No photo of Sam Trammell
  • Blegdamsvej 3

    2200 København N.

  • Blegdamsvej 3B, Mærsk Tårnet, 8. sal

    2200 København N.

  • Source: Scopus
20122024

Research activity per year

Personal profile

Short presentation

The Grevengoed group is interested in a novel class of lipids known as n-acyl taurines (NATs). As a conjugate of a fatty acid and taurine, these amphiphilic lipids are excellent, endogenously produced detergents. Dr. Grevengoed has previously revealed a role of these metabolites in cell signaling through GPR119 and in fat absorption. Through my experience in metabolomics, I aided in her studies of the kinetics of NAT metabolism and revealed that NATs are a biliary lipid class whose concentration increases with dietary fish oil to comparable levels of bile acids. While continuing to improve NAT analytical methods, we are uncovering how NATs are synthesized, localized to bile and how NATs cause fat malabsorption.

In parallel with my work on n-acyl taurine biology, I am interested in appetite regulation. Fibroblast growth factor 21 (FGF21) is a macronutrient responsive hepatokine known to regulate lipid metabolism and macronutrient preference. Circulating FGF21 increases in response to carbohydrates, protein restriction and alcohol ingestion. In converse, high protein diets blunt FGF21 in the presence of its secretagogues. How these macronutrient signals integrate to regulate hepatic FGF21 remains poorly understood. Using mass spectrometry based metabolomics, I am uncovering a relationship between small molecule metabolites and FGF21.

CV

Assistant Professor, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen.

Education

  • May 2016: PhD in Genetics. Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA, USA. Advisor: Prof. Charles Brenner, PhD.
  • May 2009: B.Sc. in Genetics. Genetics Department, University of Wisconsin – Madison.
    Current position
  • 2021-present: Assistant Prof. Department of Biomedical Sciences, University of Copenhagen. Group leader: Assistant Prof. Trisha Grevengoed, PhD

Previous positions

  • April 2021 – June 2021: Staff Scientist in Metabolomics, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen. Group Leader: Prof. Jens Juul Holst, MD
  • May 2020 – December 2020: Staff Scientist in Metabolomics, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen. Group Leader: Associate Prof. Matthew P. Gillum, PhD
  • 2016-2020: Post Doctoral Research Fellow in Metabolomics, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen. Advisor: Associate Prof. Matthew P. Gillum, PhD
  • 2009 - 2016: PhD Candidate, Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA, USA. Advisor: Prof. Charles Brenner, PhD.

Academic awards and honors 

  • 2018: Marion Dave Francis Innovator Award. University of Iowa, Iowa City, IA
  • 2017: University of Iowa Graduate Dean’s Distinguished Dissertation Prize awarded for Thesis entitled “Novel NAD+ Metabolomic Technologies and their Applications to Nicotinamide Riboside Interventions”. University of Iowa, Iowa City, IA
  • June 2012 – June 2013: MCB-0822581 from the National Science Foundation and by NIH Pre-Doctoral Training Program in Genetics T32 grant GM008629.

Keywords

  • Faculty of Health and Medical Sciences
  • hormone secretagogues
  • molecular trafficking
  • lipid metabolism
  • Metabolomics
  • Mass spectrometry

Collaborations and top research areas from the last five years

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