Signe Mathiasen

Search results

• 2024

  Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes

  Kizilkaya, H. S., Sørensen, K. V., Madsen, J. S., Lindquist, P., Douros, J. D., Bork-Jensen, J., Berghella, A., Gerlach, P. A., Gasbjerg, L. S., Mokrosiński, J., Mowery, S. A., Knerr, P. J., Finan, B., Campbell, J. E., D’Alessio, D. A., Perez-Tilve, D., Faas, F., Mathiasen, S., Rungby, J. & Sørensen, H. T. & 15 others, Vaag, A., Nielsen, J. S., Holm, J. C., Lauenborg, J., Damm, P., Pedersen, O., Linneberg, A., Hartmann, B., Holst, J. J., Hansen, T., Wright, S. C., Lauschke, V. M., Grarup, N., Hauser, A. S. & Rosenkilde, M. M., 2024, In: Nature Metabolism. 6, p. 1268–1281

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  16 Citations (Scopus)

  15 Downloads (Pure)
• 2023

  Adhesion G protein‐coupled receptor's structure, function and role in biology—Status from the 10^th adhesion GPCR workshop in Copenhagen, 2022

  Rosenkilde, M. M. & Mathiasen, S., 2023, In: Basic & clinical pharmacology & toxicology. 133, 4, p. 281-284

  Research output: Contribution to journal › Editorial › Research › peer-review

  Open Access

  File
  5 Downloads (Pure)

• Re-routing GPR56 signalling using Gα_12/13 G protein chimeras

  Faas, F., Nørskov, A., Holst, P. J., Andersson, A. M., Qvortrup, K., Mathiasen, S. & Rosenkilde, M. M., 2023, In: Basic and Clinical Pharmacology and Toxicology. 133, 4, p. 378-389

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  2 Citations (Scopus)

  20 Downloads (Pure)
• 2021

  Single-molecule FRET imaging of GPCR dimers in living cells

  Asher, W. B., Geggier, P., Holsey, M. D., Gilmore, G. T., Pati, A. K., Meszaros, J., Terry, D. S., Mathiasen, S., Kaliszewski, M. J., McCauley, M. D., Govindaraju, A., Zhou, Z., Harikumar, K. G., Jaqaman, K., Miller, L. J., Smith, A. W., Blanchard, S. C. & Javitch, J. A., 2021, In: Nature Methods. 18, 4, p. 397-405 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  132 Citations (Scopus)

  30 Downloads (Pure)
• 2020

  Agonist-induced formation of unproductive receptor-G₁₂ complexes

  Okashah, N., Wright, S. C., Kawakami, K., Mathiasen, S., Zhou, J., Lu, S., Javitch, J. A., Inoue, A., Bouvier, M. & Lambert, N. A., 1 Sept 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 35, p. 21723-21730 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  37 Citations (Scopus)

• G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

  Mathiasen, S., Palmisano, T., Perry, N. A., Stoveken, H. M., Vizurraga, A., McEwen, D. P., Okashah, N., Langenhan, T., Inoue, A., Lambert, N. A., Tall, G. G. & Javitch, J. A., Dec 2020, In: Nature Chemical Biology. 16, 12, p. 1343–1350

  Research output: Contribution to journal › Journal article › Research › peer-review
  43 Citations (Scopus)

• Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter

  Guthrie, D. A., Klein Herenbrink, C., Lycas, M. D., Ku, T., Bonifazi, A., Devree, B. T., Mathiasen, S., Javitch, J. A., Grimm, J. B., Lavis, L., Gether, U. & Newman, A. H., 2020, In: ACS Chemical Neuroscience. 11, 20, p. 3288-3300 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  12 Citations (Scopus)
• 2018

  Single Proteoliposome High-Content Analysis Reveals Differences in the Homo-Oligomerization of GPCRs

  Walsh, S. M., Mathiasen, S., Christensen, S. M., Fay, J. F., King, C., Provasi, D., Borrero, E., Rasmussen, S. G. F., Fung, J. J., Filizola, M., Hristova, K., Kobilka, B., Farrens, D. L. & Stamou, D., 17 Jul 2018, In: Biophysical Journal. 115, 2, p. 300-312 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  20 Citations (Scopus)
• 2017

  Extreme vetting of dopamine receptor oligomerization

  Asher, W. B., Mathiasen, S., Holsey, M. D., Grinnell, S. G., Lambert, N. A. & Javitch, J. A., 2017, Receptors. Humana Press, p. 99-127 29 p. (Receptors, Vol. 33).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  5 Citations (Scopus)

• Single-molecule analysis of ligand efficacy in β₂AR-G-protein activation

  Gregorio, G. G., Masureel, M., Hilger, D., Terry, D. S., Juette, M., Zhao, H., Zhou, Z., Perez-Aguilar, J. M., Hauge, M., Mathiasen, S., Javitch, J. A., Weinstein, H., Kobilka, B. K. & Blanchard, S. C., 2017, In: Nature. 547, 7661, p. 68–73

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  253 Citations (Scopus)
• 2016

  Electronic tuning of self-healing fluorophores for live-cell and single-molecule imaging

  Zheng, Q., Jockusch, S., Zhou, Z., Altman, R. B., Zhao, H., Asher, W., Holsey, M., Mathiasen, S., Geggier, P., Javitch, J. A. & Blanchard, S. C., 2016, In: Chemical Science. 8, 1, p. 755-762 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  52 Citations (Scopus)
• 2015

  CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature

  Miller, S. E., Mathiasen, S., Bright, N. A., Pierre, F., Kelly, B. T., Kladt, N., Schauss, A., Merrifield, C. J., Stamou, D., Höning, S. & Owen, D. J., 2015, In: Developmental Cell. 33, 2, p. 163-175 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  160 Citations (Scopus)

  502 Downloads (Pure)

• Impact of PI(3,4,5)P3-Mediated beta-Arrestin-1 Recruitment on Structure of Asymmetric Lipid Bilayers: Biophysical Society Annual Meeting. Baltimore, Maryland, Febr. 7-11 2015

  Nzulumike, A. N. O., Mathiasen, S., Mahoney, J. P., Cardenas Gomez, M., Stamou, D. & Mortensen, K., 7 Feb 2015, In: Biophysical Journal. 108, 2, Suppl., p. 342A-342A

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• Membrane curvature bends the laws of physics and chemistry

  Iversen, L., Mathiasen, S., Larsen, J. B. & Stamou, D., 2015, In: Nature Chemical Biology. 11, 11, p. 822-825 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  70 Citations (Scopus)
• 2014

  Nanoscale high-content analysis using compositional heterogeneities of single proteoliposomes

  Mathiasen, S., Christensen, S. M., Fung, J. J., Rasmussen, S. G. F., Fay, J. F., Jørgensen, S. K., Veshaguri, S., Farrens, D. L., Kiskowski, M., Kobilka, B. & Stamou, D., 2014, In: Nature Methods. 11, p. 931-934 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  58 Citations (Scopus)
• 2013

  Biophysical characterization of GPCR oligomerization

  Mathiasen, S., 2013, Department of Chemistry, Faculty of Science, University of Copenhagen. 167 p.

  Research output: Book/Report › Ph.D. thesis

  File

• Developing an Assay to Probe Activtion and Conformational Dynamics of beta 2-Adrenergic Receptor on Single Molecule Level

  Veshaguri, S., Tutkus, M., Lundgaard, C. V., Tonnesen, A., Mathiasen, S., Jorgensen, S. K., Iversen, L., Hatzakis, N. S., Rasmussen, S. G. & Stamou, D., 2013, In: Biophysical Journal. 104, 2, 1 p.

  Research output: Contribution to journal › Conference abstract in journal › Research

  Open Access

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  14 Downloads (Pure)
• 2011

  Particle-dissociating peptides

  Brown, S. & Mathiasen, S., 4 Jan 2011, In: Advanced Materials. 23, 1, p. 132-135 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)