p. 1-12

  Research output: Contribution to journal › Journal article › Research › peer-review
  47 Citations (Scopus)

• Cyanogenesis in arthropods: from chemical warfare to nuptial gifts

  Zagrobelny, M., Pinheiro de Castro, É. C., Møller, B. L. & Bak, S., Jun 2018, In: Insects. 9, 2, 39 p., 51.

  Research output: Contribution to journal › Review › peer-review

  Open Access

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  40 Citations (Scopus)

  150 Downloads (Pure)

• Evolution of the biosynthetic pathway for cyanogenic glucosides in Lepidoptera

  Zagrobelny, M., Jensen, M. K., Vogel, H., Feyereisen, R. & Bak, S., 1 Jul 2018, In: Journal of Molecular Evolution. 86, 6, p. 379-394 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)

• Glucosinolate turnover in Brassicales species to an oxazolidin-2-one, formed via the 2-thione and without formation of thioamide

  Agerbirk, N., Matthes, A., Erthmann, P. Ø., Ugolini, L., Cinti, S., Lazaridi, E., Nuzillard, J.-M., Mueller, C., Bak, S., Rollin, P. & Lazzeri, L., 2018, In: Phytochemistry. 153, p. 79-93

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)

• The arms race between heliconiine butterflies and Passiflora plants - new insights on an ancient subject

  Pinheiro de Castro, É. C., Zagrobelny, M., Cardoso, M. Z. & Bak, S., 1 Feb 2018, In: Biological Reviews. 93, 1, p. 555-573 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  44 Citations (Scopus)

• The TriForC database: a comprehensive up-to-date resource of plant triterpene biosynthesis

  Miettinen, K. A., Inigo, S., Kreft, L., Pollier, J., De Bo, C., Botzki, A., Coppens, F., Bak, S. & Goossens, A., 1 Jan 2018, In: Nucleic Acids Research. 46, D1, p. D586-D594 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  49 Citations (Scopus)

  178 Downloads (Pure)

• Triterpene Messages from the EU-FP7 Project TriForC

  Goossens, A., Osbourn, A., Michoux, F. & Bak, S., 2018, In: Trends in Plant Science. 23, 4, p. 273-276

  Research output: Contribution to journal › Editorial › Research › peer-review
  4 Citations (Scopus)
• 2017

  Developmentally regulated glucosylation of bitter triterpenoid in cucumber by the Udp-Glucosyltransferase Ugt73am3

  Zhong, Y., Xue, X., Liu, Z., Ma, Y., Zeng, K., Han, L., Qi, J., Ro, D.-K., Bak, S., Huang, S., Zhou, Y. & Shang, Y., 2017, In: Molecular Plant. 10, 7, p. 1000-1003 4 p.

  Research output: Contribution to journal › Letter › peer-review
  21 Citations (Scopus)

• Quinoa seed coats as an expanding and sustainable source of bioactive compounds: an investigation of genotypic diversity in saponin profiles

  Ruiz, K. B., Khakimov, B., Engelsen, S. B., Bak, S., Biondi, S. & Jacobsen, S.-E., 2017, In: Industrial Crops and Products. 104, p. 156-163 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  58 Citations (Scopus)

• Spatial separation of the cyanogenic β-glucosidase ZfBGD2 and cyanogenic glucosides in the haemolymph of Zygaena larvae facilitates cyanide release

  Pentzold, S., Jensen, M. K., Matthes, A., Olsen, C. E., Petersen, B. L., Clausen, H., Møller, B. L., Bak, S. & Zagrobelny, M., 2017, In: Royal Society Open Science. 4, 13 p., 170262.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  18 Citations (Scopus)

  177 Downloads (Pure)

• The genome sequence of Barbarea vulgaris facilitates the study of ecological biochemistry

  Byrne, S. L., Erthmann, P. Ø., Agerbirk, N., Bak, S., Hauser, T. P., Nagy, I., Paina, C. & Asp, T., 2017, In: Scientific Reports. 7, 14 p., 40728.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  38 Citations (Scopus)

  204 Downloads (Pure)
• 2016

  Lepidopteran defence droplets - a composite physical and chemical weapon against potential predators

  Pentzold, S., Zagrobelny, M., Khakimov, B., Engelsen, S. B., Clausen, H., Petersen, B. L., Borch, J., Møller, B. L. & Bak, S., 2016, In: Scientific Reports. 6, 11 p., 22407 .

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  16 Citations (Scopus)

  205 Downloads (Pure)

• Screening for triterpenoid saponins in plants using hyphenated analytical platforms

  Khakimov, B., Tseng, L. H., Godejohann, M., Bak, S. & Engelsen, S. B., 2016, In: Molecules. 21, 12, 19 p., 1614.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  31 Citations (Scopus)

  472 Downloads (Pure)
• 2015

  Identification and genome organization of saponin pathway genes from a wild crucifer, and their use for transient production of saponins in Nicotiana benthamiana

  Khakimov, B., Poulsen, V. K., Erthmann, P. Ø., Fukushima, E. O., Augustin, J. M., Olsen, C. E., Scholtalbers, J., Volpin, H., Andersen, S. B., Hauser, T. P., Muranaka, T. & Bak, S., 2015, In: The Plant Journal. 84, 3, p. 478-490 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  78 Citations (Scopus)

• Metabolism, excretion and avoidance of cyanogenic glucosides in insects with different feeding specialisations

  Pentzold, S., Zagrobelny, M., Bjarnholt, N., Kroymann, J., Vogel, H., Olsen, C. E., Møller, B. L. & Bak, S., 2015, In: Insect Biochemistry and Molecular Biology. 66, p. 119-128 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  33 Citations (Scopus)

• Multiple hydroxyphenethyl glucosinolate isomers and their tandem mass spectrometric destinction in a geographically structured polymorphism in the crucifer Barbarea vulgaris

  Agerbirk, N., Olsen, C. E., Heimes, C., Christensen, S., Bak, S. & Hauser, T. P., 2015, In: Phytochemistry. 115, p. 130-142 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  37 Citations (Scopus)

• The bifurcation of the cyanogenic glucoside and glucosinolate biosynthetic pathways

  Clausen, M., Kannangara, R. M., Olsen, C. E., Blomstedt, C. K., Gleadow, R. M., Jørgensen, K., Bak, S., Motawie, M. S. & Møller, B. L., 2015, In: The Plant Journal. 84, 3, p. 558-573 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  44 Citations (Scopus)

• Volatiles from the burnet Moth Zygaena filipendulae (Lepidoptera) and Associated flowers, and their involvement in mating communication

  Zagrobelny, M., Simonsen, H. T., Olsen, C. E., Bak, S. & Møller, B. L., 2015, In: Physiological Entomology. 40, 4, p. 284-295 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)
• 2014

  Chemical defense balanced by sequestration and de novo biosynthesis in a lepidopteran specialist

  Fürstenberg-Hägg, J., Zagrobelny, M., Jørgensen, K., Vogel, H., Møller, B. L. & Bak, S., 2014, In: P L o S One. 9, 10, 9 p., e108745.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  18 Citations (Scopus)

  2213 Downloads (Pure)

• High-throughput cereal metabolomics: current analytical technologies, challenges and perspectives

  Khakimov, B., Bak, S. & Engelsen, S. B., 2014, In: Journal of Cereal Science. 59, 3, p. 393-418 26 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  101 Citations (Scopus)

• How insects overcome two-component plant chemical defence: plant β-glucosidases as the main target for herbivore adaptation

  Pentzold, S., Zagrobelny, M., Rook, F. & Bak, S., 2014, In: Biological Reviews. 89, 3, p. 531-551 21 p.

  Research output: Contribution to journal › Review › peer-review
  121 Citations (Scopus)

• Sequestration, tissue distribution and developmental transmission of cyanogenic glucosides in a specialist insect herbivore

  Zagrobelny, M., Olsen, C. E., Pentzold, S., Fürstenberg-Hägg, J., Jørgensen, K., Bak, S., Møller, B. L. & Motawie, M. S., 2014, In: Insect Biochemistry and Molecular Biology. 44, p. 44-53 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  34 Citations (Scopus)

• The multiple strategies of an insect herbivore to overcome plant cyanogenic glucoside defence

  Pentzold, S., Zagrobelny, M., Roelsgaard, P. S., Møller, B. L. & Bak, S., 2014, In: PLOS ONE. 9, 3, 8 p., e91337.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  62 Citations (Scopus)

  1750 Downloads (Pure)

• Transcriptional regulation of de novo biosynthesis of cyanogenic glucosides throughout the life-cycle of the burnet moth Zyagena filipendulae (Lepidoptera)

  Fürstenberg-Hägg, J., Zagrobelny, M., Olsen, C. E., Jørgensen, K., Møller, B. L. & Bak, S., 2014, In: Insect Biochemistry and Molecular Biology. 49, p. 80-89 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)
• 2013

  Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants

  Geisler, K., Hughes, R. K., Sainsbury, F., Lomonossoff, G. P., Rejzek, M., Fairhurst, S., Olsen, C. E., Motawie, M. S., Melton, R. E., Hemmings, A. M., Bak, S. & Osbourn, A., 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 35, p. E3360-E3367 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  152 Citations (Scopus)