Søren Brunak

Search results

• 2023

  Complex effects of sequence variants on lipid levels and coronary artery disease

  Snaebjarnarson, A. S., Helgadottir, A., Arnadottir, G. A., Ivarsdottir, E. V., Thorleifsson, G., Ferkingstad, E., Einarsson, G., Sveinbjornsson, G., Thorgeirsson, T. E., Ulfarsson, M. O., Halldorsson, B. V., Olafsson, I., Erikstrup, C., Pedersen, O. B., Nyegaard, M., Bruun, M. T., Ullum, H., Brunak, S., Iversen, K. K., Christensen, A. H. & 14 others, Olesen, M. S., Ghouse, J., Banasik, K., Knowlton, K. U., Arnar, D. O., Thorgeirsson, G., Nadauld, L., Ostrowski, S. R., Bundgaard, H., Holm, H., Sulem, P., Stefansson, K., Gudbjartsson, D. F. & DBDS Genomic Consortium, 2023, In: Cell. 186, 19, p. 4085-4099.e15

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)

• DanMAC5: a browser of aggregated sequence variants from 8,671 whole genome sequenced Danish individuals

  Banasik, K., Møller, P. L., Techlo, T. R., Holm, P. C., Walters, G. B., Ingason, A., Rosengren, A., Rohde, P. D., Kogelman, L. J. A., Westergaard, D., Siggaard, T., Chmura, P. J., Chalmer, M. A., Magnússon, Ó., Þórisson, G., Stefánsson, H., Guðbjartsson, D. F., Stefánsson, K., Olesen, J., Winther, S. & 5 others, Bøttcher, M., Brunak, S., Werge, T., Nyegaard, M. & Hansen, T. F., 2023, In: BMC Genomic Data. 24, 1, 4 p., 30.

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  2 Citations (Scopus)

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• Deep integrative models for large-scale human genomics

  Sigurdsson, A. I., Louloudis, I., Banasik, K., Westergaard, D., Winther, O., Lund, O., Ostrowski, S. R., Erikstrup, C., Pedersen, O. B., Nyegaard, M., Brunak, S., Vilhjálmsson, BJ. & Rasmussen, S., 2023, In: Nucleic Acids Symposium Series. 51, 12, 16 p.

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• Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality

  Oddsson, A., Sulem, P., Sveinbjornsson, G., Arnadottir, G. A., Steinthorsdottir, V., Halldorsson, G. H., Atlason, B. A., Oskarsson, G. R., Helgason, H., Nielsen, H. S., Westergaard, D., Karjalainen, J. M., Katrinardottir, H., Fridriksdottir, R., Jensson, B. O., Tragante, V., Ferkingstad, E., Jonsson, H., Gudjonsson, S. A., Beyter, D. & 31 others, Moore, K. H. S., Thordardottir, H. B., Kristmundsdottir, S., Stefansson, O. A., Rantapää-Dahlqvist, S., Sonderby, I. E., Didriksen, M., Stridh, P., Haavik, J., Tryggvadottir, L., Frei, O., Walters, G. B., Kockum, I., Hjalgrim, H., Olafsdottir, T. A., Selbaek, G., Nyegaard, M., Erikstrup, C., Brodersen, T., Saevarsdottir, S., Olsson, T., Nielsen, K. R., Hansen, T. F., Brunak, S., Jacobsen, R. L., Brunak, S., Banasik, K., Askling, J., Pedersen, O. B., Ostrowski, S. R. & DBDS Genomic Consortium, 2023, In: Nature Communications. 14, 15 p., 3453.

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  7 Citations (Scopus)

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• Development of a dynamic prediction model for unplanned ICU admission and mortality in hospitalized patients

  Placido, D., Thorsen-Meyer, H-C., Kaas-Hansen, B. S., Reguant, R. & Brunak, S., 2023, In: PLOS Digital Health. 2, 6, 18 p., e0000116.

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  3 Citations (Scopus)

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• Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models: [with Author Correction]

  Allesøe, R. L., Lundgaard, A. T., Hernández Medina, R., Aguayo-Orozco, A., Johansen, J., Nissen, J. N., Brorsson, C., Mazzoni, G., Niu, L., Biel, J. H., Brasas, V., Webel, H., Benros, M. E., Pedersen, A. G., Chmura, P. J., Jacobsen, U. P., Mari, A., Koivula, R., Mahajan, A., Vinuela, A. & 31 others, Tajes, J. F., Sharma, S., Haid, M., Hong, M-G., Musholt, P. B., De Masi, F., Vogt, J., Pedersen, H. K., Gudmundsdottir, V., Jones, A., Kennedy, G., Bell, J., Thomas, E. L., Frost, G., Thomsen, H., Hansen, E., Hansen, T. H., Vestergaard, H., Muilwijk, M., Blom, M. T., 't Hart, L. M., Pattou, F., Raverdy, V., Brage, S., Ridderstråle, M., Pedersen, O., Hansen, T., Banasik, K., Rasmussen, S., Brunak, S. & IMI-DIRECT consortium, 2023, In: Nature Biotechnology. 41, 3, p. 399–408 18 p.

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• Drug dosage modifications in 24 million in-patient prescriptions covering eight years: A Danish population-wide study of polypharmacy

  Leal Rodríguez, C., Haue, A. D., Mazzoni, G., Eriksson, R., Hernansanz Biel, J., Cantwell, L., Westergaard, D., Belling, K. G. & Brunak, S., 2023, In: PLOS Digital Health. 2, 9, 27 p., e0000336.

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• eTRANSAFE: data science to empower translational safety assessment

  Sanz, F., Pognan, F., Steger-Hartmann, T., Díaz, C., Asakura, S., Amberg, A., Bécourt-Lhote, N., Blomberg, N., Bosc, N., Briggs, K., Bringezu, F., Brulle-Wohlhueter, C., Brunak, S., Bueters, R., Callegaro, G., Capella-Gutierrez, S., Centeno, E., Corvi, J., Cronin, M. T. D., Drew, P. & 41 others, Duchateau-Nguyen, G., Ecker, G. F., Escher, S., Felix, E., Ferreiro, M., Frericks, M., Furlong, L. I., Geiger, R., George, C., Grandits, M., Ivanov-Draganov, D., Kilgour-Christie, J., Kiziloren, T., Kors, J. A., Koyama, N., Kreuchwig, A., Leach, A. R., Mayer, M. A., Monecke, P., Muster, W., Nakazawa, C. M., Nicholson, G., Parry, R., Pastor, M., Piñero, J., Oberhauser, N., Ramírez-Anguita, J. M., Rodrigo, A., Smajic, A., Schaefer, M., Schieferdecker, S., Soininen, I., Terricabras, E., Trairatphisan, P., Turner, S. C., Valencia, A., van de Water, B., van der Lei, J. L., van Mulligen, E. M., Vock, E. & Wilkinson, D., 2023, In: Nature Reviews Drug Discovery. 22, 8, p. 605-606 2 p.

  Research output: Contribution to journal › Comment/debate › Research
  8 Citations (Scopus)

• Gene expression signature predicts rate of type 1 diabetes progression

  Suomi, T., Starskaia, I., Kalim, U. U., Rasool, O., Jaakkola, M. K., Grönroos, T., Välikangas, T., Brorsson, C., Mazzoni, G., Bruggraber, S., Overbergh, L., Dunger, D., Peakman, M., Chmura, P., Brunak, S., Schulte, A. M., Mathieu, C., Knip, M., Lahesmaa, R., Elo, L. L. & 4 others, Pociot, F., Johannesen, J., Rossing, P. & INNODIA consortium, 2023, In: EBioMedicine. 92, 18 p., 104625.

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  9 Citations (Scopus)

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• Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

  Brown, A. A., Fernandez-Tajes, J. J., Hong, M. G., Brorsson, C. A., Koivula, R. W., Davtian, D., Dupuis, T., Sartori, A., Michalettou, T. D., Forgie, I. M., Adam, J., Allin, K. H., Caiazzo, R., Cederberg, H., De Masi, F., Elders, P. J. M., Giordano, G. N., Haid, M., Hansen, T., Hansen, T. H. & 134 others, Hattersley, A. T., Heggie, A. J., Howald, C., Jones, A. G., Kokkola, T., Laakso, M., Mahajan, A., Mari, A., McDonald, T. J., McEvoy, D., Mourby, M., Musholt, P. B., Nilsson, B., Pattou, F., Penet, D., Raverdy, V., Ridderstråle, M., Romano, L., Rutters, F., Sharma, S., Teare, H., ‘t Hart, L., Tsirigos, K. D., Vangipurapu, J., Vestergaard, H., Brunak, S., Franks, P. W., Frost, G., Grallert, H., Jablonka, B., McCarthy, M. I., Pavo, I., Pedersen, O., Ruetten, H., Walker, M., Adragni, K., Allesøe, R. L. L., Artati, A. A., Arumugam, M., Atabaki-Pasdar, N., Baltauss, T., Banasik, K., Barnett, A. L., Baum, P., Bell, J. D., Beulens, J. W., Bianzano, S. B., Bizzotto, R., Bonnefond, A., Cabrelli, L., Dale, M., Dawed, A. Y., de Preville, N., Dekkers, K. F., Deshmukh, H. A., Dings, C., Donnelly, L., Dutta, A., Ehrhardt, B., Engelbrechtsen, L., Eriksen, R., Fan, Y., Ferrer, J., Fitipaldi, H., Forman, A., Fritsche, A., Froguel, P., Gassenhuber, J., Gough, S., Graefe-Mody, U., Grempler, R., Groeneveld, L., Groop, L., Gudmundsdóttir, V., Gupta, R., Hennige, A. M. H., Hill, A. V., Holl, R. W., Hudson, M., Jacobsen, U. P., Jennison, C., Johansen, J., Jonsson, A., Karaderi, T., Kaye, J., Kennedy, G., Klintenberg, M., Kuulasmaa, T., Lehr, T., Loftus, H., Lundgaard, A. T. T., Mazzoni, G., McRobert, N., McVittie, I., Nice, R., Nicolay, C., Nijpels, G., Palmer, C. N., Pedersen, H. K., Perry, M. H., Pomares-Millan, H., Prehn, C. P., Ramisch, A., Rasmussen, S., Robertson, N., Rodriquez, M., Sackett, P., Scherer, N., Shah, N., Sihinevich, I., Slieker, R. C., Sondertoft, N. B., Steckel-Hamann, B., Thomas, M. K., Thomas, C. E. E., Thomas, E. L. L., Thorand, B., Thorne, C. E., Tillner, J., Tura, A., Uhlen, M., van Leeuwen, N., van Oort, S., Verkindt, H., Vogt, J., Wad Sackett, P. W., Wesolowska-Andersen, A., Whitcher, B., White, M. W., Adamski, J., Schwenk, J. M., Pearson, E. R., Dermitzakis, E. T. & Viñuela, A., 2023, In: Nature Communications. 14, 17 p., 5062.

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• Genetic prediction of 33 blood group phenotypes using an existing genotype dataset

  Moslemi, C., Sækmose, S. G., Larsen, R., Bay, J. T., Brodersen, T., Didriksen, M., Hjalgrim, H., Banasik, K., Nielsen, K. R., Bruun, M. T., Dowsett, J., Dinh, K. M., Mikkelsen, S., Mikkelsen, C., Hansen, T. F., Ullum, H., Erikstrup, C., Brunak, S., Krogfelt, K. A., Storry, J. R. & 3 others, Ostrowski, S. R., Olsson, M. L. & Pedersen, O. B., 2023, In: Transfusion. 63, 12, p. 2297-2310 14 p.

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• Genetic variants associated with syncope implicate neural and autonomic processes

  Aegisdottir, H. M., Thorolfsdottir, R. B., Sveinbjornsson, G., Stefansson, O. A., Gunnarsson, B., Tragante, V., Thorleifsson, G., Stefansdottir, L., Thorgeirsson, T. E., Ferkingstad, E., Sulem, P., Norddahl, G., Rutsdottir, G., Banasik, K., Christensen, A. H., Mikkelsen, C., Pedersen, O. B., Brunak, S., Bruun, M. T., Erikstrup, C. & 26 others, Jacobsen, R. L., Nielsen, K. R., Sorensen, E., Frigge, M. L., Hjorleifsson, K. E., Ivarsdottir, E., Helgadottir, A., Gretarsdottir, S., Steinthorsdottir, V., Oddsson, A., Eggertsson, H. P., Halldorsson, G. H., Jones, D. A., Anderson, J. L., Knowlton, K. U., Nadauld, L. D., DBDS Genomic Consortium, D. B. D. S. G. C., Haraldsson, M., Thorgeirsson, G., Bundgaard, H., Arnar, D. O., Thorsteinsdottir, U., Gudbjartsson, D. F., Ostrowsk, S. R., Holm, H. & Stefansson, K., 2023, In: European Heart Journal. 44, 12, p. 1070–1080 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

  Roychowdhury, T., Klarin, D., Levin, M. G., Spin, J. M., Rhee, Y. H., Deng, A., Headley, C. A., Tsao, N. L., Gellatly, C., Zuber, V., Shen, F., Hornsby, W. E., Laursen, I. H., Verma, S. S., Locke, A. E., Einarsson, G., Thorleifsson, G., Graham, S. E., Dikilitas, O., Pattee, J. W. & 74 others, Judy, R. L., Pauls-Verges, F., Nielsen, J. B., Wolford, B. N., Brumpton, B. M., Dilmé, J., Peypoch, O., Juscafresa, L. C., Edwards, T. L., Li, D., Banasik, K., Brunak, S., Jacobsen, R. L., Garcia-Barrio, M. T., Zhang, J., Rasmussen, L. M., Lee, R., Handa, A., Wanhainen, A., Mani, K., Lindholt, J. S., Obel, L. M., Strauss, E., Oszkinis, G., Nelson, C. P., Saxby, K. L., van Herwaarden, J. A., van der Laan, S. W., van Setten, J., Camacho, M., Davis, F. M., Wasikowski, R., Tsoi, L. C., Gudjonsson, J. E., Eliason, J. L., Coleman, D. M., Henke, P. K., Ganesh, S. K., Chen, Y. E., Guan, W., Pankow, J. S., Pankratz, N., Pedersen, O. B., Erikstrup, C., Tang, W., Hveem, K., Gudbjartsson, D., Gretarsdottir, S., Thorsteinsdottir, U., Holm, H., Stefansson, K., Ferreira, M. A., Baras, A., Kullo, I. J., Ritchie, M. D., Christensen, A. H., Iversen, K. K., Eldrup, N., Sillesen, H., Ostrowski, S. R., Bundgaard, H., Ullum, H., Burgess, S., Gill, D., Gallagher, K., Sabater-Lleal, M., Dudbridge, F., Samani, N. J., Surakka, I., Jones, G. T., Bown, M. J., Tsao, P. S., Willer, C. J. & Damrauer, S. M., 2023, In: Nature Genetics. 55, p. 1831–1842 13 p.

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• Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement

  Henkel, C., Styrkársdóttir, U., Thorleifsson, G., Stefánsdóttir, L., Björnsdóttir, G., Banasik, K., Brunak, S., Erikstrup, C., Dinh, K. M., Hansen, T. F., Nielsen, K. R., Bruun, M. T., Dowsett, J., Brodersen, T., Thorgeirsson, T. E., Gromov, K., Boesen, M. P., Ullum, H., Ostrowski, S. R., Pedersen, O. B. & 3 others, Stefánsson, K., Troelsen, A. & DBDS Genomic Consortium, 2023, In: Annals of the Rheumatic Diseases. 82, p. 384-392

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth

  Beaumont, R. N., Flatley, C., Vaudel, M., Wu, X., Chen, J., Moen, G. H., Skotte, L., Helgeland, Ø., Solé-Navais, P., Banasik, K., Albiñana, C., Ronkainen, J., Fadista, J., Stinson, S. E., Trajanoska, K., Wang, C. A., Westergaard, D., Srinivasan, S., Sánchez-Soriano, C., Bilbao, J. R. & 68 others, Allard, C., Groleau, M., Kuulasmaa, T., Leirer, D. J., White, F., Jacques, P. É., Cheng, H., Hao, K., Andreassen, O. A., Åsvold, B. O., Atalay, M., Bhatta, L., Bouchard, L., Brumpton, B. M., Brunak, S., Bybjerg-Grauholm, J., Ebbing, C., Elliott, P., Engelbrechtsen, L., Erikstrup, C., Estarlich, M., Franks, S., Gaillard, R., Geller, F., Grove, J., Hougaard, D. M., Kajantie, E., Morgen, C. S., Nohr, E. A., Nyegaard, M., Palmer, C. N. A., Pedersen, O. B., Rivadeneira, F., Sebert, S., Shields, B. M., Stoltenberg, C., Surakka, I., Thørner, L. W., Ullum, H., Vaarasmaki, M., Vilhjalmsson, B. J., Willer, C. J., Lakka, T. A., Gybel-Brask, D., Bustamante, M., Hansen, T., Pearson, E. R., Reynolds, R. M., Ostrowski, S. R., Pennell, C. E., Jaddoe, V. W. V., Felix, J. F., Hattersley, A. T., Melbye, M., Lawlor, D. A., Hveem, K., Werge, T., Nielsen, H. S., Magnus, P., Evans, D. M., Jacobsson, B., Järvelin, M. R., Zhang, G., Hivert, M. F., Johansson, S., Freathy, R. M., Feenstra, B. & Njølstad, P. R., 2023, In: Nature Genetics. 55, 11, p. 1807-1819 13 p.

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• Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism

  Ghouse, J., Tragante, V., Ahlberg, G., Rand, S. A., Jespersen, J. B., Leinøe, E. B., Vissing, C. R., Trudsø, L., Jonsdottir, I., Banasik, K., Brunak, S., Ostrowski, S. R., Pedersen, O. B., Sørensen, E., Erikstrup, C., Bruun, M. T., Nielsen, K. R., Køber, L., Christensen, A. H., Iversen, K. & 16 others, Jones, D., Knowlton, K. U., Nadauld, L., Halldorsson, G. H., Ferkingstad, E., Olafsson, I., Gretarsdottir, S., Onundarson, P. T., Sulem, P., Thorsteinsdottir, U., Thorgeirsson, G., Gudbjartsson, D. F., Stefansson, K., Holm, H., Olesen, M. S. & Bundgaard, H., 2023, In: Nature Genetics. 55, p. 399-409 18 p.

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  53 Citations (Scopus)

• Identification of biomarkers for glycaemic deterioration in type 2 diabetes

  Slieker, R. C., Donnelly, L. A., Akalestou, E., Lopez-Noriega, L., Melhem, R., Güneş, A., Abou Azar, F., Efanov, A., Georgiadou, E., Muniangi-Muhitu, H., Sheikh, M., Giordano, G. N., Åkerlund, M., Ahlqvist, E., Ali, A., Banasik, K., Brunak, S., Barovic, M., Bouland, G. A., Burdet, F. & 46 others, Canouil, M., Dragan, I., Elders, P. J. M., Fernandez, C., Festa, A., Fitipaldi, H., Froguel, P., Gudmundsdottir, V., Gudnason, V., Gerl, M. J., van der Heijden, A. A., Jennings, L. L., Hansen, M. K., Kim, M., Leclerc, I., Klose, C., Kuznetsov, D., Mansour Aly, D., Mehl, F., Marek, D., Melander, O., Niknejad, A., Ottosson, F., Pavo, I., Duffin, K., Syed, S. K., Shaw, J. L., Cabrera, O., Pullen, T. J., Simons, K., Solimena, M., Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Legido Quigley, C., Groop, L., Thorens, B., Franks, P. W., Lim, G. E., Estall, J., Ibberson, M., Beulens, J. W. J., 't Hart, L. M., Pearson, E. R. & Rutter, G. A., 2023, In: Nature Communications. 14, 18 p., 2533.

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• Pancreatic cancer symptom trajectories from Danish registry data and free text in electronic health records

  Hjaltelin, J. X., Novitski, S. I., Jørgensen, I. F., Siggaard, T., Vulpius, S. A., Westergaard, D., Johansen, J. S., Chen, I. M., Juhl Jensen, L. & Brunak, S., 2023, In: eLife. 12, 15 p., e84919.

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• Plasma YKL-40 is associated with prognosis in patients with metastatic pancreatic cancer receiving immune checkpoint inhibitors in combination with radiotherapy

  Johansen, A. Z., Novitski, S. I., Hjaltelin, J. X., Theile, S., Boisen, M. K., Brunak, S., Madsen, D. H., Nielsen, D. L. & Chen, I. M., 2023, In: Frontiers in Immunology. 14, 10 p., 1228907.

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• Population-Based Characterization of Menstrual Migraine and Proposed Diagnostic Criteria

  Chalmer, M. A., Kogelman, L. J. A., Ullum, H., Sørensen, E., Didriksen, M., Mikkelsen, S., Dinh, K. M., Brodersen, T., Nielsen, K. R., Bruun, M. T., Banasik, K., Brunak, S., Erikstrup, C., Pedersen, O. B., Ostrowski, S. R., Olesen, J. & Hansen, T. F., 2023, In: JAMA network open. 6, 5, 12 p., e2313235.

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• Population-wide analysis of hospital laboratory tests to assess seasonal variation and temporal reference interval modification

  Muse, V. P., Aguayo-Orozco, A., Balaganeshan, S. B. & Brunak, S., 2023, In: Patterns. 4, 8, 14 p., 100778.

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  4 Citations (Scopus)

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• Precision medicine in complex diseases - Molecular subgrouping for improved prediction and treatment stratification

  Johansson, Å., Andreassen, O. A., Brunak, S., Franks, P. W., Hedman, H., Loos, R. J. F., Meder, B., Melén, E., Wheelock, C. E. & Jacobsson, B., 2023, In: Journal of Internal Medicine. 294, 4, p. 378-396 19 p.

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• Pregnancy-Associated Bleeding and Genetics: Five Sequence Variants in the Myometrium and Progesterone Signaling Pathway are associated with postpartum hemorrhage

  Westergaard, D., Steinthorsdottir, V., Stefansdottir, L., Rohde, P. D., Wu, X., Geller, F., Tyrmi, J., Havulinna, A. S., Navais, P. S., Flatley, C., Ostrowski, S. R., Pedersen, O. B., Erikstrup, C., Sørensen, E., Mikkelsen, C., Brun, M. T., Jensen, B. A., Brodersen, T., Ullum, H., Magnus, P. & 8 others, Andreassen, O. A., Njolstad, P. R., Krebs, L., Hansen, T. F., Banasik, K., Brunak, S., Nielsen, H. S. & FinnGen, 2023, medRxiv, 51 p. (medRxiv).

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• Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura

  Bjornsdottir, G., Chalmer, M. A., Stefansdottir, L., Skuladottir, A. T., Einarsson, G., Andresdottir, M., Beyter, D., Ferkingstad, E., Gretarsdottir, S., Halldorsson, B. V., Halldorsson, G. H., Helgadottir, A., Helgason, H., Hjorleifsson Eldjarn, G., Jonasdottir, A., Jonasdottir, A., Jonsdottir, I., Knowlton, K. U., Nadauld, L. D., Lund, S. H. & 30 others, Magnusson, O. T., Melsted, P., Moore, K. H. S., Oddsson, A., Olason, P. I., Sigurdsson, A., Banasik, K., Brunak, S., Didriksen, M., Kogelman, L. J. A., Nielsen, K. R., Sørensen, E., Pedersen, O. B., Ullum, H., Bay, J., Burgdorf, K., Dowsett, J., Hjalgrim, H., Jacobsen, R. L., Louloudis, I., Lundgaard, A., Mikkelsen, C., Nyegaard, M., Henriksen, A. P., Werge, T., Westergaard, D., Olesen, J., Ostrowski, S. R., Hansen, T. F. & DBDS Genetic Consortium, 2023, In: Nature Genetics. 55, 11, p. 1843-1853

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• Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory

  Moulder, R., Välikangas, T., Hirvonen, M. K., Suomi, T., Brorsson, C. A., Lietzén, N., Bruggraber, S. F. A., Overbergh, L., Dunger, D. B., Peakman, M., Chmura, P. J., Brunak, S., Schulte, A. M., Mathieu, C., Knip, M., Elo, L. L., Lahesmaa, R. & on behalf of the INNODIA consortium, 2023, In: Diabetologia. 66, p. 1983-1996

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• The promise of digital healthcare technologies

  Yeung, A. W. K., Torkamani, A., Butte, A. J., Glicksberg, B. S., Schuller, B., Rodriguez, B., Ting, D. S. W., Bates, D., Schaden, E., Peng, H., Willschke, H., van der Laak, J., Car, J., Rahimi, K., Celi, L. A., Banach, M., Kletecka-Pulker, M., Kimberger, O., Eils, R., Islam, S. M. S. & 5 others, Wong, S. T., Wong, T. Y., Gao, W., Brunak, S. & Atanasov, A. G., 2023, In: Frontiers in Public Health. 11, 12 p., 1196596.

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• The small and large intestine contain related mesenchymal subsets that derive from embryonic Gli1⁺ precursors

  Pærregaard, S. I., Wulff, L., Schussek, S., Niss, K., Mörbe, U., Jendholm, J., Wendland, K., Andrusaite, A. T., Brulois, K. F., Nibbs, R. J. B., Sitnik, K., Mowat, A. M. I., Butcher, E. C., Brunak, S. & Agace, W. W., 2023, In: Nature Communications. 14, 1, 2307.

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• Visualising disease trajectories from population-wide data

  Hjaltelin, J. X., Currant, H., Jørgensen, I. F. & Brunak, S., 2023, In: Frontiers in Bioinformatics. 3, 5 p., 1112113.

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• 2022

  A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome

  Skuladottir, A. T., Bjornsdottir, G., Ferkingstad, E., Einarsson, G., Stefansdottir, L., Nawaz, M. S., Oddsson, A., Olafsdottir, T. A., Saevarsdottir, S., Walters, G. B., Magnusson, S. H., Bjornsdottir, A., Sveinsson, O. A., Vikingsson, A., Hansen, T. F., Jacobsen, R. L., Erikstrup, C., Schwinn, M., Brunak, S., Banasik, K. & 11 others, Ostrowski, S. R., Troelsen, A., Henkel, C., Pedersen, O. B., Jonsdottir, I., Gudbjartsson, D. F., Sulem, P., Thorgeirsson, T. E., Stefansson, H., Stefansson, K. & DBDS Genetic Consortium, 2022, In: Nature Communications. 13, 1, 9 p., 1598.

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• Cholesterol not particle concentration mediates the atherogenic risk conferred by apolipoprotein B particles - A Mendelian randomization analysis

  Helgadottir, A., Thorleifsson, G., Snaebjarnarson, A., Stefansdottir, L., Sveinbjornsson, G., Tragante, V., Björnsson, E., Steinthorsdottir, V., Gretarsdottir, S., Helgason, H., Saemundsdottir, J., Olafsson, I., Thune, J. J., Axelsson Raja, A., Ghouse, J., Olesen, M. S., Christensen, A., Jacobsen, R. L., Dowsett, J., Bruun, M. T. & 18 others, Nielsen, K., Knowlton, K., Nadauld, L., Benediktsson, R., Erikstrup, C., Pedersen, O. B., Banasik, K., Brunak, S., Bundgaard, H., Ostrowski, S. R., Sulem, P., Arnar, D. O., Thorgeirsson, G., Thorsteinsdottir, U., Gudbjartsson, D. F., Stefansson, K., Holm, H. & DBDS Genomic Consortium, 2022, In: European Journal of Preventive Cardiology. 29, 18, p. 2374–2385

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• Classification of Left and Right Coronary Arteries in Coronary Angiographies Using Deep Learning

  Eschen, C. K., Banasik, K., Christensen, A. H., Chmura, P. J., Pedersen, F., Køber, L., Engstrøm, T., Dahl, A. B., Brunak, S. & Bundgaard, H., 2022, In: Electronics (Switzerland). 11, 13, 9 p., 2087.

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• Clinical, genetic, and experimental increase in soluble urokinase plasminogen activator receptor levels promotes atherosclerosis

  Hindy, G., Tyrrell, D. J., Vasbinder, A., Wei, C., Presswalla, F., Wang, H., Blakely, P. K., Ozel, A. B., Graham, S. E., Holton, G. H., Dowsett, J., Fahed, A. C., Amadi, K-M., Erne, G. K., Tekumulla, A., Ismail, A., Launius, C., Sotoodehnia, N., Pankow, J. S., Thørner, L. W. & 22 others, Erikstrup, C., Pedersen, O. B., Banasik, K., Brunak, S., Ullum, H., Eugen-Olsen, J., Ostrowski, S. R., Haas, M. E., Nielsen, J. B., Lotta, L. A., Engström, G., Melander, O., Orho-Melander, M., Zhao, L., Murthy, V. L., Pinsky, D. J., Willer, C. J., Heckbert, S. R., Reiser, J., Goldstein, D. R., Desch, K. C. & Hayek, S. S., 2022, In: Journal of Clinical Investigation. 132, 24, 14 p., e158788.

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• Cross-tissue transcriptome-wide association studies identify susceptibility genes shared between schizophrenia and inflammatory bowel disease

  Uellendahl-Werth, F., Maj, C., Borisov, O., Juzenas, S., Wacker, E. M., Jorgensen, I. F., Steiert, T. A., Bej, S., Krawitz, P., Hoffmann, P., Schramm, C., Wolkenhauer, O., Banasik, K., Brunak, S., Schreiber, S., Karlsen, T. H., Degenhardt, F., Noethen, M., Franke, A., Folseraas, T. & 1 others, Ellinghaus, D., 2022, In: Communications Biology. 5, 15 p., 80.

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• Detailed stratified GWAS analysis for severe COVID-19 in four European populations

  Degenhardt, F., Ellinghaus, D., Juzenas, S., Lerga-Jaso, J., Wendorff, M., Maya-Miles, D., Uellendahl-Werth, F., ElAbd, H., Rühlemann, M. C., Arora, J., Özer, O., Lenning, O. B., Myhre, R., Vadla, M. S., Wacker, E. M., Wienbrandt, L., Ortiz, A. B., Salazar, A., Chercoles, A. G., Palom, A. & 31 others, Ruiz, A., Garcia-Fernandez, A-E., Blanco-Grau, A., Mantovani, A., Zanella, A., Holten, A. R., Mayer, A., Bandera, A., Cherubini, A., Protti, A., Aghemo, A., Gerussi, A., Ramirez, A., Braun, A., Nebel, A., Barreira, A., Lleo, A., Teles, A., Kildal, A. B., Biondi, A., Caballero-Garralda, A., Ganna, A., Gori, A., Glück, A., Lind, A., Hinney, A., Jensen, B., Banasik, K., Castro, P., Brunak, S. & COVICAT study group, Aachen Study (COVAS), 2022, In: Human Molecular Genetics. 31, 23, p. 3945-3966 22 p.

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• Development and validation of a dynamic prediction model for unplanned ICU admission and mortality in hospitalized patients

  Placido, D., Thorsen-Meyer, H-C., Kaas-Hansen, B. S., Reguant, R. & Brunak, S., 2022.

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• Discrete-time survival analysis in the critically ill: a deep learning approach using heterogeneous data

  Thorsen-Meyer, H-C., Placido, D., Kaas-Hansen, B. S., Nielsen, A. P., Lange, T., Nielsen, A. B., Toft, P., Schierbeck, J., Strøm, T., Chmura, P. J., Heimann, M., Belling, K., Perner, A. & Brunak, S., 2022, In: npj Digital Medicine. 5, 10 p., 142.

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• Drug interactions in hospital prescriptions in Denmark: Prevalence and associations with adverse outcomes

  Rodríguez, C. L., Kaas-Hansen, B. S., Eriksson, R., Biel, J. H., Belling, K. G., Andersen, S. E. & Brunak, S., 2022, In: Pharmacoepidemiology and Drug Safety. 31, 6, p. 632-642 11 p.

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• Eliciting drug safety signals from patient records: a language-agnostic approach

  Kaas-Hansen, B., Placido, D., Rodriguez, C., Thorsen-Meyer, H., Gentile, S., Nielsen, A., Brunak, S., Jurgens, G. & Andersen, S., 2022, p. S15-S16. 2 p.

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• Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: A Danish genome-wide association study

  DBDS Genomic Consortium, 2022, In: Joint Bone Spine. 89, 4, 105357.

  Research output: Contribution to journal › Comment/debate › Research › peer-review
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• Estimating the effect of donor sex on red blood cell transfused patient mortality: A retrospective cohort study using a targeted learning and emulated trials-based approach

  Bruun-Rasmussen, P., Andersen, P. K., Banasik, K., Brunak, S. & Johansson, P. I., 2022, In: EClinicalMedicine. 51, 10 p., 101628.

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• Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study

  Wesolowska-Andersen, A., Brorsson, C. A., Bizzotto, R., Mari, A., Tura, A., Koivula, R., Mahajan, A., Vinuela, A., Tajes, J. F., Sharma, S., Haid, M., Prehn, C., Artati, A., Hong, M. G., Musholt, P. B., Kurbasic, A., Masi, F. D., Tsirigos, K., Pedersen, H. K., Gudmundsdottir, V. & 31 others, Thomas, C. E., Banasik, K., Jennison, C., Jones, A., Kennedy, G., Bell, J., Thomas, L., Frost, G., Thomsen, H., Allin, K., Hansen, T. H., Vestergaard, H., Hansen, T., Rutters, F., Elders, P., t'Hart, L., Bonnefond, A., Canouil, M., Brage, S., Kokkola, T., Heggie, A., McEvoy, D., Hattersley, A., McDonald, T., Teare, H., Ridderstrale, M., Walker, M., Forgie, I., Pedersen, O., Brunak, S. & IMI-DIRECT consortium, 2022, In: Cell Reports Medicine. 3, 1, 25 p., 100477.

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• Genetic Variants Close to TTN, NKX2-5, and MYH6 Associate With AVNRT

  Andreasen, L., Ahlberg, G., Ægisdóttir, H. M., Sveinbjörnsson, G., Lundegaard, P. R., Hartmann, J. P., Paludan-Müller, C., Hadji-Turdeghal, K., Ghouse, J., Pehrson, S., Jensen, H. K., Riahi, S., Hansen, J., Sandgaard, N., Sørensen, E., Banasik, K., Sækmose, S. G., Bruun, M. T., Hjalgrim, H., Erikstrup, C. & 18 others, Pedersen, O. B., Wittig, M., Haunsø, S., Ostrowski, S. R., Genomic Consortium, D., Franke, A., Brunak, S., Kanters, J. K., Ellervik, C., Bundgaard, H., Ullum, H., Gudbjartsson, D. F., Thorsteinsdottir, U., Holm, H., Arnar, D. O., Stefansson, K., Svendsen, J. H. & Olesen, M. S., 2022, In: Circulation Research. 131, 10, p. 862-865

  Research output: Contribution to journal › Letter › Research › peer-review
  4 Citations (Scopus)

• Global priorities for large-scale biomarker-based prospective cohorts

  Collins, R., Balaconis, M. K., Brunak, S., Chen, Z., De Silva, M., Gaziano, J. M., Ginsburg, G. S., Jha, P., Kuri, P., Metspalu, A., Mulder, N. & Risch, N., 2022, In: Cell Genomics. 2, 6, 4 p., 100141.

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• Intervening on the Storage Time of RBC Units and its Effects on Adverse Recipient Outcomes using Real-World Data

  Bruun-Rasmussen, P., Andersen, P. K., Banasik, K., Brunak, S. & Johansson, P. I., 2022, In: Blood. 139, 25, p. 3647–3654

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• Language-agnostic pharmacovigilant text mining to elicit side effects from clinical notes and hospital medication records

  Kaas-Hansen, B. S., Placido, D., Rodríguez, C. L., Thorsen-Meyer, H-C., Gentile, S., Nielsen, A. P., Brunak, S., Jürgens, G. & Andersen, S. E., 2022, In: Basic & clinical pharmacology & toxicology. 131, 4, p. 282-293 12 p.

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• Language-agnostic pharmacovigilant text mining to elicit side effects from clinical notes and hospital medication records

  Kaas-Hansen, B. S., Placido, D., Rodrìguez, C. L., Thorsen-Meyer, H-C., Gentile, S., Nielsen, A. P., Brunak, S., Jürgens, G. & Andersen, S. E., 2022, Authorea, (Authorea Preprints).

  Research output: Working paper › Preprint

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• Machine Learning to Identify Patients at Risk of Inappropriate Dosing for Renal Risk Medications: A Critical Comment on Kaas-Hansen et al [Response to Letter]

  Kaas-Hansen, B. S., Leal Rodríguez, C., Placido, D., Thorsen-Meyer, H-C., Nielsen, A. P., Dérian, N., Brunak, S. & Andersen, S. E., 2022, In: Clinical Epidemiology. 14, p. 765-766 2 p.

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• Modeling of waning immunity after SARS-CoV-2 vaccination and influencing factors

  Pérez-Alós, L., Armenteros, J. J. A., Madsen, J. R., Hansen, C. B., Jarlhelt, I., Hamm, S. R., Heftdal, L. D., Pries-Heje, M. M., Møller, D. L., Fogh, K., Hasselbalch, R. B., Rosbjerg, A., Brunak, S., Sørensen, E., Larsen, M. A. H., Ostrowski, S. R., Frikke-Schmidt, R., Bayarri-Olmos, R., Hilsted, L. M., Iversen, K. K. & 3 others, Bundgaard, H., Nielsen, S. D. & Garred, P., 2022, In: Nature Communications. 13, 1, 11 p., 1614.

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• Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

  Saevarsdottir, S., Stefansdottir, L., Sulem, P., Thorleifsson, G., Ferkingstad, E., Rutsdottir, G., Glintborg, B., Westerlind, H., Grondal, G., Loft, I. C., Sorensen, S. B., Lie, B. A., Brink, M., Ärlestig, L., Arnthorsson, A. O., Baecklund, E., Banasik, K., Bank, S., Bjorkman, L. I., Ellingsen, T. & 31 others, Erikstrup, C., Frei, O., Gjertsson, I., Gudbjartsson, D. F., Gudjonsson, S. A., Halldorsson, G. H., Hendricks, O., Hillert, J., Hogdall, E., Jacobsen, S., Jensen, D. V., Jonsson, H., Kastbom, A., Kockum, I., Kristensen, S., Kristjansdottir, H., Larsen, M. H., Linauskas, A., Hauge, E-M., Loft, A. G., Ludviksson, B. R., Lund, S. H., Ostrowski, S. R., Sørensen, E., Sørensen, I. J., Brunak, S., Andersen, V., Hetland, M. L., Askling, J., Pedersen, O. B. & Members of the DBDS Genomic Consortium, 2022, In: Annals of the Rheumatic Diseases. 81, 8, p. 1085-1095

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• Polygenic risk score for ACE-inhibitor-associated cough based on the discovery of new genetic loci

  Ghouse, J., Tragante, V., Muhammad, A., Ahlberg, G., Skov, M. W., Roden, D. M., Jonsdottir, I., Andreasen, L., Lundegaard, P. R., Trudsø, L. C., Banasik, K., Brunak, S., Ostrowski, S. R., Torp-Pedersen, C., Pedersen, O. V., Sørensen, E., Køber, L., Iversen, K., Thorsteinsdottir, U., Thorgeirsson, G. & 8 others, Ullum, H., Gudbjartsson, D. F., Mosley, J. D., Holm, H., Stefansson, K., Bundgaard, H., Olesen, M. S. & eMERGE consortium, 2022, In: European Heart Journal. 43, 45, p. 4707–4718

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  8 Citations (Scopus)