Steen Pedersen

Search results

• 2023

  Ketone body infusion abrogates growth hormone-induced lipolysis and insulin resistance

  Høgild, M. L., Hjelholt, A. J., Hansen, J., Pedersen, S. B., Møller, N., Wojtaszewski, J., Johannsen, M., Jessen, N. & Lunde Jørgensen, J. O., 2023, In: Journal of Clinical Endocrinology and Metabolism. 108, 3, p. 653-664 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  37 Downloads (Pure)
• 2019

  Absolute quantification of translational regulation and burden using combined sequencing approaches

  Gorochowski, T. E., Chelysheva, I., Eriksen, M., Nair, P., Pedersen, S. & Ignatova, Z., 2019, In: Molecular Systems Biology. 15, 5, 15 p., e8719.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  48 Citations (Scopus)

  142 Downloads (Pure)

• Fast Translation within the First 45 Codons Decreases mRNA Stability and Increases Premature Transcription Termination in E. coli

  Pedersen, S., Terkelsen, T. B., Eriksen, M., Hauge, M. K., Lund, C. C., Sneppen, K. & Mitarai, N., 2019, In: Journal of Molecular Biology. 431, 6, p. 1088-1097 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• Potential pharmacobezoar formation of large size extended-release tablets and their dissolution - an in vitro study

  Hoegberg, L. C. G., Refsgaard, F., Pedersen, S. H., Personne, M., Ullah, S., Panagiotidis, G., Petersen, T. S. & Annas, A., 3 Apr 2019, In: Clinical Toxicology. 57, 4, p. 271-281

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)
• 2017

  Inflammation Downregulates UCP1 Expression in Brown Adipocytes Potentially via SIRT1 and DBC1 Interaction

  Nøhr, M. K., Bobba, N., Richelsen, B., Lund, S. & Pedersen, S. B., 8 May 2017, In: International Journal of Molecular Sciences (CD-ROM). 18, 5, 1006.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  44 Citations (Scopus)

  76 Downloads (Pure)

• Occlusion of the ribosome binding site connects the translational initiation frequency, mRNA stability and premature transcription termination

  Eriksen, M., Sneppen, K., Pedersen, S. & Mitarai, N., 14 Mar 2017, In: Frontiers in Microbiology. 8, 7 p., 362.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  14 Citations (Scopus)

  181 Downloads (Pure)
• 2013

  Control of ribosome traffic by position-dependent choice of synonymous codons

  Mitarai, N. & Pedersen, S., 8 Oct 2013, In: Physical Biology. 10, 5, 056011.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• Molecular crowding limits translation and cell growth

  Klumpp, S., Scott, M., Pedersen, S. & Hwa, T., 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 42, p. 16754-16759 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  203 Citations (Scopus)
• 2011

  The functional half-life of an mRNA depends on the ribosome spacing in an early coding region

  Pedersen, M., Nissen, S., Mitarai, N., Lo Svenningsen, S., Sneppen, K. & Pedersen, S., 2011, In: Journal of Molecular Biology. 407, 1, p. 35-44 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  22 Citations (Scopus)

  2007 Downloads (Pure)
• 2010

  Economy of operon formation: cotranscription minimizes shortfall in protein complexes

  Sneppen, K., Pedersen, S., Krishna, S., Dodd, I. B. & Semsey, S., 21 Sep 2010, In: Microbe. 1, 4, p. e00177-10

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  23 Citations (Scopus)
• 2008

  Ribosome collisions and Translation efficiency: Optimization by codon usage and mRNA destabilization

  Mitarai, N., Sneppen, K. & Pedersen, S., 2008, In: Journal of Molecular Biology. 382, 1, p. 236-245 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  125 Citations (Scopus)
• 2007

  Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination.

  Ejby, M., Sørensen, M. A. & Pedersen, S., 2007, In: Proceedings of the National Academy of Science of the United States of America. 104, 49, p. 19410-5 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  52 Citations (Scopus)
• 2003

  Limiting factors in Escherichia colifed-batch production of recombinant proteins

  Sanden, A. M., Prytz, I., Tubelekas, I., Forsberg, C., Le, H., Hektor, A., Neubauer, P., Pragai, Z., Harwood, C., Ward, A., Picon, A., de Mattos, J. T., Postma, P., Farewell, A., Nystrøm, T., Reeh, S., Pedersen, S. & Larsson, G., 2003, In: Biotechnology and Bioengineering (Print). 81(2), p. 158-166

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2002

  Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome

  Buhl, E. S., Jessen, N., Pold, R., Ledet, T., Flyvbjerg, A., Pedersen, S. B., Pedersen, O., Schmitz, O. & Lund, S., 2002, In: Diabetes. 51, 7, p. 2199-206 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  214 Citations (Scopus)
• 2000

  Thermodynamics of heat-shock response. Bourke Arnvig K, Pedersen S, Sneppen K

  Pedersen, S., 2000, In: Physical Review Letters. p. Phys Rev Lett; 84: 3005-8. 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  14 Citations (Scopus)
• 1998

  Determination of the Peptide Elongation Rate in vivo

  Sørensen, M. A. & Pedersen, S., 1998, Protein Synthesis: Methods and protocols. Totowa, N.J., U.S.A.: Humana Press, p. 129-142

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  8 Citations (Scopus)

• Ribosomal Protein S1 required for translation of most, if not all, natural mRNAs in Escherichia coli in vivo

  Sørensen, M. A., Fricke, J. & Pedersen, S., 1998, In: Journal of Molecular Biology. 280, p. 561-569

  Research output: Contribution to journal › Journal article › Research › peer-review

• The modification of the wobble base of tRNA(Glu) modulates the translation rate of glutamic acid codons in vivo

  Krüger, M. K., Pedersen, S., Hagervall, T. G. & Sørensen, M. A., 4 Dec 1998, In: Journal of Molecular Biology. 284, 3, p. 621-631 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  109 Citations (Scopus)

• The modification of the wobble base of tRNA^Glu modulates the translation rate of glutamic acid codons in vivo

  Krüger, M. K., Pedersen, S., Hagervall, T. G. & Sørensen, M. A., 1998, In: J. Mol. Biol.. 284, p. 609-620

  Research output: Contribution to journal › Journal article › Research › peer-review
• 1995

  The cmk Gene Encoding Cytidine Monophosphate Kinase is located in the rpsA Operon and is required for normal replication rate in Escherichia coli

  Fricke, J., Neuhard, J., Kelln, R. A. & Pedersen, S., 1995, In: Journal of Bacteriology. Vol 177, No 3, p. 517-523

  Research output: Contribution to journal › Journal article › Research

  55 Citations (Scopus)
• 1994

  Concentrations of 4.5S RNA and Ffh Protein in Escherichia coli: the Stability of Ffh Protein is Dependent on the Concentration of 4.5S RNA

  Jensen, C. G. & Pedersen, S., 1994, In: Journal of Bacteriology. Vol 176, No 23, p. 7148-7154

  Research output: Contribution to journal › Journal article › Research

  62 Citations (Scopus)

• Effect of 4.5S RNA Depletion on Escherichia coli Protein Synthesis and Secretion

  Jensen, C. G., Brown, S. & Pedersen, S., 1994, In: Journal of Bacteriology. Vol 176, No 9, p. 2502-2506

  Research output: Contribution to journal › Journal article › Research › peer-review

  22 Citations (Scopus)

• High Concentrations of ppGpp Decrease the RNA Chain Growth Rate. Implications for Protein Synthesis and Translation Fidelity During Amino Acid Starvation in Escherichia coli

  Sørensen, M. A., Jensen, K. F. & Pedersen, S., 1994, In: Journal of Molecular Biology. Vol 236, p. 441-454

  Research output: Contribution to journal › Journal article › Research › peer-review
• 1993

  Isolation and characterization of mutants with impaired regulation of rpsA, the gene encoding ribosomal protein S1 of Escherichia coli

  Rasmussen, M. D., Sørensen, M. A. & Pedersen, S., 1993, In: Molecular Genetics and Genomics. 240, p. 23-28

  Research output: Contribution to journal › Journal article › Research › peer-review

  10 Citations (Scopus)

• Synthesis of proteins in Escherichia coli is limited by the concentration of free ribosomes

  Vind, J., Sørensen, M. A., Rasmussen, M. D. & Pedersen, S., 1993, In: Journal of Molecular Biology. Vol. 231, p. 678-688

  Research output: Contribution to journal › Journal article › Research › peer-review

  171 Citations (Scopus)
• 1992

  Decreasing transcription elongation rate in Escherichia coli exposed to amino acid starvation

  Vogel, U., Sørensen, M. A., Pedersen, S., Jensen, K. F. & Kilstrup, M., 1992, In: Molecular Microbiology. 6, 15, p. 2191-2200

  Research output: Contribution to journal › Journal article › Research › peer-review
  61 Citations (Scopus)

• The rates of macromolecular chain elongation modulate the initiation frequences for transcription and translation in Escherichia coli

  Sørensen, M. A., Vogel, U., Jensen, K. F. & Pedersen, S., 1992, In: Antonie van Leeuwenhoek. International Journal of General and Molecular Microbiology. 63, p. 323-331

  Research output: Contribution to journal › Journal article › Research

  9 Citations (Scopus)
• 1991

  Absolute in vivo translation rates of individual codons in Escherichia coli: The two glutamic acid codons GAA and GAG are translated with a threefold difference in rate

  Sørensen, M. A. & Pedersen, S., 1991, In: Journal of Molecular Biology. 222, 2, p. 265-280

  Research output: Contribution to journal › Journal article › Research › peer-review
  241 Citations (Scopus)

• An unusual correlation between ppGpp pool size and rate of ribosome synthesis during partial pyrimidine starvation of Escherichia coli

  Vogel, U., Pedersen, S. & Jensen, K. F., 1991, In: Journal of Bacteriology. 173, 3, p. 1168-1174

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• ClpB Is the Escherichia coli Heat Shock Protein F84.1

  Squires, C. L., Pedersen, S., Ross, B. M. & Squires, C., 1991, In: J. Bacteriol.. Vol.173, no.14, p. 4254-62

  Research output: Contribution to journal › Journal article › Research

• Cysteine, Even in Low Concentrations, Induces Transient Amino Acid Starvation in Escherichia coli

  Sørensen, M. A. & Pedersen, S., 1991, In: J. Bacteriol.. Vol.173, no.16, p. 5244-46

  Research output: Contribution to journal › Journal article › Research › peer-review
• 1990

  Measurement of translation rates in vivo at individual codons and implication of these rate differences for gene expression

  Sørensen, M. A., Jensen, K. F. & Pedersen, S., 1990, Post-Transcriptional Control of Gene Expression. NATO Asi Series, vol 49. Vol. 49. p. 207-216

  Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research

• Metabolic growth rate control in Escherichia coli may be a consequence of subsaturation of the macromolecular biosynthetic apparatus with substrates and catalytic components.

  Jensen, K. F. & Pedersen, S., 1990, In: Microbiology and Molecular Biology Reviews. 54, 2, p. 89-100

  Research output: Contribution to journal › Review › Research
  131 Citations (Scopus)
• 1989

  Codon usage determines translation rate in Escherichia coli

  Sørensen, M. A., Kurland, C. G. & Pedersen, S., 1989, In: Journal of Molecular Biology. 207, 2, p. 365-77 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  488 Citations (Scopus)