Short presentation

Professor in Clinical Physiology and Nuclear Medicine with special focus on haemodynamic and homoeostatic pathophysiology. Chief physician and specialist in Clinical Physiology and Nuclear Medicine at Hvidovre Hospital and University of Copenhagen. About 210 international and national publications including original papers, review articles and book chapters on haemodynamic, humoral, and metabolic aspects of chronic liver disease. Main research topics include pathophysiology and metabolism and haemodynamic and homeostatic complications to chronic liver disease and portal hypertension in particular with focus on organ-related complications and fluid retention. Current research programmes cover studies on changes in pulmonary function (hepatopulmonary syndrome), impact of bacterial translocation and inflammation of cardiac and renal function in cirrhosis, pathophysiology and epidemiology relating to cirrhotic cardiomyopathy and investigation of novel biomarkers of renal injury (NGAL), cardiac failure (hsTNT), inflammation (hsCRP,sUPAR) and the prognostic potential of these systems. In terms of treatment we conduct protocols relating to acute and chronic haemodynamic effects of betablockers and randomised controlled trials on the effects of antibiotics (Rifaximin) on  renal function and splanchnic and systemic haemodynamics. We are preparing studies on effects of vasoconstrictors (Dobutamin) on cardiac function and volumes in advanced cirrhosis. Moreover, we plan in cooperation with Rigshospitalet a study on haemodymic and humoral effects of intrahepatic shunts (TIPS) in patients with refractory ascites and bleeding oesophageal varices.