Søren Brøgger Christensen

Research output

Research output per year 1973 1993 1994 1997 2007 2008 2010 2011 2012 2015 2017 2018 2024

• 8185 Citations
• 154 Journal article
• 8 Book chapter
• 7 Review
• 4 Conference abstract in journal
• 10 More
  • 3 Conference abstract for conference
  • 3 Poster
  • 1 Compendium/lecture notes
  • 1 Comment/debate
  • 1 Conference article
  • 1 Patent

Research output per year

Research output per year

Search results

• 2024

  Development of β-lactams since 1986: Commentary on The discovery of penicillin and cephalosporins by Sydney Selwyn

  Christensen, S. B., 2024, Hemodynamics and Immune Defense: Volume 3: Discoveries in Pharmacology, Second Edition. Elsevier, Vol. 3. p. 279-282

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
• 2022

  Drugs That Changed Society: Microtubule-Targeting Agents Belonging to Taxanoids, Macrolides and Non-Ribosomal Peptides

  Christensen, S. B., 2022, In: Molecules. 27, 17, 29 p., 5648.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  42 Downloads (Pure)

• Validation of anti-malarial leads from natural products and traditional medicine for treatment of malaria

  Christensen, S. B., 2022, In Evidence-Based validation of herbal medicine. Mukherjee, P. K. (ed.). 2 ed. Amsterdam: Elsevier, p. 389-407

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
• 2021

  Drugs That Changed Society: History and Current Status of the Early Antibiotics: Salvarsan, Sulfonamides, and β-Lactams

  Christensen, S. B., 2021, In: Molecules. 26, 19, 31 p., 6057.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  58 Downloads (Pure)

• From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development

  Christensen, S. B., Simonsen, H. T., Engedal, N., Nissen, P., Møller, J. V., Denmeade, S. R. & Isaacs, J. T., 2021, In: Progress in the chemistry of organic natural products. 115, p. 59-114

  Research output: Contribution to journal › Review › Research › peer-review

  File

• Mipsagargin: The Beginning—Not the End—of Thapsigargin Prodrug-Based Cancer Therapeutics

  Isaacs, J. T., Brennen, W. N., Christensen, S. B. & Denmeade, S. R., 2021, In: Molecules. 26, 24, 7469.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  14 Citations (Scopus)

  38 Downloads (Pure)

• Natural Products that Changed Society

  Christensen, S. B., 2021, In: Biomedicines. 9, 5, 31 p., 472.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  38 Downloads (Pure)

• Targeting Toxins toward Tumors

  Franzyk, H. & Christensen, S. B., 2021, In: Molecules. 26, 5, 23 p., 1292.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  15 Citations (Scopus)

  78 Downloads (Pure)
• 2020

  Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components

  Lindner, P., Christensen, S. B., Nissen, P., Moller, J. V. & Engedal, N., 2020, In: Cell Communication and Signaling. 18, 23 p., 12.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  71 Citations (Scopus)

  68 Downloads (Pure)

• Large Scale Conversion of Trilobolide into the Payload of Mipsagargin: 8-O-(12-Aminododecanoyl)- 8-O-Debutanoylthapsigargin

  Zimmermann, T., Drasar, P., Rempelova, S., Christensen, S. B., Khripach, V. & Jurasek, M., 2020, In: Biomolecules. 10, 11 p., 1640.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  11 Citations (Scopus)

  60 Downloads (Pure)

• Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics

  Tarvainen, I., Zimmermann, T., Heinonen, P., Jäntti, M. H., Yli-Kauhaluoma, J., Talman, V., Franzyk, H., Tuominen, R. K. & Christensen, S. B., 2020, In: A C S Medicinal Chemistry Letters. 11, 5, p. 671-677 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  6 Citations (Scopus)
• 2019

  A new flavonol glycoside and other flavonoids from the aerial parts of Taverniera aegyptiaca

  Hassan, A. R., Amer, K. F., El-Toumy, S. A., Nielsen, J. & Christensen, S. B., 2019, In: Natural Product Research. 33, 8, p. 1135-1139

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy

  Andersen, T. B., Rasmussen, S. A., Christensen, S. B. & Simonsen, H. T., Jan 2019, In: Phytochemistry. 157, https://doi.org/10.1016/j.phytochem.2018.10.027, p. 168-174 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  10 Citations (Scopus)

  20 Downloads (Pure)
• 2018

  Cover Feature: LEGO-Inspired Drug Design: Unveiling a Class of Benzo[d ]thiazoles Containing a 3,4-Dihydroxyphenyl Moiety as Plasma Membrane H+ -ATPase Inhibitors (ChemMedChem 1/2018)

  Tung, T-T., Dao, T. T., Junyent, M. G., Palmgren, M., Günther-Pomorski, T., Fuglsang, A. T., Christensen, S. B. & Nielsen, J., 8 Jan 2018, In: ChemMedChem. 13, 1, 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds - Scope, Limitations and Perspectives

  Nielsen, J., Christensen, S. B. & Tung, T. T., Dec 2018, In: Synthesis. 50, 23, p. A193-A196 4 p.

  Research output: Contribution to journal › Conference article › Research › peer-review
  45 Citations (Scopus)

• Direct difluoromethylation of heterocycles using difluoroacetic acid

  Nielsen, J., Truong Thanh Tung & Christensen, S., 19 Aug 2018.

  Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

• LEGO-inspired drug design: unveiling a class of Benzo[d]thiazoles containing a 3,4-Dihydroxyphenyl moiety as plasma membrane H+-ATPase inhibitors

  Thanh Tung, T., Dao, T. T., Grifell Junyent, M., Palmgren, M. B., Günther-Pomorski, T., Fuglsang, A. T., Christensen, S. B. & Nielsen, J., 2018, In: ChemMedChem. 13, 1, 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  File
  9 Citations (Scopus)

• Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death

  Szalai, P., Parys, J. B., Bultynckb, G., Christensen, S. B., Nissen, P., Møller, J. V. & Engedal, N., Dec 2018, In: Cell Calcium. 76, p. 48-61 14 p., https://doi.org/10.1016/j.ceca.2018.09.005.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Phorbol Rearrangements

  Zimmermann, T., Franzyk, H. & Christensen, S. B., 28 Sep 2018, In: Journal of Natural Products. 81, 9, p. 2134-2137 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis

  Zimmermann, T., Christensen, S. B. & Franzyk, H., 15 Jun 2018, In: Molecules. 23, 6, 13 p., 1463.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  8 Citations (Scopus)

  204 Downloads (Pure)
• 2017

  Accelerating the domestication of new crops: feasibility and approaches

  Østerberg, J. T., Xiang, W., Olsen, L. I., Edenbrandt, A. K., Vedel, S. E., Christiansen, A., Landes, X., Andersen, M. M., Pagh, P., Sandøe, P., Nielsen, J., Christensen, S. B., Thorsen, B. J., Kappel, K., Gamborg, C. & Palmgren, M. B., 2017, In: Trends in Plant Science. 22, 5, p. 373-384 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  113 Citations (Scopus)

• Cover picture: Difluoroacetic Acid as a New Reagent for Direct C−H Difluoromethylation of Heteroaromatic Compounds

  Thanh Tung, T., Christensen, S. B. & Nielsen, J., 25 Oct 2017, In: Chemistry - A European Journal. 2 p.

  Research output: Contribution to journal › Journal article › Communication

  Open Access

  File
  105 Downloads (Pure)

• Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection

  Jensen, H. D., Struve, C., Christensen, S. B. & Krogfelt, K. A., 4 Apr 2017, In: Frontiers in Microbiology. 8, 6 p., 542.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  27 Citations (Scopus)

  221 Downloads (Pure)

• Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds

  Thanh Tung, T., Christensen, S. B. & Nielsen, J., 11 Oct 2017, In: Chemistry: A European Journal. 23, p. 18125-18128

  Research output: Contribution to journal › Journal article › Research › peer-review
  83 Citations (Scopus)

• Fusaric acid and analogues as gram-negative bacterial quorum sensing inhibitors

  Thanh Tung, T., Jakobsen, T. H., Dao, T. T., Fuglsang, A. T., Givskov, M., Christensen, S. B. & Nielsen, J., 2017, In: European Journal of Medicinal Chemistry. 126, p. 1011-1020 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  53 Citations (Scopus)

• Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response

  Sehgal, P., Szalai, P., Praetorius, H. A., Nissen, P., Christensen, S. B., Engedal, N. & Møller, J. V., 2 Oct 2017, In: Journal of Biological Chemistry. 292, 48, p. 19656-19673

  Research output: Contribution to journal › Journal article › Research › peer-review
  141 Citations (Scopus)

• LEGO-inspired drug design: Discovery of novel fungal Plasma membrane H+-ATPase (Pma1) inhibitors from small molecule libraries: An introduction of HFSA-SBS_DOS-RD strategy in drug discovery.

  Tung, T. T., Dao, T. T., Palmgren, M. B., Fuglsang, A. T., Christensen, S. B. & Nielsen, J., 2 Apr 2017.

  Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  File
  157 Downloads (Pure)

• Localization and in-vivo characterization of Thapsia garganica CYP76AE2 indicates a role in thapsigargin biosynthesis

  Andersen, T. B., Martinez-Swatson, K. A., Rasmussen, S. A., Boughton, B. A., Jørgensen, K., Andersen-Ranberg, J., Nyberg, N., Christensen, S. B. & Simonsen, H. T., 2017, In: Plant Physiology. 174, 1, p. 56-72 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  34 Citations (Scopus)

• Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

  Hassan, A. R., El-Kousy, S. M., El-Toumy, S. A., Frydenvang, K., Tung, T. T., Olsen, J., Nielsen, J. & Christensen, S. B., 27 Oct 2017, In: Journal of Natural Products. 80, p. 2830-2834 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)

• Perturbing dissimilar biomolecular targets from natural product scaffolds and focused chemical decoration.

  Nielsen, J., Tung, T. T., Tim, H. J., Trong Tuan, D., Anja T., F., Michael, G. & Christensen, S. B., 2 Apr 2017. 1 p.

  Research output: Contribution to conference › Poster › Research › peer-review

  File
  93 Downloads (Pure)

• Structure/activity Relationship of Thapsigargin Inhibition on the Purified Golgi/secretory Pathway Ca²⁺/Mn²⁺-Transport ATPase (SPCA1a)

  Jialin, C., de Raeymaecker, J., Hovgaard, J. B., Smaardijk, S., Vandecaetsbeek, I., Wuytack, F., Møller, J. V., Eggermont, J., de Meyer, M., Christensen, S. B. & Vangheluwe, P., 2017, In: Journal of Biological Chemistry. 292, 17, p. 6938-6951 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  20 Citations (Scopus)
• 2016

  Demethoxycurcumin is a potent inhibitor of P-type ATPases from diverse kingdoms of life

  Dao, T. T., Sehgal, P., Thanh Tung, T., Møller, J. V., Nielsen, J., Palmgren, M. B., Christensen, S. B. & Fuglsang, A. T., 2016, In: P L o S One. 11, 9, 19 p., e0163260.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  22 Citations (Scopus)

  368 Downloads (Pure)

• Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation

  Jensen, C. M., Chow, H-Q., Chen, M., Zhai, L., Frydenvang, K. A., Liu, H., Franzyk, H. & Christensen, S. B., 2016, In: European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Neglected diseases

  Christensen, S. B. & Bygbjerg, I. C., 2016, Textbook of Drug Design and Discovery, Fifth Edition. CRC Press, p. 347-368 22 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  1 Citation (Scopus)
• 2015

  Are we ready for back-to-nature crop breeding?

  Palmgren, M. B., Edenbrandt, A. K., Vedel, S. E., Andersen, M. M., Landes, X., Østerberg, J. T., Falhof, J., Olsen, L. I., Christensen, S. B., Sandøe, P., Gamborg, C., Kappel, K., Thorsen, B. J. & Pagh, P., 2015, In: Trends in Plant Science. 20, 3, p. 155-164 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  177 Citations (Scopus)

• Chemo- and regioselective functionalization of nortrilobolide: application for semi-synthesis of the natural product 2-acetoxytrilobolide

  Doan, T. Q. N., Crestey, F., Olsen, C. E. & Christensen, S. B., 2015, In: Journal of Natural Products. 78, 6, p. 1406-1414

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  19 Citations (Scopus)

  113 Downloads (Pure)

• Concise Synthesis of Thapsigargin from Nortrilobolide

  Crestey, F., Toma, M. & Christensen, S. B., 8 Sep 2015, In: Tetrahedron Letters. 56, 43, p. 5896-5898 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Drugs and drug leads based on natural products for treatment and prophylaxis of malaria

  Christensen, S. B., 25 Feb 2015, Evidence-based validation of herbal medicine: Elsevier. Amsterdam, p. 307-319

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  6 Citations (Scopus)

• Iminolactones from Schizophyllum commune

  Liu, X., Frydenvang, K. A., Liu, H., Zhai, L., Chen, M., Olsen, C. E. & Christensen, S. B., 2015, In: Journal of Natural Products. 78, 5, p. 1165-1168 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)

• Novel thapsigargin analogues and methods of preparing them

  Doan, T. Q. N., Christensen, S. B. & Crestey, F. L. J., 30 Dec 2015, Patent No. WO2015197860 A2, Priority date 27 Jun 2014, Priority No. DK20140070395 20140627

  Research output: Patent

• Targeting thapsigargin towards tumors

  Christensen, S. B., Doan, T. Q. N., Paulsen, E. S., Sehgal, P., Møller, J. V., Nissen, P., Denmeade, S. R., Isaacs, J. T. & Dionne, C. A., 2015, In: Steroids. 97, p. 2-7 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  108 Citations (Scopus)

• Thapsigargin, origin, chemistry, structure-activity relationships and prodrug development.

  Doan, T. Q. N. & Christensen, S. B., Oct 2015, In: Current Pharmaceutical Design. 21, 38, p. 5505-5517 13 p.

  Research output: Contribution to journal › Review › Research › peer-review
  59 Citations (Scopus)
• 2013

  Differential effects of thapsigargin analogues on apoptosis of prostate cancer cells: complex regulation by intracellular calcium

  Christensen, S. B., Dubois, C., Abeele, F. V., Sehgal, P., Olesen, C., Junker, S., Prevarskaya, N. & Møller, J. V., 2013, In: F E B S Journal. 280, 21, p. 5430-5440 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  37 Citations (Scopus)

• Guaianolide Sesquiterpenoids: Pharmacology and biosynthesis

  Simonsen, H. T., Weitzel, C. & Christensen, S. B., 2013, Natural products: phytochemistry, botany and metabolism of alkaloids, phenolics and terpenes. Ramawat, K. G. & Mérillon, J-M. (eds.). Springer, p. 3069-3098 30 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  File
  59 Citations (Scopus)

• Serotonin transporter protein (SERT) and P-glycoprotein (P-gp) binding activity of montanine and coccinine from three species of Haemanthus L. (Amaryllidaceae)

  Stafford, G. I., Birer, C., Brodin, B., Christensen, S. B., Eriksson, A. H., Jäger, A. & Rønsted, N., Sep 2013, In: South African Journal of Botany. 88, p. 101-106 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  10 Citations (Scopus)

  213 Downloads (Pure)

• Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase

  Paulsen, E. S., Villadsen, J., Tenori, E., Liu, H., Bonde, D. F., Lie, M. A., Bublitz, M., Olesen, C. L., Autzen, H. E., Dach, I., Sehgal, P., Nissen, P., Møller, J., Schiøtt, B. & Christensen, S. B., 9 May 2013, In: Journal of Medicinal Chemistry. 56, 9, p. 3609-19 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)
• 2012

  6-O-Methylkrigeine, a new Amaryllidaceae alkaloid from Nerine huttoniae Schönland

  Molander, M., Christensen, S. B., Jaeger, A. K., Olsen, C. E. & Ronsted, N., 2012, In: Natural Product Research. 26, 1, p. 56-60 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• Alkaloid analysis by high-performance liquid chromatography-solid phase extraction-nuclear magnetic resonance: New strategies going beyond the standard

  Johansen, K., Ebild, S. J., Christensen, S. B., Godejohann, M. & Jaroszewski, J. W., 28 Dec 2012, In: Journal of Chromatography A. 1270, p. 171-177 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  22 Citations (Scopus)

• Can phylogeny predict chemical diversity and potential medicinal activity of plants? A case study of Amaryllidaceae

  Rønsted, N., Symonds, M. R. E., Birkholm, T., Christensen, S. B., Meerow, A. W., Schmidt, M. M., Mølgaard, P., Petersen, G., Rasmussen, N., van Staden, J., Stafford, G. I. & Jäger, A., 14 Sep 2012, In: BMC Evolutionary Biology. 12, 12 p., 182.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  107 Citations (Scopus)

  394 Downloads (Pure)

• Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles

  Holler, J. G., Slotved, H-C., Mølgaard, P., Olsen, C. E. & Christensen, S. B., 2012, In: Bioorganic & Medicinal Chemistry. 20, 14, p. 4514 - 4521 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  67 Citations (Scopus)