Research output per year
Research output per year
Personal profile
CV
Born August
19th 1947.
Cand. Pharm. (M.Sc.) from the Danish
University of
Pharmaceutical Sciences: 1971
Lic.pharm. (Ph.D.) from the Danish
University of
Pharmaceutical Sciences: 1975
Lektor (associate professor) at the Danish University of Pharmaceutical
Sciences: 1976
Fellowship at the National Cancer Centre, Tokyo:
May 1986
Fellowship at the German Cancer Research Centre,Heidelberg: Nov. 1990
MSO Professor at the Faculty of Pharmaceutical Sciences, University of Copenhagen:
2008 - present
Censor (officially appointed censor) at the Technical University, Denmark: 1991 – present
and at University of Southern Denmark 2008 - present
Member of The Danish Academy
of Natural Sciences 1991.
Chairman of the Department
of Medicinal Chemistry, Danish
University of Pharmaceutical
Sciences: 1992 - 1995
Recipient of
The H. C. Ørsted Award, June 1971 and The Pharma Innovation Award December
2011.
Author or coauthor on 170 articles in scientific
journals, coeditor on 2 books and coinventor on 8 patents, h-index 41 (Web of Science).
Short presentation
orcid.org/0000-0002-5773-6874
CV
orcid.org/0000-0002-5773-6874
Short presentation
orcid.org/0000-0002-5773-6874
Short presentation
Author or coauthor more than 185 articles or bookchapters in scientific journals or books, coeditor on 2 books and coinventor on 8 patents, h-index 50.
The main topic of research has been isolation of natural products with biological activities and optimizing of their structures to develop new drugs. The focus points have been development of mipsagargin from thapsigargin for treatment of cancer diseases and development of malaria drugs from licochalcone A.
Keywords
- Faculty of Health and Medical Sciences
- Thapsigargin
- Medicinal chemistry
- SERCA
- Natural Product Chemistry
- G202
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells
Griend, D. J. V., Antony, L., Dalrymple, S. L., Xu, Y., Christensen, S. B., Denmeade, S. R. & Isaacs, J. T., 2009, In: Molecular Cancer Therapeutics. 8, 5, p. 1340-1349Research output: Contribution to journal › Journal article › Research › peer-review
39 Citations (Scopus) -
Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase
Paulsen, E. S., Villadsen, J., Tenori, E., Liu, H., Bonde, D. F., Lie, M. A., Bublitz, M., Olesen, C. L., Autzen, H. E., Dach, I., Sehgal, P., Nissen, P., Møller, J., Schiøtt, B. & Christensen, S. B., 9 May 2013, In: Journal of Medicinal Chemistry. 56, 9, p. 3609-19 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
24 Citations (Scopus) -
Development of β-lactams since 1986: Commentary on The discovery of penicillin and cephalosporins by Sydney Selwyn
Christensen, S. B., 2024, Hemodynamics and Immune Defense: Volume 3: Discoveries in Pharmacology, Second Edition. Elsevier, Vol. 3. p. 279-282Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Drugs That Changed Society: Microtubule-Targeting Agents Belonging to Taxanoids, Macrolides and Non-Ribosomal Peptides
Christensen, S. B., 2022, In: Molecules. 27, 17, 29 p., 5648.Research output: Contribution to journal › Review › peer-review
Open AccessFile14 Citations (Scopus)59 Downloads (Pure) -
Validation of anti-malarial leads from natural products and traditional medicine for treatment of malaria
Christensen, S. B., 2022, In Evidence-Based validation of herbal medicine. Mukherjee, P. K. (ed.). 2 ed. Amsterdam: Elsevier, p. 389-407Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
2 Citations (Scopus) -
Drugs That Changed Society: History and Current Status of the Early Antibiotics: Salvarsan, Sulfonamides, and β-Lactams
Christensen, S. B., 2021, In: Molecules. 26, 19, 31 p., 6057.Research output: Contribution to journal › Review › peer-review
Open AccessFile52 Citations (Scopus)69 Downloads (Pure) -
From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development
Christensen, S. B., Simonsen, H. T., Engedal, N., Nissen, P., Møller, J. V., Denmeade, S. R. & Isaacs, J. T., 2021, In: Progress in the chemistry of organic natural products. 115, p. 59-114Research output: Contribution to journal › Review › peer-review
File8 Citations (Scopus) -
Mipsagargin: The Beginning—Not the End—of Thapsigargin Prodrug-Based Cancer Therapeutics
Isaacs, J. T., Brennen, W. N., Christensen, S. B. & Denmeade, S. R., 2021, In: Molecules. 26, 24, 7469.Research output: Contribution to journal › Review › peer-review
Open AccessFile19 Citations (Scopus)52 Downloads (Pure)
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DD-3: Natural Products as Leads in Drug Research: Dereplication, Lead Discovery and Innovation
Nielsen, J. (Panel member) & Christensen, S. B. (Speaker)
2 Jul 2019 → 4 Jul 2019Activity: Talk or presentation types › Lecture and oral contribution
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ULLA Summer School 2017
Nielsen, J. (Speaker) & Christensen, S. B. (Speaker)
11 Jul 2017Activity: Participating in an event - types › Participation in workshop, seminar, course
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Natural Products that Changed the World
Christensen, S. B. (Lecturer)
5 Nov 2015Activity: Talk or presentation types › Lecture and oral contribution
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From Plant to Patient
Christensen, S. B. (Lecturer)
5 Oct 2015Activity: Talk or presentation types › Lecture and oral contribution
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From Plant to Patient
Christensen, S. B. (Lecturer)
21 Sept 2015 → 25 Sept 2015Activity: Talk or presentation types › Lecture and oral contribution
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From Plant to Patient
Christensen, S. B. (Lecturer)
30 Jan 2015Activity: Talk or presentation types › Lecture and oral contribution
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Essential Oils
Christensen, S. B. (Participant)
30 Jan 2015Activity: Participating in an event - types › Participation in workshop, seminar, course
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From Plant to Patient
Christensen, S. B. (Lecturer)
23 Sept 2014 → 26 Sept 2014Activity: Talk or presentation types › Lecture and oral contribution